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Skye Souter

Mentor: Gloria Lee, Ph.D.
Lab Phone: 335-8656

I am currently investigating the role of prolyl isomerase Pin1 on the confirmed association between the microtubule associated protein Tau and the tyrosine kinase Fyn. Fyn’s association with Tau leads to the phosphorylation of tyrosine-18, a modification that can be detected in Alzheimer’s disease brain. The SH3 domain necessary for the Tau-Fyn interaction is adjacent to Threonine-231, a site recognized by Pin1. We hypothesize that the actions of Pin1 inhibits the interaction between Tau and Fyn by allowing Thr-231 to be phosphorylated.

Souter S, Lee G. Tubulin-independent tau in Alzheimer's disease and cancer: implications for disease pathogenesis and treatment. Curr Alzheimer Res. 2010 Dec;7(8):697-707. Review. PubMed PMID: 20678073.

Souter S, Lee G. Microtubule-associated protein tau in human prostate cancer cells: isoforms, phosphorylation, and interactions. J Cell Biochem. 2009 Oct 15;108(3):555-64. PubMed PMID: 19681044.