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Jeffrey Recchia-Rife

Mentor: Adam Dupuy, Ph.D.
Lab Room: 1-251 BSB
Lab Phone: 319-335-7606

Whsc1 as an epigenetic regulator during T cell development and tumorigenesis

Our research uses the Sleeping Beauty (SB) transposon mutagenesis system to model T cell acute lymphocytic leukemia (T-ALL) in mice. The model is responsible for generating random insertion events that select for mutations that contribute to tumor formation. Our screen yielded a gene not previously characterized in T cell lymphomas. Wolf-Hirschhorn syndrome candidate 1 (Whsc1) encodes a histone methyltransferase enzyme. It is ubiquitously expressed during development, and mutations have been attributed to Wolf-Hirschhorn syndrome as well as multiple myeloma. We are characterizing the expression of Whsc1 throughout T cell development and tumorigenesis. Its effect on the epigenomic signature of the cell is also of great importance as the cells progress through either of these pathways.

Honors and Awards

  • Molecular & Cellular Biology Admissions Committee 2010-11