Wendy Maury, PhD
Professor of Microbiology and Immunology
Primary Office
Lab
Introduction
Research in the Maury lab seeks to understand the interaction of enveloped viruses with the host. Studies currently focus on virus entry and innate host immune responses to virus infection. Using the skin, liver, spleen, lung and peritoneal cavity as model tissues, we investigate how the cellular environment alters these interactions. Through studies with filoviruses, coronaviruses, alphaviruses and flaviviruses, we have identified a novel set of cell surface receptors that interact with lipids in viral membranes and we continue to explore the cellular biology of these interactions as well as the pathological consequences. An appreciation of the cellular attachment factors, receptors, internalization pathways and fusion events used by viruses to enter cells provides an avenue for the development of antiviral therapies.
Current Positions
- Professor of Microbiology and Immunology
- Mark Stinski Chair in Virology
Education
- BA in Botany, Duke University, Durham, North Carolina
- MS in Botany, North Carolina State University, Raleigh, North Carolina
- PhD in Biology, University of Virginia, Charlottesville, Virginia
- Postdoctoral Fellow in Molecular Microbiology, National Institutes of Health-NIAID, Bethesda, Maryland
- Postdoctoral Fellow in Virology, National Institutes of Health-NIAID, Rocky Mountain Laboratories, Hamilton, Montana
Graduate Program Affiliations
Center, Program and Institute Affiliations
Research Interests
- Antiviral therapies
- Enveloped virus entry and glycoprotein interactions
- Virus/host interactions
- Innate immune responses to enveloped virus infections
Selected Publications
- Lennemann, N.J., Corliss, L. and Maury, W. (2024) Modification of N-Linked Glycan Sites in Viral Glycoproteins. Methods Mol. Biol. 2024:2762-41, DOI: 10.1007/978-1-0716-3666-4_3. PMID: 38315358
- Richards, P.T., Aguilar Briseno, J.A., Brunton, B.A. and Maury, W. (2024) In Vivo Investigation of Filovirus Glycoprotein-Mediated Infection in a BSL2 Setting. Methods Mol Biol. 2025;2877:183-198. doi: 10.1007/978-1-0716-4256-6_13. PMID: 39585622.
- Messingham, K.A., Richards, P.T., Fleck, A., Patel, R.A., Djurkovic, M., Elliff, J., Connell, S., Crowe, T.P., Munoz Gonzalez, J.P., Gourronc, F., Dillard, J.A., Davey, R.A., Klingelhutz, A., Shtanko, O. and Maury, W. (2024) Multiple cell types support productive infection and dynamic translocation of infectious Ebola virus to the surface of human skin. Science Advances, in press.
- Aguilar-Briseño, J. A., Elliff, J. M., Patten, J. J., Wilson, L. R., Davey, R. A., Bailey, A. L. & Maury, W. J. (2023). Effect of Interferon Gamma on Ebola Virus Infection of Primary Kupffer Cells and a Kupffer Cell Line. Viruses 15 (10) 2077. DOI: 10.3390/v15102077. PMID: 37896854. PMCID: PMC10611415.
- Rogers, K. J., Richards, P. T., Zacharias, Z. R., Stunz, L. L., Vijay, R., Butler, N. S., Legge, K. L., Bishop, G. A. & Maury, W. (2023). CD40 signaling in mice elicits a broad antiviral response early during acute infection with RNA viruses. Viruses 15 (6) 1353. DOI: 10.3390/v15061353. PMIC: 37376652. PMCID: PMC10305536.
- Vijay, R., Guthmiller, J. J., Sturtz, A. J., Surette, F. A., Rogers, K. J., Sompallae, R. R., Li, F., Pope, R. L., Chan, J. A., de Labastida Rivera, F., Andrew, D., Webb, L., Maury, W. J., Xue, H., Engwerda, C. R., McCarthy, J. S., Boyle, M. J. & Butler, N. S. (2020). Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria. Nat Immunol 21 (7) 790-801. DOI: 10.1038/s41590-020-0678-5. PMID: 32424361. PMCID: PMC7316608.
- Rogers, K. J., Shtanko, O., Stunz, L. L., Mallinger, L. N., Arkee, T., Schmidt, M. E., Bohan, D., Brunton, B., White, J. M., Varga, S. M., Butler, N. S., Bishop, G. A. & Maury, W. J. (2020). Frontline Science: CD40 signaling restricts RNA virus replication in Mϕs, leading to rapid innate immune control of acute virus infection. J Leukoc Biol. DOI: 10.1002/JLB.4HI0420-285RR. PMID: 32441445. PMCID: PMC7774454.
- Rogers, K. J., Shtanko, O., Vijay, R., Mallinger, L. N., Joyner, C. J., Galinski, M. R., Butler, N. S. & Maury, W. J. (2020). Acute Plasmodium infection promotes interferon-gamma-dependent resistance to Ebola virus infection. Cell Rep 30 (12) 4041-4051. DOI: 10.1016/j.celrep.2020.02.104. PMID: 32209467. PMCID: PMC7172281.
- Rogers, K. J., Jones-Burrage, S., Maury, W. J. & Mukhopadhyay, S. (2020). TF protein of Sindbis virus antagonizes host type I interferon responses in a palmitoylation-dependent manner. Virology 542 63-70. DOI: 10.1016/j.virol.2020.01.001. PMID: 32056669. PMCID: PMC7024065.
- Rogers, K. J., Brunton, B., Mallinger, L., Bohan, D., Sevcik, K. M., Chen, J., Ruggio, N. & Maury, W. J. (2019). IL-4/IL-13 polarization of macrophages enhances Ebola virus glycoprotein-dependent infection. PLoS Negl Trop Dis 13 (12) e0007819. DOI: 10.1371/journal.pntd.0007819. PMID: 31825972. PMCID: PMC6905523.