Shunguang Wei, PhD

Portrait
Research Assistant Professor of Internal Medicine - Cardiovascular Medicine

Contact Information

Office: 514 MRC
501 Newton Road
Iowa City, Iowa 52242
319-384-4797

Education

BS, Physiology, Fudan University School of Life Sciences
MS, Cardiovascular Physiology, Shandong Medical University
PhD, Neuroscience, University of Iowa Carver College of Medicine

Research Summary

Research interests focus on the central neural mechanisms regulating cardiac function, hemodynamics, neuroendocrine release and sympathetic nervous system in cardiovascular diseases like heart failure and hypertension, with an emphasis on the role of proinflammatory cytokines and the renin-angiotensin-aldosterone system in the brain.

Publications

Yu, Y., Wei, S. G., Weiss, R. M. & Felder, R. B. (2017). TNF-a receptor 1 knockdown in subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats. American journal of physiology. Heart and circulatory physiology, ajpheart.00280.2017. PMID: 28710070.

Wei, S. G., Yu, Y., Weiss, R. M. & Felder, R. B. (2016). Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure. American journal of physiology. Heart and circulatory physiology, 311(4), H871-H880. PMID: 27496879.

Yu, Y., Wei, S. G., Zhang, Z. H., Weiss, R. M. & Felder, R. B. (2016). ERK1/2 MAPK signaling in hypothalamic paraventricular nucleus contributes to sympathetic excitation in rats with heart failure after myocardial infarction. American journal of physiology. Heart and circulatory physiology, 310(6), H732-9. PMID: 26801309.

Wei, S. G., Yu, Y., Weiss, R. M. & Felder, R. B. (2016). Inhibition of Brain Mitogen-Activated Protein Kinase Signaling Reduces Central Endoplasmic Reticulum Stress and Inflammation and Sympathetic Nerve Activity in Heart Failure Rats. Hypertension (Dallas, Tex. : 1979), 67(1), 229-36. PMID: 26573710.

Wei, S. G., Yu, Y., Zhang, Z. H. & Felder, R. B. (2015). Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat. Hypertension (Dallas, Tex. : 1979), 65(5), 1126-33. PMID: 25776070.

Yu, Y., Xue, B. J., Wei, S. G., Zhang, Z. H., Beltz, T. G., Guo, F., Johnson, A. K. & Felder, R. B. (2015). Activation of central PPAR-? attenuates angiotensin II-induced hypertension. Hypertension (Dallas, Tex. : 1979), 66(2), 403-11. PMID: 26101342.

Wei, S. G., Zhang, Z. H., Yu, Y. & Felder, R. B. (2014). Central SDF-1/CXCL12 expression and its cardiovascular and sympathetic effects: the role of angiotensin II, TNF-a, and MAP kinase signaling. American journal of physiology. Heart and circulatory physiology, 307(11), H1643-54. PMID: 25260613.

Wei, S. G., Zhang, Z. H., Beltz, T. G., Yu, Y., Johnson, A. K. & Felder, R. B. (2013). Subfornical organ mediates sympathetic and hemodynamic responses to blood-borne proinflammatory cytokines. Hypertension (Dallas, Tex. : 1979), 62(1), 118-25. PMID: 23670302.

Ganapathi, S. B., Wei, S. G., Zaremba, A., Lamb, F. S. & Shears, S. B. (2013). Functional regulation of ClC-3 in the migration of vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979), 61(1), 174-9. PMID: 23150504.

Yu, Y., Xue, B. J., Zhang, Z. H., Wei, S. G., Beltz, T. G., Guo, F., Johnson, A. K. & Felder, R. B. (2013). Early interference with p44/42 mitogen-activated protein kinase signaling in hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension. Hypertension (Dallas, Tex. : 1979), 61(4), 842-9. PMID: 23438934.

Yu, Y., Zhang, Z. H., Wei, S. G., Weiss, R. M. & Felder, R. B. (2012). Peroxisome proliferator-activated receptor-? regulates inflammation and renin-angiotensin system activity in the hypothalamic paraventricular nucleus and ameliorates peripheral manifestations of heart failure. Hypertension (Dallas, Tex. : 1979), 59(2), 477-84. PMID: 22083161.

Wei, S. G., Zhang, Z. H., Yu, Y., Weiss, R. M. & Felder, R. B. (2012). Central actions of the chemokine stromal cell-derived factor 1 contribute to neurohumoral excitation in heart failure rats. Hypertension (Dallas, Tex. : 1979), 59(5), 991-8. PMID: 22493069.

Zhang, Z. H., Yu, Y., Wei, S. G. & Felder, R. B. (2012). Aldosterone-induced brain MAPK signaling and sympathetic excitation are angiotensin II type-1 receptor dependent. American journal of physiology. Heart and circulatory physiology, 302(3), H742-51. PMID: 22081704.

Zhang, Z. H., Yu, Y., Wei, S. G., Nakamura, Y., Nakamura, K. & Felder, R. B. (2011). EP3 receptors mediate PGE2-induced hypothalamic paraventricular nucleus excitation and sympathetic activation. American journal of physiology. Heart and circulatory physiology, 301(4), H1559-69. PMID: 21803943.

Zhang, Z. H., Yu, Y., Wei, S. G. & Felder, R. B. (2010). Centrally administered lipopolysaccharide elicits sympathetic excitation via NAD(P)H oxidase-dependent mitogen-activated protein kinase signaling. Journal of hypertension, 28(4), 806-16. PMID: 20027123.

Yu, Y., Zhang, Z. H., Wei, S. G., Serrats, J., Weiss, R. M. & Felder, R. B. (2010). Brain perivascular macrophages and the sympathetic response to inflammation in rats after myocardial infarction. Hypertension (Dallas, Tex. : 1979), 55(3), 652-9. PMID: 20142564.

Tobaldini, E., Porta, A., Wei, S. G., Zhang, Z. H., Francis, J., Casali, K. R., Weiss, R. M., Felder, R. B. & Montano, N. (2009). Symbolic analysis detects alterations of cardiac autonomic modulation in congestive heart failure rats. Autonomic neuroscience : basic & clinical, 150(1-2), 21-6. PMID: 19403339.

Wei, S. G., Zhang, Z. H., Yu, Y. & Felder, R. B. (2009). Systemically administered tempol reduces neuronal activity in paraventricular nucleus of hypothalamus and rostral ventrolateral medulla in rats. Journal of hypertension, 27(3), 543-50. PMID: 19330914.

Felder, R. B., Yu, Y., Zhang, Z. H. & Wei, S. G. (2009). Pharmacological treatment for heart failure: a view from the brain. Clinical pharmacology and therapeutics, 86(2), 216-20. PMID: 19553933.

Wei, S. G., Yu, Y., Zhang, Z. H. & Felder, R. B. (2009). Angiotensin II upregulates hypothalamic AT1 receptor expression in rats via the mitogen-activated protein kinase pathway. American journal of physiology. Heart and circulatory physiology, 296(5), H1425-33. PMID: 19286949.

Tobaldini, E., Montano, N., Wei, S. G., Zhang, Z. H., Francis, J., Weiss, R. M., Casali, K. R., Felder, R. B. & Porta, A. (2009). Autonomic cardiovascular modulation. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society, 28(6), 79-85. PMID: 19914892.

Zhang, Z. H., Yu, Y., Kang, Y. M., Wei, S. G. & Felder, R. B. (2008). Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. American journal of physiology. Heart and circulatory physiology, 294(2), H1067-74. PMID: 18162560.

Wei, S. G., Yu, Y., Zhang, Z. H., Weiss, R. M. & Felder, R. B. (2008). Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats. Hypertension (Dallas, Tex. : 1979), 52(2), 342-50. PMID: 18574076.

Yu, Y., Wei, S. G., Zhang, Z. H., Gomez-Sanchez, E., Weiss, R. M. & Felder, R. B. (2008). Does aldosterone upregulate the brain renin-angiotensin system in rats with heart failure?. Hypertension (Dallas, Tex. : 1979), 51(3), 727-33. PMID: 18227408.

Wei, S. G., Yu, Y., Zhang, Z. H., Weiss, R. M. & Felder, R. B. (2008). Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats. Hypertension (Dallas, Tex. : 1979), 52(4), 679-86. PMID: 18768402.

Yu, Y., Kang, Y. M., Zhang, Z. H., Wei, S. G., Chu, Y., Weiss, R. M. & Felder, R. B. (2007). Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kappaB. Hypertension (Dallas, Tex. : 1979), 49(3), 511-8. PMID: 17242297.

Yu, Y., Zhang, Z. H., Wei, S. G., Chu, Y., Weiss, R. M., Heistad, D. D. & Felder, R. B. (2007). Central gene transfer of interleukin-10 reduces hypothalamic inflammation and evidence of heart failure in rats after myocardial infarction. Circulation research, 101(3), 304-12. PMID: 17569888.

Zhang, Z. H., Kang, Y. M., Yu, Y., Wei, S. G., Schmidt, T. J., Johnson, A. K. & Felder, R. B. (2006). 11beta-hydroxysteroid dehydrogenase type 2 activity in hypothalamic paraventricular nucleus modulates sympathetic excitation. Hypertension (Dallas, Tex. : 1979), 48(1), 127-33. PMID: 16717146.

Francis, J., Wei, S. G., Weiss, R. M. & Felder, R. B. (2004). Brain angiotensin-converting enzyme activity and autonomic regulation in heart failure. American journal of physiology. Heart and circulatory physiology, 287(5), H2138-46. PMID: 15475532.

Zhang, Z. H., Wei, S. G., Francis, J. & Felder, R. B. (2003). Cardiovascular and renal sympathetic activation by blood-borne TNF-alpha in rat: the role of central prostaglandins. American journal of physiology. Regulatory, integrative and comparative physiology, 284(4), R916-27. PMID: 12626358.

Felder, R. B., Francis, J., Zhang, Z. H., Wei, S. G., Weiss, R. M. & Johnson, A. K. (2003). Heart failure and the brain: new perspectives. American journal of physiology. Regulatory, integrative and comparative physiology, 284(2), R259-76. PMID: 12529279.

Wei, S. G., Felder, R. B. (2002). Forebrain renin-angiotensin system has a tonic excitatory influence on renal sympathetic nerve activity. American journal of physiology. Heart and circulatory physiology, 282(3), H890-5. PMID: 11834483.

Francis, J., Wei, S. G., Weiss, R. M., Beltz, T., Johnson, A. K. & Felder, R. B. (2002). Forebrain-mediated adaptations to myocardial infarction in the rat. American journal of physiology. Heart and circulatory physiology, 282(5), H1898-906. PMID: 11959657.

Felder, R. B., Francis, J., Weiss, R. M., Zhang, Z. H., Wei, S. G. & Johnson, A. K. (2001). Neurohumoral regulation in ischemia-induced heart failure. Role of the forebrain. Annals of the New York Academy of Sciences, 940, 444-53. PMID: 11458700.

Francis, J., Weiss, R. M., Wei, S. G., Johnson, A. K. & Felder, R. B. (2001). Progression of heart failure after myocardial infarction in the rat. American journal of physiology. Regulatory, integrative and comparative physiology, 281(5), R1734-45. PMID: 11641147.

Francis, J., Weiss, R. M., Wei, S. G., Johnson, A. K., Beltz, T. G., Zimmerman, K. & Felder, R. B. (2001). Central mineralocorticoid receptor blockade improves volume regulation and reduces sympathetic drive in heart failure. American journal of physiology. Heart and circulatory physiology, 281(5), H2241-51. PMID: 11668089.