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Santosh Kumar, PhD

Assistant Professor of Internal Medicine-Cardiovascular Medicine

Current Positions

  • Assistant Professor of Internal Medicine-Cardiovascular Medicine

Education

  • PhD, Cardiovascular Pharmacology, All India Institute of Medical Sciences (AIIMS), New Delhi, India
  • Postdoctoral Fellow, Vascular Biology, University of Pittsburgh, Pittsburgh, Pennsylvania
  • Postdoctoral Fellow, Vascular Biology, University of Iowa Carver College of Medicine, Iowa City, Iowa

Center, Program and Institute Affiliations

Selected Publications

  • Kumar, S. (2020). Physical activity pacifies the problematic p66Shc. (Vols. 27). (2), pp. 166-167. European journal of preventive cardiology. DOI: 10.1177/2047487319886139. PMID: 31707837.
  • Kim, Y. R., Jacobs, J. S., Li, Q., Gaddam, R. R., Vikram, A., Liu, J., Kassan, M., Irani, K. & Kumar, S. (2019). SUMO2 regulates vascular endothelial function and oxidative stress in mice. American journal of physiology. Heart and circulatory physiology 317 (6) H1292-H1300. DOI: 10.1152/ajpheart.00530.2019. PMID: 31584834.
  • Murthy, S., Koval, O. M., Ramiro Diaz, J. M., Kumar, S., Nuno, D., Scott, J. A., Allamargot, C., Zhu, L. J., Broadhurst, K., Santhana, V., Kutschke, W. J., Irani, K., Lamping, K. G. & Grumbach, I. M. (2017). Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity. PloS one 12 (10) e0186311. DOI: 10.1371/journal.pone.0186311. PMID: 29059213. PMCID: PMC5653296.
  • Singh, M. V., Cicha, M. Z., Kumar, S., Meyerholz, D. K., Irani, K., Chapleau, M. W. & Abboud, F. M. (2017). Abnormal CD161+ immune cells and retinoic acid receptor-related orphan receptor γt-mediate enhanced IL-17F expression in the setting of genetic hypertension. The Journal of allergy and clinical immunology 140 (3) 809-821.e3. DOI: 10.1016/j.jaci.2016.11.039. PMID: 28093217. PMCID: PMC5511774.
  • Kassan, M., Vikram, A., Li, Q., Kim, Y. R., Kumar, S., Gabani, M., Liu, J., Jacobs, J. S. & Irani, K. (2017). MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1. Scientific reports 7 (1) 9308. DOI: 10.1038/s41598-017-06721-y. PMID: 28839162. PMCID: PMC5571183.
  • Vikram, A., Lewarchik, C. M., Yoon, J. Y., Naqvi, A., Kumar, S., Morgan, G. M., Jacobs, J. S., Li, Q., Kim, Y. R., Kassan, M., Liu, J., Gabani, M., Kumar, A., Mehdi, H., Zhu, X., Guan, X., Kutschke, W., Zhang, X., Boudreau, R. L., Dai, S., Matasic, D. S., Jung, S. B., Margulies, K. B., Kumar, V., Bachschmid, M. M., London, B. & Irani, K. (2017). Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel. Nature medicine 23 (3) 361-367. DOI: 10.1038/nm.4284. PMID: 28191886. PMCID: PMC6218171.
  • Kumar, S. P66Shc and vascular endothelial function. Bioscience reports 39 (4). DOI: 10.1042/BSR20182134. PMID: 30918103. PMCID: PMC6488855.
  • Kassan, M., Vikram, A., Kim, Y. R., Li, Q., Kassan, A., Patel, H. H., Kumar, S., Gabani, M., Liu, J., Jacobs, J. S. & Irani, K. (2017). Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress. Scientific reports 7 42265. DOI: 10.1038/srep42265. PMID: 28181559. PMCID: PMC5299412.
  • Li, Q., Kim, Y. R., Vikram, A., Kumar, S., Kassan, M., Gabani, M., Lee, S. K., Jacobs, J. S. & Irani, K. (2016). P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1. Arteriosclerosis, thrombosis, and vascular biology 36 (12) 2394-2403. DOI: 10.1161/ATVBAHA.116.308321. PMID: 27789474. PMCID: PMC5293179.
  • Vikram, A., Kim, Y. R., Kumar, S., Li, Q., Kassan, M., Jacobs, J. S. & Irani, K. (2016). Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1. Nature communications 7 12565. DOI: 10.1038/ncomms12565. PMID: 27586459. PMCID: PMC5025761.