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Recent Research Publications - October 2020

October 16-31, 2020

A Web Application About Herd Immunity Using Personalized Avatars: Development Study.  Hakim H, Bettinger JA, Chambers CT, Driedger SM, Dubé E, Gavaruzzi T, Giguere AMC, Kavanagh É, Leask J, MacDonald SE, Orji R, Parent E, Paquette JS, Roberge J, Sander B, Scherer AM, Tremblay-Breault M, Wilson K, Reinharz D, Witteman HO. J Med Internet Res. 2020 Oct 30;22(10):e20113. doi: 10.2196/20113. PMID: 33124994

Patching the Leaks: Revitalizing and Reimagining the STEM Pipeline.  Hinton AO Jr, Termini CM, Spencer EC, Rutaganira FUN, Chery D, Roby R, Vue Z, Pack AD, Brady LJ, Garza-Lopez E, Marshall AG, Lewis SC, Shuler HD, Taylor BL, McReynolds MR, Palavicino-Maggio CB. Cell. 2020 Oct 29;183(3):568-575. doi: 10.1016/j.cell.2020.09.029. PMID: 33125882

Evaluation of Risk-Adjusted Home Time After Hospitalization for Heart Failure as a Potential Hospital Performance Metric. Pandey A, Keshvani N, Vaughan-Sarrazin MS, Gao Y, Fonarow GC, Yancy C, Girotra S. JAMA Cardiol. 2020 Oct 28. doi: 10.1001/jamacardio.2020.4928. Online ahead of print. PMID: 33112393

Multivariable Analysis of 169 Cases of Advanced Cutaneous Melanoma to Evaluate Antibiotic Exposure as Predictor of Survival to Anti-PD-1 Based Immunotherapies. Swami U, Chennamadhavuni A, Borcherding N, Bossler AD, Mott SL, Garje R, Zakharia Y, Milhem M. Antibiotics (Basel). 2020 Oct 27;9(11):E740. doi: 10.3390/antibiotics9110740. PMID: 33120998

Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Ye Y, Abu El Haija M, Morgan DA, Guo D, Song Y, Frank A, Tian L, Riedl RA, Burnett CML, Gao Z, Zhu Z, Shahi SK, Zarei K, Couvelard A, Poté N, Ribeiro-Parenti L, Bado A, Noureddine L, Bellizzi A, Kievit P, Mangalam AK, Zingman LV, Le Gall M, Grobe JL, Kaplan LM, Clegg D, Rahmouni K, Mokadem M. Cell Rep. 2020 Oct 27;33(4):108270. doi: 10.1016/j.celrep.2020.108270. PMID: 33113371

Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases. Doll M, Marra AR, Apisarnthanarak A, Al-Maani AS, Abbas S, Rosenthal VD. Int J Infect Dis. 2020 Oct 26:S1201-9712(20)32243-8. doi: 10.1016/j.ijid.2020.10.039. Online ahead of print. PMID: 33122100 Review.

Mitochondrial pyruvate carriers are required for myocardial stress adaptation. Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. Nat Metab. 2020 Oct 26. doi: 10.1038/s42255-020-00288-1. Online ahead of print. PMID: 33106689

Quantification of Body Fluid Compartmentalization by Combined Time-Domain Nuclear Magnetic Resonance and Bioimpedance Spectroscopy.  Segar JL, Balapattabi K, Reho JJ, Grobe CC, Burnett CML, Grobe JL. Am J Physiol Regul Integr Comp Physiol. 2020 Oct 21. doi: 10.1152/ajpregu.00227.2020. Online ahead of print. PMID: 33085913

Cardiovascular management following hypoxic-ischemic encephalopathy in North America: need for physiologic consideration.  Giesinger RE, Levy PT, Lauren Ruoss J, El Dib M, Mohammad K, Wintermark P, McNamara PJ. Pediatr Res. 2020 Oct 18. doi: 10.1038/s41390-020-01205-8. Online ahead of print. PMID: 33070162

Helminth-induced regulation of T-cell transfer colitis requires intact and regulated T cell Stat6 signaling in mice.  Metwali A, Winckler S, Urban JF Jr, Kaplan MH, Ince MN, Elliott DE. Eur J Immunol. 2020 Oct 16. doi: 10.1002/eji.201848072. Online ahead of print. PMID: 33067820

Atypical Large Vessel Vasculitis Presenting With Cholestatic Liver Abnormalities: Case-Based Review.  Sangha S, Lenert A, Dawoud S, Kaur A, Yazan H, Voigt MD, Lenert P. J Clin Rheumatol. 2020 Oct 15. doi: 10.1097/RHU.0000000000001596. Online ahead of print. PMID: 33065628

Quantification of Receptor Occupancy by Ligand-An Understudied Class of Potential Biomarkers.  Veeramani S, Weiner GJ. Cancers (Basel). 2020 Oct 13;12(10):2956. doi: 10.3390/cancers12102956. PMID: 33066142 Free PMC article.

Meta-Analysis of Early Intervention Versus Conservative Management for Asymptomatic Severe Aortic Stenosis.  Kumar A, Majmundar M, Doshi R, Kansara T, Shariff M, Shah P, Adalja D, Gullapalli N, Vallabhajosyula S, Panaich SS, Thourani VH. Am J Cardiol. 2020 Oct 13:S0002-9149(20)31082-1. doi: 10.1016/j.amjcard.2020.10.013. Online ahead of print. PMID: 33065088

Automated Algorithm Using Pre-Intervention Fractional Flow Reserve Pullback Curve to Predict Post-Intervention Physiological Results. Lee SH, Shin D, Lee JM, Lefieux A, Molony D, Choi KH, Hwang D, Lee HJ, Jang HJ, Kim HK, Ha SJ, Kwak JJ, Park TK, Yang JH, Song YB, Hahn JY, Doh JH, Shin ES, Nam CW, Koo BK, Choi SH, Gwon HC. JACC Cardiovasc Interv. 2020 Oct 11:S1936-8798(20)31479-5. doi: 10.1016/j.jcin.2020.06.062. Online ahead of print. PMID: 33069650

Mineral oil: safety and use as placebo in REDUCE-IT and other clinical studies. Olshansky B, Chung MK, Budoff MJ, Philip S, Jiao L, Doyle RT Jr, Copland C, Giaquinto A, Juliano RA, Bhatt DL. Eur Heart J Suppl. 2020 Oct 6;22(Suppl J):J34-J48. doi: 10.1093/eurheartj/suaa117. eCollection 2020 Oct. PMID: 33061866 Free PMC article.

Plasma Cathelicidin is Independently Associated with Reduced Lung Function in COPD: Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort. Burkes RM, Ceppe AS, Couper DJ, Comellas AP, Wells JM, Peters SP, Criner GJ, Kanner RE, Paine R 3rd, Christenson SA, Cooper CB, Barjaktarevic IZ, Krishnan JA, Labaki WW, Han MK, Curtis JL, Hansel NN, Wise RA, Drummond MB; SPIROMICS collaborators. Chronic Obstr Pulm Dis. 2020 Oct;7(4):370-381. doi: 10.15326/jcopdf.7.4.2020.0142. PMID: 33108110

In situ immunization of a TLR9 agonist virus-like particle enhances anti-PD1 therapy. Cheng Y, Lemke-Miltner CD, Wongpattaraworakul W, Wang Z, Chan CHF, Salem AK, Weiner GJ, Simons AL. J Immunother Cancer. 2020 Oct;8(2):e000940. doi: 10.1136/jitc-2020-000940. PMID: 33060147 Free PMC article.

Adipocyte Ceramides-The Nexus of Inflammation and Metabolic Disease. Chaurasia B, Talbot CL, Summers SA. Front Immunol. 2020 Sep 23;11:576347. doi: 10.3389/fimmu.2020.576347. eCollection 2020. PMID: 33072120 Free PMC article. Review.

Targeted Temperature Management for Treatment of Cardiac Arrest. Rasmussen TP, Bullis TC, Girotra S. Curr Treat Options Cardiovasc Med. 2020;22(11):39. doi: 10.1007/s11936-020-00846-6. Epub 2020 Oct 10. PMID: 33071538 Free PMC article. Review.

October 1-15, 2020

WNK1 regulates uterine homeostasis and its ability to support pregnancy.  Chi RA, Wang T, Huang CL, Wu SP, Young S, Lydon J, DeMayo F. JCI Insight. 2020 Oct 13:141832. doi: 10.1172/jci.insight.141832. Online ahead of print. PMID: 33048843

The association of health behaviors with quality of life in lymphoma survivors.  Pophali PA, Larson MC, Rosenthal AC, Robinson D, Habermann TM, Thanarajasingam G, Call T, Allmer C, Farooq U, Maurer MJ, Yost KJ, Cerhan JR, Thompson CA. Leuk Lymphoma. 2020 Oct 13:1-10. doi: 10.1080/10428194.2020.1830389. Online ahead of print. PMID: 33047636

Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners.  Evans AM, O'Donovan C, Playdon M, Beecher C, Beger RD, Bowden JA, Broadhurst D, Clish CB, Dasari S, Dunn WB, Griffin JL, Hartung T, Hsu PC, Huan T, Jans J, Jones CM, Kachman M, Kleensang A, Lewis MR, Monge ME, Mosley JD, Taylor E, Tayyari F, Theodoridis G, Torta F, Ubhi BK, Vuckovic D; Metabolomics Quality Assurance, Quality Control Consortium (mQACC). Metabolomics. 2020 Oct 12;16(10):113. doi: 10.1007/s11306-020-01728-5. PMID: 33044703

Survival of Pregnant Coronavirus Patient on Extracorporeal Membrane Oxygenation.  Larson SB, Watson SN, Eberlein M, Simmons JS, Doerschug KC, Leslie KK. Ann Thorac Surg. 2020 Oct 8:S0003-4975(20)31634-9. doi: 10.1016/j.athoracsur.2020.09.004. Online ahead of print. PMID: 33039361 Free PMC article.

Effect of germline mutations in homologous recombination repair genes on overall survival of patients with pancreatic adenocarcinoma.  Yadav S, Kasi PM, Bamlet WR, Ho TP, Polley EC, Hu C, Hart SN, Rabe KG, Boddicker NJ, Gnanaolivu RD, Lee KY, Lindstrom T, Petersen GM, Couch FJ, McWilliams RR. Clin Cancer Res. 2020 Oct 7:clincanres.1788.2020. doi: 10.1158/1078-0432.CCR-20-1788. Online ahead of print. PMID: 33028596

Lack of airway submucosal glands impairs respiratory host defenses.  Ostedgaard LS, Price MP, Whitworth KM, Abou Alaiwa MH, Fischer AJ, Warrier A, Samuel M, Spate LD, Allen PD, Hilkin BM, Romano Ibarra GS, Ortiz Bezara ME, Goodell BJ, Mather SE, Powers LS, Stroik MR, Gansemer ND, Hippee CE, Zarei K, Goeken JA, Businga TR, Hoffman EA, Meyerholz DK, Prather RS, Stoltz DA, Welsh MJ. Elife. 2020 Oct 7;9:e59653. doi: 10.7554/eLife.59653. PMID: 33026343 Free PMC article.

Detargeting Lentiviral-Mediated CFTR Expression in Airway Basal Cells Using miR-106b.  Choi SH, Reeves RE, Romano Ibarra GS, Lynch TJ, Shahin WS, Feng Z, Gasser GN, Winter MC, Evans TIA, Liu X, Luo M, Zhang Y, Stoltz DA, Devor EJ, Yan Z, Engelhardt JF. Genes (Basel). 2020 Oct 6;11(10):E1169. doi: 10.3390/genes11101169. PMID: 33036232

Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.  Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO Jr, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. Cell Metab. 2020 Oct 6;32(4):561-574.e7. doi: 10.1016/j.cmet.2020.09.012. PMID: 33027675

Correction: Initial experience from a renal genetics clinic demonstrates a distinct role in patient management.  Thomas CP, Freese ME, Ounda A, Jetton JG, Holida M, Noureddine L, Smith RJ. Genet Med. 2020 Oct 6. doi: 10.1038/s41436-020-01000-0. Online ahead of print. PMID: 33024316

Development and implementation of a Telenephrology dashboard for active surveillance of kidney disease: a quality improvement project.  Swee ML, Sanders ML, Phisitkul K, Bailey G, Thumann A, Neuzil N, Kumar B, O'Shea AMJ, Dixon BS. BMC Nephrol. 2020 Oct 6;21(1):424. doi: 10.1186/s12882-020-02077-0. PMID: 33023489 Free PMC article.

Successful termination of an outbreak of Mycobacterium chimaera infections associated with contaminated heater-cooler devices.  Marra AR, Diekema DJ, Edmond MB. Infect Control Hosp Epidemiol. 2020 Oct 6:1-3. doi: 10.1017/ice.2020.468. Online ahead of print. PMID: 33019949

Bone Health and Osteoporosis Prevention and Treatment.  MuÑoz M, Robinson K, Shibli-Rahhal A. Clin Obstet Gynecol. 2020 Oct 2. doi: 10.1097/GRF.0000000000000572. Online ahead of print. PMID: 33017332

Contribution of Individual and Neighborhood Factors to Racial Disparities in Respiratory Outcomes.  Ejike CO, Woo H, Galiatsatos P, Paulin LM, Krishnan JA, Cooper CB, Couper DJ, Kanner RE, Bowler RP, Hoffman EA, Comellas AP, Criner GJ, Barr RG, Martinez FJ, Han MK, Martinez CH, Ortega VE, Parekh TM, Christenson SA, Thakur N, Baugh A, Belz DC, Raju S, Gassett AJ, Kaufman JD, Putcha N, Hansel NN. Am J Respir Crit Care Med. 2020 Oct 2. doi: 10.1164/rccm.202002-0253OC. Online ahead of print. PMID: 33007162

Effect of apical chloride concentration on the measurement of responses to CFTR modulation in airway epithelia cultured from nasal brushings.  Bratcher PE, Yadav S, Shaughnessy CA, Thornell IM, Zeitlin PL. Physiol Rep. 2020 Oct;8(19):e14603. doi: 10.14814/phy2.14603. PMID: 33038073

Electrostatic Surface Properties of Blood and Semen Extracellular Vesicles: Implications of Sialylation and HIV-Induced Changes on EV Internalization.  Kaddour H, Panzner TD, Welch JL, Shouman N, Mohan M, Stapleton JT, Okeoma CM. Viruses. 2020 Oct 1;12(10):E1117. doi: 10.3390/v12101117. PMID: 33019624

Temporal trends and outcomes of critical limb ischemia among patients with chronic kidney disease.  Elbadawi A, Elgendy IY, Megaly M, Elzeneini M, Mentias A, Omer M, Ogunbayo G, Rai D, Drachman DE, Shishehbor MH. Vasc Med. 2020 Oct 1:1358863X20951270. doi: 10.1177/1358863X20951270. Online ahead of print. PMID: 33002372

A simplified critical illness severity scoring system (CISSS): Development and internal validation.  Fortis S, O'Shea AMJ, Beck Mae BF, Nair R, Goto M, Schmidt GA, Kaboli PJ, Perencevich EN, Reisinger HS, Sarrazin MV. J Crit Care. 2020 Sep 30;61:21-28. doi: 10.1016/j.jcrc.2020.09.029. Online ahead of print. PMID: 33049489

Late prosthetic shoulder joint infection due to Actinomyces neuii in an adult man.  Chen BC, Kobayashi T, Ford B, Sekar P. BMJ Case Rep. 2020 Sep 29;13(9):e236350. doi: 10.1136/bcr-2020-236350. PMID: 32994271

Favorable Outcomes in FGFR Fusion-Positive Cholangiocarcinomas and Evolution on Treatment Noted on Circulating Tumor DNA Liquid Biopsies.  Kasi PM. Case Rep Oncol. 2020 Aug 5;13(2):941-947. doi: 10.1159/000509075. eCollection 2020 May-Aug. PMID: 32999653 Free PMC article.

Symptomatic iron deficiency anemia from neglected giant basal cell carcinoma.  Laageide L, Wendl E, Wadle J, Powers J. JAAD Case Rep. 2020 Aug 1;6(10):1019-1023. doi: 10.1016/j.jdcr.2020.07.041. eCollection 2020 Oct. PMID: 32995435 Free PMC article. No abstract available.