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Hyperkeratosis causing laryngeal leukoplakia

last modified on: Wed, 11/07/2018 - 11:20

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Hyperkeratosis causing laryngeal leukoplakia

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Hyperkeratosis is a mucosal abnormality in which dense orthokeratin accumulates on the mucosal surface.  Among other causes, cigarette smoke and other inhalational irritants, induce the mucosa to "epidermalize" and it is frequently accompanyied by the formation of a granular cell layer.  Dysplasia, a precursor to carcinoma, can occur with or without hyperkeratosis.  Biopsies of leukoplakic lesions are performed to exclude a dysplastic process.

Examples of hyperkeratosis

This mucosa shows a dense granular cell layer (brackets) beneath dense orthokeratin.

A dense layer of hyperkeratosis (braces) tops this mucosa, making it appear more skin-like rather than mucosal.