Paloma Giangrande, Ph.D.

Associate Professor
Internal Medicine

Office Room #:5202 MERF
Office Phone #:319-384-3242

paloma-giangrande@uiowa.edu

Lab Room #:5241 MERF
Lab Phone #:319-384-3243

Lab Website: https://giangrande.lab.uiowa.edu/

The central goal of our lab is to develop synthetic targeted RNA reagents (aptamers) to proteins involved in disease

The central goal of our lab is to develop synthetic targeted RNA reagents (aptamers) to proteins involved in disease (ex. receptors expressed on the surface of target-cells or soluble proteins secreted in blood) with SELEX (Systematic Evolution of Ligands by EXponential Enrichment) for the purpose of:

1) Intervening therapeutically
2) Delivering therapeutic molecules (e.g. siRNAs, anti-miRs, drugs/toxins) into specific cell types
3) Diagnostics
4) Acquiring mechanistic insights into a disease state

We are an internationally recognized group of experts in oligonucleotide therapeutics and delivery. We were the first to demonstrate that RNA aptamers can be used to deliver therapeutic siRNAs to target cells. Our group continues to pioneer efforts to optimize the aptamer delivery technology and have developed novel cell-based methodologies and bioinformatics approaches to implement the broad application of the aptamer delivery approach. One of the primary research efforts in my laboratory includes targeting therapeutic siRNAs/miRNAs to specific cell-types/tissues in vivo. Toward this end, my work with aptamer-based cell-type specific siRNA/miRNA delivery is currently focused on targeting multiple disease pathways with one reagent. This is expected to reduce or eliminate off-target effects, while increasing therapeutic efficacy. In addition, these multifunctional inhibitors are coupled with imaging and/or sensing capabilities to facilitate tracking of delivery and assessment of therapeutic efficacy and safety.

PubMed link

Department/Program Affiliations:
Free Radical and Radiation Biology
Internal Medicine
Molecular Medicine
MSTP
Radiation Oncology