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Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia.

The nasal mucosa is an important component of mucosal immunity. Immunogenic particles in inspired air are known to activate the local nasal mucosal immune system and can lead to sinonasal inflammation; however, little is known about the effect of this activation on the lung immune environment.

Hua X, Vijay R, Channappanvar R, Athmer J, Meyerholz DK, Pagedar N, Tilley S, Perlman S

JCI Insight. 2018 Jun 7;3(11). pii: 99025. doi: 10.1172/jci.insight.99025. [Epub ahead of print]