Georgina Aldridge, MD, PhD

Portrait
Associate
Assistant Professor
Assistant Professor of Neurology

Contact Information

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Education

BS, Biology, Cornell University, Ithaca, NY
PhD, University of Illinois
MD/PhD, University of Illinois
Resident, Neurology, University of Iowa Hospitals and Clinics

Licensure and Certifications

Neurology - American Board of Psychiatry and Neurology

Research Summary

In patient with lewy body disease, the protein alpha-synuclein aggregates, leading to severe multi-system symptoms, including hallucinations, loss of smell, dementia, imbalance, fluctuating confusion, and anxiety/depression. The main research goal of the Aldridge Laboratory is to understand the roles that synuclein pathology and protein misfolding in the cortex play in the development of these symptoms.

Publications

Aldridge, G. M., Birnschein, A., Denburg, N. D. & Narayanan, N. S. (2018). Parkinson’s disease dementia and dementia with Lewy bodies have similar neuropsychological profiles. (Vols. 9). (123) Frontiers in Neurology. PMID: 29593630.

Aldridge, G., Birnschein, A., Denburg, N. & Narayanan, N. (2018). Parkinson’s disease dementia and dementia with Lewy bodies have similar neuropsychological profiles. Frontiers in Neurology.

Aldridge, G., Warwick, C., Nathwani, m., Usachev, M. & Narayanan, N. (2018). The effect of alpha-synuclein overexpression on calcium dynamics and dendritic spines in cortical neurons.

Serrano-Pozo, A., Aldridge, G. M. & Zhang, Q. (2017). Four Decades of Research in Alzheimer's Disease (1975-2014): A Bibliometric and Scientometric Analysis. (Vols. 59). (2), pp. 763-783. Journal of Alzheimer's Disease. DOI: 10.3233/JAD-170184.

Barry, C. S., Aldridge, G. M., Herzog, G., Ma, Q., McQuinn, R. P., Hirschberg, J. & Giovannoni, J. J. (2012). Altered chloroplast development and delayed fruit ripening caused by mutations in a zinc metalloprotease at the lutescent2 locus of tomato. Plant Physiology, 159(3), 1086-1098. DOI: 10.1104/pp.112.197483.

Mitchell, A. C., Aldridge, G., Kohler, S., Stanton, G., Sullivan, E., Garbett, K., Faludi, G., Mirnics, K., Cameron, J. L. & Greenough, W. (2010). Molecular correlates of spontaneous activity in non-human primates. Journal of neural transmission (Vienna, Austria : 1996), 117(12), 1353-8. PMID: 20838826.

Pan, F., Aldridge, G. M., Greenough, W. T. & Gan, W. B. (2010). Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome. Proceedings of the National Academy of Sciences of the United States of America, 107(41), 17768-73. PMID: 20861447.

Grossman, A. W., Aldridge, G. M., Lee, K. J., Zeman, M. K., Jun, C. S., Azam, H. S., Arii, T., Imoto, K., Greenough, W. T. & Rhyu, I. J. (2010). Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice. Brain research, 1355, 221-7. PMID: 20682298.

Kao, D. I., Aldridge, G. M., Weiler, I. J. & Greenough, W. T. (2010). Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein. Proceedings of the National Academy of Sciences of the United States of America, 107(35), 15601-6. PMID: 20713728.

Aldridge, G. M., Podrebarac, D. M., Greenough, W. T. & Weiler, I. J. (2008). The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting. Journal of neuroscience methods, 172(2), 250-4. PMID: 18571732.

Grossman, A. W., Aldridge, G. M., Weiler, I. J. & Greenough, W. T. (2006). Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(27), 7151-5. PMID: 16822971.