Henry T. Hoffman, MD

Portrait
Professor of Otolaryngology
Professor of Radiation Oncology

Contact Information

Primary Office: 21264 Pomerantz Family Pavillion
200 Hawkins Drive
Iowa City, IA 52242
319-356-2166

319-356-2166

Education

BS, University of the South
MD, MD, University of California
MS, (Microbiology, University of Michigan

Resident, General surgery, LaCrosse Lutheran Hospital
Resident, Head and Neck Surgery, University of Iowa Hospitals and Clinics, Department of Otolaryngology
Fellow, Facial Plastics and Reconstructive Surgery, University of Michigan
Fellow, Head and Neck Surgery, University of Michigan

Research Summary

I have published over 200 articles and book chapters and am the Editor of the Iowa Head and Neck Protocols published as a book in 2003 and now a frequently used resource for medical information that has received over 3 million page visits over the past 5 years. I have directed clinical research, correlative basic science research, and education addressing disorders of the head and neck with more recent focus on the salivary and laryngeal disorders. Collaboration with Wendell Johnson Speech and Hearing faculty and students has been productive in developing conferences and research highlighting a productive cross-fertilization. Examples of this fruitful interaction with Speech Scientists include the recent applications of “MERS” (micro-endoscopy of Reinkes’ space developed by Hoffman et al) to successfully treat glottic scarring with stem cell implantation through several studies in live porcine models. Further collaboration with the University of Wisconsin is planned to apply this technology in an upcoming human clinical trial centered in Madison and Iowa City. Limited access, external, endoscopic approaches to the larynx have been developed and studied at the University of Iowa resulting in an established patent (“Methods and Devices for Arytenoid Repositioning” (US 9,056,005) and another pending (“Transilluminating Obturator” UIK-04301) that are both under commercial development. More recent collaboration with COOK Medical Inc has supported research developing other innovative approaches to the larynx (recently presented: AAO HNS Chicago 9-11-2017 “Two Nostril Transnasal Office Laryngoscopy”) and multiple presentations addressing salivary gland pathology (COSM New Orleans Jan 19-20th2017) Completion of the multicenter celecoxib trial as a prospective randomized study of treatment of patients with recurrent respiratory papillomatosis highlights our involvement in national research efforts now expanded to include involvement with the North American Airway Collaborative¹s prospective study of iSGS (idiopathic subglottic stenosis) (NoAAC PR-02). Clinical experience developed at the University of Iowa in pulmonary function testing for patients with upper airway obstruction will play a role in the outcome measurements in this study. Past Research Support Research Associate, Department of Health and Human Services, Public Health Service, 1R01 DC 4681-01 A1: “Medialization Vs. Reinnervation For Vocal Cord Paralysis” (revision submitted 7/2/01; funding 4/1/02-3/31/07), Randal C. Paniello, BS, MS, MD, PI (direct costs $2,173,668; total costs $3,000,826). Co-Investigator, Public Health Service/NIH/NIDR: “HPV Transmission and the Risk of Oral Cancer” (funding 4/1/97-3/31/02), Eileen M. Smith, MPH, PhD, PI (2% time; $740,000). Co-Investigator, Department of Health and Human Services, Public Health Service 1 R01 DC04291-01: “The Role of Pressure-Sensitive Reflexes During Phonation” (funding 12/1/99-11/3/03), Eileen M. Finnegan, PhD., PI (10% time; $12,590 salary support; annual direct costs $108,142). Co-Investigator, Department of Health and Human Services, Public Health Service DE98-008 approved: “Mechanisms of p16/CDKN2 Inactivation in Oral Cancer” (funding 4/1/99-3/31/04), Frederick Domann, MD, PI (5% time; direct costs $142,240). Co-Investigator, Department of Health and Human Services, Public Health Service DE13110-01 approved: “Genetic Epidemiology and Mechanisms in Oral Cancer” (funding 9/24/99-8/31/04), Eileen M. Smith, MPH, PhD, PI (3% time; $4,589 salary support; direct costs $242,428).