Katherine D. Mathews, MD

Vice Chair for Clinical Investigation
Director, Muscular Dystrophy Clinic
Director, Iowa Neuromuscular Program
Professor of Pediatrics - Neurology
Professor of Neurology

Contact Information

Primary Office
1317 BT
200 Hawkins Drive
Iowa City, IA 52242


BS, Psychology, with highest distinction, University of Iowa
MD, Medicine, University of Iowa Carver College of Medicine
Resident, Pediatrics, University of Iowa
Resident, Neurology, University of Iowa
Fellow, Child Neurology, University of Iowa
Fellow, Genetics, University of Iowa

Licensure and Certifications

Diplomate, American Board of Psychiatry and Neurology, with special competence in Child Neurology
Diplomate, American Board of Pediatrics

Research Summary

I am interested in all aspects of Clinical Pediatric Neurology. Particular interests include neuromuscular disorders and the neuropsychological outcome of childhood stroke. My research career began with using genetic linkage, then a putative mouse model, to identify the gene causing facioscapulohumeral dystrophy. I closed my laboratory in 1998 due to increasing clinical and administrative demands, and my current academic efforts have been focused on improving the quality of care for patients with neuromuscular disease. I have maintained an active interest in the impact of molecular genetics on neuromuscular diseases (diagnosis, pathophysiology and treatment). I have served on NIH and CDC working groups to define the direction of research on neuromuscular disease in the future. I have become increasingly involved in collaborative clinical research efforts, many of which are laying a groundwork for clinical trials. I am currently a co-PI (with Paul Romitti, PhD) on the Iowa MDSTARnet project, a CDC sponsored, multi-center Duchenne/Becker Muscular Dystrophy surveillance and epidemiology project. I am co-PI on one project of the University of Iowa's NIH funded Wellstone Center, directed by Kevin Campbell, PhD and Steve Moore, MD, PhD. My project involves defining the phenotypes of patients with FRKP mutations and will extend nationwide. This clinical project was a key component of this successful NIH application. I am also the Iowa PI in the United Dystrophinopathy project; a genotype-phenotype study headed by Dr. Kevin Flanigan at the University of Utah and recently funded by the NIH.