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Kamal Rahmouni, PhD

Professor of Neuroscience and Pharmacology
Professor of Internal Medicine
Fraternal Order of Eagles Diabetes Center Research Chair

Contact Information

Primary Office
2-248 BSB
51 Newton Rd.
Iowa City, IA 52242

2-200 BSB
Iowa City, IA 52242

524 MRC
Iowa City, IA 52242


BS, Biochemistry, University of Science and Technology, Algiers, Algeria
MS, Pharmacology, Pharmacochemistry, University of Louis Pasteur, Strasbourg, France
PhD, Pharmacology, University of Louis Pasteur, Strasbourg, France
Postdoctoral Fellow, University of Iowa, Department of Internal Medicine

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Molecular Medicine, Interdisciplinary Graduate Program in Neuroscience, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Fraternal Order of Eagles Diabetes Research Center, Obesity Initiative

Research Summary

The work in my laboratory is focused on the neurobiology of metabolism, energy homeostasis and cardiovascular function and related disorders such as obesity, diabetes and hypertension. The central nervous system is a major player in the regulation of energy homeostasis as well as cardiovascular system. Our research is aimed at the identification of the neuroanatomical and molecular pathways involved in the regulation of metabolic, autonomic and cardiovascular functions. We also investigate the dysregulation of these pathways in disease condition such us obesity and diabetes. The lab uses multidisciplinary approaches including basic research tools, genetic models and sophisticated physiological techniques that allow us to address physiological questions at the molecular level. There are currently several ongoing studies aimed at elucidating the intracellular pathways involved in the central nervous system control of energy homeostasis and autonomic cardiovascular function by insulin and adipocyte-derived hormone, leptin. Specifically, we are focused at understanding the exact role of the different downstream pathways associated with the insulin and leptin receptors in the regulation of the physiological cues. For these studies, we rely on mouse models that have deletion is specific intracellular signaling pathways. We also use the Cre-LoxP technology to target specific areas in the brain to delineate the neuronal architectural network that control metabolism and autonomic cardiovascular function. Disease mechanisms are investigated in animal models of obesity and diabetes such as diet-induced obesity, but also rare monogenic models including mouse models of Bardet-Biedl Syndrome that mimic the human disorders. The study of monogenic models allow us to elucidate how basic cell biological mechanisms conserved in all organisms (i.e. intracellular transport and cilia function) and complex phenotypes (such as obesity and hypertension) that result when these mechanisms are perturbed.


Watanabe, M., Singhal, G., Fisher, F. M., Beck, T. C., Morgan, D. A., Socciarelli, F., Mather, M. L., Risi, R., Bourke, J., Rahmouni, K., McGuinness, O. P., Flier, J. S. & Maratos-Flier, E. (2020). Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis. Endocrine, 67(1), 95-108. PMID: 31728756.

Guo, D. F., Reho, J. J., Morgan, D. A. & Rahmouni, K. (In Press). Cardiovascular Regulation by the Neuronal BBSome. Hypertension.

Al-Massadi, O., Quiñones, M., Clasadonte, J., Hernandez-Bautista, R., Romero-Picó, A., Folgueira, C., Morgan, D. A., Kalló, I., Heras, V., Senra, A., Funderburk, S. C., Krashes, M. J., Souto, Y., Fidalgo, M., Luquet, S., Chee, M. J., Imbernon, M., Beiroa, D., García-Caballero, L., Gallego, R., Lam BYH,, Yeo, G., Lopez, M., Liposits, Z., Rahmouni, K., Prevot, V., Dieguez, C. & Nogueiras, R. (2019). MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance. Diabetes, 68(12), 2210-2222. PMID: 31530579.

Berger, J. M., Singh, P., Khrimian, L., Morgan, D. A., Chowdhury, S., Arteaga-Solis, E., Horvath, T. L., Domingos, A. I., Marsland, A. L., Yadav, V. K., Rahmouni, K., Gao, X. B. & Karsenty, G. (2019). Mediation of the Acute Stress Response by the Skeleton. Cell metabolism, 30(5), 890-902.e8. PMID: 31523009.

Reho, J. J., Guo, D. F., Morgan, D. A. & Rahmouni, K. (2019). Smooth Muscle Cell-Specific Disruption of the BBSome Causes Vascular Dysfunction. Hypertension (Dallas, Tex. : 1979), 74(4), 817-825. PMID: 31422694.

Seoane-Collazo, P., Liñares-Pose, L., Rial-Pensado, E., Romero-Picó, A., Moreno-Navarrete, J. M., Martínez-Sánchez, N., Garrido-Gil, P., Iglesias-Rey, R., Morgan, D. A., Tomasini, N., Malone, S. A., Senra, A., Folgueira, C., Medina-Gomez, G., Sobrino, T., Labandeira-García, J. L., Nogueiras, R., Domingos, A. I., Fernández-Real, J. M., Rahmouni, K., Diéguez, C. & López, M. (2019). Central nicotine induces browning through hypothalamic ? opioid receptor. Nature communications, 10(1), 4037. PMID: 31492869.

Hurr, C., Simonyan, H., Morgan, D. A., Rahmouni, K. & Young, C. N. (2019). Liver sympathetic denervation reverses obesity-induced hepatic steatosis. The Journal of physiology, 597(17), 4565-4580. PMID: 31278754.

Guo, D. F., Rahmouni, K. (2019). The Bardet-Biedl syndrome protein complex regulates cell migration and tissue repair through a Cullin-3/RhoA pathway. American journal of physiology. Cell physiology, 317(3), C457-C465. PMID: 31216194.

Guo, D. F., Lin, Z., Wu, Y., Searby, C., Thedens, D. R., Richerson, G. B., Usachev, Y. M., Grobe, J. L., Sheffield, V. C. & Rahmouni, K. (2019). The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors. Diabetes, 68(8), 1591-1603. PMID: 31127052.

Xu, J., Molinas AJR,, Mukerjee, S., Morgan, D. A., Rahmouni, K., Zsombok, A. & Lazartigues, E. (2019). Activation of ADAM17 (A Disintegrin and Metalloprotease 17) on Glutamatergic Neurons Selectively Promotes Sympathoexcitation. Hypertension (Dallas, Tex. : 1979), 73(6), 1266-1274. PMID: 31006330.

Saito, K., Davis, K. C., Morgan, D. A., Toth, B. A., Jiang, J., Singh, U., Berglund, E. D., Grobe, J. L., Rahmouni, K. & Cui, H. (2019). Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions. Diabetes, 68(6), 1210-1220. PMID: 30894367.

Reho, J. J., Guo, D. F. & Rahmouni, K. (2019). Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species. Journal of the American Heart Association, 8(9), e010662. PMID: 31020916.

Ameka, M., Markan, K. R., Morgan, D. A., BonDurant, L. D., Idiga, S. O., Naber, M. C., Zhu, Z., Zingman, L. V., Grobe, J. L., Rahmouni, K. & Potthoff, M. J. (2019). Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure. Scientific reports, 9(1), 630. PMID: 30679672.

Pellegrinelli, V., Peirce, V. J., Howard, L., Virtue, S., Türei, D., Senzacqua, M., Frontini, A., Dalley, J. W., Horton, A. R., Bidault, G., Severi, I., Whittle, A., Rahmouni, K., Saez-Rodriguez, J., Cinti, S., Davies, A. M. & Vidal-Puig, A. (2018). Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue. Nature communications, 9(1), 4974. PMID: 30478315.

Brandt, C., Nolte, H., Henschke, S., Engström Ruud, L., Awazawa, M., Morgan, D. A., Gabel, P., Sprenger, H. G., Hess, M. E., Günther, S., Langer, T., Rahmouni, K., Fenselau, H., Krüger, M. & Brüning, J. C. (2018). Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation. Cell, 175(5), 1321-1335.e20. PMID: 30445039.

Seoane-Collazo, P., Roa, J., Rial-Pensado, E., Liñares-Pose, L., Beiroa, D., Ruíz-Pino, F., López-González, T., Morgan, D. A., Pardavila, J. Á., Sánchez-Tapia, M. J., Martínez-Sánchez, N., Contreras, C., Fidalgo, M., Diéguez, C., Coppari, R., Rahmouni, K., Nogueiras, R., Tena-Sempere, M. & López, M. (2018). SF1-Specific AMPKa1 Deletion Protects Against Diet-Induced Obesity. Diabetes, 67(11), 2213-2226. PMID: 30104247.

Guilherme, A., Pedersen, D. J., Henriques, F., Bedard, A. H., Henchey, E., Kelly, M., Morgan, D. A., Rahmouni, K. & Czech, M. P. (2018). Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis. Molecular metabolism, 16, 116-125. PMID: 30005879.

Yoon, Y. S., Tsai, W. W., Van de Velde, S., Chen, Z., Lee, K. F., Morgan, D. A., Rahmouni, K., Matsumura, S., Wiater, E., Song, Y. & Montminy, M. (2018). cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis. Proceedings of the National Academy of Sciences of the United States of America, 115(23), E5289-E5297. PMID: 29784793.

Schmidt, E. A., Despas, F., Pavy-Le Traon, A., Czosnyka, Z., Pickard, J. D., Rahmouni, K., Pathak, A. & Senard, J. M. (2018). Intracranial Pressure Is a Determinant of Sympathetic Activity. Frontiers in physiology, 9, 11. PMID: 29472865.

Bell, B. B., Harlan, S. M., Morgan, D. A., Guo, D. F., Cui, H. & Rahmouni, K. (2018). Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin. Molecular metabolism, 8, 1-12. PMID: 29289646.

Jiang, J., Cui, H. & Rahmouni, K. (2017). Optogenetics and pharmacogenetics: principles and applications. American journal of physiology. Regulatory, integrative and comparative physiology, 313(6), R633-R645. PMID: 28794102.

Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A. & Mangelsdorf, D. J. (2017). FGF19, FGF21, and an FGFR1/ß-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia. Cell metabolism, 26(5), 709-718.e3. PMID: 28988823.

Shinohara, K., Nakagawa, P., Gomez, J., Morgan, D. A., Littlejohn, N. K., Folchert, M. D., Weidemann, B. J., Liu, X., Walsh, S. A., Ponto, L. L., Rahmouni, K., Grobe, J. L. & Sigmund, C. D. (2017). Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. Hypertension (Dallas, Tex. : 1979), 70(5), 990-997. PMID: 28874461.

Chhabra, K. H., Morgan, D. A., Tooke, B. P., Adams, J. M., Rahmouni, K. & Low, M. J. (2017). Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice. Molecular metabolism, 6(10), 1274-1285. PMID: 29031726.

Flak, J. N., Arble, D., Pan, W., Patterson, C., Lanigan, T., Goforth, P. B., Sacksner, J., Joosten, M., Morgan, D. A., Allison, M. B., Hayes, J., Feldman, E., Seeley, R. J., Olson, D. P., Rahmouni, K. & Myers, Jr, M. G. (2017). A leptin-regulated circuit controls glucose mobilization during noxious stimuli. The Journal of clinical investigation, 127(8), 3103-3113. PMID: 28714862.

Contreras, C., Nogueiras, R., Diéguez, C., Rahmouni, K. & López, M. (2017). Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway. Redox biology, 12, 854-863. PMID: 28448947.

Martínez-Sánchez, N., Seoane-Collazo, P., Contreras, C., Varela, L., Villarroya, J., Rial-Pensado, E., Buqué, X., Aurrekoetxea, I., Delgado, T. C., Vázquez-Martínez, R., González-García, I., Roa, J., Whittle, A. J., Gomez-Santos, B., Velagapudi, V., Tung YCL,, Morgan, D. A., Voshol, P. J., de Martínez Morentin, P. B., López-González, T., Liñares-Pose, L., Gonzalez, F., Chatterjee, K., Sobrino, T., Medina-Gómez, G., Davis, R. J., Casals, N., Orešic, M., Coll, A. P., Vidal-Puig, A., Mittag, J., Tena-Sempere, M., Malagón, M. M., Diéguez, C., Martínez-Chantar, M. L., Aspichueta, P., Rahmouni, K., Nogueiras, R., Sabio, G., Villarroya, F. & López, M. (2017). Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell metabolism, 26(1), 212-229.e12. PMID: 28683288.

Mukohda, M., Lu, K. T., Guo, D. F., Wu, J., Keen, H. L., Liu, X., Ketsawatsomkron, P., Stump, M., Rahmouni, K., Quelle, F. W. & Sigmund, C. D. (2017). Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor ? Impairs Nuclear Export of Nuclear Factor-?B p65 in Vascular Smooth Muscle. Hypertension (Dallas, Tex. : 1979), 70(1), 174-182. PMID: 28507170.

Douris, N., Desai, B. N., Fisher, F. M., Cisu, T., Fowler, A. J., Zarebidaki, E., Nguyen NLT,, Morgan, D. A., Bartness, T. J., Rahmouni, K., Flier, J. S. & Maratos-Flier, E. (2017). Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice. Molecular metabolism, 6(8), 854-862. PMID: 28752049.

Cui, H., López, M. & Rahmouni, K. (2017). The cellular and molecular bases of leptin and ghrelin resistance in obesity. Nature reviews. Endocrinology, 13(6), 338-351. PMID: 28232667.

DeZwaan-McCabe, D., Sheldon, R. D., Gorecki, M. C., Guo, D. F., Gansemer, E. R., Kaufman, R. J., Rahmouni, K., Gillum, M. P., Taylor, E. B., Teesch, L. M. & Rutkowski, D. T. (2017). ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. Cell reports, 19(9), 1794-1806. PMID: 28564599.

Claflin, K. E., Sandgren, J. A., Lambertz, A. M., Weidemann, B. J., Littlejohn, N. K., Burnett, C. M., Pearson, N. A., Morgan, D. A., Gibson-Corley, K. N., Rahmouni, K. & Grobe, J. L. (2017). Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism. The Journal of clinical investigation, 127(4), 1414-1424. PMID: 28263184.

Fink, B. D., Guo, D. F., Kulkarni, C. A., Rahmouni, K., Kerns, R. J. & Sivitz, W. I. (2017). Metabolic effects of a mitochondrial-targeted coenzyme Q analog in high fat fed obese mice. Pharmacology research & perspectives, 5(2), e00301. PMID: 28357127.

Shinohara, K., Liu, X., Morgan, D. A., Davis, D. R., Sequeira-Lopez, M. L., Cassell, M. D., Grobe, J. L., Rahmouni, K. & Sigmund, C. D. (2016). Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. Hypertension (Dallas, Tex. : 1979), 68(6), 1385-1392. PMID: 27754863.

Bell, B. B., Rahmouni, K. (2016). Leptin as a Mediator of Obesity-Induced Hypertension. Current obesity reports, 5(4), 397-404. PMID: 27665107.

Stump, M., Guo, D. F., Lu, K. T., Mukohda, M., Cassell, M. D., Norris, A. W., Rahmouni, K. & Sigmund, C. D. (2016). Nervous System Expression of PPAR? and Mutant PPAR? Has Profound Effects on Metabolic Regulation and Brain Development. Endocrinology, 157(11), 4266-4275. PMID: 27575030.

Littlejohn, N. K., Keen, H. L., Weidemann, B. J., Claflin, K. E., Tobin, K. V., Markan, K. R., Park, S., Naber, M. C., Gourronc, F. A., Pearson, N. A., Liu, X., Morgan, D. A., Klingelhutz, A. J., Potthoff, M. J., Rahmouni, K., Sigmund, C. D. & Grobe, J. L. (2016). Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell reports, 16(6), 1548-1560. PMID: 27477281.

Muta, K., Morgan, D. A., Grobe, J. L., Sigmund, C. D. & Rahmouni, K. (2016). mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II. Endocrinology, 157(8), 3140-8. PMID: 27254006.

Peotta, V., Rahmouni, K., Segar, J. L., Morgan, D. A., Pitz, K. M., Rice, O. M. & Roghair, R. D. (2016). Neonatal growth restriction-related leptin deficiency enhances leptin-triggered sympathetic activation and central angiotensin II receptor-dependent stress-evoked hypertension. Pediatric research, 80(2), 244-51. PMID: 27049292.

Chapleau, M. W., Rotella, D. L., Reho, J. J., Rahmouni, K. & Stauss, H. M. (2016). Chronic vagal nerve stimulation prevents high-salt diet-induced endothelial dysfunction and aortic stiffening in stroke-prone spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology, 311(1), H276-85. PMID: 27208157.

Stump, M., Guo, D. F., Lu, K. T., Mukohda, M., Liu, X., Rahmouni, K. & Sigmund, C. D. (2016). Effect of selective expression of dominant-negative PPAR? in pro-opiomelanocortin neurons on the control of energy balance. Physiological genomics, 48(7), 491-501. PMID: 27199455.

Rahmouni, K. (2016). Cardiovascular Regulation by the Arcuate Nucleus of the Hypothalamus: Neurocircuitry and Signaling Systems. Hypertension (Dallas, Tex. : 1979), 67(6), 1064-71. PMID: 27045026.

Steculorum, S. M., Ruud, J., Karakasilioti, I., Backes, H., Engström Ruud, L., Timper, K., Hess, M. E., Tsaousidou, E., Mauer, J., Vogt, M. C., Paeger, L., Bremser, S., Klein, A. C., Morgan, D. A., Frommolt, P., Brinkkötter, P. T., Hammerschmidt, P., Benzing, T., Rahmouni, K., Wunderlich, F. T., Kloppenburg, P. & Brüning, J. C. (2016). AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue. Cell, 165(1), 125-138. PMID: 27015310.

Guo, D. F., Cui, H., Zhang, Q., Morgan, D. A., Thedens, D. R., Nishimura, D., Grobe, J. L., Sheffield, V. C. & Rahmouni, K. (2016). The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane. PLoS genetics, 12(2), e1005890. PMID: 26926121.

von Holstein-Rathlou, S., BonDurant, L. D., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Urizar, A. I., Madsen, A. N., Ratner, C., Holst, B., Karstoft, K., Vandenbeuch, A., Anderson, C. B., Cassell, M. D., Thompson, A. P., Solomon, T. P., Rahmouni, K., Kinnamon, S. C., Pieper, A. A., Gillum, M. P. & Potthoff, M. J. (2016). FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver. Cell metabolism, 23(2), 335-43. PMID: 26724858.

Meyers, E. E., Kronemberger, A., Lira, V., Rahmouni, K. & Stauss, H. M. (2016). Contrasting effects of afferent and efferent vagal nerve stimulation on insulin secretion and blood glucose regulation. Physiological reports, 4(4). PMID: 26884478.

Morgan, D. A., Despas, F. & Rahmouni, K. (2015). Effects of leptin on sympathetic nerve activity in conscious mice. Physiological reports, 3(9). PMID: 26381017.

Starks, R. D., Beyer, A. M., Guo, D. F., Boland, L., Zhang, Q., Sheffield, V. C. & Rahmouni, K. (2015). Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins. PLoS genetics, 11(6), e1005311. PMID: 26103456.

Prasad, A. M., Morgan, D. A., Nuno, D. W., Ketsawatsomkron, P., Bair, T. B., Venema, A. N., Dibbern, M. E., Kutschke, W. J., Weiss, R. M., Lamping, K. G., Chapleau, M. W., Sigmund, C. D., Rahmouni, K. & Grumbach, I. M. (2015). Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function. Journal of the American Heart Association, 4(6), e001949. PMID: 26077587.

Morgan, D. A., McDaniel, L. N., Yin, T., Khan, M., Jiang, J., Acevedo, M. R., Walsh, S. A., Ponto, L. L., Norris, A. W., Lutter, M., Rahmouni, K. & Cui, H. (2015). Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus. Diabetes, 64(6), 1976-87. PMID: 25605803.

Muta, K., Morgan, D. A. & Rahmouni, K. (2015). The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight, and sympathetic nerve activity in male mice. Endocrinology, 156(4), 1398-407. PMID: 25574706.

Contreras, C., Gonzalez, F., Fernø, J., Diéguez, C., Rahmouni, K., Nogueiras, R. & López, M. (2015). The brain and brown fat. Annals of medicine, 47(2), 150-68. PMID: 24915455.

Young, C. N., Morgan, D. A., Butler, S. D., Rahmouni, K., Gurley, S. B., Coffman, T. M., Mark, A. L. & Davisson, R. L. (2015). Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis. Molecular metabolism, 4(4), 337-43. PMID: 25830096.

Tanida, M., Yamamoto, N., Morgan, D. A., Kurata, Y., Shibamoto, T. & Rahmouni, K. (2015). Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 474-84. PMID: 25589743.

Fink, B. D., Herlein, J. A., Guo, D. F., Kulkarni, C., Weidemann, B. J., Yu, L., Grobe, J. L., Rahmouni, K., Kerns, R. J. & Sivitz, W. I. (2014). A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice. The Journal of pharmacology and experimental therapeutics, 351(3), 699-708. PMID: 25301169.

Contreras, C., González-García, I., Martínez-Sánchez, N., Seoane-Collazo, P., Jacas, J., Morgan, D. A., Serra, D., Gallego, R., Gonzalez, F., Casals, N., Nogueiras, R., Rahmouni, K., Diéguez, C. & López, M. (2014). Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance. Cell reports, 9(1), 366-77. PMID: 25284795.

Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A. & Mangelsdorf, D. J. (2014). FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell metabolism, 20(4), 670-7. PMID: 25130400.

Tillman, E. J., Morgan, D. A., Rahmouni, K. & Swoap, S. J. (2014). Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice. PloS one, 9(9), e107206. PMID: 25211467.

Borges, G. R., Morgan, D. A., Ketsawatsomkron, P., Mickle, A. D., Thompson, A. P., Cassell, M. D., Mohapatra, D. P., Rahmouni, K. & Sigmund, C. D. (2014). Interference with peroxisome proliferator-activated receptor-? in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction. Hypertension (Dallas, Tex. : 1979), 64(3), 590-6. PMID: 24914194.

Rahmouni, K. (2014). Obesity-associated hypertension: recent progress in deciphering the pathogenesis. Hypertension (Dallas, Tex. : 1979), 64(2), 215-21. PMID: 24821943.

Mark, A. L., Norris, A. W. & Rahmouni, K. (2014). Sympathetic inhibition after bariatric surgery. Hypertension (Dallas, Tex. : 1979), 64(2), 235-6. PMID: 24866141.

de Martínez Morentin, P. B., González-García, I., Martins, L., Lage, R., Fernández-Mallo, D., Martínez-Sánchez, N., Ruíz-Pino, F., Liu, J., Morgan, D. A., Pinilla, L., Gallego, R., Saha, A. K., Kalsbeek, A., Fliers, E., Bisschop, P. H., Diéguez, C., Nogueiras, R., Rahmouni, K., Tena-Sempere, M. & López, M. (2014). Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell metabolism, 20(1), 41-53. PMID: 24856932.

Dexter, B. C., Rahmouni, K., Cushman, T., Hermann, G. M., Ni, C., Nopoulos, P. C., Thedens, D. L. & Roghair, R. D. (2014). Neonatal leptin deficiency reduces frontal cortex volumes and programs adult hyperactivity in mice. Behavioural brain research, 263, 115-21. PMID: 24472638.

Agassandian, K., Patel, M., Agassandian, M., Steren, K. E., Rahmouni, K., Sheffield, V. C. & Card, J. P. (2014). Ciliopathy is differentially distributed in the brain of a Bardet-Biedl syndrome mouse model. PloS one, 9(4), e93484. PMID: 24695551.

Tovar, S., Paeger, L., Hess, S., Morgan, D. A., Hausen, A. C., Brönneke, H. S., Hampel, B., Ackermann, P. J., Evers, N., Büning, H., Wunderlich, F. T., Rahmouni, K., Kloppenburg, P. & Brüning, J. C. (2013). K(ATP)-channel-dependent regulation of catecholaminergic neurons controls BAT sympathetic nerve activity and energy homeostasis. Cell metabolism, 18(3), 445-55. PMID: 24011078.

Fernandes-Santos, C., Zhang, Z., Morgan, D. A., Guo, D. F., Russo, A. F. & Rahmouni, K. (2013). Amylin acts in the central nervous system to increase sympathetic nerve activity. Endocrinology, 154(7), 2481-8. PMID: 23645151.

Tanida, M., Hayata, A., Shintani, N., Yamamoto, N., Kurata, Y., Shibamoto, T., Morgan, D. A., Rahmouni, K. & Hashimoto, H. (2013). Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner. Neuroscience, 238, 297-304. PMID: 23454538.

Harlan, S. M., Guo, D. F., Morgan, D. A., Fernandes-Santos, C. & Rahmouni, K. (2013). Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects. Cell metabolism, 17(4), 599-606. PMID: 23541372.

Beyer, A. M., Guo, D. F. & Rahmouni, K. (2013). Prolonged treatment with angiotensin 1-7 improves endothelial function in diet-induced obesity. Journal of hypertension, 31(4), 730-8. PMID: 23425706.

Harlan, S. M., Rahmouni, K. (2013). PI3K signaling: A key pathway in the control of sympathetic traffic and arterial pressure by leptin. Molecular metabolism, 2(2), 69-73. PMID: 24199153.

Imbernon, M., Beiroa, D., Vazquez, M. J., Morgan, D. A., Veyrat-Durebex, C., Porteiro, B., Diaz-Arteaga, A., Senra, A., Busquets, S., Velasquez, D. A., Al-Massadi, O., Varela, L., Gandara, M., Lopez-Soriano, F. J., Gallego, R., Seoane, L. M., Argiles, J. M., Lopez, M., Davis, R. J., Sabio, G., Rohner-Jeanrenaud, F., Rahmouni, K., Dieguez, C. & Nogueiras, R. (2013). Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. Gastroenterology, 144(3), 636-649. PMID: 23142626.

Harlan, S. M., Rahmouni, K. (2013). Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin. Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 23(1), 1-7. PMID: 22714900.

Chamling, X., Seo, S., Bugge, K., Searby, C., Guo, D. F., Drack, A. V., Rahmouni, K. & Sheffield, V. C. (2013). Ectopic expression of human BBS4 can rescue Bardet-Biedl syndrome phenotypes in Bbs4 null mice. PloS one, 8(3), e59101. PMID: 23554981.

Tanida, M., Yamamoto, N., Shibamoto, T. & Rahmouni, K. (2013). Involvement of hypothalamic AMP-activated protein kinase in leptin-induced sympathetic nerve activation. PloS one, 8(2), e56660. PMID: 23418591.

Grobe, J. L., Rahmouni, K., Liu, X. & Sigmund, C. D. (2013). Metabolic rate regulation by the renin-angiotensin system: brain vs. body. Pflugers Archiv : European journal of physiology, 465(1), 167-75. PMID: 22491893.

Grobe, J. L., Rahmouni, K. (2012). The adipose/circulating renin-angiotensin system cross-talk enters a new dimension. Hypertension, 60(6), 1389-90. PMID: 23108659.

Lockie, S. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat-Durebex, C., Ananthakrishnan, G., Rohner-Jeanrenaud, F., Drucker, D. J., DiMarchi, R., Rahmouni, K., Oldfield, B. J., Tschop, M. H. & Perez-Tilve, D. (2012). Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes, 61(11), 2753-62. PMID: 22933116.

Hilzendeger, A. M., Morgan, D. A., Brooks, L., Dellsperger, D., Liu, X., Grobe, J. L., Rahmouni, K., Sigmund, C. D. & Mark, A. L. (2012). A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. American journal of physiology. Heart and circulatory physiology, 303(2), H197-206. PMID: 22610169.

Whittle, A. J., Carobbio, S., Martins, L., Slawik, M., Hondares, E., Vazquez, M. J., Morgan, D., Csikasz, R. I., Gallego, R., Rodriguez-Cuenca, S., Dale, M., Virtue, S., Villarroya, F., Cannon, B., Rahmouni, K., Lopez, M. & Vidal-Puig, A. (2012). BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 149(4), 871-85. PMID: 22579288.

Patel, P. R., Ramakrishnan, S. K., Kaw, M. K., Raphael, C. K., Ghosh, S., Marino, J. S., Heinrich, G., Lee, S. J., Bourey, R. E., Hill, J. W., Jung, D. Y., Morgan, D. A., Kim, J. K., Rahmouni, K., Rahmouni, S. K. & Najjar, S. M. (2012). Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2. Diabetologia, 55(3), 763-72. PMID: 22159884.

Tschop, M. H., Speakman, J. R., Arch, J. R., Auwerx, J., Bruning, J. C., Chan, L., Eckel, R. H., Farese, R. V., Galgani, J. E., Hambly, C., Herman, M. A., Horvath, T. L., Kahn, B. B., Kozma, S. C., Maratos-Flier, E., Muller, T. D., Munzberg, H., Pfluger, P. T., Plum, L., Reitman, M. L., Rahmouni, K., Shulman, G. I., Thomas, G., Kahn, C. R. & Ravussin, E. (2012). A guide to analysis of mouse energy metabolism. Nature methods, 9(1), 57-63. PMID: 22205519.

Grobe, J. L., Rahmouni, K. (2012). Editorial focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic. American journal of physiology. Regulatory, integrative and comparative physiology, 302(2), R242-3. PMID: 22071163.

Rahmouni, K. (2012). Leptin Signaling in the brain and energy homeostasis. In D. Robertson (Eds.) Primer on the Autonomic Nervous System. (3), pp. 131-134. Academic Press.

Castaneda, T. R., Abplanalp, W., Um, S. H., Pfluger, P. T., Schrott, B., Brown, K., Grant, E., Carnevalli, L., Benoit, S. C., Morgan, D. A., Gilham, D., Hui, D. Y., Rahmouni, K., Thomas, G., Kozma, S. C., Clegg, D. J. & Tschop, M. H. (2012). Metabolic control by S6 kinases depends on dietary lipids. PloS one, 7(3), e32631. PMID: 22412899.

Zhang, Q., Nishimura, D., Seo, S., Vogel, T., Morgan, D. A., Searby, C., Bugge, K., Stone, E. M., Rahmouni, K. & Sheffield, V. C. (2011). Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 108(51), 20678-83. PMID: 22139371.

Rahmouni, K., Davisson, R. L. & Sigmund, C. D. (2011). Inflaming hypothalamic neurons raises blood pressure. Cell metabolism, 14(1), 3-4. PMID: 21723497.

Guo, D. F., Rahmouni, K. (2011). Molecular basis of the obesity associated with Bardet-Biedl syndrome. Trends in endocrinology and metabolism: TEM, 22(7), 286-93. PMID: 21514177.

Harlan, S. M., Morgan, D. A., Agassandian, K., Guo, D. F., Cassell, M. D., Sigmund, C. D., Mark, A. L. & Rahmouni, K. (2011). Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circulation research, 108(7), 808-12. PMID: 21311043.

Zhang, Z., Liu, X., Morgan, D. A., Kuburas, A., Thedens, D. R., Russo, A. F. & Rahmouni, K. (2011). Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice. Diabetes, 60(4), 1063-71. PMID: 21357463.

Harlan, S. M., Morgan, D. A., Dellsperger, D. J., Myers, M. G., Mark, A. L. & Rahmouni, K. (2011). Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor. Hypertension, 57(3), 627-32. PMID: 21263121.

Guo, D. F., Beyer, A. M., Yang, B., Nishimura, D. Y., Sheffield, V. C. & Rahmouni, K. (2011). Inactivation of Bardet-Biedl syndrome genes causes kidney defects. American journal of physiology. Renal physiology, 300(2), F574-80. PMID: 21106857.

Pezzulo, A. A., Gutierrez, J., Duschner, K. S., McConnell, K. S., Taft, P. J., Ernst, S. E., Yahr, T. L., Rahmouni, K., Klesney-Tait, J., Stoltz, D. A. & Zabner, J. (2011). Glucose depletion in the airway surface liquid is essential for sterility of the airways. PloS one, 6(1), e16166. PMID: 21311590.

Beyer, A. M., Guo, D. F., Sheffield, V. C. & Rahmouni, K. (2010). Contrasting vascular effects caused by loss of Bardet-Biedl syndrome genes. American journal of physiology. Heart and circulatory physiology, 299(6), H1902-7. PMID: 20852044.

Grobe, J. L., Grobe, C. L., Beltz, T. G., Westphal, S. G., Morgan, D. A., Xu, D., de Lange, W. J., Li, H., Sakai, K., Thedens, D. R., Cassis, L. A., Rahmouni, K., Mark, A. L., Johnson, A. K. & Sigmund, C. D. (2010). The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell metabolism, 12(5), 431-42. PMID: 21035755.

Morgan, D. A., Rahmouni, K. (2010). Differential effects of insulin on sympathetic nerve activity in agouti obese mice. Journal of hypertension, 28(9), 1913-9. PMID: 20577122.

Lopez, M., Varela, L., Vazquez, M. J., Rodriguez-Cuenca, S., Gonzalez, C. R., Velagapudi, V. R., Morgan, D. A., Schoenmakers, E., Agassandian, K., Lage, R., Martinez de Morentin, P. B., Tovar, S., Nogueiras, R., Carling, D., Lelliott, C., Gallego, R., Oresic, M., Chatterjee, K., Saha, A. K., Rahmouni, K., Dieguez, C. & Vidal-Puig, A. (2010). Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nature medicine, 16(9), 1001-8. PMID: 20802499.

Ramadori, G., Fujikawa, T., Fukuda, M., Anderson, J., Morgan, D. A., Mostoslavsky, R., Stuart, R. C., Perello, M., Vianna, C. R., Nillni, E. A., Rahmouni, K. & Coppari, R. (2010). SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell metabolism, 12(1), 78-87. PMID: 20620997.

Rahmouni, K. (2010). Leptin-Induced Sympathetic Nerve Activation: Signaling Mechanisms and Cardiovascular Consequences in Obesity. Current hypertension reviews, 6(2), 104-109. PMID: 21562617.

Rahmouni, K. (2010). Obesity, sympathetic overdrive, and hypertension: the leptin connection. Hypertension, 55(4), 844-5. PMID: 20194295.

Rahmouni, K. (2010). Sympathetic tone in the young: the mother weighs in. Hypertension, 55(1), 21-2. PMID: 19901157.

Lu, Y., Ma, X., Sabharwal, R., Snitsarev, V., Morgan, D., Rahmouni, K., Drummond, H. A., Whiteis, C. A., Costa, V., Price, M., Benson, C., Welsh, M. J., Chapleau, M. W. & Abboud, F. M. (2009). The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron, 64(6), 885-97. PMID: 20064394.

Nogueiras, R., Perez-Tilve, D., Veyrat-Durebex, C., Morgan, D. A., Varela, L., Haynes, W. G., Patterson, J. T., Disse, E., Pfluger, P. T., Lopez, M., Woods, S. C., DiMarchi, R., Dieguez, C., Rahmouni, K., Rohner-Jeanrenaud, F. & Tschop, M. H. (2009). Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(18), 5916-25. PMID: 19420258.

Seo, S., Guo, D. F., Bugge, K., Morgan, D. A., Rahmouni, K. & Sheffield, V. C. (2009). Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Human molecular genetics, 18(7), 1323-31. PMID: 19150989.

Rahmouni, K., Sigmund, C. D., Haynes, W. G. & Mark, A. L. (2009). Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes, 58(3), 536-42. PMID: 19066310.

Mark, A. L., Agassandian, K., Morgan, D. A., Liu, X., Cassell, M. D. & Rahmouni, K. (2009). Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney. Hypertension, 53(2), 375-80. PMID: 19103999.

Morgan, D. A., Thedens, D. R., Weiss, R. & Rahmouni, K. (2008). Mechanisms mediating renal sympathetic activation to leptin in obesity. American journal of physiology. Regulatory, integrative and comparative physiology, 295(6), R1730-6. PMID: 18815209.

Rahmouni, K., Sigmund, C. D. (2008). Id3, E47, and SREBP-1c: fat factors controlling adiponectin expression. Circulation research, 103(6), 565-7. PMID: 18796641.

Rahmouni, K. (2008). Does genetic variation in the leptin receptor influence the sympathetic tone in obesity?. Hypertension research : official journal of the Japanese Society of Hypertension, 31(6), 1057-9. PMID: 18716350.

Rahmouni, K., Fath, M. A., Seo, S., Thedens, D. R., Berry, C. J., Weiss, R., Nishimura, D. Y. & Sheffield, V. C. (2008). Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome. The Journal of clinical investigation, 118(4), 1458-67. PMID: 18317593.

Davis, R. E., Swiderski, R. E., Rahmouni, K., Nishimura, D. Y., Mullins, R. F., Agassandian, K., Philp, A. R., Searby, C. C., Andrews, M. P., Thompson, S., Berry, C. J., Thedens, D. R., Yang, B., Weiss, R. M., Cassell, M. D., Stone, E. M. & Sheffield, V. C. (2007). A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity. Proceedings of the National Academy of Sciences of the United States of America, 104(49), 19422-7. PMID: 18032602.

Plum, L., Rother, E., Munzberg, H., Wunderlich, F. T., Morgan, D. A., Hampel, B., Shanabrough, M., Janoschek, R., Konner, A. C., Alber, J., Suzuki, A., Krone, W., Horvath, T. L., Rahmouni, K. & Bruning, J. C. (2007). Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell metabolism, 6(6), 431-45. PMID: 18054313.

Rahmouni, K. (2007). Differential Control of the Sympathetic Nervous System by Leptin: Implications for Obesity. Clinical and experimental pharmacology & physiology. Supplement, 34 Suppl(s1), S8-S10. PMID: 21546982.

Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., Howles, P. N., Morgan, D. A., Benoit, S. C., Szanto, I., Schrott, B., Schurmann, A., Joost, H. G., Hammond, C., Hui, D. Y., Woods, S. C., Rahmouni, K., Butler, A. A., Farooqi, I. S., O'Rahilly, S., Rohner-Jeanrenaud, F. & Tschop, M. H. (2007). The central melanocortin system directly controls peripheral lipid metabolism. The Journal of clinical investigation, 117(11), 3475-88. PMID: 17885689.

Rahmouni, K., Morgan, D. A. (2007). Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin. Hypertension, 49(3), 647-52. PMID: 17190874.

Dickson, M. E., Zimmerman, M. B., Rahmouni, K. & Sigmund, C. D. (2007). The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells. Hypertension, 49(3), 631-9. PMID: 17200439.

Correia, M. L., Rahmouni, K. (2006). Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome. Diabetes, obesity & metabolism, 8(6), 603-10. PMID: 17026484.

Rahmouni, K., Correia, M. & Haynes, W. G. (2006). Leptin and cardiovascular disease. In V. D. Castracane , M. C. Henson (Eds.) Comprehensive Endocrinology Update. pp. 183-199. Springer.

Rahmouni, K., Correia, M. (2006). Role of leptin and obesity-related leptin resistance in the pathophysiology of metabolic syndrome. Brazilian Journal of Hypertension, 13, 171-176.

Rahmouni, K., Haynes, W. G. (2005). Endothelial effects of leptin: implications in health and diseases. Current diabetes reports, 5(4), 260-6. PMID: 16033675.

Rahmouni, K., Jalali, A., Morgan, D. A. & Haynes, W. G. (2005). Lack of dilator effect of leptin in the hindlimb vascular bed of conscious rats. European journal of pharmacology, 518(2-3), 175-81. PMID: 16054621.

Rahmouni, K., Morgan, D. A., Morgan, G. M., Mark, A. L. & Haynes, W. G. (2005). Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes, 54(7), 2012-8. PMID: 15983201.

Fath, M. A., Mullins, R. F., Searby, C., Nishimura, D. Y., Wei, J., Rahmouni, K., Davis, R. E., Tayeh, M. K., Andrews, M., Yang, B., Sigmund, C. D., Stone, E. M. & Sheffield, V. C. (2005). Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome. Human molecular genetics, 14(9), 1109-18. PMID: 15772095.

Rahmouni, K., Sigmund, C. D. (2005). Local production of angiotensinogen: Insights from genetic manipulation of mice. In Raizada (Eds.) Cardiovascular Genomics. pp. 59-70. The Humana Press Inc.

Rahmouni, K., Correia, M. L., Haynes, W. G. & Mark, A. L. (2005). Obesity-associated hypertension: new insights into mechanisms. Hypertension, 45(1), 9-14. PMID: 15583075.

Rahmouni, K., Morgan, D. A., Morgan, G. M., Liu, X., Sigmund, C. D., Mark, A. L. & Haynes, W. G. (2004). Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. The Journal of clinical investigation, 114(5), 652-8. PMID: 15343383.

Rahmouni, K., Mark, A. L., Haynes, W. G. & Sigmund, C. D. (2004). Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity. American journal of physiology. Endocrinology and metabolism, 286(6), E891-5. PMID: 14749209.

Rahmouni, K., Haynes, W. G. (2004). Leptin and the cardiovascular system. Recent progress in hormone research, 59, 225-44. PMID: 14749504.

Rahmouni, K., Haynes, W. G. & Mark, A. L. (2004). Leptin signaling in the central nervous system. Academic Press, 86-89.

Rahmouni, K., Haynes, W. G. & Mark, A. L. (2004). Leptin signaling in the central nervous system. In D. Robertson (Eds.) Primer on the Autonomic Nervous System. pp. 86-89. Academic Press.

Mark, A. L., Correia, M. L., Rahmouni, K. & Haynes, W. G. (2004). Loss of leptin actions in obesity: two concepts with cardiovascular implications. Clinical and experimental hypertension (New York, N.Y. : 1993), 26(7-8), 629-36. PMID: 15702617.

Rahmouni, K. (2003). Brain effects of leptin: what intracellular mechanism?. Current diabetes reports, 3(6), 427-9. PMID: 14611736.

Rahmouni, K., Haynes, W. G., Morgan, D. A. & Mark, A. L. (2003). Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(14), 5998-6004. PMID: 12853417.

Mark, A. L., Rahmouni, K., Correia, M. & Haynes, W. G. (2003). A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat. Acta physiologica Scandinavica, 177(3), 345-9. PMID: 12609005.

Rahmouni, K., Haynes, W. G., Morgan, D. A. & Mark, A. L. (2003). Intracellular mechanisms involved in leptin regulation of sympathetic outflow. Hypertension, 41(3 Pt 2), 763-7. PMID: 12623993.

Rahmouni, K., G Haynes, W. (2002). Leptin and the central neural mechanisms of obesity hypertension. Drugs of today (Barcelona, Spain : 1998), 38(12), 807-17. PMID: 12582470.

Rahmouni, K., Barthelmebs, M., Grima, M., Imbs, J. L. & De Jong, W. (2002). Influence of sodium intake on the cardiovascular and renal effects of brain mineralocorticoid receptor blockade in normotensive rats. Journal of hypertension, 20(9), 1829-34. PMID: 12195126.

Mark, A. L., Correia, M. L., Rahmouni, K. & Haynes, W. G. (2002). Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. Journal of hypertension, 20(7), 1245-50. PMID: 12131511.

Rahmouni, K., Haynes, W. G. & Mark, A. L. (2002). Cardiovascular and sympathetic effects of leptin. Current hypertension reports, 4(2), 119-25. PMID: 11884267.

Rahmouni, K., Sibug, R. M., De Kloet, E. R., Barthelmebs, M., Grima, M., Imbs, J. L. & De Jong, W. (2002). Effects of brain mineralocorticoid receptor blockade on blood pressure and renal functions in DOCA-salt hypertension. European journal of pharmacology, 436(3), 207-16. PMID: 11858800.

Rahmouni, K., Haynes, W. G., Morgan, D. A. & Mark, A. L. (2002). Selective resistance to central neural administration of leptin in agouti obese mice. Hypertension, 39(2 Pt 2), 486-90. PMID: 11882595.

Correia, M. L., Haynes, W. G., Rahmouni, K., Morgan, D. A., Sivitz, W. I. & Mark, A. L. (2002). The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes, 51(2), 439-42. PMID: 11812752.

Rahmouni, K., Haynes, W. G. (2001). Leptin signaling pathways in the central nervous system: interactions between neuropeptide Y and melanocortins. BioEssays : news and reviews in molecular, cellular and developmental biology, 23(12), 1095-9. PMID: 11746228.

Rahmouni, K., Barthelmebs, M., Grima, M., Imbs, J. L. & De Jong, W. (2001). Involvement of brain mineralocorticoid receptor in salt-enhanced hypertension in spontaneously hypertensive rats. Hypertension, 38(4), 902-6. PMID: 11641306.

de Kloet, E. R., Van Acker, S. A., Sibug, R. M., Oitzl, M. S., Meijer, O. C., Rahmouni, K. & de Jong, W. (2000). Brain mineralocorticoid receptors and centrally regulated functions. Kidney international, 57(4), 1329-36. PMID: 10760063.

Rahmouni, K., Barthelmebs, M., Grima, M., Imbs, J. L. & De Jong, W. (1999). Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in conscious female rats. European journal of pharmacology, 385(2-3), 199-202. PMID: 10607876.

Rahmouni, K., Barthelmebs, M., Grima, M., Imbs, J. L. & Wybren De, J. (1999). Brain mineralocorticoid receptor control of blood pressure and kidney function in normotensive rats. Hypertension, 33(5), 1201-6. PMID: 10334812.

Rahmouni, K., Barthelmebs, M., Imbs, J. L. & De Jong, W. (1998). [Brain mineralocorticoid receptor and blood pressure control in the conscious normotensive rat]. Archives des maladies du coeur et des vaisseaux, 91(8), 1009-12. PMID: 9749155.