📅 Published: June 13, 2025

📚 Infection and Immunity

👩‍🔬Author: Filiz Korkmaz, PhD

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🔍 Research Summary

Microbial-derived lipids and their interactions with diverse host receptors are central to immune regulation and microbial virulence, with pathogens leveraging unique lipid structures to evade detection and resist treatment. This review explores the structural and functional diversity of lipids across bacteria, viruses, fungi, and parasites, emphasizing their roles at the host-pathogen interface. Understanding these lipid-mediated mechanisms may unlock new therapeutic strategies targeting lipid-based immune modulation.

👥 Author

Filiz Korkmaz

📅 Published: May 30, 2025

📚 mBio

👩‍🔬 Corresponding Author: Jessica M. Tucker, PhD

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🔍 Research Summary

This study uncovers how gammaherpesvirus infection leads to the generation of tRNA fragments from premature tRNAs, shedding light on a previously underexplored aspect of host-virus interactions. The findings suggest that viral infection disrupts tRNA maturation, resulting in the accumulation of tRNA-derived fragments (tRFs) with potential regulatory roles.

👥 Authors

Aidan C. Manning, Mahmoud M. Bashir, Kyle Rapchak, Calyssa J. Huff, Ariana R. Jimenez, Sheila Gonzalez, Courtney L. Woodruff, Heather E. Upton, Kathleen Collins, Todd M. Lowe, Jessica M. Tucker