Seth Tomchik, PhD
Introduction
Plasticity is a fundamental feature of the nervous system, which allows an organism to alter its neurodevelopmental trajectory, retain memories of experiences in order to guide future actions, and respond to changes in environmental conditions. I am interested in how these processes work, as well as how genetic disorders impact them. My research addresses three major areas:
I) Neurodevelopmental disorders, hyperactivity, and repetitive behaviors: how do mutations underlying genetic disorders – such as neurofibromatosis type 1 – influence motor activity and repetitive behaviors?
II) Learning and memory: how do neuromodulatory circuits influence the acquisition and storage of sensory information, allowing an animal to form predictions about the world that influence subsequent behavior?
III) Metabolic homeostasis: how do mutations in genetic disorder risk factor genes influence neuronal circuit function and alter metabolic homeostasis?
My lab’s research dissects these processes at the molecular, cellular, and neuronal circuit levels. This research leverages a range of techniques, from genetics and molecular biology through in vivo imaging, optogenetics, and behavioral analysis. Ultimately, we aim to understand how neuronal plasticity allows animals to adjust their physiology and behavior adaptively, and how these processes are disrupted in genetic disorders.
Current Positions
- Professor of Neuroscience and Pharmacology
- Professor of Pediatrics
- Roy J. Carver Professor of Neuroscience and Pharmacology
- Associate Director of Research in the Iowa Neuroscience Institute
Education
- BA w/ Honors in Psychology, University of Miami
- PhD in Biology, University of Miami
- Postdoctoral Fellow, UM Miller School of Medicine
- Postdoctoral Fellow, Baylor College of Medicine
Graduate Program Affiliations
Center, Program and Institute Affiliations
Selected Publications
- Stahl A, Noyes NC, Boto T, Botero V, Broyles CN, Jing M, Zeng J, King LB, Li Y, Davis RL, Tomchik SM.: Associative learning drives longitudinally graded presynaptic plasticity of neurotransmitter release along axonal compartments. Elife . 2022 Mar 14;11:e76712. doi: 10.7554/eLife.76712.
- Botero V, Stanhope BA, Brown EB, Grenci EC, Boto T, Park SJ, King LB, Murphy KR, Colodner KJ, Walker JA, Keene AC, Ja WW, Tomchik SM.: Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila. Nat Commun . 2021 Jul 13;12(1):4285. doi: 10.1038/s41467-021-24505-x.
- Kaldun JC, Lone SR, Humbert Camps AM, Fritsch C, Widmer YF, Stein JV, Tomchik SM, Sprecher SG.: Dopamine, sleep, and neuronal excitability modulate amyloid-β-mediated forgetting in Drosophila. PLoS Biol . 2021 Oct 6;19(10):e3001412. doi: 10.1371/journal.pbio.3001412. eCollection 2021 Oct.
- Murphy KR, Deshpande SA, Yurgel ME, Quinn JP, Weissbach JL, Keene AC, Dawson-Scully K, Huber R, Tomchik SM, Ja WW.: Postprandial sleep mechanics in Drosophila. Elife . 2016 Nov 22;5:e19334. doi: 10.7554/eLife.19334.
- Boto T, Stahl A, Tomchik SM.: Cellular and circuit mechanisms of olfactory associative learning in Drosophila. J Neurogenet . 2020 Mar;34(1):36-46. doi: 10.1080/01677063.2020.1715971. Epub 2020 Feb 11. Review
- King LB, Boto T, Botero V, Aviles AM, Jomsky BM, Joseph C, Walker JA, Tomchik SM.: Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila. PLoS Genet . 2020 Jul 22;16(7):e1008920. doi: 10.1371/journal.pgen.1008920. eCollection 2020 Jul.
- Boto T, Tomchik SM.: The Excitatory, the Inhibitory, and the Modulatory: Mapping Chemical Neurotransmission in the Brain. Neuron . 2019 Mar 6;101(5):763-765. doi: 10.1016/j.neuron.2019.02.021. Comment
- Boto T, Stahl A, Zhang X, Louis T, Tomchik SM.: Independent Contributions of Discrete Dopaminergic Circuits to Cellular Plasticity, Memory Strength, and Valence in Drosophila. Cell Rep . 2019 May 14;27(7):2014-2021.e2. doi: 10.1016/j.celrep.2019.04.069.
- Yu D, Tan Y, Chakraborty M, Tomchik S, Davis RL.: Elongator complex is required for long-term olfactory memory formation in Drosophila. Learn Mem . 2018 Mar 15;25(4):183-196. doi: 10.1101/lm.046557.117. Print 2018 Apr.
- Louis T, Stahl A, Boto T, Tomchik SM.: Cyclic AMP-dependent plasticity underlies rapid changes in odor coding associated with reward learning. Proc Natl Acad Sci U S A . 2018 Jan 16;115(3):E448-E457. doi: 10.1073/pnas.1709037115. Epub 2017 Dec 28.