Gordon F. Buchanan, MD, PhD

Portrait
Associate Professor of Neurology

Contact Information

200 Hawkins Dr.
Iowa City, IA 52242
319-335-9812

Education

BS, Biology, University of Illinois at Urbana-Champaign
MS, Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign
PhD, Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign
MD, University of Illinois at Urbana-Champaign
Resident, Neurology, Yale-New Haven Hospital
Fellow, Neurology, Yale University School of Medicine

Licensure and Certifications

American Board of Psychiatry and Neurology
American Board of Medical Examiners

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Publications

Petrucci, A., Joyal, K., Purnell, B. & Buchanan, G. (In Press). Serotonin and sudden unexpected death in epilepsy.

Buchanan, G. (2019). Impaired CO2-induced arousal in SIDS and SUDEP. Trends Neurosci..

Li, R., Buchanan, G. (2019). Scurrying to understand sudden unexpected death in epilepsy: insights from animal models. Epi Currents..

Hauser, C., Zocher, A. & Buchanan, G. (2019). Examination of a role for the locus coeruleus inCO2-induced arousal from sleep.

Joyal, K., Purnell, B. & Buchanan, G. (2019). The effect of serotonergic neurotransmission and vigilance state on apnea during and after kindled seizures in mice.

Li, R., Claycomb, K., Matkovich, M. & Buchanan, G. (2019). Effect of serotonin replacement on seizure profile in genetically serotonin neuron deficient mice subjected to the pilocarpine model of temporal lobe epilepsy.

Petrucci, A., Chou, J., Vencer, K., Joyal, K. & Buchanan, G. (2019). Stimulation of DRN serotonin neurons decreases PGES length and reduces seizure-induced mortality.

Purnell, B., Buchanan, G. (2019). Circadian rhythmicity in vulnerability to seizure induced death.

Singh, U., Toth, B., David, K., Saito, J., Jang, J., Buchanan, G. & Cui, H. (2019).

Petrucci, A., Chou, J., Joyal, K., Vencer, K. & Buchanan, G. (2019). PGES duration and seizure-induced mortality are reduced by enhancing serotonergic neurotransmission at the DRN. American Epilepsy Society Annual Meeting.

Purnell, B., Buchanan, G. (2019). The effect of circadian phase on maximal electroshock seizure induced mortality. American Epilepsy Society Annual Meeting..

Smith, R., Leiboid, D., Rappoport, M., Ginapp, S., Purnell, M., Bode, L., Alberico, C., Kim, E., Audero, C., Gross, T. & Buchanan, G. (2018). Dorsal raphe serotonin neurons medicate CO2-induced arousal from sleep.

Buchanan, G., Li, R., Petrucci, A. & Purnell, B. (2018). Sleep, night and SUDEP.

Gorter, J., van Vilet, E., dedeeurwaerdere, S., Buchanan, G., Friedman, K., Borges, H., Grabenstatter, K., Lukazuki, K., Scharfman, H. & Nehlig, A. (2018). A companion to the Preclinical Common Data Elements for physiological data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force.

Kruse, S., Rysted, J., Purnell, B., Gnanasekarnan, A., Hardie, J., Shutov, L., Hamilton, J., Brustovetsky, T., Houlihan, P., Warwick, C., Anderson, E., Rahatbeck, K., Wu, J., Dayton, K., Campbell, R., Lee, A., Strack, S., Brustovetsky, N., Buchanan, G. & Usachev, Y. (2018). The Mitochondrial Ca2+ Uniporter Regulates Neuronal Ca2+ Dynamics and Controls Susceptibility to Epileptiform Network Activity and Seizures.

Petrucci, A., Buchanan, G. (2018). EEG suppression following induced seizures in mice can be reduced with serotonergic manipulations.

Petrucci, A., Joyal, K. & Buchanan, G. (2018). Stimulation of dorsal raphe serotonin neurons decreases post-ictal generalized EEG suppression and reduces arousal impairment following seizures in mice.

Purnell, B., Buchanan, G. (2018). Suprachiasmatic nucleus lesion eliminates circadian rhythms of baseline breathing and hypercapnic ventilatory responses in mice.

Goldman, A. M., Buchanan, G. F., Aiba, I. & Noebels, J. L. (2017). Animal models of sudden unexpected death in epilepsy. In A. Pitkanen , P. A. Schwartzkroin , A. S. Galamopoulou & S. L. Moshe (Eds.) Models of Seizures and Epilepsy. San Diego, CA: Elsevier, Academic Press.

Goldman, M., Buchanan, G., Noebels, A. & Noebels, J. (2017). Animal models of sudden unexpected death in epilepsy. In Models of Seizures and Epilepsy, eds.

Buchana, G., Richerson, G. (2017). 2018 Update of Current evidence for a role of serotonin in SUDEP.

Leibold, N. K., van den Hove, D. L., Viechtbauer, W., Buchanan, G. F., Goossens, L., Lange, I., Knuts, I., Lesch, K. P., Steinbusch, H. W. & Schruers, K. R. (2016). CO2 exposure as translational cross-species experimental model for panic. Translational psychiatry, 6(9), e885. PMID: 27598969.

Hsieh, L. S., Wen, J. H., Claycomb, K., Huang, Y., Harrsch, F. A., Naegele, J. R., Hyder, F., Buchanan, G. F. & Bordey, A. (2016). Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement. Nature communications, 7, 11753. PMID: 27249187.

Buchanan, G. F., Richerson, G. B. (2016). Current evidence for a role of serotonin in SUDEP. In J. Hanna , R. Panelli , T. Jeffs , D. Chapman (Eds.) Continuing the global conversation [online]. (Updated) SUDEP Action, SUDEP Aware & Epilepsy Australia.

Hajek, M. A., Buchanan, G. F. (2016). Influence of vigilance state on physiological consequences of seizures and seizure-induced death in mice. Journal of neurophysiology, 115(5), 2286-93. PMID: 26888097.

Zhan, Q., Buchanan, G. F., Motelow, J. E., Andrews, J., Vitkovskiy, P., Chen, W. C., Serout, F., Gummadavelli, A., Kundishora, A., Furman, M., Li, W., Bo, X., Richerson, G. B. & Blumenfeld, H. (2016). Impaired Serotonergic Brainstem Function during and after Seizures. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(9), 2711-22. PMID: 26937010.

Buchanan, G., Richerson, G. (2016). Epilepsy: A dietary supplement for SUDEP prevention?. Nature Reviews Neurology, 12(9), 495–496. PMID: 27514288.

Murray, N. M., Buchanan, G. F. & Richerson, G. B. (2015). Insomnia Caused by Serotonin Depletion is Due to Hypothermia. Sleep, 38(12), 1985-93. PMID: 26194567.

Furman, M., Zhan, Q., McCafferty, C., Lerner, B. A., Motelow, J. E., Meng, J., Ma, C., Buchanan, G. F., Witten, I. B., Deisseroth, K., Cardin, J. A. & Blumenfeld, H. (2015). Optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: Effects on cortical physiology. Epilepsia, 56(12), e198-202. PMID: 26530287.

Buchanan, G. F., Smith, H. R., MacAskill, A. & Richerson, G. B. (2015). 5-HT2A receptor activation is necessary for CO2-induced arousal. Journal of neurophysiology, 114(1), 233-43. PMID: 25925320.

Leibold, N. K., van den Hove, D. L., Esquivel, G., De Cort, K., Goossens, L., Strackx, E., Buchanan, G. F., Steinbusch, H. W., Lesch, K. P. & Schruers, K. R. (2015). The brain acid-base homeostasis and serotonin: A perspective on the use of carbon dioxide as human and rodent experimental model of panic. Progress in neurobiology, 129, 58-78. PMID: 25930682.

Pogorelov, V., Xu, M., Smith, H. R., Buchanan, G. F. & Pittenger, C. (2015). Corticostriatal interactions in the generation of tic-like behaviors after local striatal disinhibition. Experimental neurology, 265, 122-8. PMID: 25597650.

Buchanan, G. F., Murray, N. M., Hajek, M. A. & Richerson, G. B. (2014). Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality. The Journal of physiology, 592(19), 4395-410. PMID: 25107926.

Price, M. P., Gong, H., Parsons, M. G., Kundert, J. R., Reznikov, L. R., Bernardinelli, L., Chaloner, K., Buchanan, G. F., Wemmie, J. A., Richerson, G. B., Cassell, M. D. & Welsh, M. J. (2014). Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli. Genes, brain, and behavior, 13(2), 179-94. PMID: 24256442.

Buchanan, G. F., Richerson, G. B. (2014). Current evidence for a role of serotonin in SUDEP [Part 2: Questions]. In J. Hanna , R. Panelli , T. Jeffs , D. Chapman (Eds.) Continuing the Global Conversation. SUDEP Action, SUDEP Aware & Epilepsy Australia.

Buchanan, G. F., Blumenfeld, H. (2014). Session Summary: SUDEP Mechanisms - Sleep & Arousal Systems [Partners Against Mortality in Epilepsy Conference Summary]. Epilepsy Currents, 14(Suppl 6), 18-20.

Buchanan, G. F. (2013). Timing, sleep, and respiration in health and disease. Progress in molecular biology and translational science, 119, 191-219. PMID: 23899599.

Richerson, G. B., Buchanan, G. F. (2011). The serotonin axis: Shared mechanisms in seizures, depression, and SUDEP. Epilepsia, 52 Suppl 1, 28-38. PMID: 21214537.

Buchanan, G. F., Richerson, G. B. (2011). The role of the neurotransmitter serotonin in SUDEP. In D. Chapman , R. Panelli , J. Hanna & T. Jeffs (Eds.) Sudden unexpected death in epilepsy: continuing the global conversation. pp. 56-57. Camberwell, Victoria: Epilepsy Australia : Epilepsy Bereaved : SUDEP Aware..

Buchanan, G. F., Richerson, G. B. (2010). Central serotonin neurons are required for arousal to CO2. Proceedings of the National Academy of Sciences of the United States of America, 107(37), 16354-9. PMID: 20805497.

Buchanan, G. F., Richerson, G. B. (2009). Role of chemoreceptors in mediating dyspnea. Respiratory physiology & neurobiology, 167(1), 9-19. PMID: 19118647.

Buchanan, G. F., Hodges, M. R. & Richerson, G. B. (2008). Contribution of chemosensitive serotonergic neurons to interactions between the sleep-wake cycle and respiratory control. In J. M. Monti (Eds.) Serotonin and Sleep Molecular, Functional and Clinical Aspects. pp. 529-554. Basel: Birkhäuser Basel.

Buchanan, G. F., Gillette, M. U. (2005). New light on an old paradox: site-dependent effects of carbachol on circadian rhythms. Experimental neurology, 193(2), 489-96. PMID: 15869951.

Tischkau, S. A., Mitchell, J. W., Tyan, S. H., Buchanan, G. F. & Gillette, M. U. (2003). Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock. The Journal of biological chemistry, 278(2), 718-23. PMID: 12409294.

Buchanan, G. F. (2003). Cholinergic regulation of the mammalian circadian system: Phase shifting in vivo and in vitro in wildtype and M(1) knockout mice induced by cholinergic agonists. United States – Illinois: University of Illinois at Urbana-Champaign.

Gillette, M. U., Buchanan, G. F., Artinian, L., Hamilton, S. E., Nathanson, N. M. & Liu, C. (2001). Role of the M1 receptor in regulating circadian rhythms. Life sciences, 68(22-23), 2467-72. PMID: 11392614.

Tischkau, S. A., Gallman, E. A., Buchanan, G. F. & Gillette, M. U. (2000). Differential cAMP gating of glutamatergic signaling regulates long-term state changes in the suprachiasmatic circadian clock. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(20), 7830-7. PMID: 11027248.

Chen, D., Buchanan, G. F., Ding, J. M., Hannibal, J. & Gillette, M. U. (1999). Pituitary adenylyl cyclase-activating peptide: a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock. Proceedings of the National Academy of Sciences of the United States of America, 96(23), 13468-73. PMID: 10557344.

Ding, J. M., Buchanan, G. F., Tischkau, S. A., Chen, D., Kuriashkina, L., Faiman, L. E., Alster, J. M., McPherson, P. S., Campbell, K. P. & Gillette, M. U. (1998). A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock. Nature, 394(6691), 381-4. PMID: 9690474.