Bradley D. Jones, PhD

Portrait
Professor of Microbiology and Immunology

Contact Information

Office: 3-330A Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
319-353-5457

Lab: 3-330 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
319-335-7794

Education

BS, Microbiology, University of Maryland
PhD, Biochemistry, University of Maryland School of Medicine, Baltimore

Post Doctoral Fellow, Pathogenic Microbiology, Stanford University

Education/Training Program Affiliations

Biomedical Science Program, Department of Microbiology Graduate Program, Interdisciplinary Graduate Program in Genetics, Medical Scientist Training Program

Center, Program and Institute Affiliations

Bacterial Respiratory Pathogens Research Unit, Inflammation Program

Research Summary

The Jones laboratory is carrying out research on two different bacterial pathogens, Francisella tularensis and Salmonella spp. Several projects are being pursued with the Select Agent bacterium Francisella tularensis. This organism is a significant biodefense concern because of its extreme pathogenicity and low infectivity. Key advances in our laboratory were the development of genetic systems, including a Tn5 transposition system, which has allowed the creation of bacterial mutants so that various virulence properties of this organism can be deleted and studied. Current work in our laboratory is focused on identifying and characterizing Francisella tularensis mutants with alterations in a variety of virulence mechanisms in this organism including growth and survival in human macrophages, inactivation of human neutrophil responses, entry and growth in primary human small airway epithelial cells and regulation of known and unknown virulence factors. Each of these projects is active and ongoing in the Jones laboratory with collaboration with other laboratories at The University of Iowa.

Other work in the laboratory is focused on understanding the regulators, and the signals that they respond to, in pathogenic Salmonella species. These pathogenic bacteria cause disease in a host by invading epithelial cells of the intestine and subsequently entering and growing within macrophages of the lymphatic system. Salmonella invasion of host cells is accompanied by dramatic changes of the host cell membrane that indicate that these bacteria activate existing cellular signal transduction pathways. The ability of Salmonella to invade host cells is tightly regulated by a number of environmental and genetic signals. One significant project is aimed at understanding how Salmonella establishes colonization of a host intestinal surface (biofilm formation). Recent work from the lab indicates that both extracellular matrix components and adherence factors such as fimbriae play specific and important roles in establishing the extensive biofilm that we observe in the colonization of tissue culture cells and host intestinal tissue. GFP-labelled bacteria are being used to study these events by fluorescent confocal microscopy. Future goals of this work will be aimed at identifying genes involved in the formation of biofilm formation as well as identifying and studying in detail the cells that serve as the attachment sites of the bacteria. In addition, we have developed a genetic screen to identify small molecule inhibitors of various checkpoints in these regulatory cascades which can be disrupted as part of a strategy to intervene in the development of colonization and disease. This work has implications for understanding colonization of Salmonella in domestic animals such as chickens and pigs as well as the establishment of human disease.

Publications

Roberts, L. M., Crane, D. D., Wehrly, T. D., Fletcher, J. R., Jones, B. D. & Bosio, C. M. (2016). Inclusion of Epitopes That Expand High-Avidity CD4+ T Cells Transforms Subprotective Vaccines to Efficacious Immunogens against Virulent Francisella tularensis. J Immunol, 197(7), 2738-47. PMID: 27543611.

Wyatt, E. V., Diaz, K., Griffin, A. J., Rasmussen, J. A., Crane, D. D., Jones, B. D. & Bosio, C. M. (2016). Metabolic Reprogramming of Host Cells by Virulent Francisella tularensis for Optimal Replication and Modulation of Inflammation. J Immunol, 196(10), 4227-36. PMID: 27029588.

Chen, L., Valentine, J. L., Huang, C. J., Endicott, C. E., Moeller, T. D., Rasmussen, J. A., Fletcher, J. R., Boll, J. M., Rosenthal, J. A., Dobruchowska, J., Wang, Z., Heiss, C., Azadi, P., Putnam, D., Trent, M. S., Jones, B. D. & DeLisa, M. P. (2016). Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies. Proc Natl Acad Sci U S A, 113(26), E3609-18. PMID: 27274048.

Baxter, M. A., Jones, B. D. (2015). Two-Component Regulators Control hilA Expression by Controlling fimZ and hilE Expression within Salmonella enterica Serovar Typhimurium. Infect Immun, 83(3), 978-85. PMID: 25547794.

Rasmussen, J. A., Fletcher, J. R., Long, M. E., Allen, L. A. & Jones, B. D. (2015). Characterization of Francisella tularensis Schu S4 mutants identified from a transposon library screened for O-antigen and capsule deficiencies. Front Microbiol, 6, 338. PMID: 25999917.

Faron, M., Fletcher, J. R., Rasmussen, J. A., Apicella, M. A. & Jones, B. D. (2015). Interactions of Francisella tularensis with Alveolar Type II Epithelial Cells and the Murine Respiratory Epithelium. PLoS One, 10(5), e0127458. PMID: 26010977.

Workalemahu, G., Wang, H., Puan, K. J., Nada, M. H., Kuzuyama, T., Jones, B. D., Jin, C. & Morita, C. T. (2014). Metabolic Engineering of Salmonella Vaccine Bacteria To Boost Human V?2Vd2 T Cell Immunity. J Immunol, 193(2), 708-21. PMID: 24943221.

Jones, B. D., Faron, M., Rasmussen, J. A. & Fletcher, J. R. (2014). Uncovering the components of the Francisella tularensis virulence stealth strategy. Front Cell Infect Microbiol, 4, 32. PMID: 24639953.

Rasmussen, J. A., Post, D. M., Gibson, B. W., Lindemann, S. R., Apicella, M. A., Meyerholz, D. K. & Jones, B. D. (2014). Francisella tularensis Schu S4 lipopolysaccharide core sugar and O-antigen mutants are attenuated in a mouse model of tularemia. Infect Immun, 82(4), 1523-39. PMID: 24452684.

Faron, M., Fletcher, J. R., Rasmussen, J. A., Long, M. E., Allen, L. A. & Jones, B. D. (2013). The Francisella tularensis migR, trmE, and cphA genes contribute to FPI gene regulation and intracellular growth by modulation of the stress alarmone ppGpp. Infect Immun, 81(8), 2800-11. PMID: 23716606.

Ulland, T. K., Janowski, A. M., Buchan, B. W., Faron, M., Cassel, S. L., Jones, B. D. & Sutterwala, F. S. (2013). Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation. Infect Immun, 81(1), 201-8. PMID: 23115038.

Long, M. E., Lindemann, S. R., Rasmussen, J. A., Jones, B. D. & Allen, L. A. (2013). Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC Genes Results in Attenuation for Growth in Human Macrophages and In Vivo Virulence in Mice and Reveals a Unique Phenotype for pdpC. Infect Immun, 81(3), 850-61. PMID: 23275090.

Lindemann, S. R., Peng, K., Long, M. E., Hunt, J. R., Apicella, M. A., Monack, D. M., Allen, L. A. & Jones, B. D. (2011). Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages. Infect Immun, 79(2), 581-94. PMID: 21078861.

Apicella, M. A., Post, D. M., Fowler, A. C., Jones, B. D., Rasmussen, J. A., Hunt, J. R., Imagawa, S., Choudhury, B., Inzana, T. J., Maier, T. M., Frank, D. W., Zahrt, T. C., Chaloner, K., Jennings, M. P., McLendon, M. K. & Gibson, B. W. (2010). Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of Francisella tularensis. PLoS One, 5(7), e11060. PMID: 20625403.

McCaffrey, R. L., Schwartz, J. T., Lindemann, S. R., Moreland, J. G., Buchan, B. W., Jones, B. D. & Allen, L. A. (2010). Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis. J Leukoc Biol, 88(4), 791-805. PMID: 20610796.

Ulland, T. K., Buchan, B. W., Ketterer, M. R., Fernandes-Alnemri, T., Meyerholz, D. K., Apicella, M. A., Alnemri, E. S., Jones, B. D., Nauseef, W. M. & Sutterwala, F. S. (2010). Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence. J Immunol, 185(5), 2670-4. PMID: 20679532.

Schulert, G. S., McCaffrey, R. L., Buchan, B. W., Lindemann, S. R., Hollenback, C., Jones, B. D. & Allen, L. A. (2009). Francisella tularensis genes required for inhibition of the neutrophil respiratory burst and intramacrophage growth identified by random transposon mutagenesis of strain LVS. Infect Immun, 77(4), 1324-36. PMID: 19204089.

Buchan, B. W., McCaffrey, R. L., Lindemann, S. R., Allen, L. A. & Jones, B. D. (2009). Identification of migR, a regulatory element of the Francisella tularensis live vaccine strain iglABCD virulence operon required for normal replication and trafficking in macrophages. Infect Immun, 77(6), 2517-29. PMID: 19349423.

Buchan, B. W., McLendon, M. K. & Jones, B. D. (2008). Identification of differentially regulated Francisella tularensis genes by use of a newly developed Tn5-based transposon delivery system. Appl Environ Microbiol, 74(9), 2637-45. PMID: 18344342.

Lindemann, S. R., McLendon, M. K., Apicella, M. A. & Jones, B. D. (2007). An in vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells. Infect Immun, 75(6), 3178-82. PMID: 17339345.

Ledeboer, N. A., Frye, J. G., McClelland, M. & Jones, B. D. (2006). Salmonella enterica serovar Typhimurium requires the Lpf, Pef, and Tafi fimbriae for biofilm formation on HEp-2 tissue culture cells and chicken intestinal epithelium. Infect Immun, 74(6), 3156-69. PMID: 16714543.

Jones, B. D. (2006). Foodborne microbe mechanisms of colonization, attachment, and invasion.

Jones, B. D. (2005). Salmonella invasion gene regulation: a story of environmental awareness. J Microbiol, 43 Spec No, 110-7. PMID: 15765064.

Esteves, C. L., Jones, B. D. & Clegg, S. (2005). Biofilm formation by Salmonella enterica serovar Typhimurium and Escherichia coli on epithelial cells following mixed inoculations. Infect Immun, 73(8), 5198-203. PMID: 16041039.

Baxter, M. A., Jones, B. D. (2005). The fimYZ genes regulate Salmonella enterica serovar Typhimurium invasion in addition to type 1 fimbrial expression and bacterial motility. Infect Immun, 73(3), 1377-85. PMID: 15731035.

Ledeboer, N. A., Jones, B. D. (2005). Exopolysaccharide sugars contribute to biofilm formation by Salmonella enterica serovar Typhimurium on HEp-2 cells and chicken intestinal epithelium. J Bacteriol, 187(9), 3214-26. PMID: 15838049.

Catron, D. M., Lange, Y., Borensztajn, J., Sylvester, M. D., Jones, B. D. & Haldar, K. (2004). Salmonella enterica serovar Typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferation. Infect Immun, 72(2), 1036-42. PMID: 14742551.

Frana, T. S., Carlson, S. A., Rauser, D. C., Jones, B. D., Fergen, B. J. & Griffith, R. W. (2004). Effects of microcin 24-producing Escherichia coli on shedding and multiple-antimicrobial resistance of Salmonella enterica serotype typhimurium in pigs. Am J Vet Res, 65(12), 1616-20. PMID: 15631023.

Boddicker, J., Jones, B. D. (2004). Lon protease activity causes down-regulation of Salmonella pathogenicity island 1 invasion gene expression after infection of epithelial cells. Infect Immun, 72(4), 2002-13. PMID: 15039320.

Boddicker, J., Knosp, B. M. & Jones, B. D. (2003). Transcription of the Salmonella invasion gene activator, hilA, requires HilD activation in the absence of negative regulators. J Bacteriol, 185(2), 525-33. PMID: 12511499.

Baxter, M. A., Fahlen, T. F., Wilson, R. L. & Jones, B. D. (2003). HilE interacts with HilD and negatively regulates hilA transcription and expression of the Salmonella enterica serovar Typhimurium invasive phenotype. Infect Immun, 71(3), 1295-305. PMID: 12595445.

Boddicker, J. D., Jones, B. D. (2002). Salmonella invasion gene regulation: Being sensitive to the environment. Seoul National University, 1-30.

Carlson, S. A., Omary, M. B. & Jones, B. D. (2002). Identification of cytokeratins as accessory mediators of Salmonella entry into eukaryotic cells. Life Sci, 70(12), 1415-26. PMID: 11883717.

Catron, D. M., Sylvester, M. D., Lange, Y., Kadekoppala, M., Jones, B. D., Monack, D. M., Falkow, S. & Haldar, K. (2002). The Salmonella-containing vacuole is a major site of intracellular cholesterol accumulation and recruits the GPI-anchored protein CD55. Cell Microbiol, 4(6), 315-28. PMID: 12067317.

Boddicker, J., Ledeboer, N. A., Jagnow, J., Jones, B. D. & Clegg, S. (2002). Differential binding to and biofilm formation on, HEp-2 cells by Salmonella enterica serovar Typhimurium is dependent upon allelic variation in the fimH gene of the fim gene cluster. Mol Microbiol, 45(5), 1255-65. PMID: 12207694.

Meyerholz, D., Stabel, T. J., Ackermann, M. R., Carlson, S. A., Jones, B. D. & Pohlenz, J. (2002). Early epithelial invasion by Salmonella enterica serovar Typhimurium DT104 in the swine ileum. Vet Pathol, 39(6), 712-20. PMID: 12450202.

Carlson, S. A., Casey, T. A., Wu, M. T., Hammes, B. D. & Jones, B. D. (2002). A high-throughput genetic system for assessing the inhibition of proteins: identification of antibiotic resistance and virulence targets and their cognate inhibitors in Salmonella. Anal Biochem, 310(1), 72-83. PMID: 12413476.

Wilson, R. L., Libby, S. J., Freet, A. M., Boddicker, J., Fahlen, T. F. & Jones, B. D. (2001). Fis, a DNA nucleoid-associated protein, is involved in Salmonella typhimurium SPI-1 invasion gene expression. Mol Microbiol, 39(1), 79-88. PMID: 11123690.

Klein, J. R., Jones, B. D. (2001). Salmonella pathogenicity island 2-encoded proteins SseC and SseD are essential for virulence and are substrates of the type III secretion system. Infect Immun, 69(2), 737-43. PMID: 11159962.

Gallois, A., Klein, J. R., Allen, L. H., Jones, B. D. & Nauseef, W. M. (2001). Salmonella pathogenicity island 2-encoded type III secretion system mediates exclusion of NADPH oxidase assembly from the phagosomal membrane. J Immunol, 166(9), 5741-8. PMID: 11313417.

Fahlen, T. F., Wilson, R. L., Boddicker, J. & Jones, B. D. (2001). Hha is a negative modulator of transcription of hilA, the Salmonella enterica serovar Typhimurium invasion gene transcriptional activator. J Bacteriol, 183(22), 6620-9. PMID: 11673432.

Wilson, R. L., Tvinnereim, A. R., Jones, B. D. & Harty, J. T. (2001). Identification of Listeria monocytogenes in vivo-induced genes by fluorescence-activated cell sorting. Infect Immun, 69(8), 5016-24. PMID: 11447181.

Carlson, S. A., Meyerholz, D., Stabel, T. J. & Jones, B. D. (2001). Secretion of a putative cytotoxin in multiple antibiotic resistant Salmonella enterica serotype Typhimurium phagetype DT104. Microb Pathog, 31(4), 201-4. PMID: 11562173.

Fahlen, T. F., Mathur, N. & Jones, B. D. (2000). Identification and characterization of mutants with increased expression of hilA, the invasion gene transcriptional activator of Salmonella typhimurium. FEMS Immunol Med Microbiol, 28(1), 25-35. PMID: 10767604.

Carlson, S. A., Browning, M., Ferris, K. E. & Jones, B. D. (2000). Identification of diminished tissue culture invasiveness among multiple antibiotic resistant Salmonella typhimurium DT104. Microb Pathog, 28(1), 37-44. PMID: 10623562.

Klein, J. R., Fahlen, T. F. & Jones, B. D. (2000). Transcriptional organization and function of invasion genes within Salmonella enterica serovar Typhimurium pathogenicity island 1, including the prgH, prgI, prgJ, prgK, orgA, orgB, and orgC genes. Infect Immun, 68(6), 3368-76. PMID: 10816487.

Wilson, R. L., Elthon, J., Clegg, S. & Jones, B. D. (2000). Salmonella enterica serovars Gallinarum and Pullorum expressing Salmonella enterica serovar typhimurium type 1 fimbriae exhibit increased invasiveness for mammalian cells. Infect Immun, 68(8), 4782-5. PMID: 10899888.

Fahlen, T., Mathur, N. & Jones, B. D. (1999). Identification of Tn5 Transposon Insertions which Alter the Expression of the Invasion Gene Regulator hilA. The Sixth Midwest Pathogenesis Meeting, Milwaukee, WI.

Baxter, A., Jones, B. D. (1999). Identification of interactions between Salmonella invasion proteins of SPI-1 that are required for secretion of effector proteins. The Sixth Midwest Pathogenesis Meeting, Milwaukee, WI.

Wilson, R., Elthon, J., Clegg, S. & Jones, B. D. (1999). Salmonella gallinarum and Salmonella pullorum encoding Salmonella typhimurium type 1 fimbriae exhibit increased invasiveness for mammalian cells. pp. 24. Abstracts, Cold Spring Harbor Microbial Pathogenesis and Host Response Meeting, Cold Spring Harbor, NY.

Carlson, S. A., Bolton, L. F., Briggs, C. E., Hurd, H. S., Sharma, V. K., Fedorka-Cray, P. J. & Jones, B. D. (1999). Detection of multiresistant Salmonella typhimurium DT104 using multiplex and fluorogenic PCR. Mol Cell Probes, 13(3), 213-22. PMID: 10369747.

Fahlen, T., Mathur, N. & Jones, B. D. (1999). Identification and Analysis of a Tn5 Insertion which Results in Hyperinvasive S. typhimurium. pp. 65. Abstracts, Annual Meeting, ASM, Chicago, IL.

Carlson, S., Wilson, R., Omary, B. & Jones, B. D. (1999). Cytokeratin-18 as a potential mediator of Salmonella invasion. A Cell Biology Approach to Microbial Pathogenesis. pp. 9-10. Abstracts, ASM, Portland, OR.

Boddicker, J., Klein, J., Latzke, A. & Jones, B. D. (1999). Cloning and Characterization of Salmonella Pathogenicity Island 1. pp. 95. Abstracts, Annual Meeting, ASM, Chicago, IL.

Klein, J., Latzke, A. & Jones, B. D. (1999). Cloning and Characterization of Salmonella Pathogenicity Island 2. pp. 94. Abstracts, Annual Meeting, ASM, Chicago, IL.

Baxter, A., Jones, B. D. (1998). Characterization of the Role of the OrgA Protein in Salmonella Invasion of Mammalian Cells. pp. I-7. Abstracts, Midwest Pathogenesis Meeting, St Louis, MO.

Klein, J., Jones, B. D. (1998). Analysis of a Salmonella operon required for host cell invasion. pp. I-40. Abstracts, Midwest Pathogenesis Meeting, St Louis, MO.

Fahlen, T., Jones, B. D. (1998). A chromosomal Tn5 insertion causes increased expression of hilA and magnesium regulates hilA expression independent of phoP/Q. pp. I-23. Abstracts, Midwest Pathogenesis Meeting, St Louis, MO.

Jensen, V. B., Harty, J. T. & Jones, B. D. (1998). Interactions of the invasive pathogens Salmonella typhimurium, Listeria monocytogenes, and Shigella flexneri with M cells and murine Peyer's patches. Infect Immun, 66(8), 3758-66. PMID: 9673259.

Carlson, S. A., Jones, B. D. (1998). Inhibition of Salmonella typhimurium invasion by host cell expression of secreted bacterial invasion proteins. Infect Immun, 66(11), 5295-300. PMID: 9784535.

Fahlen, T., Mathur, N. & Jones, B. D. (1997). Regulation of Invasion of Salmonella typhimurium phoP and Identification of a Negative Regulator of hilA. pp. 33. Abstracts, Cold Spring Harbor Microbial Pathogenesis and Host Response Meeting, Cold Spring Harbor, NY.

Werner, J., Jones, B. D. (1997). Construction of a Variable-copy Cloning Vector. pp. 298. Abstracts, Annual Meeting, ASM, Miami Beach, FL.

Fahlen, T., Jones, B. D. (1997). Effect of a phoP-mutation on invasion in S. typhimurium. pp. 80. Abstracts, Annual Meeting, ASM, Miami Beach, FL.

Jones, B. D. (1997). Host responses to pathogenic Salmonella infection. Genes Dev, 11(6), 679-87. PMID: 9087423.

Jones, B. D., Nichols, W. A., Gibson, B. W., Sunshine, M. G. & Apicella, M. A. (1997). Study of the role of the htrB gene in Salmonella typhimurium virulence. Infect Immun, 65(11), 4778-83. PMID: 9353064.

Sunshine, M. G., Gibson, B. W., Engstrom, J. J., Nichols, W. A., Jones, B. D. & Apicella, M. A. (1997). Mutation of the htrB gene in a virulent Salmonella typhimurium strain by intergeneric transduction: strain construction and phenotypic characterization. J Bacteriol, 179(17), 5521-33. PMID: 9287009.

Penheiter, K. L., Mathur, N., Giles, D., Fahlen, T. & Jones, B. D. (1997). Non-invasive Salmonella typhimurium mutants are avirulent because of an inability to enter and destroy M cells of ileal Peyer's patches. Mol Microbiol, 24(4), 697-709. PMID: 9194698.

Fahlen, T., Penheiter, K., Mathur, N. & Jones, B. D. (1996). Salmonella Oxygen-regulated Invasion Genes are Essential for Entry and Destruction of M cells and in the Establishment of Infection by an Oral Route. pp. 200. Abstracts, Annual Meeting, ASM, New Orleans, LA.

Jones, B. D., Falkow, S. (1996). Salmonellosis: host immune responses and bacterial virulence determinants. Annu Rev Immunol, 14, 533-61. PMID: 8717524.

Jones, B. D. (1995). Characterization of Oxygen-Regulated Genes Required for S. typhimurium Host Cell Entry. pp. 219. Abstracts, Annual Meeting, ASM, Washington, DC.

Jones, B. D., Pascopella, L. & Falkow, S. (1995). Entry of microbes into the host: using M cells to break the mucosal barrier. Curr Opin Immunol, 7(4), 474-8. PMID: 7495510.

Jones, B. D., Ghori, N. & Falkow, S. (1994). Salmonella-host cell interactions which lead to membrane ruffling and bacterial entry. pp. 40. Abstracts, J of Cellular Biochemistry, Keystone Symposia on Molecular and Cellular Biology, Santa Fe, NM.

Jones, B. D. (1994). Salmonella-host cell interactions which lead to bacterial invasion.

Jones, B. D., Ghori, N. & Falkow, S. (1994). Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches. J Exp Med, 180(1), 15-23. PMID: 8006579.

Jones, B. D., Falkow, S. (1994). Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization. Infect Immun, 62(9), 3745-52. PMID: 8063389.

Jones, B. D., Falkow, S. (1993). Identification and characterization of an oxygen-regulated S. typhimurium invasion gene. pp. 246. Abstracts, Annual Meeting, ASM, Atlanta, GA.

Jones, B. D., Falkow, S. (1993). Phenotypic and genetic aspects of Salmonella invasion. In C. Kado , J. Crosa (Eds.) Molecular mechanisms of bacterial virulence. Kluwer Academic Publishers.

Jones, B. D., Paterson, H., Hall, A. & Falkow, S. (1993). S. typhimurium induces membrane ruffling by a rac-independent mechanism. The First Bristol-Myers Squibb Symposium on Infectious Disease Research. The Cell and Molecular Biology of Bacterial-Host Cell Interactions. Monterey, CA.

Jones, B. D., Paterson, H. F., Hall, A. & Falkow, S. (1993). Salmonella typhimurium induces membrane ruffling by a growth factor-receptor-independent mechanism. Proc Natl Acad Sci U S A, 90(21), 10390-4. PMID: 8234304.

Francis, C. L., Ryan, T. A., Jones, B. D., Smith, S. J. & Falkow, S. (1993). Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria. Nature, 364(6438), 639-42. PMID: 8350922.

Jones, B. D., Falkow, S. (1992). Characterization of Salmonella typhimurium mutants defective in invasion. pp. 14. Abstracts, Fallen Leaf Lake Conference, South Lake Tahoe, CA.

Jones, B. D., Lee, C. A. & Falkow, S. (1992). Invasion by Salmonella typhimurium is affected by the direction of flagellar rotation. Infect Immun, 60(6), 2475-80. PMID: 1587617.

Lee, C. A., Jones, B. D. & Falkow, S. (1992). Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants. Proc Natl Acad Sci U S A, 89(5), 1847-51. PMID: 1311853.

Jones, B. D., Lockatell, V., Johnson, D., Warren, J. & Mobley, H. (1990). Construction of a urease-negative mutant of Proteus mirabilis: analysis of virulence in a mouse model of ascending urinary tract infection. pp. 44. Abstracts, Annual Meeting, ASM, Anaheim, CA.

Hu, L. T., Jones, B. D., Nicholson, E. B. & Mobley, H. L. (1990). Purified ureases from Helicobacter (Campylobacter) pylori, Morganella morganii, and jack bean and sequenced urease genes of Proteus mirabilis suggest a common genetic origin. pp. 64. Abstracts, Annual Meeting, ASM, Anaheim, CA.

Mobley, H. L., Green, D. M., Trifillis, A. L., Johnson, D. E., Chippendale, G. R., Lockatell, C. V., Jones, B. D. & Warren, J. W. (1990). Pyelonephritogenic Escherichia coli and killing of cultured human renal proximal tubular epithelial cells: role of hemolysin in some strains. Infect Immun, 58(5), 1281-9. PMID: 2182540.

Jones, B. D., Lockatell, C. V., Johnson, D. E., Warren, J. W. & Mobley, H. L. (1990). Construction of a urease-negative mutant of Proteus mirabilis: analysis of virulence in a mouse model of ascending urinary tract infection. Infect Immun, 58(4), 1120-3. PMID: 2180821.

Hu, L. T., Nicholson, E. B., Jones, B. D., Lynch, M. J. & Mobley, H. L. (1990). Morganella morganii urease: purification, characterization, and isolation of gene sequences. J Bacteriol, 172(6), 3073-80. PMID: 2345135.

Jones, B. D., Mobley, H. L. (1989). Nucleotide sequence of the urease operon of Proteus mirabilis. pp. 41. Abstracts, Annual Meeting, ASM, New Orleans, LA.

Mobley, H. L., Rosenthal, L. E., Trofa, A. F. & Jones, B. D. (1989). Optimization of detection of Campylobacter pylori by urease and DNA hybridization. In F. Megraud , H. Lamouliatte (Eds.) Gastroduodenal pathology and Campylobacter pylori. pp. 127-31. Excerpta Medica.

Hu, L., Jones, B. D., Fox, M., Nicholson, E. & Mobley, H. (1989). Morganella morganii urease: purification and cloning of gene sequences. pp. 41. Abstracts, Annual Meeting, ASM, New Orleans, LA.

Jones, B. D., Mobley, H. L. (1989). Proteus mirabilis urease: nucleotide sequence determination and comparison with jack bean urease. J Bacteriol, 171(12), 6414-22. PMID: 2687233.

Trofa, A. F., Jones, B. D., Rosenthal, L. E., Green, D., Chippendale, G. & Mobley, H. L. (1988). A DNA probe for the detection of Campylobacter pylori. pp. 81. Abstracts, Annual Meeting, ASM, Miami Beach, FL.

Jones, B. D., Lynch, M. J. & Mobley, H. L. (1988). Genetic organization of the Proteus mirabilis urease operon. pp. 64. Abstracts, Annual Meeting, ASM, Miami Beach, FL.

Mobley, H., Rosenthal, L., Trofa, A. & Jones, B. D. (1988). Optimization of detection of Campylobacter pylori by urease and DNA hybridization. Workshop of Gastroduodenal Pathology and Campylobacter pylori, Bordeaux, France.

Jones, B. D., Mobley, H. L. (1988). Proteus mirabilis urease: genetic organization, regulation, and expression of structural genes. J Bacteriol, 170(8), 3342-9. PMID: 2841283.

Mobley, H. L., Cortesia, M. J., Rosenthal, L. E. & Jones, B. D. (1988). Characterization of urease from Campylobacter pylori. J Clin Microbiol, 26(5), 831-6. PMID: 3384908.

Jones, B. D., Mobley, H. L. (1987). Genetic and biochemical diversity among ureases of Proteus, Providencia, and Morganella species isolated from urinary tract infection. pp. 73. Abstracts, Annual Meeting, ASM, Atlanta, GA.

Mobley, H. L., Jones, B. D. & Penner, J. L. (1987). Urease activity of Proteus penneri. J Clin Microbiol, 25(12), 2302-5. PMID: 3429622.

Jones, B. D., Mobley, H. L. (1987). Genetic and biochemical diversity among ureases of Proteus, Providencia, and Morganella species isolated from urinary tract infection. Maryland-Washington, DC Meeting, ASM, Baltimore, MD.

Jones, B. D., Mobley, H. L. (1987). Genetic and biochemical diversity of ureases of Proteus, Providencia, and Morganella species isolated from urinary tract infection. Infect Immun, 55(9), 2198-203. PMID: 3623698.

Jones, B. D., Mobley, H. L. (1986). Cloning and characterization of urease from Providencia stuartii. pp. 61. Abstracts, Annual Meeting, ASM, Washington, DC.

Mobley, H. L., Jones, B. D. & Jerse, A. E. (1986). Cloning of urease gene sequences from Providencia stuartii. Infect Immun, 54(1), 161-9. PMID: 3759233.