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Levi Sowers


levi-sowers@uiowa.edu
Mentor: Alexander Bassuk, M.D./Ph.D.
Lab Room: 2158 ML
Lab Phone: 319-384-4648

My current research concentrates on elucidating the role of the Prickle2 gene in the development and progression of Epilepsy through the use of Prickle2 null mice. I am also studying the effects of Prickle2 loss on mouse behavior which will help us understand Prickle2’s role in the mammalian brain. These studies will involve the use of behavioral, electrophysiological, and immunofluorescence techniques.

Publications:

Tao H, Manak JR, Sowers L, Mei X, Kiyonari H, Abe T, Dahdaleh NS, Yang T, Wu S, Chen S, Fox MH, Gurnett C, Montine T, Bird T, Shaffer LG, Rosenfeld JA, McConnell J, Madan-Khetarpal S, Berry-Kravis E, Griesbach H, Saneto RP, Scott MP, Antic D, Reed J, Boland R, Ehaideb SN, El-Shanti H, Mahajan VB, Ferguson PJ, Axelrod JD, Lehesjoki AE, Fritzsch B, Slusarski DC, Wemmie J, Ueno N, Bassuk AG. Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am J Hum Genet. 2011 Feb 11;88(2):138-49. Epub 2011 Feb 3. PubMed PMID: 21276947.



Honors and Awards

  • Molecular & Cellular Biology Travel Award for best presentation 2010