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Recent Publication

Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment


Background The temporal response to checkpoint blockade (CB) is incompletely understood. Here, we profiled the tumor infiltrating lymphocyte (TIL) landscape in response to combination checkpoint blockade at two distinct timepoints of solid tumor growth.

  • Shota Aoyama, Ryosuke Nakagawa, Satoshi Nemoto, Patricio Perez-Villarroel, James J Mulé, Adam W Mailloux