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Rachel Starks


rachel-starks@uiowa.edu
Mentor: Kamal Rahmouni, Ph.D.
Lab Room: 3125 MERF
Lab Phone: 319-335-7895

Role of BBS Proteins in Insulin Receptor Signaling

Bardet Biedl Syndrome (BBS) is a pleiotropic, autosomal recessive and heterogenous disorder with 15 BBS genes identified to date. The cardinal clinic features of BBS include obesity, degenerative retinopathy, polydactyly, renal dysfunction, hypogonadism, and mental retardation. In addition, diabetes mellitus is commonly associated with BBS, but the mechanisms remain unknown. Seven BBS proteins (BBS1, 2, 4, 5, 7, 8 and 9) have been shown to form a stable complex termed BBSome, which is involved in vesicle trafficking. Three chaperonin-like BBS proteins (BBS6, BBS10 and BBS12) were also found to interact together and form another complex in combination with other chaperonin proteins of the CCT (also known as TRiC) family. Our laboratory has previously shown the requirement of BBS proteins for leptin receptor trafficking. We hypothesized that BBS proteins may also be required for proper insulin receptor signaling. I plan to use both cell culture and Bbs null mice to investigate the interaction between BBS proteins and insulin receptor signaling in a tissue specific manner.

Abstracts:

Diaz, R., Smith, D.F., Prapapanich, V., Cox, M.B. and Riggs, D.L. Functional Analysis of Co-evolving Residues Hypothesized to Participate in the Interaction between Hop and Hsp70/Hsp90. Annual Research Conference for Minority Students, 2006

Starks, R., Beyer, A., Guo, D. and Rahmouni, K. Diabetes and Insulin Resistance Associated with Bardet-Biedl Syndrome: Insight into Mechanisms. University of Iowa Carver College of Medicine Medical Student Research Day, Iowa City, IA, 2009.

Starks, R., Beyer, A., Guo, D.F., Sheffield, V.C. and Rahmouni, K. Critical Role for BBS Proteins in Insulin Receptor Signaling. I Heart Science Poster Session, University of Iowa MSTP, Iowa City, IA, 2011.

Starks R.D., Guo D.F., Beyers A.M., Rahmouni K., Sheffield V.C. Critical Role for BBS Proteins in Insulin Receptor Signaling. CTSA National Pre-doctoral Meeting, Mayo Clinic, Rochester, MN, 2012.

Starks R.D., Guo D.F., Beyers A.M., Rahmouni K., Sheffield V.C. Critical Role for BBS Proteins in Insulin Receptor Signaling. Poster Session, Health Sciences Research Week, University of Iowa, Iowa City, IA, 2012.

Starks R.D., Guo D.F., Beyers A.M., Rahmouni K., Sheffield V.C. A Common Mutation in a Rare Disease Offers Insight into A Novel Mechanism of Insulin Resistance, Poster Session, Health Sciences Research Week, University of Iowa, Iowa City, IA, 2013.

Starks RD; Guo DF; Beyers AM; Rahmouni K; Sheffield VC. A Common Mutation in a Rare Disease Offers Insight into a Novel Mechanism of Insulin Resistance. CTSA National Pre-doctoral Meeting, Mayo Clinic, Rochester, MN, 2013.

Starks, R.D., Guo, D.F., Beyer, A., Sheffield, V.C. and Rahmouni, K. A Novel Mechanism of Insulin Resistance Unraveled by a Rare Disease. Oral Communication, 73rd Scientific Sessions. American Diabetes Association, Chicago, IL 2013.



Honors and Awards

  • Medical Student Research Day Outstanding Presentation, 2009
  • The Institute for Clinical and Translational Linked Training Award, 2011-14
  • Poster Award Health Sciences Research Week, 2013