Logo for University of Iowa Health Care This logo represents the University of Iowa Health Care

Recent Research Publications - July 2020

July 16-31, 2020

Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis. Gourronc FA, Markan KR, Kulhankova K, Zhu Z, Sheehy R, Quelle DE, Zingman LV, Kurago ZB, Ankrum JA, Klingelhutz AJ. PLoS One. 2020 Jul 30;15(7):e0236741. doi: 10.1371/journal.pone.0236741. eCollection 2020. PMID: 32730300

Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model. Zarei K, Stroik MR, Gansemer ND, Thurman AL, Ostedgaard LS, Ernst SE, Thornell IM, Powers LS, Pezzulo AA, Meyerholz DK, Stoltz DA. Lab Invest. 2020 Jul 27. doi: 10.1038/s41374-020-0474-8. Online ahead of print. PMID: 32719544

Tumor subtype determines therapeutic response to chimeric polypeptide nanoparticle-based chemotherapy in Pten-deleted mouse models of sarcoma.  Dodd RD, Scherer A, Huang W, McGivney GR, Gutierrez WR, Laverty E, Ashcraft KA, Stephens VR, Yousefpour P, Saha S, Knepper-Adrian VL, Floyd W, Chen M, Ma Y, Mastria EM, Cardona DM, Eward WC, Chilkoti A, Kirsch DG. Clin Cancer Res. 2020 Jul 27:clincanres.2597.2019. doi: 10.1158/1078-0432.CCR-19-2597. Online ahead of print. PMID: 32718998

Acidic Submucosal Gland pH and Elevated Protein Concentration Produce Abnormal Cystic Fibrosis Mucus.  Xie Y, Lu L, Tang XX, Moninger TO, Huang TJ, Stoltz DA, Welsh MJ. Dev Cell. 2020 Jul 23:S1534-5807(20)30550-5. doi: 10.1016/j.devcel.2020.07.002. Online ahead of print. PMID: 32730755

Noninvasive measurement of arterial blood pressure in patients with continuous-flow left ventricular assist devices: a systematic review.  Alvarez PA, Ponnapureddy R, Voruganti D, Duque ER, Briasoulis A. Heart Fail Rev. 2020 Jul 21. doi: 10.1007/s10741-020-10006-4. Online ahead of print. PMID: 32696152 Review.

Non-Conventional Treatments for Conventional Chondrosarcoma. Monga V, Mani H, Hirbe A, Milhem M. Cancers (Basel). 2020 Jul 19;12(7):E1962. doi: 10.3390/cancers12071962. PMID: 32707689 Review.

Colon mucosal neoplasia referred for endoscopic mucosal resection: Recurrence of adenomas and prediction of submucosal invasion. Rashid MU, Khetpal N, Zafar H, Ali S, Idrisov E, Du Y, Stein A, Jain D, Hasan MK. World J Gastrointest Endosc. 2020 Jul 16;12(7):198-211. doi: 10.4253/wjge.v12.i7.198. PMID: 32733641 Free PMC article.

The cardiovascular effects of treatment with hydroxychloroquine and azithromycin. Simmering JE, Polgreen LA, Polgreen PM, Teske RE, Comellas AP, Carter BL. Pharmacotherapy. 2020 Jul 16. doi: 10.1002/phar.2445. Online ahead of print. PMID: 32677113

A systematic review and meta-analysis comparing second-generation cryoballoon and contact force radiofrequency ablation for initial ablation of paroxysmal and persistent atrial fibrillation.  Ravi V, Poudyal A, Pulipati P, Larsen T, Krishnan K, Trohman RG, Sharma PS, Huang HD. J Cardiovasc Electrophysiol. 2020 Jul 16. doi: 10.1111/jce.14676. Online ahead of print. PMID: 32671920

July 1-15, 2020

A Systematic Review and Meta-Analysis Comparing Second-Generation Cryoballoon and Contact Force Radiofrequency Ablation for Initial Ablation of Paroxysmal and Persistent Atrial Fibrillation. Ravi V, Poudyal A, Pulipati P, Larsen T, Krishnan K, Trohman RG, Sharma PS, Huang HD. J Cardiovasc Electrophysiol. 2020 Jul 16. doi: 10.1111/jce.14676. Online ahead of print. PMID: 32671920

Fyn depletion ameliorates tauP301L-induced neuropathology. Liu G, Fiock KL, Levites Y, Golde TE, Hefti MM, Lee G. Acta Neuropathol Commun. 2020 Jul 14;8(1):108. doi: 10.1186/s40478-020-00979-6. PMID: 32665013

It Is Time to Rethink Biomarkers for Surveillance of Small Bowel Neuroendocrine Tumors. Tran CG, Sherman SK, Scott AT, Ear PH, Chandrasekharan C, Bellizzi AM, Dillon JS, O'Dorisio TM, Howe JR. Ann Surg Oncol. 2020 Jul 11. doi: 10.1245/s10434-020-08784-0. Online ahead of print. PMID: 32656719

Well-Being, Burnout, and Resiliency Among Early-Career Rheumatologists: A Qualitative Study. Kumar B, Swee ML, Suneja M, Iyer P. J Clin Rheumatol. 2020 Jul 9. doi: 10.1097/RHU.0000000000001485. Online ahead of print. PMID: 32658045

Peritoneal Cell-Free Tumor DNA as Biomarker for Peritoneal Surface Malignancies. Leick KM, Kazarian AG, Rajput M, Tomanek-Chalkley A, Miller A, Shrader HR, McCarthy A, Coleman KL, Kasi PM, Chan CHF. Ann Surg Oncol. 2020 Jul 9. doi: 10.1245/s10434-020-08832-9. Online ahead of print. PMID: 32648179

Adolph Lecture: Skeletal Muscle Atrophy: Multiple Pathways Leading to a Common Outcome. Bodine SC. J Appl Physiol (1985). 2020 Jul 9. doi: 10.1152/japplphysiol.00381.2020. Online ahead of print. PMID: 32644910

Nexilin is a New Player for Shaping T-Tubules in Cardiomyocytes. Wang J, Hall DD, Song LS. Circ Heart Fail. 2020 Jul 8:CIRCHEARTFAILURE120007196. doi: 10.1161/CIRCHEARTFAILURE.120.007196. Online ahead of print. PMID: 32635767 No abstract available.

Recent insights on the use of topical steroids in eosinophilic esophagitis. Reddy A, Ashat D, Murali AR. Expert Rev Gastroenterol Hepatol. 2020 Jul 7:1-11. doi: 10.1080/17474124.2020.1785869. Online ahead of print. PMID: 32567417

Donor-derived human herpesvirus 8 and development of Kaposi sarcoma among six recipients of organs from donors with high risk sexual and substance use behavior. Dollard SC, Annambhotla P, Wong P, Meneses K, Amin MM, La Hoz RM, Lease ED, Budev M, Arrossi AV, Basavaraju SV, Thomas CP. Am J Transplant. 2020 Jul 6. doi: 10.1111/ajt.16181. Online ahead of print. PMID: 32633035

Patient Aligned Care Team (PACT) Performance in Urban and Rural VHA Primary Care Clinics: A Mixed Methods Study. Lampman MA, Steffensmeier KRS, Reisinger HS, Sarrazin MV, Steffen MJA, Solimeo SL, Stewart GL, Mueller KJ. J Rural Health. 2020 Jul 6. doi: 10.1111/jrh.12490. Online ahead of print. PMID: 32632998

Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH. Thornell IM, Rehman T, Pezzulo AA, Welsh MJ. J Physiol. 2020 Jul 5. doi: 10.1113/JP280120. Online ahead of print. PMID: 32627187

Stopping the Routine use of Contact Precautions for Management of MRSA and VRE at Three Academic Medical Centers: An Interrupted Time Series Analysis. Haessler S, Martin EM, Scales ME, Kang L, Doll M, Stevens MP, Uslan DZ, Pryor R, Edmond MB, Godbout E, Abbas S, Bearman G. Am J Infect Control. 2020 Jul 4:S0196-6553(20)30642-8. doi: 10.1016/j.ajic.2020.06.219. Online ahead of print. PMID: 32634537

Residual functional SYNTAX score by quantitative flow ratio and improvement of exercise capacity after revascularization. Lee SH, Choi KH, Lee JM, Shin D, Hwang D, Kim HK, Doh JH, Nam CW, Shin ES, Jang MJ, Im SY, Park TK, Yang JH, Song YB, Hahn JY, Choi SH, Koo BK, Gwon HC. Catheter Cardiovasc Interv. 2020 Jul 3. doi: 10.1002/ccd.29118. Online ahead of print. PMID: 32618423

Do ICD Diagnostics Predict Failure of Ventricular Tachycardia Response to Anti-tachycardia Pacing and Need for Shock? Al-Damluji MS, Singhvi A, Snuckel M, Zaghloul A, Kluger J. Pacing Clin Electrophysiol. 2020 Jul 3. doi: 10.1111/pace.14002. Online ahead of print. PMID: 32617992

Is the Emergency Department an Inappropriate Venue for Code Status Discussions? Miller DG, Vakkalanka JP, Swanson MB, Nugent AS, Hagiwara Y. Am J Hosp Palliat Care. 2020 Jul 2:1049909120938332. doi: 10.1177/1049909120938332. Online ahead of print. PMID: 32613837

Association of Hospital-Level Acute Resuscitation and Postresuscitation Survival With Overall Risk-Standardized Survival to Discharge for In-Hospital Cardiac Arrest. Girotra S, Nallamothu BK, Tang Y, Chan PS; American Heart Association Get With The Guidelines–Resuscitation Investigators. JAMA Netw Open. 2020 Jul 1;3(7):e2010403. doi: 10.1001/jamanetworkopen.2020.10403. PMID: 32648925

Trends of lymphoma incidence in US veterans with rheumatoid arthritis, 2002-2017. Singh N, Gao Y, Field E, Link BK, Weiss N, Curtis JR, Lynch CF, Vaughan-Sarrazin M. RMD Open. 2020 Jul;6(2):e001241. doi: 10.1136/rmdopen-2020-001241. PMID: 32646953

An American Physiological Society cross-journal Call for Papers on "Deconstructing organs: Single-cell analyses, decellularized organs, organoids, and organ-on-a-chip models". Adams JC, Darwin Bell P, Bodine SC, Brooks HL, Bunnett NW, Joe B, Hansell Keehan K, Kleyman TR, Marette A, Morty RE, Ramirez JM, Thomsen MB, Yates BJ, Zucker IH. Am J Physiol Lung Cell Mol Physiol. 2020 Jul 1. doi: 10.1152/ajplung.00311.2020. Online ahead of print. PMID: 32609556 No abstract available.

'Comment on: "The Case for Retiring Flexibility as a Major Component of Physical Fitness". Kruse NT. Sports Med. 2020 Jul;50(7):1405-1407. doi: 10.1007/s40279-020-01291-y. PMID: 32385621 No abstract available.

Five Percent Monolaurin Vaginal Gel for the Treatment of Bacterial Vaginosis: A Randomized Placebo-Controlled Trial. Mancuso AC, Widdice LE, Hughes BL, Schlievert P, Swamy GK, Stockdale CK, Bernstein DI, Winokur PL. J Low Genit Tract Dis. 2020 Jul;24(3):277-283. doi: 10.1097/LGT.0000000000000543. PMID: 32379102

Comment on: Clinical characteristics and comorbidities in adult-onset Still's disease using a large US administrative claims database: reply. Lenert A, Oh G, Ombrello MJ, Kim S. Rheumatology (Oxford). 2020 Jul 1;59(7):1788. doi: 10.1093/rheumatology/keaa154. PMID: 32375168 No abstract available.

Clinical characteristics and comorbidities in adult-onset Still's disease using a large US administrative claims database. Lenert A, Oh G, Ombrello MJ, Kim S. Rheumatology (Oxford). 2020 Jul 1;59(7):1725-1733. doi: 10.1093/rheumatology/kez622. PMID: 31965185

Late Graft Loss After Kidney Transplantation: Is "Death With Function" Really Death With a Functioning Allograft? Gaston RS, Fieberg A, Helgeson ES, Eversull J, Hunsicker L, Kasiske BL, Leduc R, Rush D, Matas AJ; DeKAF Investigators*. Transplantation. 2020 Jul;104(7):1483-1490. doi: 10.1097/TP.0000000000002961. PMID: 31568212

The power of saying no.  Hinton AO Jr, McReynolds MR, Martinez D, Shuler HD, Termini CM. EMBO Rep. 2020 Jul 3;21(7):e50918. doi: 10.15252/embr.202050918. Epub 2020 Jun 28. PMID: 32596868

Comparative Effectiveness of Rivaroxaban, Apixaban, and Warfarin in Atrial Fibrillation Patients With Polypharmacy. Mentias A, Heller E, Vaughan Sarrazin M. Stroke. 2020 Jul;51(7):2076-2086. doi: 10.1161/STROKEAHA.120.029541. Epub 2020 Jun 10. PMID: 32517580

Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL. Hypertension. 2020 Aug;76(2):589-597. doi: 10.1161/HYPERTENSIONAHA.120.15137. Epub 2020 Jun 8. PMID: 32507042

ASICs are required for immediate exercise-induced muscle pain and are downregulated in sensory neurons by exercise training. Khataei T, Harding AMS, Janahmadi M, El-Geneidy M, Agha-Alinejad H, Rajabi H, Snyder PM, Sluka KA, Benson CJ. J Appl Physiol (1985). 2020 Jul 1;129(1):17-26. doi: 10.1152/japplphysiol.00033.2020. Epub 2020 May 28. PMID: 32463731

Aortic stiffness is associated with changes in retinal arteriole flow pulsatility mediated by local vasodilation in healthy young/middle-age adults. Holwerda SW, Kardon RH, Hashimoto R, Full JM, Nellis JK, DuBose LE, Fiedorowicz JG, Pierce GL. J Appl Physiol (1985). 2020 Jul 1;129(1):84-93. doi: 10.1152/japplphysiol.00252.2020. Epub 2020 May 21. PMID: 32437246

Differential Roles of Endothelial Cell-Derived and Smooth Muscle Cell-Derived Fibronectin Containing Extra Domain A in Early and Late Atherosclerosis. Doddapattar P, Dev R, Jain M, Dhanesha N, Chauhan AK. Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1738-1747. doi: 10.1161/ATVBAHA.120.314459. Epub 2020 May 21. PMID: 32434411

Sex differences in endothelial function in chronic kidney disease. Kruse NT, You Z, Moreau K, Kendrick J, Jalal D. Am J Physiol Renal Physiol. 2020 Jul 1;319(1):F33-F40. doi: 10.1152/ajprenal.00156.2020. Epub 2020 May 18. PMID: 32421350

Evaluation of Risk-Adjusted Home Time After Acute Myocardial Infarction as a Novel Hospital-Level Performance Metric for Medicare Beneficiaries. Pandey A, Keshvani N, Vaughan-Sarrazin MS, Gao Y, Girotra S. Circulation. 2020 Jul 7;142(1):29-39. doi: 10.1161/CIRCULATIONAHA.119.044765. Epub 2020 May 15. PMID: 32408764

Meta-analysis of Dual Antiplatelet Therapy Versus Monotherapy With P2Y12 Inhibitors in Patients After Percutaneous Coronary Intervention. Malik AH, Yandrapalli S, Shetty SS, Aronow WS, Cooper HA, Panza JA. Am J Cardiol. 2020 Jul 15;127:25-29. doi: 10.1016/j.amjcard.2020.04.027. Epub 2020 Apr 22. PMID: 32389351

Viral eradication restores normal iron status in chronic hepatitis C patients with abnormal iron studies. Hasan Y, Brown K. Ann Hepatol. 2020 Jul-Aug;19(4):422-426. doi: 10.1016/j.aohep.2020.03.002. Epub 2020 Mar 17. PMID: 32278667

Melanoma Characteristics in Patients with a History of UV Tanning Bed Usage. Truong K, Milhem M, Pagedar NA. Ann Otol Rhinol Laryngol. 2020 Jul;129(7):684-688. doi: 10.1177/0003489420904744. Epub 2020 Feb 6. PMID: 32028781

Investigating the validity of web-enabled mechanistic case diagramming scores to assess students' integration of foundational and clinical sciences. Ferguson KJ, Kreiter CD, Franklin E, Haugen TH, Dee FR. Adv Health Sci Educ Theory Pract. 2020 Aug;25(3):629-639. doi: 10.1007/s10459-019-09944-y. Epub 2019 Nov 13. PMID: 31720878

Loop Diuretics-Analysis of Efficacy Data for the Perioperative Clinician. Sharma A, Kuppachi S, Subramani S, Walia A, Thomas J, Ramakrishna H. J Cardiothorac Vasc Anesth. 2020 Aug;34(8):2253-2259. doi: 10.1053/j.jvca.2019.10.035. Epub 2019 Oct 25. PMID: 31879151 Review.

Outcomes of urgent versus nonurgent transcatheter aortic valve replacement. Elbadawi A, Elgendy IY, Mentias A, Saad M, Mohamed AH, Choudhry MW, Ogunbayo GO, Gilani S, Jneid H. Catheter Cardiovasc Interv. 2020 Jul;96(1):189-195. doi: 10.1002/ccd.28563. Epub 2019 Oct 24. PMID: 31647180