1. People

Asgar Zaheer, PhD

Emeritus Associate Professor of Neurology

Introduction

My laboratory has a long-term commitment to study the properties and functions of Glia Maturation Factor, a brain specific protein that we discovered in our laboratory at the Department of Neurology, the University of Iowa. My research group uses interdisciplinary approaches to understand the function of GMF and the regulation of inflammatory signaling pathways relevant to neurodegenerative diseases. I have an NIH RO1 funded program on GMF-depended neuro inflammation and neuro degeneration, an NIH RO1 funded program on GMF in CNS Inflammation and a VA Merit Review Award funded program on the role of GMF in Dementia. Our work embraces neuroimmunology, neuropathology, molecular biology, and neurochemistry. The lab is highly collaborative and multidisciplinary, offering a rich training environment in neuroscience. My laboratory has many years experience in using immunocytochemical techniques to examine tissue samples using both light and epifluorescence microscopy. I will provide any training and guidance to the best of my ability.

Current Positions

  • Emeritus Associate Professor of Neurology
  • Specialty: Neurobiology

Education

  • PhD in Biochemistry, Bombay University, India, Mumbai, Maharashtra, India
  • Postdoctoral Fellow in Biochemistry, University of Iowa, Iowa City, Iowa, United States

Graduate Program Affiliations

Selected Publications

  • Kempuraj, D., Khan, M. M., Thangavel, R., Xiong, Z., Yang, E. & Zaheer, A. (2013). Glia Maturation Factor Induces Interleukin-33 Release from Astrocytes: Implications for Neurodegenerative Diseases. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. PMID: 23397250.
  • Khan, M. M., Kempuraj, D., Thangavel, R. & Zaheer, A. (2013). Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol. Neurochemistry international 62 (4) 379-388. PMID: 23391521.
  • Zaheer, S., Thangavel, R., Wu, Y., Khan, M. M., Kempuraj, D. & Zaheer, A. (2013). Enhanced expression of glia maturation factor correlates with glial activation in the brain of triple transgenic Alzheimer's disease mice. Neurochemical research 38 (1) 218-25. PMID: 23086473. PMCID: PMC3527678.
  • Thangavel, R., Stolmeier, D., Yang, X., Anantharam, P. & Zaheer, A. (2012). Expression of glia maturation factor in neuropathological lesions of Alzheimer's disease. Neuropathology and applied neurobiology 38 (6) 572-81. PMID: 22035352. PMCID: PMC3290752.
  • Zaheer, S., Wu, Y., Yang, X., Thangavel, R., Sahu, S. K. & Zaheer, A. (2012). Efficient down-regulation of glia maturation factor expression in mouse brain and spinal cord. Neurochemical research 37 (7) 1578-83. PMID: 22446845. PMCID: PMC3369007.
  • Zaheer, S., Wu, Y., Yang, X., Ahrens, M., Sahu, S. K. & Zaheer, A. (2012). Clinical course of myelin oligodendrocyte glycoprotein 35-55 induced experimental autoimmune encephalomyelitis is aggravated by glia maturation factor. Neurochemistry international 60 (3) 215-9. PMID: 22226840. PMCID: PMC3288541.
  • Zaheer, S., Thangavel, R., Sahu, S. K. & Zaheer, A. (2011). Augmented expression of glia maturation factor in Alzheimer's disease. Neuroscience 194 227-33. PMID: 21835226. PMCID: PMC3183233.
  • Zaheer, S., Wu, Y., Sahu, S. K. & Zaheer, A. (2011). Suppression of neuro inflammation in experimental autoimmune encephalomyelitis by glia maturation factor antibody. Brain research 1373 230-9. PMID: 21146509. PMCID: PMC3026915.
  • Zaheer, S., Wu, Y., Sahu, S. K. & Zaheer, A. (2010). Overexpression of glia maturation factor reinstates susceptibility to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in glia maturation factor deficient mice. Neurobiology of disease 40 (3) 593-8. PMID: 20696246. PMCID: PMC2955779.
  • Thangavel, R., Sahu, S. K., Van Hoesen, G. W. & Zaheer, A. (2009). Loss of nonphosphorylated neurofilament immunoreactivity in temporal cortical areas in Alzheimer's disease. Neuroscience 160 (2) 427-33. PMID: 19250962. PMCID: PMC2669695.