Enrique C. Leira, MD, MS
Introduction
Enrique C. Leira MD MS is the Director of the Division of Cerebrovascular Disease and Head of the Comprehensive Stroke Center. He is an experienced board-certified vascular neurologist, and a trained epidemiologist. Dr. Leira is a tenured Professor in Neurology with secondary appointments in Neurosurgery and Epidemiology. He is also a member of the Operator Performance laboratory in the College of Engineering. His research focus is acute stroke management and prevention, including evidence-based strategies to improve and accelerate stroke treatment in rural areas. He conducted a pivotal clinical trial of delivering an intervention during the helicopter evacuation of patients to a comprehensive stroke center. This led into novel translational animal studies studying the effect of helicopter transport on acute stroke and reperfusion, which lead to the discovery of low frequency vibration as a synergistic intervention to thrombolytic therapy. Dr. Leira research has been funded by the NINDS-NIH. He is a principal investigator he University of Iowa StrokeNet Regional Coordinating Center Infrastructure (https://www.nihstrokenet.org/). He is also a principal investigator for the SPAN Network for advancing neuroprotective therapies through multicenter translational animal studies (https://spannetwork.org/). Dr. Leira has been very active in leadership positions with the American Stroke Association. American Academy of Neurology, and American Board of Psychiatry and Neurology. He is currently an associate editor for the journal Stroke.
Current Positions
- Professor of Neurology
- Professor of Neurosurgery
- Professor of Epidemiology
- Director, Cerebrovascular Diseases, Neurology
- Stoppelmoor-Adams Professor in Vascular Neurology
Education
- MD, Universidad de Santiago de Compostela, Santiago de Compostela, Galicia, Spain
- MS in Epidemiology, University of Iowa, Iowa City, Iowa, United States
- Resident in Neurology, St. Louis University, St. Louis, Missouri, United States
- Fellow in Cerebrovascular Diseases, University of Iowa College of Medicine, Iowa City, Iowa, United States
Center, Program and Institute Affiliations
Research Interests
- Delivery of Clinical trials and Stroke Treatments to Remote Rural Populations.
- Efficacy of Uric Acid supplementation in improving outcomes in patients with acute stroke treated with mechanical thrombectomy. With co-PI Angel Chamorro MD (University of Barcelona) we are working on a NIH clinical trial application through StrokeNet (URIC)
- Effect of Helicopter Transportation on Stroke Patients receiving rtPA and Reperfusion. Working on a R21 application.
Selected Publications
- Li, L., Molian, V. A., Seaman, S. C., Zanaty, M., Howard, M. A., Greenlee, J. D., Hasan, D. M. & Leira, E. C. (2021). Impact of Intracerebral Hematoma Evacuation During Decompressive Hemicraniectomy on Functional Outcomes. Stroke STROKEAHA120032224. DOI: 10.1161/STROKEAHA.120.032224. PMID: 33504184.
- Garg, A., Limaye, K., Shaban, A., Leira, E. C. & Adams, H. P. (2020). Risk of Ischemic Stroke after an Inpatient Hospitalization for Transient Ischemic Attack in the United States. Neuroepidemiology 1-7. DOI: 10.1159/000511829. PMID: 33260176.
- Leira, E. C., Russman, A. N., Biller, J., Brown, D. L., Bushnell, C. D., Caso, V., Chamorro, A., Creutzfeldt, C. J., Cruz-Flores, S., Elkind MSV, Fayad, P., Froehler, M. T., Goldstein, L. B., Gonzales, N. R., Kaskie, B., Khatri, P., Livesay, S., Liebeskind, D. S., Majersik, J. J., Moheet, A. M., Romano, J. G., Sanossian, N., Sansing, L. H., Silver, B., Simpkins, A. N., Smith, W., Tirschwell, D. L., Wang, D. Z., Yavagal, D. R. & Worrall, B. B. (2020). Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions. Neurology 95 (3) 124-133. DOI: 10.1212/WNL.0000000000009713. PMID: 32385186. PMCID: PMC7455350.
- Zimmerman, M. B., Pieper, A. A., Chauhan, A. K., Leira, E. C., Dhanesha, N., Schnell, T., Rahmatalla, S., DeShaw, J., Thedens, D. & Parker, B. M. (2020). Low-Frequency Vibrations Enhance Thrombolytic Therapy and Improve Stroke Outcomes. Stroke 51 (6) 1855-1861. PMID: 32397935. DOI: 10.1161/STROKEAHA.120.029405.
- Leira, E. C. & Muir, K. W. (2019). EXTEND Trial. Stroke 50 (9) 2637-2639. DOI: 10.1161/STROKEAHA.119.026249. PMID: 31449480.
- Leira, E. C. (2019). Tips for a Successful Scientific Presentation. Stroke STROKEAHA119025337. DOI: 10.1161/STROKEAHA.119.025337. PMID: 31272322.
- Faine, B. A., Dayal, S., Kumar, R., Lentz, S. R. & Leira, E. C. (2018). Helicopter "Drip and Ship" Flights Do Not Alter the Pharmacological Integrity of rtPA. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 27 (10) 2720-2724. DOI: 10.1016/j.jstrokecerebrovasdis.2018.05.049. PMID: 30037651. PMCID: PMC6139266.
- Aliena-Valero, A., López-Morales, M. A., Burguete, M. C., Castelló-Ruiz, M., Jover-Mengual, T., Hervás, D., Torregrosa, G., Leira, E. C., Chamorro, Á. & Salom, J. B. (2018). Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats. Neuroscience 388 263-273. DOI: 10.1016/j.neuroscience.2018.07.045. PMID: 30077000.
- Leira, E. C. & Savitz, S. I. (2018). In the Era of Thrombectomy, Let Us Also Protect the Majority of Patients With Stroke Who Only Require Medical Treatment!. Stroke 49 (6) 1538-1540. DOI: 10.1161/STROKEAHA.118.021411. PMID: 29748421.
- Dhanesha, N., Vázquez-Rosa, E., Cintrón-Pérez, C. J., Thedens, D., Kort, A. J., Chuong, V., Rivera-Dompenciel, A. M., Chauhan, A. K., Leira, E. C. & Pieper, A. A. (2018). Treatment with Uric Acid Reduces Infarct and Improves Neurologic Function in Female Mice After Transient Cerebral Ischemia. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 27 (5) 1412-1416. DOI: 10.1016/j.jstrokecerebrovasdis.2017.12.043. PMID: 29398531.