Michael J. Goodheart, MD

Portrait
Assistant Professor
Fellowship Director
Assistant Professor of Obstetrics and Gynecology - Gynecologic Oncology
Assistant Professor of Anatomy and Cell Biology

Contact Information

Primary Office: 31508 PFP
200 Hawkins Dr
Iowa City, IA 52242
319-356-2015

Education

BA, Chemistry, North Carolina State University, Raleigh, North Carolina
BS, North Carolina State University, Raleigh, North Carolina
MD, Medicine, East Carolina State University School of Medicine, Greenville, North Carolina

Chief Resident, Chief Administrative Resident; Department of Obstetrics & Gynecology, Louisiana State University School of Medicine
Resident, Obstetrics and Gynecology, Louisiana State University School of Medicine, New Orleans, Louisiana
Resident, Surgery, University of South Florida School of Medicine, Tampa, Florida
Fellow, Gynecologic Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Licensure and Certifications

Board Certified, Gynecologic Oncology - ABOG
General Obstetrics and Gynecology
Iowa Medical License, #33538

Research Summary

Relating p53 mutation types to angiogenesis and immunohistochemical expression in epithelial ovarian cancers, and mutations of the BRCA2 gene in ovarian cancers.

Transcriptional regulation of the lymphoid enhancer factor-1 (Lef-1) promoter and its relevance in the pathogenesis of ovarian and endometrial cancer.

Publications

Kristeleit, R., Davidenko, I., Shrinkin, V., El-Khouly, F., Bondarenko, I., Goodheart, M. J., Gorbunova, V., Penning, C. A., Shi, J. G., Liu, X., Newton, R. C., Zhao, Y., Maleski, J., Leopold, L. & Schilder, R. J. (2017). A randomised, open-label, phase 2 study of the IDO1 inhibitor epacadostat (INCB024360) versus tamoxifen as therapy for biochemically recurrent (CA-125 relapse)-only epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube cancer. Gynecol Oncol, 143(3), 484-490. PMID: 28698009.

Rungruang, B. J., Miller, A., Krivak, T. C., Horowitz, H. S., Rodriguez, N., Hamilton, C. A., Backes, F. J., Carson, L. F., Friedlander, M., Mutch, D. G., Goodheart, M. J., Tewari, K. S., Wenham, R. M., Bookman, B. A., Maxwell, G. L. & Richard, S. D. (2017). What is the role of retroperitoneal exploration in optimally debulked stage IIIC epithelial ovarian cancer? An NRG Oncology/Gynecologic Oncology Group ancillary data study. Cancer, 123(6), 985-993. PMID: 27864921.

Thenuwara, K., Thomas, J., Ibsen, M., Ituk, U., Choi, K., Nickel, E. & Goodheart, M. J. (2017). Use of hyperbaric oxygen therapy and PEGylated carboxyhemoglobin bovine in a Jehovah's Witness with life-threatening anemia following postpartum hemorrhage. Int J Obstet Anesth,(29), 78-30. PMID: 27890467.

Devor, E. J., Gonzalez-Bosquet, J., Warrier, A., Reyes, H. D., Ibik, N. V., Schickling, B. M., Newtson, A., Goodheart, M. J. & Leslie, K. K. (2017). p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers. Int J Oncol, 50(5), 1721-1728. PMID: 28339050.

Hamilton, C. A., Miller, A., Casablanca, Y., Horowitz, N. S., Rungruang, B., Krivak, T. C., Richard, S. D., Rodriguez, N., Birrer, M. J., Backes, F. J., Geller, M. A., Quinn, M., Goodheart, M. J., Mutch, D. G., Kavanagh, J. J., Maxwell, G. L. & Bookman, M. A. (2017). Clinicopathologic characteristics associated with long-term survival in advanced epithelial ovarian cancer: an NRG Oncology/Gynecologic Oncology Group ancillary data study. Gynecol Oncol [Epub ahead of print]. PMID: 29195926.

Cuneo, M. G., Schrepf, A., Slavich, G. M., Thaker, P. H., Goodheart, M., Bender, D., Cole, S. W., Sood, A. K. & Lutgendorf, S. K. (2017). Diurnal cortisol rhythms, fatigue and psychosocial factors in five-year survivors of ovarian cancer. Psychoneuroendocrinology [Epub ahead of print], 84, 139-142. PMID: 28711723.

Lutgendorf, S. K., Thaker, P. H., Arevalo, J. M., Goodheart, M. J., Slavich, G. M., Sood, A. K. & Cole, S. W. (2017). Biobehavioral modulation of the exosome transcriptome in ovarian carcinoma. Cancer [Epub ahead of print]. PMID: 29112229.

Kremer, K. M., McDonald, M. E. & Goodheart, M. J. (2017). Uterine Clostridium perfringens infection related to gynecologic malignancy. Gynecol Oncol Rep, 22, 55-57. PMID: 29034307.

Christensen, D. K., Armaiz-Pena, G. N., Ramirez, E., Matsuo, K., Zimmerman, B., Zand, B., Shinn, E., Goodheart, M. J., Bender, D., Thacker, P. H., Ahmed, A. J., Penedo, F. J., DeGeest, K., Mendez, L. K., Domann, F., Sood, A. K. & Lutgendorf, S. K. (2016). SSRI use and clinical outcomes in epithelial ovarian cancer. Oncotarget, 7(22), 33179-91. PMID: 27121207.

Reyes, H. D., Carlson, M. J., Devor, E. J., Zhang, Y., Thiel, K. W., Samuelson, M. I., McDonald, M., Yang, S., Stephan, J. M., Savage, E. C., Dai, D., Goodheart, M. J. & Leslie, K. K. (2016). Downregulation of FOXO1 mRNA levels predicts treatment failure in patients with endometrial pathology conservatively managed with progestin-containing intrauterine devices. Gynecol Oncol, 140(1), 152-60. PMID: 26524723.

Devor, E. J., Schickling, B. M., Reyes, H. D., Warrier, A., Lindsay, B., Goodheart, M. J., Santillan, D. A. & Leslie, K. K. (2016). Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182. Oncol Rep, 35(4), 2461-5. PMID: 26847831.

Guimarães-Young, A., Neff, T., Dupuy, A. J. & Goodheart, M. J. (2016). Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function. Dev Biol, 414(2), 219-27. PMID: 27102016.

Uhlman, M. A., Bevill, M. D., Goodheart, M. J., Brown, J. A. & O'Donnell, M. A. (2016). Bladder cancer will grow anywhere: report of a urothelial carcinoma drop metastasis to the vagina and literature review. Can J Urol, 23(4), 8379-81. PMID: 27544563.

Gonzalez Bosquet, J., Newtson, A. M., Chung, R. K., Thiel, K. W., Ginader, T., Goodheart, M. J., Leslie, K. K. & Smith, B. J. (2016). Prediction of chemo-response in serous ovarian cancer. Mol Cancer, 15(1), 66. PMID: 27756408.

Dai, D., Thiel, K. W., Salinas, E. A., Goodheart, M. J., Leslie, K. K. & Gonzalez Bosquet, J. (2016). Stratification of endometrioid endometrial cancer patients into risk levels using somatic mutations. Gynecol Oncol, 142(1), 150-157. PMID: 27181389.

Sun, Z., Yu, W., Navarro, M. S., Sweat, M., Eliason, S., Sharp, T., Liu, H., Seidel, K., Zhang, L., Moreno, M., Lynch, T., Holton, N. E., Rogers, L., Neff, T., Goodheart, M. J., Michon, F., Klein, O. D., Chai, Y., Dupuy, A., Engelhardt, J. F., Chen, Z. & Amendt, B. A. (2016). Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development, 143(22), 4115-4126. PMID: 27660324.

Salinas, E., Dai, D., Newtson, A., McDonald, M., Goodheart, M., Leslie, K. & Gonzalez Bosquet, J. (2016). Pre-treatment Prediction Model in Endometrioid Adenocarcinoma of the Uterus Using Somatic Mutations. (Vols. 143). (1), pp. 215. Gynecol Onc.

Brachova, P., Mueting, S. R., Carlson, M. J., Goodheart, M. J., Button, A. M., Mott, S. L., Dai, D., Thiel, K. W., Devor, E. J. & Leslie, K. K. (2015). TP53 oncomorphic mutations predict resistance to platinum- and taxane-based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma. Int J Oncol, 46(2), 607-18. PMID: 25385265.

Xie, W., Fisher, J. T., Lynch, T. J., Luo, M., Evans, T. I., Neff, T. L., Zhou, W., Zhang, Y., Ou, Y., Bunnett, N. W., Russo, A. F., Goodheart, M. J., Parekh, K. R., Liu, X. & Engelhardt, J. F. (2015). CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. J Clin Invest, 125(5), 2179. PMID: 25932677.

Davis, L. Z., Slavich, G. M., Thacker, P. H., Goodheart, M. J., Bender, D. P., Dahmoush, L., Farley, D. M., Markon, K. E., Penedo, E. J., Lubaroff, D. M., Cole, S. W., Sood, A. K. & Lutgendorf, S. K. (2015). Eudaimonic well-being and tumor norepinephrine in patients with epithelial ovarian cancer. Cancer, 121(19), 3543-50. PMID: 26096769.

Hansen, J., Stephan, J. M., Freesmeier, M., Bender, D., Button, A. & Goodheart, M. J. (2015). The effect of weight-based chemotherapy dosing in a cohort of gynecologic oncology patients. Gynecol Oncol, 138(1), 154-8. PMID: 25958318.

Stephan, J. M., Goodheart, M. J., McDonald, M., Hansen, J., Reyes, H. D. & Bender, D. (2015). Robotic surgery in super-morbidly obese patients with endometrial cancer. Am J Obstet Gynecol. PMID: 25644437.

Schrepf, A., Thaker, P. H., Goodheart, M. J., Bender, D., Slavich, G. M., Dahmoush, L., Penedo, F., DeGeest, K., Mendez, L., Lubaroff, D. M., Cole, S. W., Sood, A. K. & Lutgendorf, S. K. (2015). Diurnal cortisol and survival in epithelial ovarian cancer. Psychoneuroendocrinology, 563, 256-67. PMID: 25647344.

Zhang, Z., Kim, K., Li, X., Moreno, M., Sharp, T., Goodheart, M. J., Safe, S., Dupuy, A. J. & Amendt, B. A. (2014). MicroRNA-26b Represses Colon Cancer Cell Proliferation by Inhibiting Lymphoid Enhancer Factor 1 (LEF-1) Expression. Mol Cancer Ther, 13(7), 1942-51. PMID: 24785257.

Stephan, J. M., McDonald, M., Hansen, J. & Goodheart, M. J. (2014). Staging Endometrial Cancer. pp. e2014.00246. CRSLS. DOI: 10.4293/CRSLS.2014.00246.

Stephan, J. M., Hansen, J., Samuelson, M., McDonald, M., Chin, Y., Bender, D., Reyes, H. D., Button, A. & Goodheart, M. J. (2014). Intra-operative frozen section results reliably predict final pathology in endometrial cancer. Gynecol Oncol., 133(3), 499-505. PMID: 2469930.

Xie, W., Lynch, T. J., Liu, X., Tyler, S. R., Yu, S., Zhou, X., Luo, M., Kusner, D. M., Sun, X., Yi, Y., Zhang, Y., Goodheart, M. J., Parekh, K. R., Wells, J. M., Xue, H. H., Pevny, L. H. & Engelhardt, J. F. (2014). Sox2 modulates Lef-1 expression during airway submucosal gland development. Am J Physiol Lung Cell Mol Physiol, 306(7), L645-60. PMID: 24487391.

Martin, L. P., Sill, M., Shahin, M. S., Powell, M., DiSilvestro, P., Landrum, L. M., Gaillard, G. L., Goodheart, M. J., Hoffman, J. & Schilder, R. J. (2014). A phase II evaluation of AMG 102 (rilotumumab) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol, 132(3), 526-30. PMID: 24361733.

Devor, E. J., Reyes, H. D., Santillan, D. A., Santillan, M. K., Onukwugha, C., Goodheart, M. J. & Leslie, K. K. (2014). Placenta-specific protein 1: a potential key to many oncofetal-placental OB/GYN research questions. Obstet Gynecol Int., 2014, 5 pages. DOI: 10.1155/2014/678984.

Lutgendorf, S. K., Slavich, G. M., Degeest, K., Goodheart, M. J., Bender, D., Thacker, P. H., Penedo, F., Zimmerman, B., Lucci 3rd, J., Mendez, L., Collins, K. & Sood, A. K. (2013). Non-cancer life stressors contribute to impaired quality of life in ovarian cancer patients. Gynecol Oncol, 131(3), 667-73. PMID: 24096110.

Schrepf, A., Clevenger, L., Christensen, D., DeGeest, K., Bender, D., Ahmed, A., Goodheart, M. J., Dahmoush, L., Penedo, F., Lucci, J. A., Ganjei-Azar, P., Mendez, L., Markon, K., Lubaroff, D. M., Thaker, P. H., Slavich, G. M., Sood, A. K. & Lutgendorf, S. K. (2013). Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: relationships with depression, fatigue, and disability. Brain, behavior, and immunity, 30 Suppl, S126-34. PMID: 22884960.

Clevenger, L., Schrepf, A., Degeest, K., Bender, D., Goodheart, M. J., Ahmed, A., Dahmoush, L., Penedo, F., Lucci 3rd, J., Thacker, P. H., Mendez, L., Sood, A. K., Slavich, G. M. & Lutgendorf, S. K. (2013). Sleep disturbance, distress, and quality of life in ovarian cancer patients during the first year after diagnosis. Cancer, 119(17), 3234-41. PMID: 23797955.

Nadkarni, N. J., Geest, K. D., Neff, T., Young, B. D., Bender, D. P., Ahmed, A., Smith, B. J., Button, A. & Goodheart, M. J. (2013). Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer. Cancer letters, 331(1), 99-104. PMID: 23268330.

Engle, D. B., Connor, J. P., Morris, P. C., Bender, D. P., De Geest, K., Ahmed, A. & Goodheart, M. J. (2012). Intraoperative autologous blood transfusion use during radical hysterectomy for cervical cancer: long-term follow-up of a prospective trial. Archives of gynecology and obstetrics, 286(3), 717-21. PMID: 22569711.

Devor, E. J., DE Mik, J. N., Ramachandran, S., Goodheart, M. J. & Leslie, K. K. (2012). Global dysregulation of the chromosome 14q32 imprinted region in uterine carcinosarcoma. Experimental and therapeutic medicine, 3(4), 677-682. PMID: 22969950.

Clevenger, L., Schrepf, A., Christensen, D., DeGeest, K., Bender, D., Ahmed, A., Goodheart, M. J., Penedo, F., Lubaroff, D. M., Sood, A. K. & Lutgendorf, S. K. (2012). Sleep disturbance, cytokines, and fatigue in women with ovarian cancer. Brain, behavior, and immunity, 26(7), 1037-44. PMID: 22543257.

Leslie, K. K., Thiel, K. W., Goodheart, M. J., De Geest, K., Jia, Y. & Yang, S. (2012). Endometrial cancer. Obstetrics and gynecology clinics of North America, 39(2), 255-68. PMID: 22640714.

Abu-Hejleh, T., Mezhir, J. J., Goodheart, M. J. & Halfdanarson, T. R. (2012). Incidence and management of gastrointestinal perforation from bevacizumab in advanced cancers. Current oncology reports, 14(4), 277-84. PMID: 22532266.

Fornalik, H., Goodheart, M. J., Buekers, T. E., De Geest, K. & Jacobson, G. M. (2012). Aspirin and Warfarin are associated with Improved Overall Survival in Medically Inoperable Endometrial Cancer Patients Treated with Radiation Therapy. Gynecology & Obstetrics S4:002.

Shelton, D. N., Fornalik, H., Neff, T., Park, S. Y., Bender, D., DeGeest, K., Liu, X., Xie, W., Meyerholz, D. K., Engelhardt, J. F. & Goodheart, M. J. (2012). The role of LEF1 in endometrial gland formation and carcinogenesis. PloS one, 7(7), e40312. PMID: 22792274.

Lutgendorf, S. K., De Geest, K., Bender, D., Ahmed, A., Goodheart, M. J., Dahmoush, L., Zimmerman, M. B., Penedo, F. J., Lucci, J. A., Ganjei-Azar, P., Thaker, P. H., Mendez, L., Lubaroff, D. M., Slavich, G. M., Cole, S. W. & Sood, A. K. (2012). Social influences on clinical outcomes of patients with ovarian cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30(23), 2885-90. PMID: 22802321.

Lutgendorf, S. K., DeGeest, K., Dahmoush, L., Farley, D., Penedo, F., Bender, D., Goodheart, M., Buekers, T. E., Mendez, L., Krueger, G., Clevenger, L., Lubaroff, D. M., Sood, A. K. & Cole, S. W. (2011). Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain, behavior, and immunity, 25(2), 250-5. PMID: 20955777.

Devor, E. J., Hovey, A. M., Goodheart, M. J., Ramachandran, S. & Leslie, K. K. (2011). microRNA expression profiling of endometrial endometrioid adenocarcinomas and serous adenocarcinomas reveals profiles containing shared, unique and differentiating groups of microRNAs. Oncology reports, 26(4), 995-1002. PMID: 21725615.

Shamshirsaz, A. A., Buekers, T., Degeest, K., Bender, D., Zamba, G. & Goodheart, M. J. (2011). A single-institution evaluation of factors important in fallopian tube carcinoma recurrence and survival. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 21(7), 1232-40. PMID: 21720254.

Xie, W., Fisher, J. T., Lynch, T. J., Luo, M., Evans, T. I., Neff, T. L., Zhou, W., Zhang, Y., Ou, Y., Bunnett, N. W., Russo, A. F., Goodheart, M. J., Parekh, K. R., Liu, X. & Engelhardt, J. F. (2011). CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. The Journal of clinical investigation, 121(8), 3144-58. PMID: 21765217.

Zhang, Z., Liu, X., Wu, T., Liu, J., Zhang, X., Yang, X., Goodheart, M. J., Engelhardt, J. F. & Wang, Y. (2011). Selective suppression of cervical cancer Hela cells by 2-O-ß-D-glucopyranosyl-L-ascorbic acid isolated from the fruit of Lycium barbarum L. Cell biology and toxicology, 27(2), 107-21. PMID: 20717715.

Liu, X., Luo, M., Xie, W., Wells, J. M., Goodheart, M. J. & Engelhardt, J. F. (2010). Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter. American journal of physiology. Lung cellular and molecular physiology, 299(5), L694-710. PMID: 20802155.

Lutgendorf, S. K., Mullen-Houser, E., Russell, D., Degeest, K., Jacobson, G., Hart, L., Bender, D., Anderson, B., Buekers, T. E., Goodheart, M. J., Antoni, M. H., Sood, A. K. & Lubaroff, D. M. (2010). Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach. Brain, behavior, and immunity, 24(8), 1231-40. PMID: 20600809.

Steines, J. C., Larson, J. H., Wilkinson, N., Kirby, P. & Goodheart, M. J. (2010). Intestinal lymphangiectasia mimicking primary peritoneal carcinoma. American journal of obstetrics and gynecology, 203(4), e9-e11. PMID: 20801422.

Jacobson, G., Lammli, J., Zamba, G., Hua, L. & Goodheart, M. J. (2009). Thromboembolic events in patients with cervical carcinoma: Incidence and effect on survival. Gynecologic oncology, 113(2), 240-4. PMID: 19251310.

Lutgendorf, S. K., DeGeest, K., Sung, C. Y., Arevalo, J. M., Penedo, F., Lucci, J., Goodheart, M., Lubaroff, D., Farley, D. M., Sood, A. K. & Cole, S. W. (2009). Depression, social support, and beta-adrenergic transcription control in human ovarian cancer. Brain, behavior, and immunity, 23(2), 176-83. PMID: 18550328.

Goodheart, M. J., Rose, S. L., Hattermann-Zogg, M., Smith, B. J., De Young, B. R. & Buller, R. E. (2009). BRCA2 alteration is important in clear cell carcinoma of the ovary. Clinical genetics, 76(2), 161-7. PMID: 19656163.

Petersen, E. E., Shamshirsaz, A. A., Brennan, T. M., Demetroulis, E. M. & Goodheart, M. J. (2009). Malignant pericardial effusion with cardiac tamponade in ovarian adenocarcinoma. Archives of gynecology and obstetrics, 280(4), 675-8. PMID: 19225795.

Goodheart, M., Jacobson, G., Smith, B. J. & Zhou, L. (2008). Chemoradiation for invasive cervical cancer in elderly patients: outcomes and morbidity. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 18(1), 95-103. PMID: 17466049.

Driskell, R. R., Goodheart, M., Neff, T., Liu, X., Luo, M., Moothart, C., Sigmund, C. D., Hosokawa, R., Chai, Y. & Engelhardt, J. F. (2007). Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Developmental biology, 305(1), 90-102. PMID: 17335794.

Goodheart, M. J., Ritchie, J. M., Rose, S. L., Fruehauf, J. P., De Young, B. R. & Buller, R. E. (2005). The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 11(10), 3733-42. PMID: 15897570.

Jacobson, G. M., Kamath, R. S., Smith, B. J. & Goodheart, M. J. (2005). Thromboembolic events in patients treated with definitive chemotherapy and radiation therapy for invasive cervical cancer. Gynecologic oncology, 96(2), 470-4. PMID: 15661237.

Rose, S. L., Goodheart, M. J., DeYoung, B. R., Smith, B. J. & Buller, R. E. (2003). p21 expression predicts outcome in p53-null ovarian carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 9(3), 1028-32. PMID: 12631602.

Rose, S. L., Robertson, A. D., Goodheart, M. J., Smith, B. J., DeYoung, B. R. & Buller, R. E. (2003). The impact of p53 protein core domain structural alteration on ovarian cancer survival. Clinical cancer research : an official journal of the American Association for Cancer Research, 9(11), 4139-44. PMID: 14519637.

Geisler, J. P., Goodheart, M. J., Sood, A. K., Holmes, R. J., Hattermann-Zogg, M. A. & Buller, R. E. (2003). Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma. Cancer, 98(10), 2199-206. PMID: 14601090.

Stone, P. J., Goodheart, M. J., Rose, S. L., Smith, B. J., DeYoung, B. R. & Buller, R. E. (2003). The influence of microvessel density on ovarian carcinogenesis. Gynecologic oncology, 90(3), 566-71. PMID: 13678725.

Goodheart, M. J., Vasef, M. A., Sood, A. K., Davis, C. S. & Buller, R. E. (2002). Ovarian cancer p53 mutation is associated with tumor microvessel density. Gynecologic oncology, 86(1), 85-90. PMID: 12079305.