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Hannah Van Ert, M5G

hanora-vanert@uiowa.edu

 

MSTP Learning Community:  McCowen

MSTP Entry Date:  June 11, 2018

PhD Program:

Immunology

Mentor:

Wendy Maury, PhD

Graduate Profile Lab Website

Investigating the role of CD40 in regulating the innate immune response to Ebola Virus infections

The Maury lab, while with a long history working with many enveloped viruses, has in recent years been focused on Ebola virus (EBOV), and its interactions with the host innate immune system –particularly macrophages and other mononuclear cells. My thesis project will most likely continue some of that work particularly in a project investigating the role of CD40 on macrophages in the context of EBOV infection. As an MSTP student with a clinical interest in obstetrics and gynecology, coupled with the paucity of data surrounding EBOV infection in pregnancy and the maternal immune response, I am interested in integrating the lab’s past work with investigating EBOV in the setting of the placental immune response.

Additionally, I joined the lab amid the COVID-19 pandemic when work in the lab was predominantly focused on SARS-CoV-2 research and have luckily been able to help contribute to a couple of projects. One project has been a collaboration with the DeGowin blood bank evaluating convalescent plasma from recovered COVID-19 patient and determining if commercial ELISA assays are predictive of neutralizing capabilities of the convalescent plasma. Lastly, I have been investigating the role of phosphatidylserine receptors in the TIM and TAM families in the viral of SARS-CoV-2, and have began developing a BSL2 mouse model of COVID-19 using recombinant VSV expressing SARS-Cov-2 glycoprotein for that project.


Committees:

2018-2020 - McCowen Leadership

2018-2020 - Medical Students for Choice, Secretary

2019-2020 - Emma Goldman Clinic Committee for Services of Health Outreach and Education

2019-2020 - Student Physician for Human Rights: Executive Board Member

2019-2020 - Leopold Society Executive Board Member

2020-2022 - Medical Students for Choice, Co-President

2020-2021 - MSTP Women's Group (Chair)

2021-present - MSTP Mondays Committee

2021-present - MSTP Podcast Crew

Awards:

2019 - Lauretta Bender Research Award In Psychiatry - Medical Student Research Day, Sept 20

Individual Funding Awards:

11/15/2022 - 08/30/2026
F30 AI 174686 - (National Institute of Allergy and Infectious Diseases)
Determining Tropism and Mechanisms of Ebola Virus Entry in Placental Tissues

Teaching:

2019 Fall - M1 Anatomy Tutor

2021 SUMR - Case-Based Learning (CBL) co-leader for group of SUMR students during two sessions

2021 SUMR - Facilitated two sessions of Clinical Skills Session (patient-provider encounters) to SUMR students

Education:

2015 - BS, Nursing - University of Wisconsin

Publications:

ORCiD:  https://orcid.org/0000-0002-3259-1912

Bohan D, Van Ert H, Ruggio N, Rogers KJ, Badreddine M, Aguilar Briseño JA, Elliff JM, Rojas Chavez RA, Gao B, Stokowy T, Christakou E, Kursula P, Micklem D, Gausdal G, Haim H, Minna J, Lorens JB, Maury W. Phosphatidylserine receptors enhance SARS-CoV-2 infection. PLoS Pathog. 2021 Nov;17(11):e1009743. doi: 10.1371/journal.ppat.1009743. eCollection 2021 Nov. PubMed PMID: 34797899; PubMed Central PMCID: PMC8641883.

Van Ert HA, Bohan DW, Rogers K, Fili M, Rojas Chávez RA, Qing E, Han C, Dempewolf S, Hu G, Schwery N, Sevcik K, Ruggio N, Boyt D, Pentella MA, Gallagher T, Jackson JB, Merrill AE, Knudson CM, Brown GD, Maury W, Haim H. Limited Variation between SARS-CoV-2-Infected Individuals in Domain Specificity and Relative Potency of the Antibody Response against the Spike Glycoprotein. Microbiol Spectr. 2022 Jan 26:e0267621. doi: 10.1128/spectrum.02676-21. Epub ahead of print. PMID: 35080430.