Jian Zheng

Postdoctoral Research ScholarJian Zheng

Address: 3-730 BSB
Phone: (319) 335-7576
Email: jian-zheng-1@uiowa.edu

Mentor: Stanley Perlman, MD, PhD

Year enter the program: 2016

PhD Institution: The University of Hong Kong

Other Trainings

2011 Research Assistant, Department of Pediatrics & Adolescent Medicine, University of Hong Kong
2012-2015 Postdoctoral Fellow,  Department of Pediatrics & Adolescent Medicine, University of Hong Kong
2015-2016 Research Assistant Professor, Department of Pediatrics & Adolescent Medicine, University of Hong Kong

Research Description

My research focuses on immune regulation and anti-viral immunology.

Publication(s)

Liu M, Zhou C, Zheng J.Cigarette smoking impairs the response of EGFR-TKIs therapy in lung adenocarcinoma patients by promoting EGFR signaling and epithelial-mesenchymal transition. Am J Transl Res. 2015 Oct 15;7(10):2026-35. (Corresponding author)

Tu W, Zheng J. Application of Humanized Mice in Immunological Research. Methods Mol Biol. 2016;1371:157-76.

Zheng J, Wu WL, Liu Y, Xiang Z, Liu M, Chan KH, Lau SY, Lam KT, To KK, Chan JF, Li L, Chen H, Lau YL, Yuen KY, Tu W. 2015. The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice. PLoS One. Aug 18;10(8):e0135999.

Liu M, Ren D, Wu D, Zheng J, Tu W. 2015. Stem cell and Idiopathic pulmonary fibrosis: mechanisms and treatment. Curr Stem Cell Res Ther May 18.

Qin G, Shao JG, Wang B, Shen Y, Zheng J, Liu XJ, Zhang YY, Liu YM, Qin Y, Wang LJ. 2014. Artificial liver support system improves short- and long-term outcomes of patients with HBV-associated acute-on-chronic liver failure: a single-center experience. Medicine (Baltimore). 93(28):e338.

Xiang Z, Liu Y, Zheng J, Liu M, Lv A, Gao Y, Hu H, Lam KT, Chan GC, Yang Y, Chen H, Tsao GS, Bonneville M, Lau YL, Tu W. 2014. Targeted activation of human Vγ9Vδ2-T cells controls Epstein-Barr virus-induced B cell lymphoproliferative disease. Cancer Cell 26:565-76.

Han Y, Ling MT, Mao H, Zheng J, Liu M, Lam KT, Liu Y, Tu W, Lau YL. 2014. Influenza virus-induced lung inflammation was modulated by cigarette smoke exposure in mice. PLoS One 9:e86166.

Zheng J, Chan PL, Liu Y, Qin G, Xiang Z, Lam KT, Lewis DB, Lau YL, Tu W. 2013. ICOS regulates the generation and function of human CD4+ Treg in a CTLA-4 dependent manner. PLoS One 8:e82203.

Chan PL, Zheng J, Liu Y, Lam KT, Xiang Z, Mao H, Liu Y, Qin G, Lau YL, Tu W. 2013. TLR5 Signaling Enhances the Proliferation of Human Allogeneic CD40-Activated B Cell Induced CD4(hi)CD25(+) Regulatory T Cells. PLoS One 8:e67969.

Zheng J, Liu Y, Liu Y, Liu M, Xiang Z, Lam KT, Lewis DB, Lau YL, Tu W. 2013. Human CD8+ Regulatory T cells Inhibit GVHD and Preserve General Immunity in Humanized Mice. Science translational medicine 5:168ra9.

Zheng J, Liu Y, Lau YL, Tu W. 2013. gammadelta T cell: an unpolished sword in human anti-infection immunity. Cellular & molecular immunology 10:50-7.

Jiao D, Liu Y, Lu X, Pan Q, Zheng J, Liu B, Liu Y, Wang Y, Fu N. 2012. Characteristics of Anaphylaxis-inducing IgG Immune Complexes Triggering Murine Passive Systemic Anaphylaxis. Allergy 68:236-45.

Qin G, Liu Y, Zheng J, Xiang Z, Ng IH, Malik Peiris JS, Lau YL, Tu W. 2012. Phenotypic and Functional Characterization of Human gammadelta T-Cell Subsets in Response to Influenza A Viruses. The Journal of infectious diseases 205: 1646-53.

Bao Y, Zheng J, Han C, Jin J, Han H, Liu Y, Lau YL, Tu W, Cao X. 2012. Tyrosine kinase Btk is required for NK cell activation. The Journal of biological chemistry 287: 23769-78. (co-first author)

Zheng J, Liu Y, Qin G, Lam KT, Guan J, Xiang Z, Lewis DB, Lau YL, Tu W. 2011. Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-gamma- and T-bet-dependent pathway. European journal of immunology 41: 128-39.

Tu W, Zheng J, Liu Y, Sia SF, Liu M, Qin G, Ng IH, Xiang Z, Lam KT, Peiris JS, Lau YL. 2011. The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice. The Journal of experimental medicine 208: 1511-22.


Qin G, Liu Y, Zheng J, Ng IH, Xiang Z, Lam KT, Mao H, Li H, Peiris JS, Lau YL, Tu W. 2011. Type 1 responses of human Vgamma9Vdelta2 T cells to influenza A viruses. Journal of virology 85: 10109-16.

Zheng J, Liu Y, Lau YL, Tu W. 2010. CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells. Cellular & molecular immunology 7: 44-50.

Tu W, Mao H, Zheng J, Liu Y, Chiu SS, Qin G, Chan PL, Lam KT, Guan J, Zhang L, Guan Y, Yuen KY, Peiris JS, Lau YL. 2010. Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus. Journal of virology 84: 6527-35. (co-second author )

Pan Q, Liu Y, Zheng J, Lu X, Wu S, Zhu P, Fu N. 2010. Protective effect of chloral hydrate against lipopolysaccharide/D-galactosamine-induced acute lethal liver injury and zymosan-induced peritonitis in mice. International immunopharmacology 10: 967-77.

Mao H, Tu W, Liu Y, Qin G, Zheng J, Chan PL, Lam KT, Peiris JS, Lau YL. 2010. Inhibition of human natural killer cell activity by influenza virions and hemagglutinin. Journal of virology 84: 4148-57.

Tu W, Mao H, Qin G, Zheng J, Li H, Lau YL. 2010. Challenges and opportunities from the pandemic of influenza A (H1N1). Zhonghua Er Ke Za Zhi 48:561-3.

Zheng J, Liu Y, Qin G, Chan PL, Mao H, Lam KT, Lewis DB, Lau YL, Tu W. 2009. Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells. Journal of immunology 183: 3742-5.

Tang L, Zhu P, Zhou WJ, Zheng J, Zhou YQ, Fu N, Xu XM. 2009. Development and validation of a zeta-globin-specific ELISA for carrier screening of the (--SEA) alpha thalassaemia deletion. Journal of clinical pathology 62: 147-51.

Qin G, Mao H, Zheng J, Sia SF, Liu Y, Chan PL, Lam KT, Peiris JS, Lau YL, Tu W. 2009. Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses. The Journal of infectious diseases 200: 858-65.

Mao H, Tu W, Qin G, Law HK, Sia SF, Chan PL, Liu Y, Lam KT, Zheng J, Peiris M, Lau YL. 2009. Influenza virus directly infects human natural killer cells and induces cell apoptosis. Journal of virology 83: 9215-22.

Tu W, Zheng J, Liu Y, and Lau YL. 2009. Response: Stimulatory or tolerogenic role of CD40-activated B cells depends on the strength of the activation to T cells. Blood 114: 747-748.

Tu W, Lau YL, Zheng J, Liu Y, Chan PL, Mao H, Dionis K, Schneider P, Lewis DB. 2008. Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells. Blood 112: 2554-62.