William T. Talman, MD

Portrait
Professor Emeritus
Specialty: Autonomic Disorders
Director, VA Medical Center Program, Neurology
Emeritus Professor of Neurology

Contact Information

Primary Office: S209 GH
Iowa City, IA 52242
319-356-8750

Education

BA, Virginia Military Institute
MD, University of Virginia School of Medicine

Fellow, Neurology, Cornell University
Internship, Internal Medicine, Case Western Reserve University
Resident, Internal Medicine, Case Western Reserve University
Resident, Neurology, Cornell University

Licensure and Certifications

State of Iowa
Neurology
State of Virginia License

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

Cardiovascular regulation by the CNS. pharmacology, neuroanatomy, immunohistochemistry, physiology, baroreflex, dominant negative, neurotransmitter, cerebral blood flow, neurogenic hypertension, glutamate, nitric oxide, cardiovascular Our laboratory research focuses on central cardiovascular and circulatory control. We study the role played by excitatory amino acids and nitric oxide as possible neurotransmitters in central cardiovascular reflex signal transduction. Current studies investigate the link between activation of excitatory amino acid receptors and release of nitric oxide in specific nuclei of the brain stem. In separate studies we investigate the role played by arterial baroreceptor reflexes in cerebrovascular control. Those studies focus on the role played by nitroxidergic parasympathetic nerves in cerebrovascular control and on the preganglionic central pathways that regulate those nerves.

Publications

Talman, W. T., Dragon, D. N. & Lin, L. H. (2017). Reduced Responses to Glutamate Agonists Follow Loss of Astrocytes and Astroglial Glutamate Markers in the Nucleus Tractus Solitarii. Physiological Reports, 5. DOI: 10.14814/phy2.13158.

Lin, L. H., Jin, J., Nashelsky, M. B. & Talman, W. T. (2014). Acid-sensing ion channel 1 and nitric oxide synthase are in adjacent layers in the wall of rat and human cerebral arteries. Journal of chemical neuroanatomy, 61-62, 161-8. PMID: 25462386.

MD, W. T. (2014). Death by a Thousand Cuts. Huffington Post.

Talman, W. T., Lin, L. H. (2013). Sudden death following selective neuronal lesions in the rat nucleus tractus solitarii. Autonomic neuroscience : basic & clinical, 175(1-2), 9-16. PMID: 23245583.

MD, W. T. (2013). No One’s Moral But You and Me – and Now I Wonder About You. Huffington Post.

MD, W. T. (2013). A Big Hole Where a Cliff Used to Be. Huffington Post.

Lin, L. H., Moore, S. A., Jones, S. Y., McGlashon, J. & Talman, W. T. (2013). Astrocytes in the rat nucleus tractus solitarii are critical for cardiovascular reflex control. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(47), 18608-17. PMID: 24259582.

MD, W. T. (2013). The National Health Debt. Huffington Post.

Talman, W. T. (2012). Views of translational research from a somewhat translational scientist. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 60(6), 863-8. PMID: 22781556.

MD, W. T. (2012). Back to Basics. Huffington Post.

MD, W. T. (2012). What Will I Be When I Grow Up?. Huffington Post.

MD, W. T. (2012). The Benefits of Studying Chimpanzees. Huffington Post.

Lin, L. H., Nitschke Dragon, D., Jin, J., Tian, X., Chu, Y., Sigmund, C. & Talman, W. T. (2012). Decreased expression of neuronal nitric oxide synthase in the nucleus tractus solitarii inhibits sympathetically mediated baroreflex responses in rat. The Journal of physiology, 590(Pt 15), 3545-59. PMID: 22687614.

MD, W. T. (2012). Don’t Have the Wool Pulled Over Your Eyes. Huffington Post.

Hobin, J. A., Deschamps, A. M., Bockman, R., Cohen, S., Dechow, P., Eng, C., Galey, W., Morris, M., Prabhakar, S., Raj, U., Rubenstein, P., Smith, J. A., Stover, P., Sung, N., Talman, W. & Galbraith, R. (2012). Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles. Journal of translational medicine, 10, 72. PMID: 22500917.

Lin, L. H., Nitschke Dragon, D. & Talman, W. T. (2012). Collateral damage and compensatory changes after injection of a toxin targeting neurons with the neurokinin-1 receptor in the nucleus tractus solitarii of rat. Journal of chemical neuroanatomy, 43(2), 141-8. PMID: 22414622.

Talman, W. T., Dragon, D. N., Jones, S. Y., Moore, S. A. & Lin, L. H. (2012). Sudden death and myocardial lesions after damage to catecholamine neurons of the nucleus tractus solitarii in rat. Cellular and molecular neurobiology, 32(7), 1119-26. PMID: 22484855.

Lin, L. H., Dragon, D. N., Jin, J. & Talman, W. T. (2011). Targeting neurons of rat nucleus tractus solitarii with the gene transfer vector adeno-associated virus type 2 to up-regulate neuronal nitric oxide synthase. Cellular and molecular neurobiology, 31(6), 847-59. PMID: 21431420.

Nazarali, A. J., Talman, W. T. (2011). Special Issue on A Tribute to Marshall Nirenberg. Introduction. (Vols. 31). (6), pp. 803. Cellular and molecular neurobiology. PMID: 21630008.

Talman, W. T. (2010). From the cardiovascular system to the brain and back again: the baroreflex in health and disease. In A. Ally , M. Wyss , T. Maher (Eds.) Recent advances in cardiovascular research: from sleep to exercise. pp. 113-125.

Lin, L. H., Langasek, J. E., Talman, L. S., Taktakishvili, O. M. & Talman, W. T. (2010). Feline immunodeficiency virus as a gene transfer vector in the rat nucleus tractus solitarii. Cellular and molecular neurobiology, 30(3), 339-46. PMID: 19777342.

Taktakishvili, O. M., Lin, L. H., Vanderheyden, A. D., Nashelsky, M. B. & Talman, W. T. (2010). Nitroxidergic innervation of human cerebral arteries. Autonomic neuroscience : basic & clinical, 156(1-2), 152-3. PMID: 20537599.

Boysen, N. C., Dragon, D. N. & Talman, W. T. (2009). Parasympathetic tonic dilatory influences on cerebral vessels. Autonomic neuroscience : basic & clinical, 147(1-2), 101-4. PMID: 19195933.

Nayate, A., Moore, S. A., Weiss, R., Taktakishvili, O. M., Lin, L. H. & Talman, W. T. (2009). Cardiac damage after lesions of the nucleus tractus solitarii. American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R272-9. PMID: 19020288.

Heistad, D. D., Faraci, F. M. & Talman, W. T. (2008). Pathogensis of acute hypertertensive encephalopathy. In J. L. Izzo , H. R. Black (Eds.) Hypertension primer : the essentials of high blood pressure. (4th edition) Philadelphia, PA: Lippincott Williams & Wilkins.

Lin, L. H., Taktakishvili, O. M. & Talman, W. T. (2008). Colocalization of neurokinin-1, N-methyl-D-aspartate, and AMPA receptors on neurons of the rat nucleus tractus solitarii. Neuroscience, 154(2), 690-700. PMID: 18479828.

Talman, W. T. (2008). Keeping the CAT(echolamine) Out of the Bag [reviewing Wilde AAM et al. N Engl J Med 2008 May 8]. Journal Watch Neurology, 10(9), 69.

Talman, W. T., Nitschke Dragon, D. (2007). Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension. Brain research, 1139, 126-32. PMID: 17291465.

Musch, T. I., Carroll, R. G., Just, A., Lane, P. H. & Talman, W. T. (2007). A broader view of animal research. (Vols. 334). (7588), pp. 274. BMJ (Clinical research ed.). PMID: 17289697.

Talman, W. T., Corr, J., Nitschke Dragon, D. & Wang, D. (2007). Parasympathetic stimulation elicits cerebral vasodilatation in rat. Autonomic neuroscience : basic & clinical, 133(2), 153-7. PMID: 17275420.

Lin, L. H., Taktakishvili, O. & Talman, W. T. (2007). Identification and localization of cell types that express endothelial and neuronal nitric oxide synthase in the rat nucleus tractus solitarii. Brain research, 1171, 42-51. PMID: 17761150.

Talman, W. T., Lin, L. -. (2006). Glutamatergic and nitroxidergic neurotrasmission in the nucleus tractus solitarii. In Y. Misu , Y. Goshima (Eds.) Neurobiology of DOPA as a neurotransmitter. Boca Raton, FL: CRC Press.

Lin, L. H., Talman, W. T. (2006). Vesicular glutamate transporters and neuronal nitric oxide synthase colocalize in aortic depressor afferent neurons. Journal of chemical neuroanatomy, 32(1), 54-64. PMID: 16735103.

Talman, W. T. (2006). NO and central cardiovascular control: a simple molecule with a complex story. (Vols. 48). (4), pp. 552-4. Hypertension. PMID: 16940228.

Lin, L. H., Talman, W. T. (2005). Nitroxidergic neurons in rat nucleus tractus solitarii express vesicular glutamate transporter 3. Journal of chemical neuroanatomy, 29(3), 179-91. PMID: 15820620.

Lin, L. H., Talman, W. T. (2005). Soluble guanylate cyclase and neuronal nitric oxide synthase colocalize in rat nucleus tractus solitarii. Journal of chemical neuroanatomy, 29(2), 127-36. PMID: 15652699.

Talman, W. T. (2004). As a scientific community we must examine open access both for its positive aspects and its negative impact. Iowa City, IA: Hardin Scholarly Communication News [Hardin Library, University of Iowa].

Talman, W. T. (2004). Amino acid neurotransmission. In D. I. Robertson , G. Burnstock , P. A. Low , J. F. Paton (Eds.) Primer on the autonomic nervous system. (2nd edition), pp. 81-82. Burlington: Elsevier Science. DOI: 10.1016/b978-012589762-4/50020-7.

Talman, W. T. (2004). Parasympathetic influences on cerebral circulation: a link to arterial baroreflexes. In N. Dun (Eds.) Neural mechanisms of cardiovascular regulation. pp. 357-370. Boston: Kluwer Academic Publishers.

DA Chianca, Jr,, Lin, L. H., Dragon, D. N. & Talman, W. T. (2004). NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase. American journal of physiology. Heart and circulatory physiology, 286(4), H1521-7. PMID: 15020305.

Lin, L. H., Edwards, R. H., Fremeau, R. T., Fujiyama, F., Kaneko, T. & Talman, W. T. (2004). Localization of vesicular glutamate transporters and neuronal nitric oxide synthase in rat nucleus tractus solitarii. Neuroscience, 123(1), 247-55. PMID: 14667459.

Talman, W. T., Dragon, D. N. (2004). Transmission of arterial baroreflex signals depends on neuronal nitric oxide synthase. Hypertension, 43(4), 820-4. PMID: 14981065.

Talman, W. T. (2003). Evidence for Altered Cardiac Repolarization After Stroke [reviewing Afsar N et al. Arch Neurol 2003 Mar.]. Journal Watch Neurology.

Talman, W. T. (2003). Cardiac arrhythmias and sudden death. In J. Noseworthy , M. A. Samuels (Eds.) Neurological therapeutics: principles and practice. pp. 1255-1257. London ; New York : Independence, KY: Martin Dunitz ; Distributed in the USA by Taylor & Francis.

Lin, L. H., Agassandian, K., Fujiyama, F., Kaneko, T. & Talman, W. T. (2003). Evidence for a glutamatergic input to pontine preganglionic neurons of the superior salivatory nucleus in rat. Journal of chemical neuroanatomy, 25(4), 261-8. PMID: 12842271.

Talman, W. T., Davis, P. H. (2003). Myocardial damage and cardiac arrhythmias. In M. A. Samuels , S. Feske (Eds.) Office Practice of Neurology. (2nd edition), pp. 1199-1201. Philadelphia: Churchill Livingstone.

Talman, W. T. (2003). Glutamate and blood pressure in multiple system atrophy. (Vols. 13). (4), pp. 239-41. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. PMID: 12955546.

Doba, N., Talman, W. T. & Sved, A. F. (2003). Dedication and Introduction. Cellular and Molecular Neurobiology, 23(4-5), 451–454. DOI: 10.1023/A:1025091125403.

Talman, W. T., Sved, A. (2003). Thoughts About Dr. Donald J. Reis. Cellular and Molecular Neurobiology, 23(4-5), 455–456. DOI: 10.1023/A:1025055609473.

Agassandian, K., Fazan, V. P., Margaryan, N., Dragon, D. N., Riley, J. & Talman, W. T. (2003). A novel central pathway links arterial baroreceptors and pontine parasympathetic neurons in cerebrovascular control. Cellular and molecular neurobiology, 23(4-5), 463-78. PMID: 14514008.

Talman, W. T., Nitschke Dragon, D. (2002). Inhibiting the nucleus tractus solitarii extends cerebrovascular autoregulation during hypertension. Brain research, 931(1), 92-5. PMID: 11897093.

Victor, R. G., Talman, W. T. (2002). Comparative effects of clonidine and dihydroergotamine on venomotor tone and orthostatic tolerance in patients with severe hypoadrenergic orthostatic hypotension. The American journal of medicine, 112(5), 361-8. PMID: 11904110.

Bauman, N. M., Wang, D., Luschei, E. S. & Talman, W. T. (2002). Effect of substance P injection into the nucleus tractus solitarius of rats on cricothyroid and thyroarytenoid motor activity and cardiovascular and respiratory systems. The Annals of otology, rhinology, and laryngology, 111(10), 875-83. PMID: 12389854.

Agassandian, K., Fazan, V. P., Adanina, V. & Talman, W. T. (2002). Direct projections from the cardiovascular nucleus tractus solitarii to pontine preganglionic parasympathetic neurons: a link to cerebrovascular regulation. The Journal of comparative neurology, 452(3), 242-54. PMID: 12353220.

Riley, J., Lin, L., Chianca, D. A. & Talman, W. T. (2002). Ablation of NK1 Receptors in Rat Nucleus Tractus Solitarii Blocks Baroreflexes. Hypertension, 40(6), 823-826. DOI: 10.1161/01.hyp.0000042089.34004.cf.

Lin, L. H., Talman, W. T. (2002). Coexistence of NMDA and AMPA receptor subunits with nNOS in the nucleus tractus solitarii of rat. Journal of chemical neuroanatomy, 24(4), 287-96. PMID: 12406503.

Talman, W. T. (2001). Atrial Ectopic Beats: Another Risk Factor for Stroke [reviewing Engstrom G et al. Stroke 2000 Dec.]. Journal Watch Neurology.

Talman, W. T. (2001). Obituary -- Donald Jeffrey Reis. The Physiologist, 44(1), 53-54.

Lin, L. H., Talman, W. T. (2001). Colocalization of GluR1 and neuronal nitric oxide synthase in rat nucleus tractus solitarii neurons. Neuroscience, 106(4), 801-9. PMID: 11682165.

Rodrigues Dias, A. C., Talman, W. T. & Colombari, E. (2001). Hemodynamic effects elicited by microinjection of glutamatergic agonists into NTS of conscious rats. American journal of physiology. Heart and circulatory physiology, 281(3), H1026-34. PMID: 11514267.

Talman, W. T. (2001). Donald Jeffrey Reis, MD : September 9, 1931-November 1, 2000 [obituary]. Hypertension, 37(3), 825-826. DOI: 10.1161/01.hyp.37.3.825.

Talman, W. T., Dragon, D. N., Ohta, H. & Lin, L. H. (2001). Nitroxidergic influences on cardiovascular control by NTS: a link with glutamate. Annals of the New York Academy of Sciences, 940, 169-78. PMID: 11458675.

Lin, L. H., Emson, P. C. & Talman, W. T. (2000). Apposition of neuronal elements containing nitric oxide synthase and glutamate in the nucleus tractus solitarii of rat: a confocal microscopic analysis. Neuroscience, 96(2), 341-50. PMID: 10683574.

Cassell, M. D., Yi, H. & Talman, W. T. (2000). Glycine receptor (gephyrin) immunoreactivity is present on cholinergic neurons in the dorsal vagal complex. Neuroscience, 95(2), 489-97. PMID: 10658629.

Lin, L. H., Talman, W. T. (2000). N-methyl-D-aspartate receptors on neurons that synthesize nitric oxide in rat nucleus tractus solitarii. Neuroscience, 100(3), 581-8. PMID: 11098121.

Lin, L. H., Sahai, A. K., Rockland, K. S. & Talman, W. T. (2000). The distribution of neuronal nitric oxide synthase in the nucleus tractus solitarii of the squirrel monkey. Brain research, 856(1-2), 84-92. PMID: 10677614.

Talman, W. T. (2000). Seizure-Like Spells and the Heart [reviewing Zaidi A et al. J Am Coll Cardiol 2000 Jul. ]. Journal Watch Neurology.

Talman, W. T., Dragon, D. N. (2000). Parasympathetic nerves influence cerebral blood flow during hypertension in rat. Brain research, 873(1), 145-8. PMID: 10915822.

Fong, A. Y., Talman, W. T. & Lawrence, A. J. (2000). Axonal transport of NADPH-diaphorase and [(3)H]nitro-L-arginine binding, but not [(3)H]cGMP binding, by the rat vagus nerve. Brain research, 878(1-2), 240-6. PMID: 10996159.

Talman, W. T. (1999). Myocardial Dysfunction and Vasospasm in Subarachnoid Hemorrhage [reviewing Mayer SA et al. Stroke 1999 Apr. ]. Journal Watch Neurology.

Talman, W. T. (1999). The central nervous system and cardiovascular control in health and disease. In P. A. Low (Eds.) Clinical autonomic disorders: evalulation and managment. pp. 177-186. Boston: Little, Brown.

Colombari, E., Davisson, R. L., Shaffer, R. A., Talman, W. T. & Lewis, S. J. (1998). Hemodynamic effects of L-glutamate in NTS of conscious rats: a possible role of vascular nitrosyl factors. The American journal of physiology, 274(4 Pt 2), H1066-74. PMID: 9575908.

Talman, W. (1998). Central Autonomic Network: Functional Organization and Clinical Correlations. Mayo Clinic Proceedings, 73(7), 710. DOI: 10.1016/s0025-6196(11)64909-4.

Lin, L. H., Cassell, M. D., Sandra, A. & Talman, W. T. (1998). Direct evidence for nitric oxide synthase in vagal afferents to the nucleus tractus solitarii. Neuroscience, 84(2), 549-58. PMID: 9539225.

Lin, L. H., Sandra, A., Boutelle, S. & Talman, W. T. (1997). Up-regulation of nitric oxide synthase and its mRNA in vagal motor nuclei following axotomy in rat. Neuroscience letters, 221(2-3), 97-100. PMID: 9121709.

Talman, W. T. (1997). Glutamatergic transmission in the nucleus tractus solitarii: from server to peripherals in the cardiovascular information superhighway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.], 30(1), 1-7. PMID: 9222396.

Ohta, H., Bates, J. N., Lewis, S. J. & Talman, W. T. (1997). Actions of S-nitrosocysteine in the nucleus tractus solitarii are unrelated to release of nitric oxide. Brain research, 746(1-2), 98-104. PMID: 9037488.

Talman, W. T. (1997). The myth of nitric oxide in central cardiovascular control by the nucleus tractus solitarii. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.], 30(4), 515-20. PMID: 9251773.

Talman, W. T. (1997). Nitroxidergic transmission in the nucleus tractus solitarii. Annals of the New York Academy of Sciences, 835, 225-33. PMID: 9616777.

Johnson, R. A., Colombari, E., Colombari, D. S., Lavesa, M., Talman, W. T. & Nasjletti, A. (1997). Role of endogenous carbon monoxide in central regulation of arterial pressure. Hypertension, 30(4), 962-7. PMID: 9336401.

Talman, W. T. (1997). [Review] Handbook of autonomic nervous system dysfunction by Amos D. Korczyn. Neurology, 48(4), 1148-1149.

Talman, W. T. (1997). The central nervous system and cardiovascular control in health and disease. In P. A. Low (Eds.) Clinical autonomic disorders: Evaluation and Management. pp. 47–59. Boston: Little Brown.

Talman, W. T., Davis, P. H. (1996). Myocardial damage and cardiac arrhythmias. In M. A. Samuels , S. Feske (Eds.) Office practice of neurology. pp. 976-978. New York: Churchill Livingstone.

Menani, J. V., Colombari, E., Talman, W. T. & Johnson, A. K. (1996). Commissural nucleus of the solitary tract lesions reduce food intake and body weight gain in rats. Brain research, 740(1-2), 102-8. PMID: 8973803.

Colombari, E., Menani, J. V. & Talman, W. T. (1996). Commissural NTS contributes to pressor responses to glutamate injected into the medial NTS of awake rats. The American journal of physiology, 270(6 Pt 2), R1220-5. PMID: 8764286.

Ohta, H., Li, X. & Talman, W. T. (1996). Release of glutamate in the nucleus tractus solitarii in response to baroreflex activation in rats. Neuroscience, 74(1), 29-37. PMID: 8843075.

Colombari, E., Talman, W. T. (1995). Denervation supersensitivity to glutamate in the nucleus tractus solitarii after removal of the nodose ganglion. Brain research, 677(1), 110-6. PMID: 7606454.

Talman, W. T., Dragon, D. N. (1995). Inhibition of nitric oxide synthesis extends cerebrovascular autoregulation during hypertension. Brain research, 672(1-2), 48-54. PMID: 7749753.

Talman, W. T. (1995). Neurocardiology. Neurology, 45(8), 1639–1639–a. DOI: 10.1212/WNL.45.8.1639-a.

Talman, W. T., Lewis, S. J. (1995). Altered cardiovascular responses to glutamate and acetylcholine microinjected into the nucleus tractus solitarii of the SHR. In H. Saito (Eds.) New advances in SHR research : pathophysiology & pharmacology. pp. 99-107. Utrecht: VSP.

Talman, W. T., Dragon, D. N. (1995). Mechanisms for preserved cerebrovascular autoregulation during hypertension in rats after sinoaortic denervation. Clinical and experimental pharmacology & physiology. Supplement, 22(1), S77-9. PMID: 9072452.

Ohta, H., Talman, W. T. (1995). Alteration of baroreceptor and chemoreceptor reflexes in spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. Supplement, 22(1), S60-1. PMID: 9072444.

Ohta, H., Talman, W. T. (1995). Baroreceptors in the carotid sinus contribute to arterial baroreceptor reflexes in normotensive rats. Clinical and experimental pharmacology & physiology. Supplement, 22(1), S62-3. PMID: 9072445.

Talman, W. T., Colombari, E. (1995). Evolution of dose-related cardiovascular responses to L-glutamate microinjected into the nucleus tractus solitarii after removal of the nodose ganglion in rat. Clinical and experimental pharmacology & physiology. Supplement, 22(1), S37-9. PMID: 9072432.

Talman, W. T. (1994). Neuroactive substances in the control of cardiovascular and visceral responses: an overview. In R. Barraco (Eds.) Nucleus of the solitary tract.. pp. 233–244. CRC Press, Inc.

Talman, W. T., Reis, D. J. (1994). Brain lesions and hypertension. In D. Ganten , W. de Jong (Eds.) Handbook of hypertension. Vol. 16 : Experimental and genetic models of hypertension. pp. 462-481. Amsterdam: Elsevier.

Yin, M., Lee, C. C., Ohta, H. & Talman, W. T. (1994). Hemodynamic effects elicited by stimulation of the nucleus tractus solitarii. Hypertension, 23(1 Suppl), I73-7. PMID: 7904259.

Talman, W. T., Wellendorf, L., Martinez, D., Ellison, S., Li, X., Cassell, M. & Ohta, H. (1994). Glycine elicits release of acetylcholine from the nucleus tractus solitarii in rat. Brain research, 650(2), 253-9. PMID: 7953690.

Ohta, H., Talman, W. T. (1994). Both NMDA and non-NMDA receptors in the NTS participate in the baroreceptor reflex in rats. The American journal of physiology, 267(4 Pt 2), R1065-70. PMID: 7943417.

Talman, W. T., Dragon, D. N. & Ohta, H. (1994). Baroreflexes influence autoregulation of cerebral blood flow during hypertension. The American journal of physiology, 267(3 Pt 2), H1183-9. PMID: 8092284.

Talman, W. T. (1993). The central nervous system and cardiovascular control in health and disease. In P. A. Low (Eds.) Clinical autonomic disorders : evaluation and management. pp. 177-186. Boston: Little, Brown.

Talman, W. T., Benaroch, E. E. (1993). Neural control of cardiac function. In P. Dyck , P. K. Thomas , J. Griffin , P. Low , J. Poduslo (Eds.) Peripheral neuropathy. (3rd), pp. 177–85. Philadelphia: W.B. Saunders, Co.

Talman, W. T. (1993). Cardiovascular presentations in primary central neurological disease. In G. C. Goetz , C. M. Tanner , M. J. Aminoff (Eds.) Handbook of clinical neurology. pp. 229-247. Amsterdam: Elsevier.

Ohta, H., Lewis, S. J. & Talman, W. T. (1993). Spermidine and cardiovascular control in nucleus tractus solitarii in rat. Brain research, 620(1), 72-7. PMID: 8104667.

Hobson, R. W., Weiss, D. G., Fields, W. S., Goldstone, J., Moore, W. S., Towne, J. B., Wright, C. B. & Group, the Veterans Affairs Cooperative Study, (1993). Efficacy of Carotid Endarterectomy for Asymptomatic Carotid Stenosis. (Vols. 328). (4), pp. 221–227. New England Journal of Medicine. PMID: 8418401.

Talman, W. T., Kelkar, P. (1993). Neural control of the heart. Central and peripheral. In J. Brillman (Eds.) Neurologic clinics. (2), pp. 239-56. Philadelphia: W.B. Saunders and Company. PMID: 8316184.

Gordon, F. J., Talman, W. T. (1992). Role of Excitatory Amino Acids and Their Receptors in Bulbospinal Control of Cardiovascular Function. In G. Kunos , J. Ciriello (Eds.) Central Neural Mechanisms in Cardiovascular Regulation. pp. 209–225. Boston: Birkhäuser Boston.

Ohta, H., Lewis, S. J. & Talman, W. T. (1992). Comparison of cardiovascular responses to stimulation of cartoid sinus and aortic depressor nerves in rats. Genet Hypertens, 218, 61-63.

Lee, C. C., Ohta, H. & Talman, W. T. (1992). Endothelin-1 microinjected into nucleus tractus solitarii of rat blocks arterial baroreflexes. Genet Hypertens, 218, 109–111.

Cassell, M. D., Roberts, L. & Talman, W. T. (1992). Glycine-containing terminals in the rat dorsal vagal complex. Neuroscience, 50(4), 907-20. PMID: 1333062.

Talman, W. T., Robertson, S. C. & Cassell, M. D. (1992). Mechanisms of cardiovascular responses to glycine injected into the dorsal vagal motor nucleus in rat. Hypertension, 19(2 Suppl), II187-92. PMID: 1310481.

Talman, W. T., Colling, J. M. & Robertson, S. C. (1991). Glycine microinjected into nucleus tractus solitarii of rat acts through cholinergic mechanisms. The American journal of physiology, 260(4 Pt 2), H1326-31. PMID: 1826413.

Talman, W. T., Lewis, S. J. (1991). Altered cardiovascular responses to glutamate and acetylcholine microinjected into the nucleus tractus solitarii of the SHR. Clinical and experimental hypertension. Part A, Theory and practice, 13(5), 661-8. PMID: 1685357.

Talman, W. T. (1991). The Central nervous system. In M. I. Weintraub , A. E. Fass (Eds.) Heart and brain: interactions of cardia and neurologic disease. Costa Mesa, CA: PMA Publishing.

Talman, W. T., Robertson, S. C. (1991). Nucleus prepositus hypoglossi. A medullary pressor region. Hypertension, 17(6 Pt 2), 1173-6. PMID: 1675202.

Talman, W. T., Andreasen, K., Calvin, J. & Eversmann-Johanns, S. (1991). Cholecystokinin in nucleus tractus solitarii modulates tonic and phasic gastric pressure. The American journal of physiology, 261(1 Pt 2), R217-22. PMID: 1858949.

Talman, W. T. (1991). Central regulation of autonomic functions. Trends in Neurosciences, 14(6), 264. DOI: 10.1016/0166-2236(91)90132-e.

Lewis, S. J., Machado, B. H., Ohta, H. & Talman, W. T. (1991). Processing of cardiopulmonary afferent input within the nucleus tractus solitarii involves activation of soluble guanylate cyclase. European journal of pharmacology, 203(2), 327-8. PMID: 1686863.

Lewis, S. J., Ohta, H., Machado, B., Bates, J. N. & Talman, W. T. (1991). Microinjection of S-nitrosocysteine into the nucleus tractus solitarii decreases arterial pressure and heart rate via activation of soluble guanylate cyclase. European journal of pharmacology, 202(1), 135-6. PMID: 1686253.

Talman, W. T., Dragon, D. M., Heistad, D. D. & Ohta, H. (1991). Cerebrovascular effects produced by electrical stimulation of fastigial nucleus. The American journal of physiology, 261(3 Pt 2), H707-13. PMID: 1887919.

Talman, W. T. (1990). Autonomic Failure:A Textbook of Clinical Disorders of the Autonomic Nervous System (2nd edn). Trends in Neurosciences, 13(6), 238. DOI: 10.1016/0166-2236(90)90171-6.

Talman, W. T., Florek, G. & Bullard, D. E. (1989). A hyperthermic syndrome in two subjects with acute hydrocephalus. In S. Matsumoto , K. Sato & N. Tamaki , S. Oi (Eds.) Annual Review of Hydrocephalus. Tokyo: Neuron Publishing.

Talman, W. T., Robertson, S. C. (1989). Glycine, like glutamate, microinjected into the nucleus tractus solitarii of rat decreases arterial pressure and heart rate. Brain research, 477(1-2), 7-13. PMID: 2564802.

Williams, J. L., Heistad, D. D., Siems, J. L. & Talman, W. T. (1989). Effects of stimulation of fastigial nucleus on cerebral blood flow in cats. The American journal of physiology, 257(1 Pt 2), H297-304. PMID: 2750944.

Talman, W. T. (1989). Kynurenic acid microinjected into the nucleus tractus solitarius of rat blocks the arterial baroreflex but not responses to glutamate. Neuroscience letters, 102(2-3), 247-52. PMID: 2682388.

Meeley, M. P., Underwood, M. D., Talman, W. T. & Reis, D. J. (1989). Content and in vitro release of endogenous amino acids in the area of the nucleus of the solitary tract of the rat. Journal of neurochemistry, 53(6), 1807-17. PMID: 2809593.

Talman, W. T. (1988). Glycine microinjected in the rat dorsal vagal nucleus increases arterial pressure. Hypertension, 11(6 Pt 2), 664-7. PMID: 3391677.

Talman, W. T., Florek, G. & Bullard, D. E. (1988). A hyperthermic syndrome in two subjects with acute hydrocephalus. Archives of neurology, 45(9), 1037-40. PMID: 3415522.

Spencer, S. E., Talman, W. T. (1987). Centrally administered bombesin modulates gastric motility. Peptides, 8(5), 887-91. PMID: 3432135.

Spencer, S. E., Talman, W. T. (1986). Central modulation of gastric pressure by substance P: a comparison with glutamate and acetylcholine. Brain research, 385(2), 371-4. PMID: 2430670.

Spencer, S. E., Talman, W. T. (1986). Modulation of gastric and arterial pressure by nucleus tractus solitarius in rat. The American journal of physiology, 250(6 Pt 2), R996-1002. PMID: 2872821.

Talman, W. T. (1985). Cardiovascular regulation and lesions of the central nervous system. Annals of neurology, 18(1), 1-13. PMID: 3898997.

Sved, A. F., Imaizumi, T., Talman, W. T. & Reis, D. J. (1985). Vasopressin contributes to hypertension caused by nucleus tractus solitarius lesions. Hypertension, 7(2), 262-7. PMID: 2858449.

Talman, W. T., Granata, A. R. & Reis, D. J. (1984). Glutamatergic mechanisms in the nucleus tractus solitarius in blood pressure control. Federation proceedings, 43(1), 39-44. PMID: 6140189.

Laguzzi, R., Reis, D. J. & Talman, W. T. (1984). Modulation of cardiovascular and electrocortical activity through serotonergic mechanisms in the nucleus tractus solitarius of the rat. Brain research, 304(2), 321-8. PMID: 6744045.

Wiley, R. G., Talman, W. T. & Reis, D. J. (1983). Ricin transport distinguishes between central and peripheral neurons. Brain research, 269(2), 357-60. PMID: 6192871.

Criscione, L., Reis, D. J. & Talman, W. T. (1983). Cholinergic mechanisms in the nucleus tractus solitarii and cardiovascular regulation in the rat. European journal of pharmacology, 88(1), 47-55. PMID: 6852105.

Talman, W. T. (1983). Neurology for the non-neurologist Edited by William J. Weiner and Christopher G. Goetz Philadelphia, Harper & Row, 1981 426 pp, illustrated, $15.75. Annals of Neurology, 14(2), 254-254. DOI: 10.1002/ana.410140216.

Talman, W. T. (1983). Basic neurology By John Gilroy and Patti L. Holliday New York, Macmillan, 1982 373 pp, illustrated, $18.95. Annals of Neurology, 14(2), 254-254. DOI: 10.1002/ana.410140217.

Talman, W. T. (1983). Morphology of the Rat Brain Ventricles, Ependyma and Periventricular Structures.Edited by A. Mitro and M. Palkovits (Vol 21 of Bibliotbeca Anatomica Edited by W. Lierse) New York, Karger, 1981 110 pp, illustrated, $58.75. Annals of Neurology, 14(4), 495-495. DOI: 10.1002/ana.410140423.

Graham, D. I., Grom, J. J., Kelly, P. A., Mackenzie, E. T., McCulloch, J., Reis, D. J. & Talman, W. T. (1982). Cerebral circulatory effect of fulminating neurogenic hypertension. In D. D. Heistad (Eds.) Cerebral blood flow: effect of nerves and neurotrasmitters; proceedings of a symposium held June 16-18, 1981 at the Cardiovascular Center, College of Medicine, The University of Iowa, Iowa City, Iowa, USA. New York: Elsevier/North-Holland.

Rudinger, E., Talman, W. T. (1982). The No more back trouble book: relief and prevention. (1st Scarborough Books ed) New York: Stein and Day.

Laguzzi, R., Talman, W. T. & Reis, D. J. (1982). Serotonergic Mechanisms in the Nucleus Tractus Solitarius May Regulate Blood Pressure and Behaviour in the Rat. Clinical Science, 63(s8), 323s-326s. DOI: 10.1042/cs063323s.

LeDoux, J. E., Del Bo, A., Tucker, L. W., Harshfield, G., Talman, W. T. & Reis, D. J. (1982). Hierarchic organization of blood pressure responses during the expression of natural behaviors in rat: mediation by sympathetic nerves. Experimental neurology, 78(1), 121-33. PMID: 6811307.

Rudinger, E., Talman, W. T. (1981). The no more back trouble book relief and prevention [Braille]. Washington, D.C.: NLS.

Reis, D. J., Perrone, M. H. & Talman, W. T. (1981). Glutamic acid as the neurotransmitter of baroreceptor afferents in the nucleus tractus solitarii: possible relationship to neurogenic hypertension. In Central nervous system mechanisms in Hypertension. pp. 37–48. New York: Raven Press.

Talman, W. T., Perrone, M. H. & Reis, D. J. (1981). Acute hypertension after the local injection of kainic acid into the nucleus tractus solitarii of rats. Circulation research, 48(2), 292-8. PMID: 7460203.

Talman, W. T., Reis, D. J. (1981). Baroreflex actions of substance P microinjected into the nucleus tractus solitarii in rat: a consequence of local distortion. Brain research, 220(2), 402-7. PMID: 6169391.

Reis, D. J., Granata, A. R., Perrone, M. H. & Talman, W. T. (1981). Evidence that glutamic acid is the neurotransmitter of baroreceptor afferent terminating in the nucleus tractus solitarius (NTS). Journal of the autonomic nervous system, 3(2-4), 321-34. PMID: 6115875.

Talman, W. T. (1981). Neural control of circulation Edited by Maysie J. Hughes and Charles D. Barnes Academic Press, New York, 1980 175 pp, illustrated, $24.00. Annals of Neurology, 10(3), 308-308. DOI: 10.1002/ana.410100322.

Talman, W. T., Perrone, M. H., Scher, P., Kwo, S. & Reis, D. J. (1981). Antagonism of the baroreceptor reflex by glutamate diethyl ester, an antagonist to L-glutamate. Brain research, 217(1), 186-91. PMID: 6266590.

Ruff, R. L., Talman, W. T. & Petito, F. (1981). Transient ischemic attacks associated with hypotension in hypertensive patients with carotid artery stenosis. Stroke; a journal of cerebral circulation, 12(3), 353-5. PMID: 7245301.

Reis, D. J., Talman, W. T., Perrone, M., Doba, N. & Kumada, M. (1980). L-glutamate as the neurotransmitter of baroreceptor afferents. In P. Sleight (Eds.) Baroreceptors and Hypertension. pp. 221–228. Oxford University Press, Oxford.

Talman, W. T., Snyder, D. & Reis, D. J. (1980). Chronic lability of arterial pressure produced by destruction of A2 catecholaminergic neurons in rat brainstem. Circulation research, 46(6), 842-53. PMID: 7379249.

Rudinger, E., Talman, W. T. (1980). The No more back trouble book: relief and prevention. New York: Stein and Day.

Talman, W. T., Perrone, M. H. & Reis, D. J. (1980). Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Science (New York, N.Y.), 209(4458), 813-5. PMID: 6105709.

Talman, W. T., Alonso, D. R. & Reis, D. J. (1980). Chronic lability of arterial pressure in the rat does not evolve into hypertension. Clinical science (London, England : 1979), 59 Suppl 6, 405s-407s. PMID: 7449291.

LeDoux, J. E., Tucker, L. W., Del Bo, A., Harshfield, G., Green, L., Talman, W. T. & Reis, D. J. (1980). A hierarchical organization of blood pressure during natural behaviour in rat and the effects of central catecholamine neurons thereon. Clinical science (London, England : 1979), 59 Suppl 6, 271s-273s. PMID: 7449269.

Snyder, D. W., Talman, W. T. & Reis, D. J. (1979). Role of A2 neurons in control of arterial pressure in rat. In E. Usdin , J. D. Barchas (Eds.) Catecholamines: basic and clinical frontiers : proceedings of the Fourth International Catecholamine Symposium, Pacific Grove. (Vols. 2). pp. 1437-1439. Pergamon Press.

Reis, D. J., Joh, T. H., Nathan, M. A., Renaud, B., Snyder, D. W. & Talman, W. T. (1979). Nucleus tractus solitarii: catecholaminergic innervation in normal and abnormal control of arterial pressure. pp. 147–164. Nervous System and Hypertension, Wiley-Flammarion, Toronto.

Rottenberg, D. A., Talman, W. & Chernik, N. L. (1976). Letter: Location of pyramidal tract questioned. (Vols. 26). (3), pp. 291-2. Neurology. PMID: 943058.

Smilack, J. D., Bellet, R. E. & Talman, Jr, W. T. (1975). Cryptococcal pleural effusion. JAMA, 232(6), 639-41. PMID: 1091754.

Lang, P. G., Talman, Jr, W. T. & Hunt, Jr, W. B. (1972). Drug overdosage due to glutethimide: a reappraisal of management. Southern medical journal, 65(4), 413-6. PMID: 4503324.