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Françoise Gourronc

Assistant Research Scientist, Klingelhutz LaboratoryFrançoise Gourronc
Email: francoise-gourronc@uiowa.edu



My work focuses on developing molecular tools and human cell-based models to study tissue-specific responses to toxic compounds, bacterial or viral infections.



1990 B.S Microbiology and Cell biology University of Rennes I (France)

1992 MS Biotechnology (1992) University of Rouen (France)

1998 PhD in Biochemistry (1998) University of Reims (France)


Professional background

1992–1994 Research Investigator (R&D Bioprocess)
ARD innovation in green (France)

1998–1999 Postdoctoral Teaching Assistant (ATER)
University of Reims (France)

1999–2001 Postdoctoral Fellow Department of Laboratory Medicine and Pathology (Pr.J.S. Malter MD)
(Epilepsy, Early response genes, Molecular Biology, RNA binding factors, RNA stability
University of Wisconsin, Madison

2001–2002 Postdoctoral Fellow Department of Anatomy and Cell Biology (Pr.R.S. Hartley PhD)
(Cell Cycle, Molecular Biology, RNA binding factors, RNA stability)
University of Iowa, Iowa City

2002–present Assistant Research Scientist
University of Iowa, Iowa City



Pubmed link use GOURRONC F 

Kohlmeyer JL, Kaemmer CA, Umesalma S, Gourronc FA, Klingelhutz AJ, Quelle DE. RABL6A regulates Schwann cell senescence in an RB1-dependent manner.  Int J Mol Sci. 2021 May 20;22(10):5367. doi: 10.3390/ijms22105367.

Gourronc FA, Markan KR, Kulhankova K, Zhu Z, Sheehy R, Quelle DE, Zingman LV, Kurago ZB, Ankrum JA, Klingelhutz AJ. Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis. PLoS One. 2020 Jul 30;15(7):e0236741. doi: 10.1371/journal.pone.0236741. eCollection 2020.PMID: 32730300

Schlievert PM, Gourronc FA, Leung DYM, Klingelhutz AJ. Human Keratinocyte Response to Superantigens. mSphere. 2020 Oct 7;5(5):e00803-20. doi: 10.1128/mSphere.00803-20.PMID: 33028686

El-Hattab MY, Nagumo Y, Gourronc FA, Klingelhutz AJ, Ankrum JA, Sander EA. Human Adipocyte Conditioned Medium Promotes In Vitro Fibroblast Conversion to Myofibroblasts. Sci Rep. 2020 Jun 24;10(1):10286. doi: 10.1038/s41598-020-67175-3.PMID: 32581231

Faris R, Andersen SE, McCullough A, Gourronc F, Klingelhutz AJ, Weber MM. Chlamydia trachomatis Serovars Drive Differential Production of Proinflammatory Cytokines and Chemokines Depending on the Type of Cell Infected. Front Cell Infect Microbiol. 2019 Nov 26;9:399. doi: 10.3389/fcimb.2019.00399. eCollection 2019. PMID: 32039039

Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, Liu LZ, Ge X, Jiang BH, Gibson-Corley K, Klingelhutz A, Tan NS, Zhu Y, Sutterwala FS, Shen X, Zhang W. Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Oncogene. 2019 Mar;38(13):2351-2363. doi: 10.1038/s41388-018-0592-6. Epub 2018 Dec 5. PMID: 30518876

Schlievert PM, Cahill MP, Hostager BS, Brosnahan AJ, Klingelhutz AJ, Gourronc FA, Bishop GA, Leung DYM. Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines. mBio. 2019 Mar 19;10(2):e00214-19. doi: 10.1128/mBio.00214-19. PMID: 30890614

Gourronc FA, Perdew GH, Robertson LW, Klingelhutz AJ. PCB126 blocks the thermogenic beiging response of adipocytes. Environ Sci Pollut Res Int. 2020 Mar;27(9):8897-8904. doi: 10.1007/s11356-019-06663-0. Epub 2019 Nov 12. PMID: 31721030

Kulhankova K, Kinney KJ, Stach JM, Gourronc FA, Grumbach IM, Klingelhutz AJ, Salgado-Pabón W. The Superantigen Toxic Shock Syndrome Toxin 1 Alters Human Aortic Endothelial Cell Function. Infect Immun. 2018 Feb 20;86(3):e00848-17. doi: 10.1128/IAI.00848-17. Print 2018 Mar. PMID: 29229737

Klingelhutz AJ, Gourronc FA, Chaly A, Wadkins DA, Burand AJ, Markan KR, Idiga SO, Wu M, Potthoff MJ, Ankrum JA. Scaffold-free generation of uniform adipose spheroids for metabolism research and drug discovery. Sci Rep. 2018 Jan 11;8(1):523. doi: 10.1038/s41598-017-19024-z. PMID: 29323267

Gourronc FA, Robertson LW, Klingelhutz AJ. A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environ Sci Pollut Res Int. 2018 Jun;25(17):16481-16492. doi: 10.1007/s11356-017-9676-z. Epub 2017 Jul 11. PMID: 28699004

Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-1560. doi: 10.1016/j.celrep.2016.07.003. Epub 2016 Jul 28. PMID: 27477281 

G. Gadupudi, FA. Gourronc, G. Ludewig, LW. Robertson and AJ. Klingelhutz. PCB126 Inhibits Adipogenesis of Human Preadipocytes. Toxicol In Vitro. 2015 Feb;29(1):132-41. doi: 10.1016/j.tiv.2014.09.015. Epub 2014 Oct 7. PMID: 25304490

J. Hagen, VP. Muniz, K. Falls, S. Reed, A. Taghiye, FW. Quelle, FA. Gourronc, AJ. Klingelhutz, HJ. Major, R. Askeland, SK. Sherman, TM. O’Dorisio, AM. Bellizzi, JR. Howe, BW. Darbro and DE. Quelle. RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner. Cancer Res. 2014 Nov 15;74(22):6661-70. doi: 10.1158/0008-5472.CAN-13-3742. Epub 2014 Oct 1. PMID: 25273089

BG. Vu, FA. Gourronc., DA. Bernlohr., PM. Schlievert. and  AJ. Klingelhutz. Staphylococcal Superantigens Stimulate Immortalized Human Adipocytes to Produce Chemokines. PLos One 2013 8(10): e77988. doi:10.1371/journal.pone.0077988

FA Gourronc, WM Rockey, WH Thiel, PH Giangrande , AJ Klingelhutz . Identification of RNA aptamers that internalize into HPV-16 E6/E7 transformed tonsillar epithelial cells.Virology 2013 Nov;446(1-2):325-33.

FA. Gourronc and A.J. Klingelhutz. Therapeutic opportunities: Telomere maintenance in inducible pluripotent stem cells Mut. Res. 730 (1–2) 1 February 2012, Pages 98–105

M. Fitzgerald, F. Gourronc, M. Teoh, M. Provenzano, A. Case, J.A. Martin and F. E. Domann. Human chondrosarcoma cells acquire an epithelial-like gene expression pattern via an epigenetic switch: evidence for mesenchymal-epithelial transition during sarcomagenesis, Sarcoma 2011 (2011): 598218 doi:10.1155/2011/598218\

F. Gourronc, M. Robertson, A. Herrig, P.M. Lansdorp, F.D. Goldman, A.J. Klingelhutz. Proliferative defects in dyskeratosis congenital skin keratinocytes are corrected by expression of the telomerase reverse transcriptase TERT or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA component TERC. Exp. Dermatol. 19(3): 279-288 (2010)

H. Zheng, F. Gourronc, J.A. Buckwalter and J.A. Martin. Nanog maintains human chondrocyte phenotype and function in vitro. J. Orthop. Res. 28 (4): 516-521 (2010)

X. Guo, F. Gourronc, Y. Audic, G. Lyons-Levy, T. Mitchell and R.S. Hartley. ElrA and AUF1 differentially bind cyclin B2 mRNA. Biochem. Biophys. Res. Commun. 377 (2): 653-657 (2008)

C.C. Oberley, F. Gourronc, S. Hakimi, M. Riordan, S. Bronner, C. Jiao and M. Dunnwald. Murine epidermal side population possess unique angiogenic properties. Experimental Cell Research 314(4):720-728 (2008)

E. Westin, E. Chavez, K.M. Lee, F. Gourronc, S. Riley, P.M. Lansdorp, F.D. Goldman and A. Klingelhutz. Telomere Restoration and Extension of Proliferative Lifespan in Dyskeratosis Congenita Cells. Aging Cell 6 (3): 383-94 (2007)

F. Gourronc, N. Ahmad, N. Nedza, T. Eggleston and M. Rebagliati. Nodal activity around Kupffer's Vesicle depends on the zebrafish T-box transcription factors Notail and Spadetail and on Notch signaling. Developmental Dynamics 236 (8): 2131-46 (2007)

M.K. Slevin, F. Gourronc, and R.S. Hartley. ElrA binding to the 3’UTR of cyclin E1 mRNA requires polyadenylation elements Nucleic Acid Research 35 (7): 2167-76 (2007)

J. Westmark, F. Gourronc, V. B. Bartleson, U. Sayin, S. Bhattacharya, T. Sutula and J. S. Malter. HuR interacts with a large number of mRNA ligands in mouse hippocampus after seizure J Neuropathol Exp Neurol. 64(12): 1037-45 (2005)

A.J. Klingelhutz, Q. Qian, S.L. Phillips, F. Gourronc, B.W. Darbro, S.R. Patil. Amplification of the chromosome 20q region is associated with expression of HPV-16 E7 in human airway and anogenital epithelial cells.Virology 340(2): 237-44 (2005)

TB. Uhm, MS. Chung, SH. Lee, F. Gourronc, I. Housen, JH. Kim, J. Van Beumen, B. Haye and J. Vandenhaute. Purification and characterization of Aspergillus ficuum endoinulinase Biosci Biotechnol Biochem 63(1):146-51 (1999)