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Jennifer Marden

Mentor: John Engelhardt, Ph.D.
Lab Phone: 335-9613

Redox Signaling Pathways in Human Disease

Part of my research focuses on redox-regulated signal transduction and gene therapy approaches in liver ischemia/reperfusion injury. Organ injury caused by transient ischemia followed by reperfusion is associated with a number of clinically and environmentally induced conditions. Ischemia/reperfusion (I/R) conditions arise during surgical interventions such as organ transplantation and coronary bypass surgery, and in diseases such as stroke and cardiac infarct. The destructive effects of I/R arise from the acute generation of reactive oxygen species subsequent to reoxygenation, which inflict direct tissue damage and initiate a cascade of deleterious cellular responses leading to inflammation, cell death, and organ failure. My research concentrates on the molecular events controlling cellular responses to I/R injury, such as the activation of AP-1.

Li Q, Zhang Y, Marden JJ, Banfi B, Engelhardt JF. Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury. Biochem J. 2008 May 1;411(3):531-41. PubMed PMID: 18397177.

Harraz MM, Marden JJ, Zhou W, Zhang Y, Williams A, Sharov VS, Nelson K, Luo M, Paulson H, Schöneich C, Engelhardt JF. SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest. 2008 Feb;118(2):659-70. PubMed PMID: 18219391; PubMed Central PMCID: PMC2213375.

Marden JJ, Zhang Y, Oakley FD, Zhou W, Luo M, Jia HP, McCray PB Jr, Yaniv M, Weitzman JB, Engelhardt JF. JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation. J Biol Chem. 2008 Mar 14;283(11):6687-95. Epub 2008 Jan 8. PubMed PMID: 18182393.

Marden JJ, Harraz MM, Williams AJ, Nelson K, Luo M, Paulson H, Engelhardt JF. Redox modifier genes in amyotrophic lateral sclerosis in mice. J Clin Invest. 2007 Oct;117(10):2913-9. PubMed PMID: 17853944; PubMed Central PMCID: PMC1974865.

Yang J, Marden JJ, Fan C, Sanlioglu S, Weiss RM, Ritchie TC, Davisson RL, Engelhardt JF. Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Mol Ther. 2003 Mar;7(3):341-53. PubMed PMID:12668130.