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Dr. Alexander Boyden receives a one-year research grant from the National Multiple Sclerosis Society investigating the role of Epstein Barr Virus-like murine viral infection on the induction of multiple sclerosis

Dr. Alexander BoydenDr. Alexander Boyden received a one-year RFA research grant award from the National MS Society entitled “Impact of gamma herpesvirus infection on required B cell:CD4 T cell interactions in a novel B cell-dependent, antibody-independent EAE model”.

This pilot study will determine how an Epstein Barr Virus-like murine viral infection impacts B cell-dependent versus B cell-independent models of multiple sclerosis in mice, focusing specifically on how the virus influences B cells’ support of autoreactive T cells. Dr. Jessica Tucker (Department of Microbiology and Immunology) is providing a fluorescent murine gamma herpesvirus-68 strain in collaboration. Dr. Boyden hopes to leverage the findings from this work into larger grant submissions aimed at understanding viral impact on pathogenic B cell function in MS.

Monday, October 9, 2023