Logo for University of Iowa Health Care This logo represents the University of Iowa Health Care

Dr. John Harty receives a five-year R01 research grant from the National Institutes of Health investigating CD8+ T cell immunity against malaria

Dr. John HartyDr. John Harty received a five-year NIH R01 award entitled ‘Immunity to Liver-Stage Malaria’ from the National Institute of Allergy and Infectious Diseases (NIAID).

Malaria, caused by Plasmodium species, is an unresolved global health burden associated with >200 million cases and >400,000 deaths per year. A recently licensed malaria vaccine designed to limit the initial liver-stage of infection may partially reduce severe malaria in children but highly effective vaccines remain elusive. Development of potent and translatable vaccines against malaria has been hampered by our incomplete understanding of the mechanisms by which the immune system can be trained to control Plasmodium infections. The long-term goals of this new five-year award are to dissect mechanisms leading to generation and function of memory CD8+ T cells that can provide potent immunity to Plasmodium liver-stage infection in order to inform development of effective human vaccines.

Wednesday, January 26, 2022