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David Stoltz, MD, PhD

Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine

Introduction

Dr. Stoltz's clinical interests include general pulmonary diseases and lung infections. His research focuses on the pathogenesis of cystic fibrosis related airway disease with a particular emphasis on studying airway epithelial and smooth muscle cells, the role of paraoxonases (PONs) on Pseudomonas aeruginosa quorum-sensing regulation, mucociliary clearance, and advanced airway imaging modalities and analysis.

Current Positions

  • Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine
  • Professor of Biomedical Engineering (BME)
  • Professor of Molecular Physiology and Biophysics
  • Director, Division of Pulmonary, Critical Care and Occupational Medicine
  • Director, Physician Scientist Training Pathway, Carver College of Medicine

Education

  • MD/PhD, Louisiana State University Medical Center, New Orleans, Louisiana
  • Resident, Internal Medicine, University of Iowa Hospitals & Clinics, Iowa City, Iowa
  • Fellow, Pulmonary and Critical Care, University of Iowa Hospitals & Clinics, Iowa City, Iowa

Graduate Program Affiliations

Center, Program and Institute Affiliations

Selected Publications

  • Meyerholz, D. K., Stoltz, D. A., Gansemer, N. D., Ernst, S. E., Cook, D. P., Strub, M. D., LeClair, E. N., Barker, C. K., Adam, R. J., Leidinger, M. R., Gibson-Corley, K. N., Karp, P. H., Welsh, M. J. & McCray, Jr, P. B. (2018). Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs. Laboratory investigation; a journal of technical methods and pathology 98 (6) 825-838. DOI: 10.1038/s41374-018-0026-7. PMID: 29467455. PMCID: PMC6019641.
  • Reznikov, L. R., Meyerholz, D. K., Abou Alaiwa, M. H., Kuan, S. P., Liao, Y. J., Bormann, N. L., Bair, T. B., Price, M., Stoltz, D. A. & Welsh, M. J. (2018). The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity. American journal of physiology. Lung cellular and molecular physiology. DOI: 10.1152/ajplung.00557.2017. PMID: 29631359.
  • Li, X., Vargas Buonfiglio, L. G., Adam, R. J., Stoltz, D. A., Zabner, J. & Comellas, A. P. (2017). Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs. Critical care medicine 45 (12) e1240-e1246. DOI: 10.1097/CCM.0000000000002720. PMID: 28953499. PMCID: PMC5693779.
  • Gray, R. D., Hardisty, G., Regan, K. H., Smith, M., Robb, C. T., Duffin, R., Mackellar, A., Felton, J. M., Paemka, L., McCullagh, B. N., Lucas, C. D., Dorward, D. A., McKone, E. F., Cooke, G., Donnelly, S. C., Singh, P. K., Stoltz, D. A., Haslett, C., McCray, P. B., Whyte MKB, Rossi, A. G. & Davidson, D. J. (2017). Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis. Thorax. DOI: 10.1136/thoraxjnl-2017-210134. PMID: 28916704.
  • Cook, D. P., Adam, R. J., Zarei, K., Deonovic, B., Stroik, M. R., Gansemer, N. D., Meyerholz, D. K., Au, K. F. & Stoltz, D. A. (2017). CF airway smooth muscle transcriptome reveals a role for PYK2. JCI insight 2 (17). DOI: 10.1172/jci.insight.95332. PMID: 28878137. PMCID: PMC5621916.
  • Adam, R. J., Abou Alaiwa, M. H., Bouzek, D. C., Cook, D. P., Gansemer, N. D., Taft, P. J., Powers, L. S., Stroik, M. R., Hoegger, M. J., McMenimen, J. D., Hoffman, E. A., Zabner, J., Welsh, M. J., Meyerholz, D. K. & Stoltz, D. A. (2017). Postnatal airway growth in cystic fibrosis piglets. Journal of applied physiology (Bethesda, Md. : 1985) 123 (3) 526-533. DOI: 10.1152/japplphysiol.00263.2017. PMID: 28620056. PMCID: PMC5625074.
  • Paemka, L., McCullagh, B. N., Abou Alaiwa, M. H., Stoltz, D. A., Dong, Q., Randak, C. O., Gray, R. D. & McCray, Jr, P. B. (2017). Monocyte derived macrophages from CF pigs exhibit increased inflammatory responses at birth. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 16 (4) 471-474. DOI: 10.1016/j.jcf.2017.03.007. PMID: 28377087. PMCID: PMC5515361.
  • Ostedgaard, L. S., Moninger, T. O., McMenimen, J. D., Sawin, N. M., Parker, C. P., Thornell, I. M., Powers, L. S., Gansemer, N. D., Bouzek, D. C., Cook, D. P., Meyerholz, D. K., Abou Alaiwa, M. H., Stoltz, D. A. & Welsh, M. J. (2017). Gel-forming mucins form distinct morphologic structures in airways. Proceedings of the National Academy of Sciences of the United States of America 114 (26) 6842-6847. DOI: 10.1073/pnas.1703228114. PMID: 28607090. PMCID: PMC5495256.
  • Hisert, K. B., Heltshe, S. L., Pope, C., Jorth, P., Wu, X., Edwards, R. M., Radey, M., Accurso, F. J., Wolter, D. J., Cooke, G., Adam, R. J., Carter, S., Grogan, B., Launspach, J. L., Donnelly, S. C., Gallagher, C. G., Bruce, J. E., Stoltz, D. A., Welsh, M. J., Hoffman, L. R., McKone, E. F. & Singh, P. K. (2017). Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections. American journal of respiratory and critical care medicine 195 (12) 1617-1628. DOI: 10.1164/rccm.201609-1954OC. PMID: 28222269. PMCID: PMC5476912.
  • Steines, B., Dickey, D. D., Bergen, J., Excoffon, K. J., Weinstein, J. R., Li, X., Yan, Z., Alaiwa, M. H., Shah, V. S., Bouzek, D. C., Powers, L. S., Gansemer, N. D., Ostedgaard, L. S., Engelhardt, J. F., Stoltz, D. A., Welsh, M. J., Sinn, P. L., Schaffer, D. V. & Zabner, J. (2016). CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes. JCI insight 1 (14) e88728. DOI: 10.1172/jci.insight.88728. PMID: 27699238.