Jeremy D. Greenlee, MD

Portrait
Arnold H. Menezes Chair in Neurosurgery
Professor of Neurosurgery

Contact Information

Office
1827 JPP
200 Hawkins Dr
Iowa City, IA 52242
319-356-2771

Education

BS, University of Michigan
MD, Indiana University School of Medicine
Internship, Neurosurgery, University of Iowa Carver College of Medicine
Fellow, Neurosurgery, University of Iowa Carver College of Medicine
Resident, Neurosurgery, University of Iowa Carver College of Medicine
Fellow, Minimally Invasive Neurosurgery

Licensure and Certifications

Board Certified, Neurosurgery - American Board of Neurological Surgery
Iowa Medical License - Iowa Board of Medicine

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

Neurophysiology of human frontal lobe, endoscopic and minimally invasive neurosurgery, pituitary tumors, colloid cysts, and deep brain stimulation for movement disorders. I study human language, audiovisual, and vocalization physiology using electrophysiological recordings from human subjects undergoing surgical treatment of intractable epilepsy.

Publications

Fam, M. D., Potash, A., Potash, M., Robinson, R., Karnell, L., O'Brien, E. & Greenlee, J. D. (2018). Skull Base Dural Thickness and Relationship to Demographic Features: A Postmortem Study and Literature Review. J Neurol Surg B Skull Base, 79(6), 614-20. PMID: 30456033.

Manes, J. L., Tjaden, K., Parrish, T., Simuni, T., Roberts, A., Greenlee, J. D., Corcos, D. M. & Kurani, A. S. (2018). Altered resting-state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease. Brain Behav, 8(9), e01073. PMID: 30047249.

Zanaty, M., Nakagawa, D., Starke, R. M., Leira, E. C., Samaniego, E. A., Guerrero, W. R., Torner, J., Nagahama, Y., Awe, O., Greenlee, J., Hudson, J. S., Allan, L., Elwy, R., Chalouhi, N., Jabbour, P., Woodroffe, R., Piscopo, A. & Hasan, D. (2018). Intraventricular extension of an aneurysmal subarachnoid hemorrhage is an independent predictor of a worse functional outcome. Clin Neurol Neurosurg, 170, 67-72. PMID: 29730271.

Menezes, A. H., Greenlee, J. D. & Dlouhy, B. J. (2018). Syringobulbia in pediatric patients with Chiari malformation type I. J Neurosurg Pediatr, 22(1), 52-60. PMID: 29701558.

Nakagawa, D., Kudo, K., Awe, O., Zanaty, M., Nagahama, Y., Cushing, C., Magnotta, V., Hayakawa, M., Allan, L., Greenlee, J., Awad, I. A., Carroll, T., Torner, J., Raghavan, M. L. & Hasan, D. M. (2018). Detection of microbleeds associated with sentinel headache using MRI quantitative susceptibility mapping: pilot study. J Neurosurg, 25, 1-7. PMID: 29799347.

Nagahama, Y., VanBeek, M. J. & Greenlee, J. D. (2018). Red man syndrome caused by vancomycin powder. J Clin Neurosci, 50, 149-50. PMID: 29398192.

Holland, M. T., Zanaty, M., Li, L., Thomsen, T., Beeghly, J. H., Greenlee, J. D. & Reddy, C. G. (2018). Successful deep brain stimulation for central post-stroke pain and dystonia in a single operation. J Clin Neurosci, 50, 190-3. PMID: 29396066.

Kelley, R., Flouty, O., Emmons, E. B., Kim, Y., Kingyon, J., Wessel, J. R., Oya, H., Greenlee, J. D. & Narayanan, N. S. (2018). A human prefrontal-subthalamic circuit for cognitive control. Brain, 141(1), 205-16. PMID: 29190362.

Flouty, O., Reddy, C., Holland, M., Kovach, C., Kawasaki, H., Oya, H., Greenlee, J., Hitchon, P. & Howard, M. (2017). Precision surgery of rolandic glioma and insights from extended functional mapping. Clin Neurol Neurosurg, 163, 60-6. PMID: 29073500.

Hudson, J. S., Nagahama, Y., Nakagawa, D., Starke, R. M., Dlouhy, B. J., Torner, J. C., Jabbour, P., Allan, L., Derdeyn, C. P., Greenlee, J. D. & Hasan, D. (2017). Hemorrhage associated with ventriculoperitoneal shunt placement in aneurysmal subarachnoid hemorrhage patients on a regimen of dual antiplatelet therapy: a retrospective analysis. J Neurosurg, 129(4), 916-21. PMID: 29125410.

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Schultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G. (2017). O2·- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. (Vols. 32). (2), pp. 268. Cancer Cell. PMID: 28810149.

Abode-Iyamah, K. O., Chiang, H. Y., Winslow, N., Park, B., Zanaty, M., Dlouhy, B. J., Flouty, O. E., Rasmussen, Z. D., Herwaldt, L. A. & Greenlee, J. D. (2017). Risk factors for surgical site infections and assessment of vancomycin powder as a preventive measure in patients undergoing first-time cranioplasty. J Neurosurg, 12, 1-9. PMID: 28498056.

Schoenfeld, J. D., Sibernaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Boedeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Shanahan Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Shultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G. (2017). O2·- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell, 31(4), 487-500.e8. PMID: 28366679.

Katlowitz, K. A., Oya, H., Howard 3rd, M. A., Greenlee, J. D. & Long, M. A. (2017). Paradoxical vocal changes in a trained singer by focally cooling the right superior temporal gyrus. Cortex, 89, 111-9. PMID: 28282570.

Haleem, A., Chiang, H. Y., Vodela, R., Behan, A., Pottinger, J. M., Smucker, J., Greenlee, J. D., Clark, C. & Herwaldt, L. A. (2016). Risk factors for surgical site infections following adult spine operations. Infect Control Hosp Epidemiol, 37(12), 1458-67. PMID: 27573067.

Simonyan, K., Ackermann, H., Chang, E. F. & Greenlee, J. D. (2016). New Developments in Understanding the Complexity of Human Speech Production. J Neurosci, 36(45), 11440-8. PMID: 27911747.

Kinyon, J., Behroozmand, R., Kelley, R., Oya, H., Kawasaki, H., Narayanan, N. S. & Greenlee, J. D. (2016). Corrigendum to "High-gamma band fronto-temporal coherence as a measure of functional connectivity in speech motor control" [Neuroscience 305 (2015) 15-25]. (Vols. 335). pp. 242. Neuroscience. PMID: 27448528.

Rasmussen, Z., Abode-Iyamah, K. O., Kirby, P. & Greenlee, J. D. (2016). Rathke's cleft cyst: A case report of recurrence and spontaneous involution. J Clin Neurosci, 32, 122-5. PMID: 27369087.

Long, M. A., Katlowitz, K. A., Svirsky, M. A., Clary, R. C., Byun, T. M., Majaj, N., Oya, H., Howard 3rd, M. A. & Greenlee, J. D. (2016). Functional Segregation of Cortical Regions Underlying Speech Timing and Articulation. Neuron, 89(6), 1187-93. PMID: 26924439.

Abode-Iyamah, K. O., Khanna, R., Rasmussen, Z. D., Flouty, O., Dahdaleh, N. S., Greenlee, J. & Howard 3rd, M. A. (2016). Risk factors associated with distal catheter migration following ventriculoperitoneal shunt placement. J Clin Neurosci, 25, 46-9. PMID: 26549674.

Behroozmand, R., Oya, H., Nourski, K. V., Kawasaki, H., Larson, C. R., Brugge, J. F., Howard 3rd, M. A. & Greenlee, J. D. (2016). Neural Correlates of Vocal Production and Motor Control in Human Heschl's Gyrus. J Neurosci, 36(7), 2302-15. PMID: 26888939.

Kingyon, J., Behroozmand, R., Kelley, R., Oya, H., Kawasaki, H., Narayanan, N. S. & Greenlee, J. D. (2015). High-gamma band fronto-temporal coherence as a measure of functional connectivity in speech motor control. Neuroscience, 305, 15-25. PMID: 26232713.

Potter, N. J., Graham, S. M., Chang, E. H. & Greenlee, J. D. (2015). Bioabsorbable plate cranial base reconstruction. Laryngoscope, 125(6), 1313-5. PMID: 25363091.

Menezes, A. H., Greenlee, J. D., Longmuir, R. A., Hansen, D. R. & Abode-Iyamah, K. (2015). Syringohydromyelia in association with syringobulbia and syringocephaly: case report. J Neurosurg Pediatr, 15(6), 657-61. PMID: 26030334.

Behroozmand, R., Shebek, R., Hansen, D. R., Oya, H., Robin, D. A., Howard 3rd, M. A. & Greenlee, J. D. (2015). Sensory-motor networks involved in speech production and motor control: An fMRI study. Neuroimage, 109, 418-28. PMID: 25623499.

Woodroffe, R. W., ASbel, T. J., Fletcher, A., Grossbach, A., Van Daele, D. J., O'Brien, E. & Greenlee, J. D. (2014). Endoscopic transnasal resection of ameloblastoma with intracranial extension. J Clin Neurosci, 21(5), 855-9. PMID: 24210807.

Grossbach, A. J., Abel, T. J., Hodis, B., Wassef, S. N. & Greenlee, J. D. (2014). Hypertensive posterior reversible encephalopathy syndrome causing posterior fossa edema and hydrocephalus. J Clin Neurosci, 21(2), 207-11. PMID: 24126039.

Chiang, H. Y., Kamath, A. S., Pottinger, J. M., Greenlee, J. D., Howard, M. A., Cavanaugh, J. E. & Herwaldt, L. A. (2014). Risk factors and outcomes associated with surgical site infections after craniotomy or craniectomy. J Neurosurg, 120(2), 509-21. PMID: 24205908.

Manes, J. L., Parkinson, A. L., Larson, C. R., Greenlee, J. D., Eickhoff, S. B., Corcos, D. M. & Robin, D. A. (2014). Connectivity of the subthalamic nucleus and globus pallidus pars interna to regions within the speech network: a meta-analytic connectivity study. Hum Brain Mapp, 35(7), 3499-516. PMID: 25050431.

Abel, T. J., Dalm, B. D., Grossbach, A. J., Jackson, A. W., Thomsen, T. & Greenlee, J. D. (2014). Lateralized effect of pallidal stimulation on self-mutilation in Lesch-Nyhan disease. J Neurosurg Pediatr, 14(6), 594-7. PMID: 25303157.

He, W., Chen, F., Dalm, B. D., Kirby, P. A. & Greenlee, J. D. (2014). Metastatic involvement of the pituitary gland: a systematic review with pooled individual patient data analysis. Pituitary, 18(1), 159-68. PMID: 24445565.

Greenlee, J. D., Behroozmand, R., Nourski, K. V., Oya, H., Kawasaki, H. & Howard, M. A. (2014). Using speech and electrocorticography to map human auditory cortex. Conf Proc IEEE Eng Med Biol Soc, 2014, 6798-801. PMID: 25571557.

Elahi, F., Callahan, D., Greenlee, J. D. & Dann, T. L. (2013). Pudendal entrapment neuropathy: a rare complication of pelvic radiation therapy. Pain Physician, 16(6), E793-7. PMID: 24284861.

Traynelis, V. C., Greenlee, J. D. (2013). Response. (Vols. 19). (4), pp. 524-5. J Neurosurg Spine. PMID: 24218668.

Wassef, S. N., Abel, T. J., Grossbach, A., Viljoen, S. V., Jackson, A. W., Howard, M. A. & Greenlee, J. D. (2013). Traumatic intracranial hemorrhage in patients taking dabigatran: report of 3 cases and review of the literature. Neurosurgery, 73(2), E368-74. PMID: 23670031.

Dahdaleh, N. S., Dlouhy, B. J., Greenlee, J. D., Smoker, W. R. & Hitchon, P. W. (2013). An algorithm for the management of posttraumatic cervical spondyloptosis. J Clin Neurosci, 20(7), 951-7. PMID: 23702373.

Behroozmand, R., Greenlee, J. D., Larson, C. R., Hansen, D., Oya, H., Kawasaki, H., Howard III, M. A. & Brugge, J. F. (2013). Distinct roles of anterolateral and posteromedial heschl's gyrus in coding human voice fundamental frequency. Society for Neuroscience.

Greenlee, J. D., Behroozmand, R., Larson, C. R., Jackson, A. W., Chen, F., Hansen, D. R., Oya, H., Kawasaki, H. & Howard, M. A. (2013). Sensory-motor interactions for vocal pitch monitoring in non-primary human auditory cortex. PLoS One, 8(4), e60783. PMID: 23577157.

Osbun, J. W., Ellenbogen, R. G., Chestnut, R. M., Chin, L. S., Connolly, P. J., Cosgrove, G. R., Delashaw Jr, J. B., Golfinos, J. G., Greenlee, J. D., Haines, S. J., Jallo, J., Muizelaar, J. P., Nanda, A., Shaffrey, M., Shah, M. V., Tew Jr, J. M., Van Loveren, H. R., Weinand, M. E., White, J. A. & Wilberger, J. E. (2012). A Multicenter, Single-Blind, Prospective Randomized Trial to Evaluate the Safety of a Polyethylene Glycol Hydrogel (Duraseal Dural Sealant System) as a Dural Sealant in Cranial Surgery. World Neurosurg, 78(5), 498-504. PMID: 22381303.

Dlouhy, B. J., Reddy, A., Dahdaleh, N. S. & Greenlee, J. D. (2012). Antibiotic impregnated catheter coverage of deep brain stimulation leads facilitates lead preservation after hardware infection. J Clin Neurosci, 19(10), 1369-75. PMID: 22854128.

Garell, P. C., Bakken, H., Greenlee, J. D., Volkov, I., Reale, R. A., Oya, H., Kawasaki, H., Howard, M. A. & Brugge, J. E. (2012). Functional connection between posterior superior temporal gyrus and ventrolateral prefrontal cortex in human. Cereb Cortex, 23(10), 2309-21. PMID: 22879355.

Kopelovich, J. C., De La Garza, G. O., Greenlee, J. D., Graham, S. M., Udeh, C. I. & O'Brien, E. K. (2012). Pneumocephalus with BiPAP use after transsphenoidal surgery. J Clin Anesth, 24(5), 415-8. PMID: 22626688.

Ahmed, R., Greenlee, J. D. & Traynelis, V. C. (2012). Preservation of spinal instrumentation after development of postoperative bacterial infections in patients undergoing spinal arthrodesis. J Spinal Disord Tech, 25(6), 299-302. PMID: 21617567.

Fletcher, A. M., Greenlee, J. D., Chang, K. E., Smoker, W. R., Kirby, P. A. & O'Brien, E. K. (2012). Endoscopic resection of calcifying pseudoneoplasm of the neuraxis (CAPNON) of the anterior skull base with sinonasal extension. J Clin Neurosci, 19(7), 1048-9. PMID: 22555125.

Dlouhy, B. J., Madhavan, K., Clinger, J. D., Reddy, A., Dawson, J. D., O'Brien, E. K., Chang, E., Graham, S. M. & Greenlee, J. D. (2012). Elevated body mass index and risk of postoperative CSF leak following transsphenoidal surgery. J Neurosurg, 116(6), 1311-7. PMID: 22443502.

Dlouhy, B. J., Greenlee, J. D. (2012). Progressive confusion, memory loss, and gait ataxia in an adult. JAMA, 307(20), 2195--6. PMID: 22618927.

Dahdaleh, N. S., Dlouhy, B. J., Kirby, P. A. & Greenlee, J. D. (2012). Unusual "double density" colloid cysts. J Clin Neurosci, 19(4), 612-4. PMID: 22249014.

Traynelis, V. C., Abode-Iyamah, K. O., Leick, K. M., Bender, S. M. & Greenlee, J. D. (2012). Cervical decompression and reconstruction without intraoperative neurophysiological monitoring. J Neurosurg Spine, 16(2), 107-13. PMID: 22077472.

Dlouhy, B. J., Capuano, A. W., Madhavan, K., Torner, J. C. & Greenlee, J. D. (2012). Preoperative third ventricular bowing as a predictor of endoscopic third ventriculostomy success. J Neurosurg Pediatr, 9(2), 182-90. PMID: 22295925.

Sutherland, J. E., Dahdaleh, N. S., Greenlee, J. D., Kirby, P. A. & Sargent, M. D. (2011). Large osteolytic skull tumor presenting as a small subcutaneous scalp lesion. J Am Board Fam Med, 24(6), 763-7. PMID: 22086822.

Chiang, H. Y., Steelman, V. M., Pottinger, J. M., Schlueter, A. J., Diekema, D. J., Greenlee, J. D., Howard, M. A. & Herweldt, L. A. (2011). Clinical significance of positive cranial bone flap cultures and associated risk of surgical site infection after craniotomies or craniectomies. J Neurosurg, 114(6), 1746-54. PMID: 21375380.

Dlouhy, B. J., Dahdaleh, N. S. & Greenlee, J. D. (2011). Emerging technology in intracranial neuroendoscopy: application of the NICO Myriad. Neurosurg Focus, 30(4), E6. PMID: 21456933.

Greenlee, J. D., Jackson, A. W., Chen, F., Larson, C. L., Oya, H., Kawasaki, H., Chen, H. & Howard III, M. A. (2011). Human auditory cortical activation during self-vocalization. PLoS One, 6(3), e14744. PMID: 21390228.

Pettit, J. E., Dahdaleh, N. S., Albert, G. W. & Greenlee, J. D. (2011). Neurosurgery resident leadership development: an innovative approach. Neurosurgery, 68(2), 546-50. PMID: 21135732.

Lindley, T., Greenlee, J. D. & Teo, C. (2010). Minimally invasive surgery (endonasal) for anterior fossa and sellar tumors. Neurosurg Clin N Am, 21(4), 607-20. PMID: 20947030.

Albert, G. W., Menezes, A. H., Hansen, D. R., Greenlee, J. D. & Weinstein, S. L. (2010). Chiari malformation type I in children younger than age 6 years: presentation and surgical outcome. J Neurosurg Pediatr, 5(6), 554-61. PMID: 20515326.

Bellinger, A., Siriwetchadarak, R., Rosenquist, R. & Greenlee, J. D. (2009). Prevention of intrathecal baclofen withdrawal syndrome: Successful use of a temporary intrathecal catheter. Reg Anes Pain Med, 34(6), 600-2. PMID: 19920430.

Graham, S. M., Iseli, T. A., Karnell, L. H., Clinger, J. D., Hitchon, P. W. & Greenlee, J. D. (2009). Endoscopic approach for pituitary surgery improves rhinologic outcomes. Ann Otol Rhinol Laryngol, 118(9), 630-635. PMID: 19810602.

Greenlee, J. D., Teo, C., Ghahreman, A. & Kwok, B. (2008). Purely endoscopic resection of colloid cysts. Neurosurgery, 62(3 suppl 1), 51-5 discussion 55-6. PMID: 18424967.

Greenlee, J. D., Oya, H., Kawasaki, H., Volkov, I. O., Severson, M. A., Howard, M. A. & Brugge, J. F. (2007). Functional connections within the human inferior frontal gyrus. J Comp Neurol, 503(4), 550-9. PMID: 17534935.

Greenlee, J. D., Fenoy, A. J., Donovan, K. A. & Menezes, A. H. (2007). Eosinophilic granuloma in the pediatric spine. Pediatr Neurosurg, 43(4), 285-92. PMID: 17627144.

Fenoy, A. J., Greenlee, J. D., Menezes, A. H., Donovan, K. A., Sato, Y., Hitchon, P. W. & Chaloupka, J. C. (2006). Primary bone tumors of the spine in children. J Neurosurg, 105(4 suppl), 252-60. PMID: 17328273.

Greenlee, J. D., Menezes, A. H., Bertoglio, B. & Donovan, K. A. (2005). Syringobulbia in a pediatric population. Neurosurgery, 57(6), 1147-53. PMID: 16331163.

Teo, C., Greenlee, J. D. (2005). Application of endoscopy to third ventricular tumors. Clin Neurosurg, 52, 24-8. PMID: 16626051.

Menezes, A. H., Greenlee, J. D. & Donovan, K. A. (2005). Honored guest presentation: lifetime experiences and where we are going: Chiari I with syringohydromyelia--controversies and development of decision trees. Clin Neurosurg, 52, 297-305. PMID: 16626086.

Segal, E., Greenlee, J. D., Hata, H. S. & Perel, A. (2004). Monitoring intravascular volumes to direct hypertensive, hypervolemic therapy in a patient with vasospasm. J Neurosurg Anesthesiol, 16(4), 296-8. PMID: 15557835.

Greenlee, J. D., Oya, h., Kawasaki, H., Volkov, I. O., Kaufman, O. P., Kovach, C., Howard, M. A. & Brugge, J. F. (2004). A functional connection between inferior frontal gyrus and orofacial motor cortex in humans. J Neurophysiol, 92(2), 1153-1164. PMID: 15056683.

Bakken, H., Kawasaki, H., Oya, H., Greenlee, J. D. & Howard, M. A. (2003). A device for cooling localized regions of human cerebral cortex. Technical note. J Neurosurg, 99(3), 604-8. PMID: 12959453.

Greenlee, J. D., Donovan, K. A., Hasan, D. M. & Menezes, A. H. (2002). Chiari I malformation in the very young child: the spectrum of presentations and experience in 31 patients under age 6. Pediatrics, 110(6), 1212-9. PMID: 12456921.

Greenlee, J. D., Ghodsi, A., Baumbach, G. L. & VanGilder, J. C. (2002). Synovial chondromatosis of the cervical spine. Case Illustration. J Neurosurg, 97(1 Suppl), 150. PMID: 12120642.

Afifi, A. K., Greenlee, J. D. & Follett, K. A. (2001). Optic Neuritis: A novel presentation of Schilder’s disease. J Child Neurol, 16(9), 693-6. PMID: 11575614.

Greenlee, J. D., Garell, P. C., Stence, N. & Menezes, A. H. (1999). Comprehensive approach to Chiari malformation in pediatric patients. Neurosurg Focus, 6(6), e4. PMID: 16972750.