Rudra Channappanavar

Rudra ChannappanavarPostdoctoral Research Scholar
Address: 3-730 BSB
Phone: (319) 335-7576
Email: rudra-c@uiowa.edu

Mentor: Stanley Perlman, MD, PhD

Education/Training

2012    Doctor of Philosophy (PhD), Oakland University, Rochester, Michigan                               

2007    Master’s in Veterinary Science (MVSc)  (Specialization: Veterinary Pathology) Indian Veterinary Research Institute, Izatnagar-Bareilly, UP, India

2005    Bachelor of Veterinary Science (equivalent to DVM), Veterinary College-KVAFSU,  Bidar, Karnataka, India

Research Description

My research goal is to study pathogenesis of highly pathogenic human coronaviruses in a mouse model. I am particularly interested in unraveling the role of innate immunity in mediating host protection vs immunopathology.

Publication(s)

Channappanavar R and Perlman S (2017) Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology. Seminars in Immunopathology (Review article, accepted for publication).

Channappanavar R, Fett C, Mack M, Ten Eyck PP, Meyerholz DK and Perlman S (2017) Sex-based differences in susceptibility to SARS-CoV infection in a mouse model. Journal of Immunology. doi: 10.4049/jimmunol.1601896.

Li K, Wohlford-Lenane CL, Channappanavar R, Park JE, Bair TB, Flaherty HA, Gallagher T, Meyerholz DK, Perlman S, McCray, Jr PB. (2017) Mouse Adapted MERS Coronavirus Causes Lethal Lung Disease in hDPP4 Receptor Knock-in Mice. Proceedings of National Academy of Sciences.  doi:10.1073/pnas.1619109114

Wang Y, Sun J, Channappanavar R, Zhao J, Perlman S* and Zhao J* (2017) Simultaneous Intranasal/Intravascular Antibody Labeling of CD4+ T Cells in Mouse Lungs. Bio-protocol. DOI: https://doi.org/10.21769/BioProtoc.2099

Fehr AR*, Channappanavar R*, Perlman S (2017). Middle East Respiratory Syndrome: Emergence of a pathogenic human coronavirus. Annual Reviews Medicine. 2017 Jan 14; 68:387-399. doi: 10.1146/annurev-med-051215-031152.
* Equal Contribution

Fehr AR, Channappanavar R, Jankevicious G, Fett C, Zhao J, Athmer J, Meyerholz DK, Ahel I and Perlman S (2016). The conserved Coronavirus macrodomain promotes virulence and suppresses innate immune response during SARS-CoV infection. mBio. 7(6). pii: e01721-16. doi: 10.1128/mBio.01721-16.

Zhao J, Zhao J, Mangalam AK, Channappanavar R, Fett C, Meyerholz DK, Agnihothram S, Baric RS, David CS, Stanley Perlman (2015). Airway memory CD4 T cells mediate protective immunity against emerging respiratory Coronaviruses.. Immunity. 2016 Jun 21; 44(6): 1379-91

Luke T, Wu H, Zhao J, Channappanavar R, Coleman CM, Jiao Jin-An, Matsushita H, Liu Ye, Postnikova E, Ork BL, Glenn G, Flyer D, Defang G, Raviprakash K, Kochel T, Wang J, Nie W, Smith G, Hensley L, Olinger G, Kuhn J, Holbrook MR, Johnson R, Perlman S, Sullivan E, Frieman M (2016). MERS-CoV human immunoglobulin produced from transchromosomic bovines inhibits MERS-CoV in vivo. Science Translational Medicine. 2016 Feb 17;8(326): 326ra21

Channappanavar R, Fehr AR, Vijay R, Mack M, Zhao J, Meyerholz DK and Perlman S (2016). Dysregulated Type I interferon and inflammatory monocyte-macrophage signalling promotes lethal disease in SARS-CoV infected mice. Cell Host and Microbe.  18: 181-193.

Zhang N, Channappanavar R, Ma C, Wang L, Tang J, Garron T, Tao X, Tasneem S, Lu L, Tseng CT, Zhou Y, Perlman S, Jiang S, Du L. (2016). Identification of an ideal adjuvant for receptor binding domain-based subunit vaccines against Middle East Respiratory Syndrone Coronavirus. Cellular and Molecular Immunology. doi: 10.1038/cmi.2015.03.

Channappanavar R, Lu L, Xia S, Du L, Meyerholz DK, Perlman S, Jiang S. (2015) Protective effect of intranasal regimens containing peptidic Middle East respiratory syndrome Coronavirus fusion inhibitor against MERS-CoV infection. Journal of Infectious Diseases, 212 (12): 1894-903.

Fehr AR, Athmer J, Channappanavar R, Phillips JM, Meyerholz DK, Perlman S (2015). The nsp3 macrodomain promotes virulence in mice with coronavirus induced encephalitis. Journal of Virology. 2015 Feb 1; 89 (3): 1523-36.

Channappanavar R, Fett C, Zhao J, Meyerholz DK and Perlman S. (2014) Virus-specific memory CD8 T cells provide substantial protection lethal SARS-CoV infection. Journal of Virology. 88(19): 11034-44.

Trujillo JA, Gras S, Twist KA, Croft NP, Channappanavar R, Rossjohn J, Purcell AW, Perlman S  (2014) The cellular redox environment alters antigen presentation. Journal of Biological Chemistry; 289 (40): 27979-91.

Trujillo JA, Gras S, Twist KA, Croft NP, Channappanavar R, Rossjohn J, Purcell AW, Perlman S (2014) Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes. Journal of Immunology 192:5245-5256.

Channappanavar R, Zhao J, Perlman S. (2014) T cell-mediated immune response to respiratory coronaviruses. Immunologic research. 2014 Aug; 59 (1-3):118-28.

Umeshappa CS, Singh KP, Channappanavar R, Sharma K, Nanjundappa RH, Singh R, Sharma AK, Singh M (2011). Enhanced clinico-pathology, and viral and immune responses following intradermal inoculation of BTV-23 serotype in Indian native sheep. Veterinary Immunology and Immunopathology. 15; 141 (3-4): 230-8.

Channappanavar R, Singh KP, Singh R and Pandey AB. (2012) Enhanced pro-inflammatory cytokine activity during experimental BTV-1 infection in Indian native sheep. Veterinary Immunology and Immunopathology. 15; 145 (1-2): 485-92.

Twardy BS, Channappanavar R, Suvas S. (2011) Level of neuropeptide Substance P correlates with the severity of herpetic stromal keratitis. Investigative Ophthalmology Visual Sciences. 4; 52 (12): 8604-13.

Umeshappa CS, Singh KP, Nanjundappa RH, Channappanavar R, Maan S, Maan NS (2012). Bluetongue virus–23 stimulates inducible nitric oxide synthase expression and nitric oxide production in mononuclear cells of blood and/or regional lymphoid organs. Veterinary Research Communication. 2012 Sep 25.

Channappanavar R, Twardy BS, Suvas S. (2012) Differential effect of blocking PD-1/PDL-1 interaction in enhancing virus specific CD8 T cell response in young and aged mice. PLoS One. 7(7): e39757.

Channappanavar R, Twardy B S, Pratima K and Suvas S. (2009) Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells. Mechanism of ageing and development. 130(10): 709-12.

Ingale SL, Singh P, Raina OK, Verma AK. Channappanavar R., Mehra UR. (2010) Interleukin-2 and interleukin-10 gene expression in calves experimentally infected with Fasciola gigantica. Livestock Science. 131 (1): 141-143.

Award(s)

2016       Post-Doctoral travel award, American Society for Virology meeting at Virginia Tech, Blacksburg, VA. USA.

2016       Trainee abstract award, American Association of Immunologists meeting at Seattle, Washington, USA.

2015       Levitt Centre for Virus Pathogenesis travel award to attend Keystone Meeting on ‘Viral Immunity’, Breckenridge, Colorado, USA.

2011       International Students Scholarly Achievement award for excellent academic achievement at the Oakland University.

2011       Provost Grant for Graduate Research from Oakland University for the proposed work on the ‘Role of Substance P in Inflamm-Aging’.

2010       Graduate Student Research Travel Grant to attend 97th Annual American Association of Immunologists meeting at Baltimore, Maryland.

2007      ‘Young Scientist Award’ conferred by Indian Association of Veterinary Pathologists  (IAVP) for the best MVSc thesis research.

2005      8th rank and Junior Research Fellowship in all India entrance exam conducted by Indian Council of Agricultural Research (ICAR) to study Masters (MVSc) in Veterinary Pathology.