Leadership

  • Ted Abel, PhD

    Director - Iowa Neuroscience Institute

    Molecular Physiology and Biophysics, Psychiatry, Biochemistry, Psychological and Brain Sciences

    The primary focus of research in the Abel lab is to understand the cellular and molecular mechanisms of long-term memory storage with a focus on the mammalian hippocampus. One of the hallmarks of long-term memory storage is that it requires the synthesis of new genes and new proteins, which act to alter the strength of synaptic connections within appropriate neuronal circuits in the brain. How are the various signals acting on a neuron integrated to give rise to appropriate changes in gene expression? How are changes in gene expression maintained to sustain memories for days, months and even years? What role does sleep play in memory storage? How is hippocampal function altered in mouse models of psychiatric and neurodevelopmental disorders?


  • Joshua Weiner

    Associate Director of Education and Outreach - Iowa Neuroscience Institute

    Biology

    The Weiner Lab is focused on identifying the molecular mechanisms regulating neural circuit formation in the developing brain. We utilize a variety of transgenic mouse models, generated using Cre/LoxP and CRISPR/Cas9 techniques, as well as cell line, neuronal, and glial cultures, protein biochemistry, transcriptomics, and confocal microscopy. Many current projects center around protocadherins, diverse cell adhesion molecules that we've shown are critical for neuronal survival, dendrite arborization, and synaptogenesis. We are also identifying functions for a poorly-understood nuclear protein, Akirin2; mice lacking this protein in the nervous system exhibit microcephaly, ataxia, defective neuronal and glial differentiation, and dysregulation of genes involved in circuit formation. Our work, funded by the NIH, March of Dimes, and other private organizations, is relevant to a wide variety of neurodevelopmental disorders associated with autism and intellectual disability.


  • John Wemmie

    Associate Director of Translational Research - Iowa Neuroscience Institute

    Psychiatry, Molecular Physiology and Biophysics, Neurosurgery

    Dr. Wemmie is interested in the role of brain pH and acid-sensing ion channels in brain function and behavior. This work has led to the discovery of critical roles for brain pH in synaptic plasticity, anxiety, and depression-related behaviors in mice. Current projects include investigating the synaptic mechanisms for acid-sensing ion channel action and also translating these discoveries to human behavior and brain function. For example, his laboratory is using non-invasive pH-sensitive magnetic resonance imaging to investigate the roles of brain pH in psychiatric illnesses such as panic disorder and bipolar affective disorder.