William Sivitz, MD
Emeritus Professor of Internal Medicine-Endocrinology and Metabolism
Current Positions
- Emeritus Professor of Internal Medicine-Endocrinology and Metabolism
Education
- MD, Hahnemann University, Philadelphia, Pennsylvania
- Resident, Internal Medicine, Baystate Medical Center, Springfield, Massachusetts
- Fellow, Endocrine and Metabolism, Baystate Medical Center, Springfield, Massachusetts
- Fellow, Endocrine and Metabolism, University of Michigan, Ann Arbor, Michigan
Graduate Program Affiliations
Center, Program and Institute Affiliations
Licenses & Certifications
- Medical License, Iowa Board of Medicine
- Certification, American Board of Internal Medicine, Endcrinology, Diabetes, and Metabolism
Selected Publications
- Yu L, Fink BD, Som R, Sivitz WI. Metabolic clearance of oxaloacetate and mitochondrial complex II respiration: divergent control in skeletal muscle and brown adipose tissue. Biochim Biophys Acta Bioenerg. 2023 Jan 1;1864(1):148930. doi: 10.1016/j.bbabio.2022.148930, 2022
- Braffett BH, Bebu I, El Ghormli L, Cowie CC, Sivitz WI, Pop-Busui R, Larkin ME, Gubitosi-Klug RA, Nathan DM, Lachin JM, Dagogo-Jack S; DCCT/EDIC Research Group. Cardiometabolic Risk Factors and Incident Cardiovascular Disease Events in Women vs Men with Type 1 Diabetes. JAMA Netw Open. PMID 36074461, 5(9): e2230710, 2022
- Fink BD, Rauckhorst AJ, Taylor EB, Yu L and Sivitz WI. Membrane potential-dependent regulation of mitochondrial complex II by oxaloacetate in interscapular brown adipose tissue. FASEB Bioadvances doi.org/10.1096/fba.2021-2013, 2021
- Mishra A, Liu S, Promes J, Harata M, Sivitz W, Fink B, Bhardwaj G, O'Neill BT, Kang C, Sah R, Strack S, Stephens S, King T, Jackson L, Greenberg AS, Anokye-Danso F, Ahima RS, Ankrum J, Imai Y. Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria. JCI Insight. 6(9):e144341. doi: 10.1172/jci.insight.144341.PMID: 33784258, 2021
- Bhardwaj G, Penniman CM, Jena J, Suarez Beltran PA, Foster C, Poro K, Junck TL, Hinton AO Jr, Souvenir R, Fuqua JD, Morales PE, Bravo-Sagua R, Sivitz WI, Lira VA, Abel ED, O'Neill BT Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle. J Clin Invest. 131(18):e146415. doi: 10.1172/JCI146415, PMID: 34343133 2021
- Fink BD, Yu L, Coppey L, Obrosov A, Shevalye H, Kerns RJ, Yorek MA, Sivitz WI: Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Pharmacol Res Perspect. Feb;9(1):e00701. doi: 10.1002/prp2.701.PMID: 33547885, 2021
- Kulkarni CA, Fink BD, Gibbs BE, Chheda PR, Wu M, Sivitz WI, Kerns RJ.J: A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation. Med Chem. Jan 14;64(1):662-676. doi: 10.1021/acs.jmedchem.0c01671. Epub 2021 Jan 4.PMID: 33395531, 2021
- Bebu I, Braffett BH, Schade D, Sivitz W, Malone JI, Pop-Busui R, Lorenzi GM, Lee P, Trapani VR, Wallia A, Herman WH, Lachin JM: An Observational Study of the Equivalence of Age and Duration of Diabetes to Glycemic Control Relative to the Risk of Complications in the Combined Cohorts of the DCCT/EDIC Study. DCCT/EDIC Research Group.Diabetes Care. Oct;43(10):2478-2484. doi: 10.2337/dc20-0226. Epub 2020 Aug 11.PMID: 32788280, 2020
- Fink B, Coppey L, Davidson E, Shevalye H, Obrosov A, Chheda PR, Kerns R, Sivitz W, Yorek M: Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model. Free Radic Res. May;54(5):311-318. doi: 10.1080/10715762.2020.1754409. Epub 2020 Apr 24.PMID: 32326763, 2020
- Liu S, Promes JA, Harata M, Mishra A, Stephens SB, Taylor EB, Burand AJ Jr, Sivitz WI, Fink BD, Ankrum JA, Imai Y: Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells. Diabetes. Jun;69(6):1178-1192. doi: 10.2337/db19-0951. Epub 2020 Apr 20.PMID: 32312867, 2020