Robert B. Felder, MD

Portrait
Professor of Internal Medicine - Cardiovascular Medicine

Contact Information

Office
E318-1 GH
Iowa City, IA 52242
319-356-3642

Education

MD, Medicine, University of North Carolina
Internship, Internal Medicine, Duke Medical Center
Resident, Internal Medicine, University of Iowa Hospitals and Clinics
Fellow, Cardiovascular Diseases, University of Iowa Hospitals and Clinics
Fellow, Physiology, Royal Free Hospital School of Medicine, University of London

Licensure and Certifications

Subspecialty Board of Cardiovascular Disease
Iowa Medical License
American Board of Internal Medicine

Research Summary

Central neural mechanisms in heart failure and hypertension, with emphasis on the effects of angiotensin II, aldosterone and the pro-inflammatory cytokines on forebrain regions regulating the sympathetic nervous system.

Publications

Yu, Y., Wei, S., Weiss, R. M. & Felder, R. B. (In Press). Sex Differences in the Central and Peripheral Manifestations of Ischemia-induced Heart Failure in Rats. American Journal of Physiology: Heart and Circulatory Physiology.

Yu, Y., Wei, S., Weiss, R. M. & Felder, R. B. (2018). Angiotensin II type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats. Neuroscience, 381, 46-58. PMID: 29684507.

Wei, S., Yu, Y. & Felder, R. B. (2018). Blood-borne Interleukin-1b Acts upon the Subfornical Organ to Upregulate the Sympathoexcitatory Milieu of the Hypothalamic Paraventricular Nucleus. Am J Physiol Regul Integr Comp Physiol, 314, R447-R458. DOI: doi:10.1152/ajpregu.00211.2017.

(2018). Sex Differences in the Central and Peripheral Manifestations of Heart Failure in Rats. (Vols. 32). pp. 593.2. FASEB J.

(2018). Epidermal Growth Factor Receptor in the Hypothalamic Paraventricular Nucleus Contributes to Tumor Necrosis Factor-a-Induced Sympathetic Excitation in Rat. (Vols. 32). pp. 732.3. FASEB J.

Yu, Y., Wei, S. G., Weiss, R. M. & Felder, R. B. (2017). TNF-a Receptor 1 Knockdown in the Subfornical Organ Ameliorates Sympathetic Excitation and Cardiac Hemodynamics in Heart Failure Rats. Am J Physiol Heart Circ Physiol, 313, H744-H756. DOI: 10.1152/ajpheart.00280.2017.

Xue, B. J., Thunhorst, R. L., Yu, Y., Guo, F., Beltz, T. G., Felder, R. B. & Johnson, A. L. (2016). Central Renin-Angiotensin System Activation and Inflammation Induced by High-Fat Diet Sensitize Angiotensin II-Elicited Hypertension. Hypertension, 67, 163-170. PMID: 26573717.

Wei, S. G., Yu, Y., Weiss, R. M. & Felder, R. B. (2016). Endoplasmic Reticulum Stress Increases Brain MAPK Signaling, Inflammation and Renin-Angiotensin System Activity and Sympathetic Nerve Activity in Heart Failure. Am J Physiol Heart Circ Physiol, 311, H871-H880. PMID: 27496879.

Yu, Y., Wei, S. G., Zhang, Z. H., Weiss, R. M. & Felder, R. B. (2016). ERK1/2 MAPK Signaling in Hypothalamic Paraventricular Nucleus Contributes to Sympathetic Excitation in Rats with Heart Failure after Myocardial Infarction. Am J Physiol Heart Circ Physiol, 310, H732-H739. PMID: 26801309.

Wei, S. G., Yu, Y., Weiss, R. M. & Felder, R. B. (2016). Inhibition of Brain Mitogen-Activated Protein Kinase Signaling Reduces Central Endoplasmic Reticulum Stress and Inflammation and Sympathetic Nerve Activity in Heart Failure Rats. Hypertension, 67, 229-236. PMID: 26573710.

Xue, B. J., Yu, Y., Zhang, Z., Guo, F., Beltz, T. G., Thunhorst, R. L., Felder, R. B. & Johnson, A. K. (2016). Leptin Mediates High-Fat Diet Sensitization of Angiotensin II-elicited Hypertension by Upregulating the Brain Renin-Angiotensin System and Inflammation. Hypertension, 67, 970-976. PMID: 27021010.

Yu, Y., Xue, B. J., Wei, S. G., Zhang, Z. H., Beltz, T. G., Guo, F., Johnson, A. K. & Felder, R. B. (2015). Activation of Central PPAR-gamma Attenuates Angiotensin II-Induced Hypertension. Hypertension, 66, 403-411. PMID: 26101342.

Wei, S. G., Yu, Y., Zhang, Z. H. & Felder, R. B. (2015). Pro-inflammatory Cytokines Upregulate Sympathoexcitatory Mechanisms in the Subfornical Organ of the Rat. Hypertension, 65, 1126-1133. PMID: 25776070.

Wei, S. G., Zhang, Z. H., Yu, Y. & Felder, R. B. (2014). Central SDF-1/CXCL12 Expression and its Cardiovascular and Sympathetic Effects: The Role of Angiotensin II, TNF-alpha and MAP Kinase Signaling. Am J Physiol Heart Circ Physiol, 307, H1643-H1654. PMID: 25260613.

Wei, S. G., Zhang, Z. H., Beltz, T. G., Yu, Y., Johnson, A. K. & Felder, R. B. (2013). Subfornical Organ Mediates Sympathetic and hemodynamic Responses to Blood-borne Proinflammatory Cytokines. Hypertension, 62(1), 118-25. PMID: 23670302.

Yu, Y., Xue, B. J., Zhang, Z. H., Wei, S. G., Beltz, T. G., Guo, F., Johnson, A. K. & Felder, R. B. (2013). Early Interference with p44/42 Mitogen-Activated Protein Kinase Signaling in Hypothalamic Paraventricular Nucleus Attenuates Angiotensin II-induced Hypertension. Hypertension, 61(4), 842-9. PMID: 23438934.

Wei, S. G., Zhang, Z. H., Yu, Y., Weiss, R. M. & Felder, R. B. (2012). Central Actions of the Chemokine Stromal Cell-derived Factor 1 Contribute to Neurohumoral Excitation in Heart Failure Rats. Hypertension, 59(5), 991-8. PMID: 22493069.

Gudmundsson, H., Curran, J., Kashef, F., Snyder, J. S., Smith, S. A., Vargas-Pinto, P., Bonilla, I. M., Weiss, R. M., Anderson, M. E., Binkley, P., Felder, R. B., Carnes, C. A., Band, H., Hund, T. J. & Mohler, P. J. (2012). Differential Regulation of EHD3 in Human and Mammalian Heart Failure. J Mol Cell Cardiol, 52(5), 1183-90. PMID: 22406195.

Zhang, Z. H., Yu, Y., Wei, S. G. & Felder, R. B. (2012). Aldosterone-induced Brain MAPK Signaling and Sympathetic Excitation are Angiotensin II Type-1 Receptor Dependent. Am J Physiol Heart Circ Physiol, 302(3), H742-51. PMID: 22081704.

Yu, Y., Zhang, Z. H., Wei, S. G., Weiss, R. M. & Felder, R. B. (2012). Peroxisome Proliferator-activated Receptor-y Regulates Inflammation and Renin-angiotensin System Activity in the Hypothalamic Paraventricular Nucleus and Ameliorates peripheral manifestations of heart failure. Hypertension, 59(2), 477-84. PMID: 22083161.

Zhang, Z. H., Yu, Y., Wei, S. G., Nakamura, Y., Nakamura, K. & Felder, R. B. (2011). EP3 Receptors Mediate PGE2?-induced Hypothalamic Paraventricular Nucleus Excitation and Sympathetic Activation. Am J Physiol Heart Circ Physiol, 301(4), H1559-69. PMID: 21803943.

Zhang, Z. H., Yu, Y., Wei, S. G. & Felder, R. B. (2010). Centrally Administered Lipopolysaccharide Elicits Sympathetic Excitation Via NAD(P)H Oxidase-dependent Mitogen-activated Protein Kinase Signaling. J Hypertens, 28(4), 806-16. PMID: 20027123.

Yu, Y., Zhang, Z. H., Wei, S. G., Serrats, J., Weiss, R. M. & Felder, R. B. (2010). Brain Perivascular Macrophages and the Sympathetic Response to Inflammation in Rats After Myocardial Infarction. Hypertension, 55(3), 652-9. PMID: 20142564.

Felder, R. B. (2010). Mineralocorticoid Receptors, Inflammation and Sympathetic Drive in a Rat Model of Systolic Heart Failure. Exp Physiol, 95(1), 19-25. PMID: 19648480.

Tobaldini, E., Porta, A., Wei, S. G., Zhang, Z. H., Francis, J., Casali, K. R., Weiss, R. M., Felder, R. B. & Montano, N. (2009). Symbolic Analysis Detects Alterations of Cardiac Autonomic Modulation in Congestive Heart Failure Rats. Auton Neurosci, 150(1-2), 21-6. PMID: 19403339.

Felder, R. B., Yu, Y., Zhang, Z. H. & Wei, S. G. (2009). Pharmacological Treatment for Heart Failure: A View from the Brain. Clin Pharmacol Ther, 86(2), 216-20. PMID: 19553933.

Wei, S. G., Yu, Y., Zhang, Z. H. & Felder, R. B. (2009). Angiotensin II Upregulates Hypothalamic AT1 Receptor Expression in Rats Aia the Mitogen-activated Protein Kinase Pathway. Am J Physiol Heart Circ Physiol, 296(5), H1425-33. PMID: 19286949.

Wei, S. G., Zhang, Z. H., Yu, Y. & Felder, R. B. (2009). Systemically Administered Tempol Reduces Neuronal Activity in Paraventricular Nucleus of Hypothalamus and Rostral Ventrolateral Medulla in Rats. J Hypertens, 27(3), 543-50. PMID: 19330914.

Tobaldini, E., Montano, N., Wei, S. G., Zhang, Z. H., Francis, J., Weiss, R. M., Casali, K. R., Felder, R. B. & Porta, A. (2009). Autonomic Cardiovascular Modulation. IEEE Engineering in Medicine and Biology Magazine: the quarterly magazine of the Engineering in Medicine & Biology Society, 28(6), 79-85. PMID: 19914892.

Wei, S. G., Yu, Y., Zhang, Z. H., Weiss, R. M. & Felder, R. B. (2008). Mitogen-activated Protein Kinases Mediate Upregulation of Hypothalamic Angiotensin II Type 1 Receptors in Heart Failure Rats. Hypertension, 52(4), 679-86. PMID: 18768402.

Wei, S. G., Yu, Y., Zhang, Z. H., Weiss, R. M. & Felder, R. B. (2008). Angiotensin II-triggered p44/42 Mitogen-Activated Protein Kinase Mediates Sympathetic Excitation in Heart Failure Rats. Hypertension, 52(2), 342-50. PMID: 18574076.

Zhang, Z. H., Felder, R. B. (2008). Hypothalamic Corticotrophin-releasing Factor and Norepinephrine Mediate Sympathetic and Cardiovascular Responses to Acute Intracarotid Injection of Tumour Necrosis Factor-alpha in the Rat. J Neuroendocrinol, 20(8), 978-87. PMID: 18777604.

Kang, Y. M., Zhang, Z. H., Xue, B., Weiss, R. M. & Felder, R. B. (2008). Inhibition of Brain Proinflammatory Cytokine Synthesis Reduces Hypothalamic Excitation in Rats With Ischemia-induced Heart Failure. Am J Physiol Heart Circ Physiol, 295(1), H227-36. PMID: 18487441.

Yu, Y., Wei, S. G., Zhang, Z. H., Gomez-Sanchez, E., Weiss, R. M. & Felder, R. B. (2008). Does Aldosterone Upregulate the Brain Renin-Angiotensin System in Rats With Heart Failure?. Hypertension, 51(3), 727-33. PMID: 18227408.

Zhang, Z. H., Yu, Y., Kang, Y. M., Wei, S. G. & Felder, R. B. (2008). Aldosterone Acts Centrally to Increase Brain Renin-angiotensin System Activity and Oxidative Stress in Normal Rats. Am J Physiol Heart Circ Physiol, 294(2), H1067-74. PMID: 18162560.

Yu, Y., Zhang, Z. H., Wei, S. G., Chu, Y., Weiss, R. M., Heistad, D. D. & Felder, R. B. (2007). Central Gene Transfer of Interleukin-10 Reduces Hypothalamic Inflammation and Evidence of Heart Failure in Rats After Myocardial Infarction. Circ Res, 101(3), 304-12. PMID: 17569888.

Yu, Y., Kang, Y. M., Zhang, Z. H., Wei, S. G., Chu, Y., Weiss, R. M. & Felder, R. B. (2007). Increased Cyclooxygenase-2 Expression in Hypothalamic Paraventricular Nucleus in Rats With Heart Failure: Role of Nuclear Factor KappaB. Hypertension, 49(3), 511-8. PMID: 17242297.

Miller, J. D., Lund, D. D., Serrano, K. M., Chu, Y., Weiss, R. M., Brooks, R. M., Richenbacher, W. E., Pena-Silva, R. A., Everett, J. E. & Heistad, D. D. (2007). Superoxide in calcified regions of stenotic human aortic valves. (Vols. 21). pp. A446. FASEB J.

Kang, Y. M., Zhang, Z. H., Johnson, R. F., Yu, Y., Beltz, T., Johnson, A. K., Weiss, R. M. & Felder, R. B. (2006). Novel Effect of Mineralocorticoid Receptor Antagonism to Reduce Proinflammatory Cytokines and Hypothalamic Activation in Rats With Ischemia-induced Heart Failure. Circ Res, 99(7), 758-66. PMID: 16960100.

Zhang, Z. H., Kang, Y. M., Yu, Y., Wei, S. G., Schmidt, T. J., Johnson, A. K. & Felder, R. B. (2006). 11Beta-Hydroxysteroid Dehydrogenase Type 2 Activity in Hypothalamic Paraventricular Nucleus Modulates Sympathetic Excitation. Hypertension, 48(1), 127-33. PMID: 16717146.

Aggarwala, G., Weiss, R. M., Iyengar, N. & Jagasia, D. (2006). Increased Prevalence of Elevated Trans-Aortic Valve Gradients in Patients with Medtronic Mosaic Bioprosthetic Valves. Presented at the ASE 17th Annual Scientific Sessions.

Yu, Y., Wei, S. G., Zhang, Z. H., Wang, H., Weiss, R. M. & Felder, R. B. (2006). Angiotensin II Type 1 receptor antagonism reduces sympatho-excitatory inflammatory mediators in paraventricular nucleus of hypothalamus in rats with heart failure. (Vols. 114). pp. II-30. Circulation.

Grippo, A. J., Francis, J., Beltz, T. G., Felder, R. B. & Johnson, A. K. (2005). Neuroendocrine and Cytokine Profile of Chronic Mild Stress-induced Anhedonia. Physiol Behav, 84(5), 697-706. PMID: 15885245.

Kang, Y., Zhang, Z., Weiss, R. M., Johnson, A. K. & Felder, R. B. (2005). Activation of central corticotropin releasing hormone by angiotensin II promotes sympathetic excitation and progression of heart failure in the rat. (Vols. 112). (17), pp. II-191. Circulation.

Francis, J., Wei, S. G., Weiss, R. M. & Felder, R. B. (2004). Brain Angiotensin-converting Enzyme Activity and Autonomic Regulation in Heart Failure. Am J Physiol Heart Circ Physiol, 287(5), H2138-46. PMID: 15475532.

Francis, J., Zhang, Z. H., Weiss, R. M. & Felder, R. B. (2004). Neural Regulation of the Proinflammatory Cytokine Response to Acute Myocardial Infarction. Am J Physiol Heart Circ Physiol, 287(2), H791-7. PMID: 15277202.

Francis, J., Chu, Y., Johnson, A. K., Weiss, R. M. & Felder, R. B. (2004). Acute Myocardial Infarction Induces Hypothalamic Cytokine Synthesis. Am J Physiol Heart Circ Physiol, 286(6), H2264-71. PMID: 15148057.

Grippo, A. J., Santos, C. M., Johnson, R. F., Beltz, T. G., Martins, J. B., Felder, R. B. & Johnson, A. K. (2004). Increased Susceptibility to Ventricular Arrhythmias in a Rodent Model of Experimental Depression. Am J Physiol Heart Circ Physiol, 286(2), H619-26. PMID: 14715499.

Zhang, Z. H., Felder, R. B. (2004). Melanocortin Receptors Mediate the Excitatory Effects of Blood-borne Murine Leptin on Hypothalamic Paraventricular Neurons in Rat. Am J Physiol Regul Integr Comp Physiol, 286(2), R303-10. PMID: 14707012.

Francis, J., Beltz, T., Johnson, A. K. & Felder, R. B. (2003). Mineralocorticoids Act Centrally to Regulate Blood-borne Tumor Necrosis Factor-alpha in Normal Fats. Am J Physiol Regul Integr Comp Physiol, 285(6), R1402-9. PMID: 14615404.

Zhang, Z. H., Wei, S. G., Francis, J. & Felder, R. B. (2003). Cardiovascular and Renal Sympathetic Activation by Blood-borne TNF-alpha in Rat: The Role of Central Prostaglandins. Am J Physiol Regul Integr Comp Physiol, 284(4), R916-27. PMID: 12626358.

Grippo, A. J., Francis, J., Weiss, R. M., Felder, R. B. & Johnson, A. K. (2003). Cytokine Mediation of Experimental Heart Failure-induced Anhedonia. Am J Physiol Regul Integr Comp Physiol, 284(3), R666-73. PMID: 12611391.

Francis, J., Weiss, R. M., Johnson, A. K. & Felder, R. B. (2003). Central Mineralocorticoid Receptor Blockade Decreases Plasma TNF-alpha After Coronary Artery Ligation in Rats. Am J Physiol Regul Integr Comp Physiol, 284(2), R328-35. PMID: 12529282.

Felder, R. B., Francis, J., Zhang, Z. H., Wei, S. G., Weiss, R. M. & Johnson, A. K. (2003). Heart Failure and the Brain: New Perspectives. Am J Physiol Regul Integr Comp Physiol, 284(2), R259-76. PMID: 12529279.

Zhang, Z. H., Francis, J., Weiss, R. M. & Felder, R. B. (2002). The Renin-angiotensin-aldosterone System Excites Hypothalamic Paraventricular Nucleus Neurons in Heart Failure. Am J Physiol Heart Circ Physiol, 283(1), H423-33. PMID: 12063317.

Hayward, L. F., Riley, A. P. & Felder, R. B. (2002). Alpha(2)-Adrenergic Receptors in NTS Facilitate Baroreflex Function in Adult Spontaneously Hypertensive Rats. Am J Physiol Heart Circ Physiol, 282(6), H2336-45. PMID: 12003844.

Francis, J., Wei, S. G., Weiss, R. M., Beltz, T., Johnson, A. K. & Felder, R. B. (2002). Forebrain-mediated Adaptations to Myocardial Infarction in the Rat. Am J Physiol Heart Circ Physiol, 282(5), H1898-906. PMID: 11959657.

Wei, S. G., Felder, R. B. (2002). Forebrain Renin-angiotensin System has a Tonic Excitatory Influence on Renal Sympathetic Nerve Activity. Am J Physiol Heart Circ Physiol, 282(3), H890-5. PMID: 11834483.

Francis, J., Weiss, R. M., Wei, S. G., Johnson, A. K., Beltz, T. G., Zimmerman, K. & Felder, R. B. (2001). Central Mineralocorticoid Receptor Blockade Improves Volume Regulation and Reduces Sympathetic Drive in Heart Failure. Am J Physiol Heart Circ Physiol, 281(5), H2241-51. PMID: 11668089.

Francis, J., Weiss, R. M., Wei, S. G., Johnson, A. K. & Felder, R. B. (2001). Progression of Heart Failure After Myocardial Infarction in the Rat. Am J Physiol Regul Integr Comp Physiol, 281(5), R1734-45. PMID: 11641147.

Felder, R. B., Francis, J., Weiss, R. M., Zhang, Z. H., Wei, S. G. & Johnson, A. K. (2001). Neurohumoral regulation in ischemia-induced heart failure. Role of the forebrain. PMID: 11458700.

Hayward, L. F., Johnson, A. K. & Felder, R. B. (1999). Arterial Chemoreflex in Conscious Normotensive and Hypertensive Adult Rats. Am J Physiol, 276(4 Pt 2), H1215-22. PMID: 10199845.

Hayward, L. F., Felder, R. B. (1999). Electrophysiological Properties of Rat Lateral Parabrachial Neurons In Vitro. Am J Physiol, 276(3 Pt 2), R696-706. PMID: 10070129.

Hayward, L. F., Felder, R. B. (1998). Lateral Parabrachial Nucleus Modulates Baroreflex Regulation of Sympathetic Nerve Activity. Am J Physiol, 274(5 Pt 2), R1274-82. PMID: 9644040.

Hegarty, A. A., Felder, R. B. (1997). Vasopressin and V1-receptor Antagonists Modulate the Activity of NTS Neurons Receiving Baroreceptor Input. Am J Physiol, 273(1 Pt 2), R143-52. PMID: 9249543.

Sundaram, K., Johnson, S. M. & Felder, R. B. (1997). Altered Expression of Delayed Excitation in Medial NTS Neurons of Spontaneously Hypertensive Rats. Neuroscience Letters, 225(3), 205-9. PMID: 9147406.

Hegarty, A. A., Hayward, L. F. & Felder, R. B. (1996). Influence of Circulating Angiotensin II and Vasopressin on Neurons of the Nucleus of the Solitary Tract. Am J Physiol, 270(3 Pt 2), R675-81. PMID: 8780236.

Hegarty, A. A., Felder, R. B. (1995). Antagonism of Vasopressin V1 Receptors in NTS Attenuates Baroreflex Control of Renal Nerve Activity. Am J Physiol, 269(3 Pt 2), H1080-6. PMID: 7573505.

Hayward, L. F., Felder, R. B. (1995). Cardiac Rhythmicity Among NTS Neurons and its Relationship to Sympathetic Outflow in Rabbits. Am J Physiol, 269(3 Pt 2), H923-33. PMID: 7573536.

Hayward, L. F., Felder, R. B. (1995). Peripheral Chemoreceptor Inputs to the Parabrachial Nucleus of the Rat. Am J Physiol, 268(3 Pt 2), R707-14. PMID: 7900914.

Hegarty, A. A., Hayward, L. F. & Felder, R. B. (1995). Sympathetic Responses to Stimulation of Area Postrema in Decerebrate and Anesthetized Rats. Am J Physiol, 268(3 Pt 2), H1086-95. PMID: 7900862.

Ma, S., Abboud, F. M. & Felder, R. B. (1995). Effects of L-arginine-derived Nitric Oxide Synthesis on Neuronal Activity in Nucleus Tractus Solitarius. Am J Physiol, 268(2 Pt 2), R487-91. PMID: 7864245.

Felder, R. B., Mifflin, S. M. (1993). Baroreceptor and Chemoreceptor Afferent Processing in the Solitary Tract Nucleus. In R. A. Barroca (Eds.) Nucleus of the Solitary Tract. pp. 169-186. Boca Raton, Florida: CRC Press.

Johnson, S. M., Felder, R. B. (1993). Effects of Aging on the Intrinsic Membrane Properties of Medial NTS Neurons of Fischer-344 Rats. J Neurophysiol, 70(5), 1975-87. PMID: 7507521.

Hayward, L., Hay, M. & Felder, R. B. (1993). Acute Resetting of the Carotid Sinus Baroreflex by Aortic Depressor Nerve Stimulation. Am J Physiol, 264(4 Pt 2), H1215-22. PMID: 8476098.

Hajduczok, G., Hade, J. S., Mark, A. L., Williams, J. L. & Felder, R. B. (1991). Central Command Increases Sympathetic Nerve Activity During Spontaneous Locomotion in Cats. Circ Res, 69(1), 66-75. PMID: 2054943.

Feldman, P. D., Felder, R. B. (1991). Effects of Gamma-aminobutyric Acid and Glycine on Synaptic Excitability of Neurones in the Solitary Tract Nucleus. Neuropharmacology, 30(3), 225-36. PMID: 1852260.

Mifflin, S. W., Felder, R. B. (1990). Synaptic Mechanisms Regulating Cardiovascular Afferent Inputs to Solitary Tract Nucleus. Am J Physiol, 259(3 Pt 2), H653-61. PMID: 2204275.

Feldman, P. D., Felder, R. B. (1989). Alpha-adrenergic Influences on Neuronal Responses to Visceral Afferent Input in the Nucleus Tractus Solitarius. Neuropharmacology, 28(10), 1081-7. PMID: 2554181.

Feldman, P. D., Felder, R. B. (1989). Alpha 2-adrenergic Modulation of Synaptic Excitability in the Rat Nucleus Tractus Solitarius. Brain Res, 480(1-2), 190-7. PMID: 2540875.

Hade, J. S., Mifflin, S. W., Donta, T. S. & Felder, R. B. (1988). Stimulation of Parabrachial Neurons Elicits a Sympathetically Mediated Pressor Response in Cats. Am J Physiol, 255(6 Pt 2), H1349-58. PMID: 3202199.

Miller, B. D., Felder, R. B. (1988). Excitatory Amino Acid Receptors Intrinsic to Synaptic Transmission in Nucleus Tractus Solitarii. Brain Res, 456(2), 333-43. PMID: 2905191.

Felder, R. B., Mifflin, S. W. (1988). Modulation of Carotid Sinus Afferent Input to Nucleus Tractus Solitarius by Parabrachial Nucleus Stimulation. Circ Res, 63(1), 35-49. PMID: 3383382.

Mifflin, S. W., Felder, R. B. (1988). An intracellular study of time-dependent cardiovascular afferent interactions in nucleus tractus solitarius. J Neurophysiol, 59(6), 1798-813. PMID: 3404205.

Felder, R. B., Heesch, C. M. (1987). Interactions in Nucleus Tractus Solitarius Between Right and Left Carotid Sinus Nerves. Am J Physiol, 253(5 Pt 2), H1127-35. PMID: 3688256.

Felder, R. B. (1986). Excitatory and Inhibitory Interactions Among Renal a Cardiovascular Afferent Nerves in Dorsomedial Medulla. Am J Physiol, 250(4 Pt 2), R580-8. PMID: 3963228.

Donoghue, S., Felder, R. B., Gilbey, M. P., Jordan, D. & Spyer, K. M. (1985). Post-synaptic Activity Evoked in the Nucleus Tractus Solitarius by Carotid Sinus and Aortic Nerve Afferents in the Cat. J Physiol, 360, 261-73. PMID: 3989716.

Donoghue, S., Felder, R. B., Jordan, D. & Spyer, K. M. (1984). The Central Projections of Carotid Baroreceptors and Chemoreceptors in the Cat: A Neurophysiological Study. J Physiol, 347, 397-409. PMID: 6707961.

Spyer, K. M., Donoghue, S., Felder, R. B. & Jordan, D. (1984). Processing of Afferent Inputs in Cardiovascular Control. Clin Exp Hypertension. Part A, Theory and practice, 6(1-2), 173-84. PMID: 6697552.

Felder, R. B., Heesch, C. M. & Thames, M. D. (1983). Reflex Modulation of Carotid Sinus Baroreceptor Activity in the Dog. Am J Physiol, 244(3), H437-43. PMID: 6829786.

Felder, R. B., Thames, M. D. (1982). Responses to Activation of Cardiac Sympathetic Afferents with Epicardial Bradykinin. Am J Physiol, 242(2), H148-53. PMID: 7065147.

Felder, R. B., Thames, M. D. (1981). The Cardiocardiac Sympathetic Reflex During Coronary Occlusion in Anesthetized Dogs. Circ Res, 48(5), 685-92. PMID: 7214677.

Felder, R. B., Thames, M. D. (1979). Interaction Between Cardiac Receptors and Sinoaortic Baroreceptors in the Control of Efferent Cardiac Sympathetic Nerve Activity During Myocardial Ischemia in Dogs. Circ Res, 45(6), 728-36. PMID: 498436.