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Donna A. Santillan, PhD

Portrait
Research Associate Professor of Obstetrics and Gynecology - Reproductive Science Research
Research Associate Professor
Director of the Early Scholars Certificate in Clinical and Translational Science (CCTS)
Vice Chair for Research

Contact Information

Primary Office
464 Medical Research Facility (MRF)
Iowa City, IA 52242
319-384-8667

Education

BA, History, Loyola University, Chicago, Illinois
BS, Chemistry, Biochemistry Emphasis, Loyola University, Chicago, Illinois
PhD, Biomedical Sciences-Molecular Biology, Loyola University, Maywood, Illinois

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases, UIHC Center for Hypertension Research

Research Summary

My work is focused on improving the health of women during and after pregnancy. To assist in accomplishing this objective, I direct the Women's Health Tissue Repository, a high-quality longitudinal collection of biological samples and clinical information from all stages of women's lives. My own research focuses on the effects of vaping during pregnancy. In addition, we study the long-term effects of hypertension in pregnancy to the mother and child.

Publications

Liu, B., Du, Y., Wu, Y., Sun, Y., Santillan, M. K., Santillan, D. A. & Bao, W. (2021). Prevalence and Distribution of Electronic Cigarette Use Before and During Pregnancy among Women in 38 States of the United States. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. PMID: 33693836.

Laageide, L., Radke, S., Santillan, D., Ten Eyck, P. & Powers, J. (2021). Postpartum Nipple Symptoms: Risk Factors and Dermatologic Characterization. Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 16(3), 215-221. PMID: 33337281.

Gumusoglu, S. B., Chilukuri ASS,, Hing BWQ,, Scroggins, S. M., Kundu, S., Sandgren, J. A., Santillan, M. K., Santillan, D. A., Grobe, J. L. & Stevens, H. E. (2021). Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model. Translational psychiatry, 11(1), 79. PMID: 33510137.

Wu, Y., Liu, B., Sun, Y., Du, Y., Santillan, M. K., Santillan, D. A., Snetselaar, L. G. & Bao, W. (2020). Association of Maternal Prepregnancy Diabetes and Gestational Diabetes Mellitus With Congenital Anomalies of the Newborn. Diabetes Care, 43(12), 2983-2990.

Nuckols, V. R., Holwerda, S. W., Luehrs, R. E., DuBose, L. E., Stroud, A. K., Brandt, D., Betz, A. M., Fiedorowicz, J. G., Scroggins, S. M., Santillan, D. A., Grobe, J. L., Sigmund, C. D., Santillan, M. K. & Pierce, G. L. (2020). Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness. Hypertension (Dallas, Tex. : 1979), 76(6), 18001-1807. PMID: 32951467.

Gumusoglu, S. B., Chilukuri ASS,, Santillan, D. A., Santillan, M. K. & Stevens, H. E. (2020). Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure. Trends in neurosciences, 43(4), 253-268. PMID: 32209456.

Martin, B. P., Stroud, A., Dubose, L., Brandt, D. S., Santillan, D., Nuckols, V., Grobe, J., Santillan, M. K. & Pierce, G. (2020). Microvascular Endothelial Glycocalyx Function in Human Pregnancy and Postpartum in Women with a History of Preeclampsia. The FASEB Journal, 34(S1), 1-1.

Burand, A. J., Di, L., Boland, L. K., Boyt, D. T., Schrodt, M. V., Santillan, D. A. & Ankrum, J. A. (2020). Aggregation of Human Mesenchymal Stromal Cells Eliminates Their Ability to Suppress Human T Cells. Front. Immunol,(11), 143. PMID: 32158443.

Perschbacher, K. J., Deng, G., Sandgren, J. A., Walsh, J. W., Witcher, P. C., Sapouckey, S. A., Owens, C. E., Zhang, S. Y., Scroggins, S. M., Pearson, N. A., Devor, E. J., Sebag, J. A., Pierce, G. L., Fisher, R. A., Kwitek, A. E., Santillan, D. A., Gibson-Corley, K. N., Sigmund, C. D., Santillan, M. K. & Grobe, J. L. (2020). Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. Hypertension, 75(2), 569-579. PMID: 31865781.

Vignato, J., Scroggins, S., Brandt, D., Thomas, K., Santillan, D. & Santillan, M. (2020). Selective serotonin reuptake inhibitors and vasopressin: an intersection of depression and preeclampsia. American Journal of Obstetrics & Gynecology, 222(1), S99.

Harville, E. W., Mishra, G. D., Yeung, E., Mumford, S. L., Schisterman, E. F., Jukic, A. M., Hatch, E. E., Mikkelsen, E. M., Jiang, H., Ehrenthal, D. B., Porucznik, C. A., Stanford, J. B., Wen, S. W., Harvey, A., Symons Downs, D., Yajnik, C., Santillan, D., Santillan, M., McElrath, T. F., Woo, J. G., Urbina, E. M., Chavarro, J. E., Sotres-Alvarez, D., Bazzano, L., Zhang, J., Steiner, A., Gunderson, E. P. & Wise, L. A. (2019). The Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium. Paediatric and perinatal epidemiology, 33(6), 490-502. PMID: 31659792.

Laageide, L., Radke, S., Santillan, D. & Powers, J. (2019). Understanding the cause and treatment of nipple pain secondary to breastfeeding. (Vols. 14). (2), pp. S28-29. Breastfeeding Medicine.

Steinbrekera, B., Colaizy, T. T., Vasilakos, L. K., Johnson, K. J., Santillan, D. A., Roghair, R. D. (2019). Origins of Neonatal Leptin Deficiency in Preterm Infants. Pediatric Research, 85(7), 1016-1023. PMID: 30845123.

Liu, B., Xu, G., Rong, S., Santillan, D. A., Santillan, M. K., Snetselaar, L. G. & Bao, W. (2019). National Estimates of e-Cigarette Use Among Pregnant and Nonpregnant Women of Reproductive Age in the United States, 2014-2017. JAMA Pediatrics, 176(6), 600-602. PMID: 31034001.

Boland, L. K., Burand, A. J., Boyt, D. T., Dobroski, H., Di, L., Liszewski, J. N., Schrodt, M. V., Frazer, M. K., Santillan, D. A. & Ankrum, J. A. (2019). Nature vs. Nurture: Defining the Effects of Mesenchymal Stromal Cell Isolation and Culture Conditions on Resiliency to Palmitate Challenge. Frontiers in immunology, 10, 1080. PMID: 31134100.

Devor, E., Santillan, D., Scroggins, S., Warrier, A. & Santillan, M. (2019). Trimester-specific plasma exosome microRNA expression profiles in preeclampsia. J Maternal Fetal Neonatal Med, 33(18), 3116-3124. PMID: 30700172.

Gadogbe, M., Bao, W., Wels, B. R., Dai, S. Y., Santillan, D. A., Santillan, M. K. & Lehmler, H. J. (2019). Levels of tin and organotin compounds in human urine samples from Iowa, United States. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 54(9), 884-890. PMID: 31057082.

Santillan, D., Wiltgen, M., Elson, M. & Santillan, M. K. (2018). Developing a program for residents to support training in research. POG In Press, Article 1 [ 4 p. ].

Sandren, J. A., Deng, G., Linggonergoro, D. W., Scroggins, S. M., Perschbacher, K. J., Nair, A. R., Nishimura, T. E., Zhang, S. Y., Agbor, L. N., Wu, J., Keen, H. L., Naber, M. C., Pearson, N. A., Zimmerman, K. A., Weiss, R. M., Bowdler, M. C., Usachev, Y. M., Santillan, D. A., Potthoff, M. J., Pierce, G. L., Gibson-Corley, K. N., Sigmund, C. D., Santillan, M. K. & Grobe, J. L. (2018). Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. JCI Insight 2018, 3(19), e99403.

Scroggins, S. M., Santillan, D. A., Lund, J. M., Sandgren, J. A., Krotz, L. K., Hamilton, W. S., Devor, E. J., Davis, H. A., Pierce, G. L., Gibson-Corley, K. N., Sigmund, C. D., Grobe, J. L. & Santillan, M. K. (2018). Elevated Vasopressin in Pregnant Mice Induces T Helper Subset Alterations Consistent with Human Preeclampsia. Clin Sci (Lond), 132(3), 419-436. PMID: 29371289.

Chabal, G., Bowdler, N. & Santillan, D. (2018). Recovery from cesarean delivery at UIHC: a comparison to Enhanced Recovery Protocols. Proceedings in Obstetrics and Gynecology, 8(3).

Scroggins, S. M., Santillan, D. A., Peterson, J. M., Huber-Kenner, K. J., Sandgren, J. A., Perschbacher, K. J., Pearson, N. A., Devor, E. J., Gomendoza, D. T., Pierce, G. L., Grobe, J. L. & Santillan, M. K. (2017). Vasopressin Antagonists Regulate Immune Responses in Preeclampsia. (Vols. 31). (1 Supplement), pp. 875.4-875.4. Federation of American Societies for Experimental Biology.

Nishimura, T., Polgreen, P. M., Polgreen, L. A., Brandt, D. S., Thomas, K. M., Scroggins, S. M., Evans, N. J., Alexander, L., Santillan, M. K. & Santillan, D. A. (2017). Determining the role of Maternal Leptin and Activity in Pregnancy Outcomes. The FASEB Journal, 31(1), 692.2.

Santillan, D. A., Davis, H., Jacobus, L., Hamilton, W., Schappet, J., Scroggins, S. M., Devor, E. j., Brandt, D., Thomas, K. M., Leslie, K. K. & Santillan, M. K. (2017). Building Bridges for Collaboration: the University of Iowa Women’s Health Tissue Repository. The FASEB Journal, 31(1), LB513.

Perschbacher, K. J., Sandgren, J. A., Saenz, L. C., Witcher, P. C., Pearson, N. A., Santillan, D. A., Devor, E. J., Pierce, G. L., Santillan, M. K., Fisher, R. A., Gibson-Corley, K. N. & Grobe, J. L. (2017). Reduced Expression of Regulator of G-Protein Signaling-2 (RGS2) in the Placenta During Preeclampsia. The FASEB Journal, 31(1), 692.3.

Deng, G., Perschbacher, K. J., Saenz, J. C., Warwick, C. A., Scroggins, S. M., Devor, E. J., Santillan, D. A., Usachev, Y. M., Gibson-Corley, K. N., Santillan, M. K. & Grobe, j. L. (2017). Arginine vasopressin acts directly upon human placental trophoblasts to elicit calcium responses. The FASEB Journal, 31(1), LB855.

Scroggins, S. M., Santillan, D. A., Peterson, J., Huber-Keener, K. J., Sandgren, J. A., Perschbacher, K. J., Pearson, N., Devor, E. J., Gomendoza, D., Pierce, G. L. & Santillan, M. K. (2017). Vasopressin Angtogonists Regulate Immune Responses in Preeclampsia. The FASEB Journal, 31(1), 875.4.

Sandgren, J. A., Linggonegoro, D. W., Pearson, N. A., Perschbacher, K. J., Santillan, D. A., Scroggins, S. M., Gibson-Corley, K. N., Pierce, G. L., Santillan, M. K. & Grobe, J. L. (2017). Vasopressin Induces Discrete Symptoms of Preeclampsia through Receptor- and Gestational Age-Specific Mechanisms. The FASEB Journal, 31(1), 1027.6.

Stilley, J. A., Guan, R., Santillan, D. A., Mitchell, B. F., Lamping, K. G. & Segaloff, D. L. (2016). Differential Regulation of Human and Mouse Myometrial Contractile Activity by FSH as a Function of FSH Receptor Density. Biol Reprod, 95(2). PMID: 27335068.

Kempuraj, D., Thangavel, R., Fattel, R., Pattani, S., Yang, E., Zaheer, S., Santillan, D. A., Santillan, M. K. & Zaheer, A. (2016). Mast Cells Release Chemokine CCL2 in Response to Parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP+). Neurochem Res, 41(5), 1042-9. PMID: 26646004.

Devor, E. J., Schickling, B. M., Reyes, H. D., Warrier, A., Lindsay, B., Goodheart, M. J., Santillan, D. A. & Leslie, K. K. (2016). Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182. Oncology Reports, 35(4), 2461-5. PMID: 26847831.

Sandgren, J. A., Scroggins, S. M., Santillan, D. A., Devor, E. J., Gibson-Corley, K. N., Pierce, G. L., Sigmund, C. D., Santillan, M. K. & Grobe, J. L. (2015). Vasopressin: The missing Link for Preeclampsia?. Am J Physiol Regul Integr Comp Physiol, 309(9), R1062-4. PMID: 25810383.

Sandgren, J. A., Scroggins, S. M., Santillan, D. A., Devor, E. J., Gibson-Corley, K. N., Pierce, G. L., Sigmund, C. D., Santillan, M. K. & Grobe, J. L. (2015). Vasopressin: The Missing Link for Preeclampsia?. A J Physiol Regul Integr Comp Physiol, 309(9), R1062-4. PMID: 25810383.

Santillan, D. A., Majors, B., Scroggins, S. M., Devor, E. J., Zamba, G., Pierce, G. L., Leslie, K. L., Sigmund, C. D., Grobe, J. L. & Santillan, M. K. (2015). Predicting Preeclampsia Using Copeptin in Women at Low Risk of Disease.

Sandgren, J. A., Pearson, N. M., Pierce, G. L., Sigmund, C. D., Santillan, D. A., Gibson-Corley, K. N., Santillan, M. K. & Grobe, J. L. (2015). Vasopressin Infusion During Pregnancy Programs Cardiovascular and Metabolic Dysfunction in Offspring.

Scroggins, S. M., Santillan, D. A., Pearson, N. A., Sandgren, J., Min, J., Devor, E. J., Pierce, G. L., Leslie, K., Grobe, J. L. & Santillan, M. K. (2015). Vasopressin Infusion in Mice During Pregnancy Results in Immune Alterations Consistent with Human Preeclampsia.

, Thangavel, R., Yang, E., Pattani, S., Zaheer, S., Santillan, D. A., Santillan, M. K. & Zaheer, A. (2015). Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins a-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators. PLoS One, 10(8), e0315776. PMID: 26275153.

Stegmann, B. J., Santillan, M., Leader, B., Smith, E. & Santillan, D. (2015). Changes in antimüllerian hormone levels in early pregnancy are associated with preterm birth. Fertil Steril, 104(2), 347-55.e3. PMID: 26074093.

Li, C., Raikwar, N. S., Santillan, M. K., Santillan, D. A. & Thomas, C. P. (2015). Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1. Placenta, 34(6), 446-53. PMID: 25638730.

Santillan, M., Santillan, D., Scroggins, S., Sandgren, J., Pearson, N., Gibson-Corley, K. & Grobe, J. (2015). [33-OR]: Chronic vasopressin infusion throughout pregnancy phenocopies the physiologic, vascular, obstetric and immunologic phenotypes of human preeclampsia in mice. (Vols. 5). (1), pp. 16. Pregnancy Hypertension. PMID: 25787384.

Santillan, M., Santillan, D., Scroggins, S., Min, J., Leslie, K., Hunter, S., Zamba, G., Gibson-Corley, K. & Grobe, J. (2015). [49-OR]: Vasopressin secretion in human pregnancy predicts the development of preeclampsia as early as the sixth week of gestation. (Vols. 5). (1), pp. 25-6. Pregnancy Hypertens. PMID: 25787398.

Santillan, M. K., Pelham, C. J., Ketsawatsomkron, P., Santillan, D. A., Davis, D. R., Devor, E. J., Gibson-Corley, K. N., Scroggins, S. M., Grobe, J. L., Yang, B., Hunter, S. K. & Sigmund, C. D. (2015). Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiol Rep, 3(1), pii: e1257. PMID: 25602015.

Cookingham, L. M., Hubb, A. J., de la Garza, J. L., Fleener, D. K., Santillan, M. K., Hunter, S. K., Smith, E. M., Stegman, B. J. & Santillan, D. A. (2014). Cancer treatment negatively impacts anti-mullerian hormone in pediatric and adolescent females.

Munch, E., Cookingham, L., Sparks, A., Santillan, D., Devor, E. & Van Voorhis, B. (2014). Differential microRNA expression in follicular fluid of lean and obese women.

Scroggins, S. M., Santillan, D. A., Pearson, N. A., Grobe, J. L. & Santillan, M. K. (2014). Immune Dysfunction in a Vasopressin-Induced Mouse Model of Preeclampsia.

Scroggins, S. M., Santillan, D. A., Pearson, N. A., Grobe, J. L. & Santillan, M. K. (2014). Immune Dysfunction in a Vasopressin-Induced Mouse Model of Preeclampsia.

Stilley, J. A., Christensen, D. E., Dahlem, K. B., Guan, R., Santillan, D. A., England, S. K., Al-Hendy, A., Kirby, P. A. & Segaloff, D. L. (2014). FSH Receptor (FSHR) Expression in Human Extra-Gonadal Reproductive Tissues and the Developing Placenta, and the Impact of Its Deletion on Pregnancy in Mice. Biol Reprod, 91(3), 74. DOI: 10.1095/?biolreprod.114.118562.

Santillan, M. K., Santillan, D. A., Scroggins, S. M., Min, J. Y., Sandgren, J. A., Pearson, N. A., Leslie, K. K., Hunter, S. K., Zamba, G. K., Gibson-Corley, K. N. & Grobe, J. L. (2014). Vasopressin in Preeclampsia: A Novel Very Early Human Pregnancy Biomarker and Clinically Relevant Mouse Model. Hypertension, 64(4), 852-9. PMID: 25001273.

Ahuja, M., Schappet, J., Lorentzan, R., Wang, Y., Hylock, R., Davis, H., Knosp, B., Santillan, M. & Santillan, D. (2014). Sample and Clinical Information Link (SCI-Link) – For Standardized Data Registry Management System.

Devor, E. J., Reyes, H. D., Santillan, D. A., Santillan, M. K., Onukwugha, C., Goodheart, M. J. & Leslie, K. K. (2014). Placenta-specific protein 1: a potential key to many oncofetal-placental OB/GYN research questions. Obstet Gynecol Int, 2014. DOI: 10.1155/2014/678984.

Santillan, M. K., Leslie, K. K., Hamilton, W. S., Boese, B. J., Ahuja, M., Hunter, S. K. & Santillan, D. A. (2014). Collection of a lifetime: A practical approach to developing a longitudinal collection of women's healthcare biological samples. European Journal of Obstetrics & Gynecology and Reproductive Biology, 179, 94-99.

Kyser, K. L., Lu, X., Santillan, D., Santillan, M., Caughey, A. B., Wilson, M. C. & Cram, P. (2014). Forceps Delivery Volumes in Teaching and Non-Teaching Hospitals: Are Volumes Sufficient for Acquisition and Maintenance of Competence. Acad Med, 89(1), 71-6. PMID: 24280847.

Santillan, D. A., Devor, E., Leslie, K. K., Hunter, S. & Santillan, M. K. (2013). A microRNA Expression Profile of Normal Placental Development. Poster presentation at Society for Gynecologic Investigation 60th Annual Meeting, Orlando, FL.

Ahuja, M., Wang, Y., Knosp, B., Leslie, K. K., Santillan, M. K. & Santillan, D. A. (2013). Automated Use of the Electronic Medical Record for Meaningful Clinical Data Extraction. Poster presentation at Society for Gynecologic Investigation 60th Annual Meeting, Orlando, FL.

Kowalski, J., Netz, R., Sinkey, C., Santillan, D. A., Fleener, D., Hamilton, W., Boese, B., Hunter, S., Leslie, K. K., Haynes, W. & Santillan, M. K. (2013). Changes in Flow Mediated Vasodilation Predicts Development of Gestational Diabetes. Poster presentation at Society for Gynecologic Investigation 60th Annual Meeting, Orlando, FL.

Abel, J., Conklin, J., Hunter, S., Empey, R., Tyler, E., Christensen, A., Talcott, K., Ballas, Z., Santillan, M. K. & Santillan, D. A. (2013). Physiologic IgG Changes Throughout Pregnancy. Poster presentation at Society for Gynecologic Investigation 60th Annual Meeting, Orlando, FL.

Talcott, K., Christensen, A., Tyler, E., Hamilton, W., Boese, B., Santillan, D. A., Hunter, S., Leslie, K. K. & Santillan, M. K. (2013). The Effect of Obesity on C-Reactive Protein Levels and Poor Pregnancy Outcomes. Poster presentation at Society for Gynecologic Investigation 60th Annual Meeting, Orlando, FL.

Santillan, D. A., Xavier, A., Santillan, M. K. & Hunter, S. K. (2013). Development of an Artificial Organ System to Prevent Maternal PKU Syndrome. pp. Abstract 664. Poster presentation at SMFM 33rd Annual Scientific Meeting, San Francisco, CA.

Devor, E., Santillan, D. A. & Santillan, M. K. (2013). Preeclampsia and MicroRNAs. Proc Obstet Gynecol, The Preeclampsia Issue, 3(1), 2.

Santillan, M. K., Leslie, K. K., Hamilton, W., Boese, B., Conklin, J., Empey, R., Tyler, E., Talcott, K., Christensen, A., Abel, J., Ahuja, M., Sanborn, A., Sweezer, E., Hunter, S. & Santillan, D. A. (2012). Collection of a Lifetime: Development of a Longitudinal Collection of Women's Healthcare Biological Samples. POG.

Snyder, M. W., Kitzman, J. O., Ventura, A. P., Lewis, A. P., Qiu, R., Simmons, L. E., Gammil, H. S., Rubens, C. E., Santillan, D. A., Santillan, M. K., Murray, J. C., Tabor, H. K., Bamshad, M. J., Eichler, E. E. & Shedure, J. A. (2012). Methods for noninvasive prenatal determination of fetal genomes. pp. Abstract 94. Oral presentation at American Society of Human Genetics, San Francisco, CA.

Kyser, K. L., Lu, X., Santillan, D. A., Santillan, M. K., Hunter, S. K., Cahill, A. G. & Cram, P. (2012). The association between hospital obstetrical volume and maternal postpartum complications. American journal of obstetrics and gynecology, 207(1), 42.e1-17. PMID: 22727347.

Kitzman, J. O., Snyder, M. W., Ventura, M., Lewis, A. P., Qiu, R., Simmons, L. E., Gammill, H. S., Rubens, C. E., Santillan, D. A., Murray, J. C., Tabor, H. K., Bamshad, M. J., Eichler, E. E. & Shendure, J. (2012). Noninvasive whole-genome sequencing of a human fetus. Science translational medicine, 4(137), 137ra76. PMID: 22674554.

Santillan, M. K., Pelham, C., Ketsawtsomkron, P., Santillan, D. A., Yang, B., Hunter, S. K. & Sigmund, C. D. (2012). Chronic Indoleamine 2,3 Dioxygenase (IDO) Deficiency: A Novel Immunologic Murine Model of Preeclampsia. Poster presentation at Society for Gynecologic Investigation 59th Annual Meeting, San Diego, CA.

Santillan, D. A., Hamilton, W., Santillan, M. K. & Hunter, S. K. (2012). Determining the Effect of Preeclampsia on Growth and Differentiation Potential of Umbilical Cord Blood Hematopoietic Stem Cells. Poster presentation at Society for Gynecologic Investigation 59th Annual Meeting, San Diego, CA.

Santillan, D. A., Leslie, K. K., Sweezer, E., Hamilton, W., Empey, R., Tyler, E., Rushing, J., Stegmann, B. J., Hunter, S. K. & Santillan, M. K. (2012). Development of a Maternal Fetal Tissue Bank: An Investment in Maternal and Fetal Health Research. Poster presentation at Society for Gynecologic Investigation 59th Annual Meeting, San Diego, CA.

Santillan, M. K., Santillan, D. A., Hamilton, W. S., Rayburn, W., Hunter, S. K. & Leslie, K. K. (2012). The Th1 versus Th2 Cytokine Milieu in Control and Preeclamptic Pregnancies: A Second Trimester Predictor of Preeclampsia?. Poster presentation at Society for Gynecologic Investigation 59th Annual Meeting, San Diego, CA.

Santillan, M. K., Raghuraman, N., Naruko-Stewart, K., Cooper, K., Santillan, D. A. & Greiner, A. (2012). The Potential Role of Diuresis Criteria in Postpartum Magnesium Management of Mild and Severe Preeclampsia. Poster presentation at SMFM 32nd Annual Scientific Meeting, Dallas, TX.

Stegmann, B., Santillan, M. K., Santillan, D. A., Smith, E. M., Van Voorhis, B. J. & Schultz, K. (2012). Anti-Mullerian Hormone concentration levels in maternal plasma during the first, second, and third trimester of pregnancy. Proc Obstet Gynecol, 2(3), Article 2.

Santillan, M. K., Raghuraman, N., Naruko-Stewart, K., Cooper, K., Santillan, D. A., Zamba, G. K. & Greiner, A. (2012). Diuresis: Physiological Cues to Decrease Postpartum Magnesium Administration. American Journal of Obstetrics and Gynecology.

Kitzman, J. O., Snyder, M. W., Ventura, M., Lewis, A. P., Qiu, R., Simmons, L. E., Gammill, H. S., Rubens, C. E., Santillan, D. A., Murray, J. C., Tabor, H. K., Bamshad, M. J., Eichler, E. E. & Shendure, J. (2012). Noninvasive whole-genome sequencing of a human fetus. Sci Transl Med, 4, 137ra76.

Santillan, M., Santillan, D., Fleener, D., Hunter, S. & Yankowitz, J. (2012). Single umbilical artery: does side matter?. Fetal diagnosis and therapy, 32(3), 201-8. PMID: 22678110.

Santillan, D. A., Hamilton, W., Christenson, A., Talcott, K., Gravatt, L., Santillan, M. K. & Hunter, S. (2012). The Effects of Preeclampsia on Signaling to Hematopoietic Progenitor Cells. POG, 3(3), Article 3 [ 11 p. ].

Empey, R., Santillan, D. A., Santillan, M. K., Tyler, E., Hunter, S., Smith, E. M. & Stegmann, B. (2012). The influence of fetal sex on patterns of change in anti-Mullerian hormone during pregnancy. Proc Obstet Gynecol, 2(3), Article 4.

Stegmann, B. J., Smith, E., Hunter, S. K. & Santillan, D. A. (2011). Variance and Stability of Antimullerian Hormone (AMH) levels based on method of collection and time to Sample Freeze. Accepted for poster presentation at Women's Reproductive Health Research Conference, Providence, RI.

Santillan, D. A., Rai, K. K., Santillan, M. K., Krishnamachari, Y., Salem, A. K. & Hunter, S. K. (2011). Efficacy of polymeric encapsulated C5a peptidase-based group B streptococcus vaccines in a murine model. American journal of obstetrics and gynecology, 205(3), 249.e1-8. PMID: 21802065.

Stegmann, B. J., Gemmill, J. A., Kino, T., Chrousos, G., Santillan, D. A., Segars, J. H. & Stratton, P. (2011). Hypothalamic-Pituitary-Adrenal responses in women with chronic pelvic pain associated with endometriosis. European Journal of Clinical Investigation, 96(3), Supplement pages S45-S46.

Santillan, D. A., Kyser, K., Santillan, M. K., Hunter, S. & Cram, P. (2011). The Association Between Obstetrical Volume and Maternal Morbidity. Poster presentation at Society of Pediatric and Perinatal Epidemiology, Montreal, Canada.

Santillan, D. A., Santillan, M. K., Hamilton, W. S. & Hunter, S. K. (2011). Determining the Effect of Preeclampsia on Growth and Differentiation Potential of Umbilical Cord Blood Hematopoietic Stem Cells. Poster presentation at College of Medicine Research Week, University of Iowa Hospitals and Clinics.

Stegmann, B. J., Santillan, D. A., Santillan, M. K., Van Voorhis, B. J. & Smith, E. (2011). Antimullerian Hormone Changes in Pregnancy and Prediction of Adverse Pregnancy Outcomes. Accepted for poster presentation as Society for Gynecologic Investigation 58th Annual Meeting, Miami, FL.

Santillan, M. K., Santillan, D. A., Hamilton, W., Rayburn, W., Hunter, S. K. & Leslie, K. K. (2011). Adaptations in Maternal Sera of Immuno-vasoactive IDO, TRAIL, and IL-4 in Response to a High sFLT-1 Preeclamptic Environment. Accepted for poster presentation at SMFM 31st Annual Scientific Meeting, San Francisco, CA.

Santillan, D. A., Santillan, M. K., Rai, K. & Hunter, S. K. (2011). Treatment of maternal PKU: Safety and Efficacy of a Novel Engineered Metabolic System. Accepted for poster presentation at SMFM 31st Annual Scientific Meeting, San Francisco, CA.

Santillan, M. K., Santillan, D. A. (2010). 2010 Updates of the CDC Guidelines for GBS in pregnancy. Iowa Perinatal Leter, 31(4).

Santillan, M. K., Pelham, C., Ketsawatsomkron, P., Santillan, D. A., Yang, B., Hunter, S. K. & Sigmund, C. D. (2010). Indoleamine 2,3 Dioxygenase (IDO) Deficiency Results in Vascular Dysfunction and Proteinuria in Pregnancy.

Santillan, M. K., Pelham, C., Ketsawatsomkron, P., Santillan, D. A., Yang, B., Hunter, S. K. & Sigmund, C. D. (2009). Development and characterization of an Indoleamine 2,3-dioxygenase (IDO) deficient mouse model of preeclampsia. (Vols. 201). (6), pp. S276. Accepted for poster presentation at SMFM 30th Annual Scientific Meeting, Chicago, IL. American Journal of Obstetrics & Gynecology.

Santillan, M., Santillan, D. A., Sigmund, C. & Hunter, S. K. (2009). From Molecules To Medicine: A Future Cure For Preeclampsia?. Drug News Perspect, 22(9), 531-41.

Santillan, D. A., Santillan, M. K. & Hunter, S. K. (2009). Cell encapsulation as a potential nondietary therapy for maternal phenylketonuria. American journal of obstetrics and gynecology, 201(3), 289.e1-6. PMID: 19631922.

Santillan, M. K., Santillan, D. A., Sigmund, C. D. & Hunter, S. K. (2009). Elucidating the Role of Indoleamine 2,3 Dioxygenase (IDO) in Preeclampsia. 2009 National Clinical Translational Research Education Annual Meeting, Washington, DC.

Santillan, D. A., Santillan, M. K. & Hunter, S. (2009). Cell Encapsulation As a Useful Non-Dietary Therapy for Maternal Phenylketonuria. (Vols. 199). (6), pp. S7. Accepted for oral presentation at SMFM 29th Annual Scientific Meeting, San Diego, CA. American Journal of Obstetrics and Gynecology.

Santillan, M. K., Santillan, D. A., Sigmund, C. D. & Hunter, S. (2009). IDO and sFLT-1: A Potential Molecular Link Between the Immune System and Preeclampsia. (Vols. 199). (6), pp. S83. Accepted for poster presentation at SMFM 29th Annual Scientific Meeting, San Diego, CA. American Journal of Obstetrics & Gynecology.

Chen, J., Santillan, D. A., Koonce, M., Wei, W., Zeleznik-Le, N. J., Luo, R., Thirman, M. J. & Diaz, M. O. (2008). Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization. Cancer research, 68(15), 6199-207. PMID: 18676843.

Santillan, D. A., Andracki, M. E. & Hunter, S. K. (2008). Protective immunization in mice against group B streptococci using encapsulated C5a peptidase. American journal of obstetrics and gynecology, 198(1), 114.e1-6. PMID: 17905172.

Santillan, D. A., Santillan, M. K. & Hunter, S. (2007). Development of a Novel Non-Dietary Therapy for Maternal Phenylketonuria. (Vols. 197). (6), pp. S118. Accepted for poster presentation SMFM 28th Annual Scientific Meeting, Dallas, TX. American Journal of Obstetrics & Gynecology.

Santillan, M. K., Santillan, D. A., Fleener, D., Hunter, S. & Yankowitz, J. (2007). Single Umbilical Artery: Does SIDE Matter?. (Vols. 197). (6), pp. S56. Accepted for poster presentation SMFM 28th Annual Scientific Meeting, Dallas, TX. American Journal of Obstetrics & Gynecology..

Santillan, M. K., Santillan, D. A., Gianopoulos, J., Mestril, R. & Koh, M. (2006). HSP60 and anti-HSP60 antibody are associated with intrapartum infection in preeclamptic mothers. (Vols. 195). (6), pp. S141. Accepted for poster presentation SMFM 28th Annual Scientific Meeting, Dallas, TX. American Journal of Obstetrics & Gynecology.

Santillan, D. A., Theisler, C. M., Ryan, A. S., Popovic, R., Stuart, T., Zhou, M. M., Alkan, S. & Zeleznik-Le, N. J. (2006). Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype. Cancer research, 66(20), 10032-9. PMID: 17047066.

Xia, Z. B., Popovic, R., Chen, J., Theisler, C., Stuart, T., Santillan, D. A., Erfurth, F., Diaz, M. O. & Zeleznik-Le, N. J. (2005). The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. Proceedings of the National Academy of Sciences of the United States of America, 102(39), 14028-33. PMID: 16169901.

Santillan, D. A., Ryan, A. & Zeleznik-Le, N. J. (2004). MLL Partner Gene Domains Contribute Critical Functional Specificity to Immortalization and Differentiation of Hematopoietic Progenitors. (Vols. 104). pp. Abstract 2555. American Society of Hematology, San Diego, CA. Blood (ASH Annual Meeting Abstracts).

Xia, Z., Popovic, R., Lorenz, T., Santillan, D. A., Erfurth, F. & Zeleznik-Le, N. J. (2004). MLL-AF4 Down-Regulates CDKN1B (P27) Independent of Cell Cycle Progression. (Vols. 104). pp. Abstract 2563. American Society of Hematology, San Diego, CA. Blood (ASH Annual Meeting Abstracts).

Santillan, D. A., Ryan, A. & Zeleznik-Le, N. (2003). Bromodomain and HAT Domain Specificity in MLL-CBP Immortalization. FASEB Summer Conference on Hematological Malignancies, Saxtons River, VT.

Santillan, D. A., Zeleznik-Le, N. (2002). Functional Specificity of MLL-CBP. Research Day 2002 at Edward Hines, Jr. VA Hospital, Hines, IL.

Santillan, D. A., Zeleznik-Le, N. (2001). Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein. Curr Opin Hematol, 8(4), 218-23.

Santillan, D. A., Romas, T. & Crumrine, D. (1997). New Approaches to Synthesis of 3,3-Diphenyltricyclo[3.2.1.0]oct-6-enes. 30th Great Lakes Regional Meeting of the American Chemical Society. Undergraduate Poster Session. Chicago, IL..

Biography

My work is focused on improving the health of women during and after pregnancy. To assist in accomplishing this objective, I direct the Women's Health Tissue Repository, a high-quality longitudinal collection of biological samples and clinical information from all stages of women's lives. My own research focuses on the effects of vaping during pregnancy. In addition, we study the long-term effects of hypertension in pregnancy to the mother and child.