William Thiel, PhD

Research Assistant Professor of Internal Medicine - Hematology, Oncology and Blood and Marrow Transplantation

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Research Summary

My research interests are investigating the mechanisms of vascular disease development and progression using specific cell-targeting agents and to develop novel treatments with these reagents. The current focus of my research is developing cell-specific RNA ligands (aptamers) specific for vascular smooth muscle cells to inhibit migration and proliferation of these cells. My long term goal with the smooth muscle cell aptamers would be to use these reagents within drug eluting stents (DES) to improve stent efficacy and safety. Future efforts will be to expand upon RNA aptamer bioinformatics approaches during aptamer discovery and extend studies towards other areas of cardiovascular disease. These areas would include, but are not limited to: 1) Developing novel aptamer bioinformatics algorithms and establish these algorithms as user-friendly tools that enhance aptamer identification and optimization; and 2) developing heart-targeted RNA aptamers to study and treat heart failure and cardiac arrhythmia.