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Kelly Mulfaul, PhD

Assistant Professor of Neuroscience and Pharmacology

Current Positions

  • Assistant Professor of Neuroscience and Pharmacology

Education

  • BA in Genetics, Trinity College Dublin
  • PhD, Trinity College Dublin
  • Research Assistant, Trinity College Dublin
  • Postdoctoral Research Fellow, School of Medicine, Trinity College of Dublin
  • Postdoctoral Research Fellow, Department of Ophthalmology, The Institute for Vision Research, University of Iowa
  • Assistant Research Scientist, Department of Ophthalmology, The Insitute for Vision Research, University of Iowa

Center, Program and Institute Affiliations

Research Interests

  • Understanding the role of immune cells in the pathogenesis of Age-related macular degeneration (AMD).

Selected Publications

  • Yuan H, Wilson CM, Xia J, Doyle SL, Li S, Fales AM, Liu Y, Ozaki E, Mulfaul K, Hanna G, Palmer GM, Wang LV, Grant GA, Vo-Dinh T. (2014). Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor. Nanoscale, 6(8):4078-82. PMCID: PMC4343032
  • Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M. (2014) IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration. Sci Transl Med., 6(230):230ra44. PMID: 24695684
  • Doyle SL, López FJ, Celkova L, Brennan K, Mulfaul K, Ozaki E, Kenna PF, Kurali E, Hudson N, Doggett T, Ferguson TA, Humphries P, Adamson P, Campbell M. (2015) IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates. Invest Ophthalmol Vis Sci. 56(9):5424-30. PMID: 26284546
  • Brennan K, O'Leary BD, Mc Laughlin D, Breen EP, Connolly E, Ali N, O'Driscoll DN, Ozaki E, Mahony R, Mulfaul K, Ryan AM, Ni Chianain A, McHugh A, Molloy EJ, Hogan AE, Paran S, McAuliffe FM, Doyle SL. (2018) Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation. J Immunol. 201(4):1131-1143. PMID: 29980613
  • Giannoudaki E, Hernandez-Santana YE, Mulfaul K, Doyle SL, Hams E, Fallon PG, Mat A, O'Shea D, Kopf M, Hogan AE, Walsh PT. (2019) Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction. Nat Commun. 10(1):4003. PMCID: PMC6728358
  • Voigt AP, Mulfaul K, Mullin NK, Flamme-Wiese MJ, Giacalone JC, Stone EM, Tucker BA, Scheetz TE, Mullins RF. (2019) Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration. Proc Natl Acad Sci U S A. 26;116(48):24100-24107. PMID: 31712411
  • Mulfaul K, Ozaki E, Fernando N, Chirco KR, Brennan K, Connolly E, Greene C, Maminishkis A, Salomon RG, Linetsky M, Natoli R, Mullins RF, Campbell M, Doyle SL. (2020) Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration. Cell Rep., 30(7):2209-2224.e5. PMCID: PMC7179253
  • Voigt AP, Whitmore SS, Mulfaul K, Chirco KR, Giacalone JC, Flamme-Wiese MJ, Stockman A, Stone EM, Tucker BA, Scheetz TE, Mullins RF. (2020) Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype. Microvasc Res., 131:104031. PMID: 32531351
  • Mulfaul K, Giacalone JC, Voigt AP, Riker MJ, Ochoa D, Han IC, Stone EM, Mullins RF, Tucker BA. (2020) Stepwise differentiation and functional characterization of human induced pluripotent stem cell-derived choroidal endothelial cells. Stem cell Res Ther., 11(1):409. PMCID: PMC7510078
  • Mulfaul K, Doyle SL. (2021) In vitro Measurement of Membrane Attack Complex in RPE Cells. Bio Protoc., 11(4):e3916. PMCID: PMC7952945