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Yumi Imai, MD

Professor of Internal Medicine-Endocrinology and Metabolism

Current Positions

  • Professor of Internal Medicine-Endocrinology and Metabolism
  • Section Chief, Endocrinology and Metabolism, Iowa City VA Healthcare System

Education

  • MD, Tohoku University, Sendai, Japan
  • Resident, Internal Medicine, Toranomon Hospital, Tokyo, Japan
  • Fellow, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

Graduate Program Affiliations

Center, Program and Institute Affiliations

Licenses & Certifications

  • Medical License, Iowa Board of Medicine
  • Certification, American Board of Internal Medicine
  • Certification, American Board of Internal Medicine, Endocrinology, Diabetes, and Metabolism

Selected Publications

  • Imai, Y., Soleimanpour, A.S., Tessem, J.S. Use of human model systems to understand pancreatic islet dysfunction in diabetes pathogenesis. Frontiers in Endocrinology. Accepted
  • O’Malley, Y., Coleman, M.C., Sun, X., Lei, J., Yao, J., Pulliam, C.F., Kluz, P., McCormick, M.L., Yi, Y., Imai, Y., Engelhardt, J.F., Norris, A.W., Spitz, D.R., & Uc, A. Oxidative Stress and Impaired Insulin Secretion in Cystic Fibrosis Pig Pancreas. Advance in Redox Research 5, 10040 (2022).
  • Gunasekar, S.K., Xie, L., Kumar, A., Hong, J., Chheda, P. R., Kang, C., Kern, D. M., My-Ta, C., Maurer, J., Heebink, J., Gerber, E. E., Grzesik, W. J., Elliot-Hudson, M., Zhang, Y., Key, P., Kulkarni, C. A., Beals, J. W., Smith, G. I., Samuel, I., Smith, J. K., Nau, P., Imai, Y., Sheldon, R. D., Taylor, E. B., Lerner, D. J., Norris, A. W., Klein, S., Brohawn, S. G. Kerns, R., & Sah, R. Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Nat Commun 13, 784 (2022).
  • Tong X, Liu S, Stein R, and Imai Y. Mini review: Lipid Droplets Role in the Regulation of Beta Cell Function and Beta Cell Demise in Type 2 Diabetes Endocrinology 163, bqac007 (2022)
  • Imai, Y. Deciphering regulatory protein activity in human pancreatic islets via reverse engineering of single-cell sequencing data. J Clin Invest 131(2021).
  • Cho, J., Tsugawa, Y., Imai, Y. & Imai, T. Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy. Biochem Biophys Res Commun 579, 110-115 (2021).
  • Li M, Shao F, Qian Q, Yu W, Zhang Z, Chen B, Su D, Guo Y, Phan A-V, Song L-S, Stephens SB, Sebag J, Imai Y, Yang L, Cao H. A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β-cells Molecular Therapy-Nucleic Acid 26, 307 (2021).
  • Mishra A, Liu S, Promes J, Harata M, Sivitz W, Fink B, Bhardwaj G, O'Neill BT, Kang C, Sah R, Strack S, Stephens S, KingT, Jackson L, Greenberg AS, Anokye-Danso F, Ahima RS, Ankrum J, Imai Y. Perilipin2 down-regulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria JCI Insight 6, e144341 (2021).
  • Imai, Y. My journey from Japan to becoming a physician-scientist in the United States. J Clin Invest 131(2021).
  • Bauchle, C.J., Rohli, K.E., Boyer, C.K., Pal, V., Rocheleau, J.V., Liu, S., Imai, Y., Taylor, E.B. & Stephens, S.B. Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet beta-Cell Function. Diabetes 70, 1717-1728 (2021).