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Matt Miller, M5G

matthew-miller-7@uiowa.edu

 

MSTP Learning Community:  Flocks

MSTP Entry Date:  June 13, 2016

PhD Program:

Genetics

Mentor:

Chris Adams, MD, PhD

Adams Mayo Profile


Regulation and Role of p21 in Skeletal Muscle Atrophy

Skeletal muscle atrophy is a common and debilitating disease with many diverse causes. Despite the broad clinical impact, there are currently no pharmacologic therapies to prevent or reverse skeletal muscle atrophy. This is partly explained by the fact that the molecular basis of skeletal muscle atrophy remains largely unexplored and thus poorly understood. The transcription factor ATF4 has emerged as a key driver of muscle atrophy in several clinically important scenarios. Previous work has shown that this effect is mediated through increased expression of the ATF4 target gene p21 in skeletal muscle fibers. My studies build upon initial findings to more deeply investigate and understand the upstream mechanisms that control p21 expression in skeletal muscle, the pathophysiological consequences of a targeted reduction in muscle p21 expression and the downstream mechanism by which p21 promotes muscle atrophy.


Awards:

  • 2016 - Edward Heath Award (outstanding communication of laboratory achievements), Medical Student Research Day, Sept 9
  • 2017 - The Thomas A. Weingeist Award for Ophthalmology Research, Medical Student Research Day, Sept 15
  • 2019 - Knights Templar Eye Foundation Travel Grant - Spring 2019

Teaching:

2020 Fall - MICR:2158 - General Microbiology Laboratory

Education:

2015 - BA, Anthropology, Biology - Grinnell College

Publications:

ORCiD:  0000-0003-1329-088X

Giacalone JC, Miller MJ, Workalemahu G, Reutzel AJ, Ochoa D, Whitmore SS, Stone EM, Tucker BA, Mullins RF. Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter. Microvasc Res. 2019 May;123:50-57. doi: 10.1016/j.mvr.2018.12.002. Epub 2018 Dec 18. PubMed PMID: 30571950; PubMed Central PMCID: PMC7401191.

Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO Jr, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes. Cell Metab. 2020 Oct 6;32(4):561-574.e7. doi: 10.1016/j.cmet.2020.09.012. PubMed PMID: 33027675; PubMed Central PMCID: PMC7819711.