Mark Santillan, MD, PhD, FACOG, FAHA
Introduction
The Santillan lab is particularly interested in the relationship between maternal health during pregnancy and the short and long-term health effects to the mother and child. Specifically, our current work focuses on the early mechanisms involved in the development of preeclampsia, including immunological and vascular function changes during pregnancy. A central focus in the lab is investigating the predictive, preventative, therapeutic and curative potential of the arginine vasopressin pathway in preeclampsia. Leveraging the group's novel discovery of a very early biomarker for preeclampsia and a novel mouse model for preeclampsia, our lab works to investigate the mechanistic underpinnings of the predictive and therapeutic potential of vasopressin in the management of preeclampsia in a translational manner. As a practicing academic high-risk obstetrician, Dr. Santillan is very qualified in caring for women with high risk pregnancies, in understanding their clinical management, and in conducting clinical/translational research in perinatal biology. He has been successful in conducting studies in both murine and human pregnancies. As the clinical research director and co-founder of the Maternal Fetal Tissue Bank, Dr. Santillan has significant experience in clinical data acquisition, management, and analysis as well as molecular biology techniques needed for translational studies. Furthermore, as the Principal Investigator of the Population project of the University of Iowa American Heart Association Strategically Focused Research Network in Hypertension, Dr. Santillan has developed the PREDICTV network of prenatal providers around the state of Iowa to collect samples and clinical information from a diverse cohort of pregnant women.
Current Positions
- Clinical Research Director, Maternal Fetal Tissue Bank, Department of Obstetrics and Gynecology
- Co-Director, OB/GYN Residency Research, Department of Obstetrics and Gynecology
- Professor of Obstetrics and Gynecology - Maternal-Fetal Medicine
Education
- BA in Philosophy, Loyola University Chicago, Chicago, Illinois
- BS in Chemistry with Biochemistry emphasis, Loyola University Chicago, Chicago, Illinois
- MD in Doctor of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois
- PhD in Translational Biomedicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
- Resident in Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Illinois
- Fellow in Maternal Fetal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Center, Program and Institute Affiliations
Research Interests
- Women's Health Tissue Repository: Clinical Database and Biorepository
- Role of Copeptin/Vasopressin in the development of preeclampsia in human pregnancies.
- OB/Gyn resident research curriculum
- The clinical and molecular effects of obesity in pregnancy
- Role of immunology and oxidative stress on perinatal diseases
- Molecular physiology of a chronic indoleamine 2,3 dioxygenase deficient murine model of preeclampsia.
- Vascular function, indoleamine 2,3 dioxygenase, and the development of preeclampsia in human pregnancies: The Preeclampsia, IDO, Vascular function, and Perinatal Outcomes (PIVPO) Study
Licenses & Certifications
- Maternal Fetal Medicine Subspecialty Board Certification, American Board of Obstetrics and Gynecology
- General OB/Gyn Board Certification, American Board of Obstetrics and Gynecology
- Iowa Controlled Substance, Iowa
- DEA Controlled Substance, Iowa
- Iowa Board of Medicine, Iowa
- Illinois Medical License, Illinois
Selected Publications
- Schickling B, Santillan MK, Santillan DA. Alternative Splicing of CADM1 in Preeclampsia: Implications for Endothelial Dysfunction and Offspring Cardiovascular Risk. Physiol Genomics. 2025 Apr 4. doi: 10.1152/physiolgenomics.00047.2025. Epub ahead of print. PMID: 40183784. https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00047.2025
- Gumusoglu SB, Schickling BM, Santillan DA, Teesch LM, Santillan MK. Disrupted fetal carbohydrate metabolism in children with autism spectrum disorder. J Neurodev Disord. 2025 Mar 29;17(1):16. doi: 10.1186/s11689-025-09601-z. PMID: 40158086; PMCID: PMC11954230. https://jneurodevdisorders.biomedcentral.com/articles/10.1186/s11689-025-09601-z
- Vignato J, Perkhounkova Y, Marilim H, Lee J, Hein M, Santillan D, Santillan M. Validation of the Patient-Reported Outcomes Measurement Information System Pain Intensity and Brief Pain Inventory During Pregnancy. West J Nurs Res. 2025 Feb 8:1939459251317270. doi: 10.1177/01939459251317270. Epub ahead of print. PMID: 39921452. https://journals.sagepub.com/doi/epub/10.1177/01939459251317270
- Schwartz KS, Sun M, Jalal DI, Santillan MK, Stanhewicz AE. Reduced AT2R Signaling Contributes to Endothelial Dysfunction After Preeclampsia. Hypertension. 2024 Dec 26. doi: 10.1161/HYPERTENSIONAHA.124.24098. Epub ahead of print. PMID: 39723536. https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.124.24098
- Faro EZ, Santillan DA, Funk ML, Boeldt K, Santillan MK. Social media provides support and education for pregnant people when healthcare does not. Front Glob Womens Health. 2024 Nov 28;5:1410831. doi: 10.3389/fgwh.2024.1410831. PMID: 39669112; PMCID: PMC11634836.
- Davis KG, Armstrong MK, Nuckols VR, Smith MN, Pewowaruk R, Gimblet CJ, Santillan DA, Santillan MK, Pierce GL. Load-dependent mechanisms contribute to increased aortic stiffness among women with a history of preeclampsia: relation with cardiovagal baroreflex sensitivity. Am J Physiol Heart Circ Physiol. 2024 Dec 1;327(6):H1406-H1412. doi: 10.1152/ajpheart.00556.2024. Epub 2024 Oct 18. PMID: 39423036. https://journals.physiology.org/doi/full/10.1152/ajpheart.00556.2024
- Blocklinger KL, Gumusoglu SB, Kenney AS, Faudel AJ, Faro E, Brandt DS, Knosp B, Davis HA, Hunter SK, Santillan MK, Santillan DA. Depression in the time of COVID-19: Examination of prenatal and postpartum depression, rurality, and the impact of COVID-19. J Affect Disord. 2025 Feb 1;370:337-347. doi: 10.1016/j.jad.2024.10.081. Epub 2024 Oct 28. PMID: 39490676; PMCID: PMC11631661. https://www.sciencedirect.com/science/article/pii/S0165032724017762?via%3Dihub
- Mathew AP, Cutshaw G, Appel O, Funk M, Synan L, Waite J, Ghazvini S, Wen X, Sarkar S, Santillan M, Santillan D, Bardhan R. Diagnosis of pregnancy disorder in the first-trimester patient plasma with Raman spectroscopy and protein analysis. Bioeng Transl Med. 2024 Jul 16;9(6):e10691. doi: 10.1002/btm2.10691. PMID: 39545096; PMCID: PMC11558203
- Ricci CA, Crysup B, Phillips NR, Ray WC, Santillan MK, Trask AJ, Woerner AE, Goulopoulou S. Machine learning: a new era for cardiovascular pregnancy physiology and cardio-obstetrics research. Am J Physiol Heart Circ Physiol. 2024 Aug 1;327(2):H417-H432. doi: 10.1152/ajpheart.00149.2024. Epub 2024 Jun 7. PMID: 38847756; PMCID: PMC11442027.https://journals.physiology.org/doi/abs/10.1152/ajpheart.00149.2024
- Meierding K, Santillan, MK. The effect of race and rurality on poor pregnancy outcomes. Proc Obstet Gynecol. 2024;13(1): Article 6 [2 p.]. doi: https://doi.org/10.17077/2154-4751.33798. https://pubs.lib.uiowa.edu/pog/article/id/33798/ Extended Abstract