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Recent Publication

Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells

Tcf1 and Lef1 have versatile functions in regulating T cell development and differentiation, but intrinsic requirements for these factors in regulatory T (T reg) cells remain to be unequivocally defined. Specific ablation of Tcf1 and Lef1 in T reg cells resulted in spontaneous multi-organ autoimmunity that became more evident with age. 

  • Xing S, Gai X, Shao P....Xue HH