Logo for University of Iowa Health Care This logo represents the University of Iowa Health Care

Peng Shao

Assistant Research Scientist, Butler LaboratoryPeng Shao
Email: peng-shao@uiowa.edu



I am currently interested in understanding the molecular and transcriptional mechanisms that determine how infection and inflammation regulate the formation of pathogen-specific T cell subsets to develop new strategies to improve immunity against globally important diseases like malaria and other microbial infections. 


2005-2008 Ph.D. in Biochemistry and Molecular Biology, Sun Yat-Sen University


2017 - present   Assistant Research Scientist, Dept. of Microbiology and Immunology; University of Iowa

2016 - 2017  Post-doctoral researcher, Dept. of Microbiology and Immunology; University of Iowa

2012 - 2016  Post-doctoral researcher, Dept. of Anatomy and Cell Biology; University of Iowa

2009 - 2014  Member of State Key Laboratory of Biocontrol, China

2009 -2014  Lecturer, School of Life Sciences, Sun Yat-Sen University


  1. Fionna A Surette, Jenna J Guthmiller, Lei Li, Alexandria J Sturtz, Rahul Vijay, Rosemary L Pope, Brandon L McClellan, Angela D Pack, Ryan A Zander, Peng Shao, Linda Yu-Ling Lan, Daniel Fernandez-Ruiz, William R Heath, Patrick C Wilson, Noah S Butler. Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity. PLoS Pathogens. 2021, 17(2):e1009288.   
  2. Fengyin Li, Xin Zhao, Yali Zhang, Peng Shao, Xiaoke Ma, William J Paradee, Chengyu Liu, Jianmin Wang, Hai-Hui Xue. TFH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function. Proc. Natl. Acad. Sci. U.S.A. 2021, 118 (2) e2014562118.
  3. Xin Zhao*, Peng Shao*, Kexin Gai, Fengyin Li, Qiang Shan, Hai-Hui Xue. β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells. eLife. 2020, 9: e55360. (*Co-first author
  4. Qi Liu, Nicholas C Borcherding, Peng Shao, Peterson K Maina, Weizhou Zhang, Hank H Qi. Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance. EBioMedicine. 2020, 51, 102612. Epub 2020 Jan 7
  5. Peng Shao, Fengyin Li, Jinyong Wang, Xia Chen, Chengyu Liu and Hai-Hui Xue. Tcf1 Instructs T follicular helper cell differentiation by repressing Blimp1 in response to acute viral infection. Journal of Immunology. 2019, 203(4):801-806. Epub 2019 Jul 12
  6. Qi Liu, Nicholas Borcherding, Peng Shao, Huojun Cao, Weizhou Zhang, Hank Heng Qi. Identification of novel TGF-β regulated genes with pro-migratory roles. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2019, 1865 (12), 165537. Epub 2019 Aug 23
  7. Shaojun Xing, Kexin Gai, Xiang Li, Peng Shao, Zhouhao Zeng, Xudong Zhao, Xin Zhao, Xia Chen, William J Paradee, David K Meyerholz, Weiqun Peng, Hai-Hui Xue. Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. Journal of Experimental Medicine. 2019, 216(4):847-866. Epub 2019 Mar 5
  8. Shaojun Xing, Peng Shao, Fengyin Li, Xudong Zhao, Wooseok Seo, Justin C Wheat, Selvi Ramasamy, Jianfeng Wang, Xiang Li, Weiqun Peng, Shuyang Yu, Chengyu Liu, Ichiro Taniuchi, David A Sweetser, Hai-Hui Xue. Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity. Journal of Experimental Medicine. 2018, 215(8): 2211-2226. Epub 2018 Jul 25
  9. Isaac J. Jensen, Christina S. Winborn, Micaela G. Fosdick, Peng Shao, Mikaela M. Tremblay, Qiang Shan, Sandeep Kumar Tripathy, Christopher M. Snyder, Hai-Hui Xue, Thomas S. Griffith, Jon C. Houtman, Vladimir P. Badovinac. Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections. PLoS Pathogens. 2018, 14(10):3
  10. Peng Shao, Qi Liu, Peterson Kariuki Maina, Jiayue Cui, Thomas B. Bair, Tiandao Li, Shaikamjad Umesalma, Weizhou Zhang, Hank Heng Qi. Histone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis. Nucleic Acids Research. 2017, 45 (4): 1687-1702
  11. Peterson Kariuki Maina, Peng Shao, Xiongfei Jia, Qi Liu, Shaikamjad Umesalma, Maximo Marin, Donald Long, Jr., Samantha Concepción-Román, Hank Heng Qi. Histone demethylase PHF8 regulates hypoxia signaling through HIF1α and H3K4me3. Biochim Biophys Acta. 2017, 1860(9): 1002-1012. Epub 2017 Jul 20
  12. Peterson Kariuki Maina*, Peng Shao*, Qi Liu, Ladan Fazli, Scott Tyler, Moman Nasir, Xuesen Dong, Hank Heng Qi. (2016) c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer. Oncotarget. 2016, 7(46): 75585-75602. (*Co-first author
  13. Zhi-Wei Dong*, Peng Shao*, Li-Ting Diao, Hui Zhou, Chun-Hong Yu, Liang-Hu Qu. (2012) RTL-P: a sensitive approach for detecting sites of 2'-O-methylation in RNA molecules. Nucleic Acids Research. 2012, 40(20): e157 (*Co-first author
  14. Ling-Ling Zheng, Yan-Zi Wen, Jian-Hua Yang, Jian-You Liao, Peng Shao, Hui Xu, Hui Zhou, Jun-Zhi Wen, Zhao-Rong Lun, Francisco J. Ayala, Liang-Hu Qu. Comparative transcriptome analysis of small noncoding RNAs in different stages of Trypanosoma brucei. RNA. 2013, 19(7):863-875. Epub 2013 May 2
  15. Peng Shao, Jian-You Liao, Dao-Gang Guan, Jian-Hua Yang, Ling-Ling Zheng, Qing Jing, Hui Zhou, Liang-Hu Qu. (2012) Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation. RNA Biology. 2012, 9(2): 213-228. Epub 2012 Feb 1. Cover articl
  16. Jian-Hua Yang, Jun-Hao Li, Peng Shao, Hui Zhou, Yue-Qin Chen, Liang-Hu Qu. starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Research. 2011, 39: D202-209. (Database issue). Epub 2010 Oct 30
  17. Jian-You Liao, Li-Ming Ma, Yan-Hua Guo, Yu-Chan Zhang, Hui Zhou, Peng Shao, Yue-Qin Chen, Liang-Hu Qu. Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailers. PLoS One. 2010, 5(5): e10563
  18. Ying Zhang, Dao-Gang Guan, Jian-Hua Yang, Peng Shao, Hui Zhou, Liang-Hu Qu. ncRNAimprint: a comprehensive database of mammalian imprinted noncoding RNAs. RNA. 2010, 16(10): 1889-1901. Epub 2010 Aug 26
  19. Bin Du, Li-Ming Ma, Mian-Bo Huang, Hui Zhou, Hui-Lin Huang, Peng Shao, Yue-Qin Chen, Liang-Hu Qu. High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells. FEBS Letter. 2010, 584: 811–816. Epub 2010 Jan 12
  20. Jian-Hua Yang, Peng Shao, Hui Zhou, Yue-Qin Chen, Liang-Hu Qu. deepBase: a database for deeply annotating and mining deep sequencing data. Nucleic Acids Research. 2010, 38: D123-130 (Database issue). Epub 2009 Dec 4
  21. Peng Shao, Jian-Hua Yang, Hui Zhou, Dao-Gang Guan, Liang-Hu Qu. Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs. BMC Genomics. 2009, 10: 86
  22. Na Liu, Zhen-Dong Xiao, Chun-Hong Yu, Peng Shao, Yin-Tong Liang, Dao-Gang Guan, Jian-Hua Yang, Chun-Long Chen, Liang-Hu Qu, Hui Zhou. SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights. BMC Genomics. 2009, 10: 515
  23. Peng Shao, Hui Zhou, Zhen-Dong Xiao, Jie-Hua He, Mian-Bo Huang, Yue-Qin Chen, Liang-Hu Qu. Identification of novel chicken microRNAs and analysis of their genomic organization. Gene. 2008, 418: 34-40. Epub 2008 Apr 15
  24. Peng Shao, Yue-Qin Chen, Hui Zhou, Jie Yuan, Liang-Hu Qu, Di Zhao, Yong-Shui Lin. Genetic variability in Gymnodiniaceae ITS regions: Implications for species identification and phylogenetic analysis. Marine Biology. 2004, 144: 215-224
  25. Peng Shao, Yueqin Chen, Hui Zhou, Lianghu Qu, Ying Ma, Heyang Li, Nianzhi Jiao. Phylogenetic diversity of Archaea in prawn farm sediment. Marine Biology. 2004, 146: 133-142
  26. Jie Yuan, Min-Yi Chen, Peng Shao, Hui Zhou, Yue-Qin Chen, Liang-Hu Qu. Genetic diversity of small eukaryotes from the coastal waters of Nansha Islands in China. FEMS microbiology letters. 2004, 240: 163-170
  27. Yueqin Chen, Peng Shao, Hui Zhou, Lianghu Qu and Linda K Medlin. Molecular identification of bloom-forming species Phaeocystis globesa (Prymnesiophyta) and its dispersal based on rDNA ITS sequence analysis. Acta Oceanologica Sinica. 2003, 22: 243-253.

  * Co-first author


Professional Contribution

Journal reviewer
PLoS ONE, 2012-present
The Journal of Urology, 2015 - present
Immunological Journal, 2017 - present
Biomolecules, 2020 - present
Genes, 2020 - present

Member of the reviewer board
Biomolecules, 2020 - present
Microorganisms, 2021 - present