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Recent Publications

Week of May 17, 2022
Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo. Kohlmeyer JL, Kaemmer CA, Lingo JJ, Voigt E, Leidinger MR, McGivney GR, Scherer A, Koppenhafer SL, Gordon DJ, Breheny P, Meyerholz DK, Tanas MR, Dodd RD, Quelle DE. Neurooncol Adv. 2022 Apr 9;4(1):vdac047. doi: 10.1093/noajnl/vdac047. eCollection 2022 Jan-Dec.

Neuropathology of COVID-19. Lin LC, Hollis B, Hefti MM. Indian J Pathol Microbiol. 2022 May;65(Supplement):S146-S152. doi: 10.4103/ijpm.ijpm_1103_21.

Transcriptional Profiling in a Novel Swine Model of Traumatic Brain Injury. Shin SS, Gottschalk AC, Mazandi VM, Kilbaugh TJ, Hefti MM. Neurotrauma Rep. 2022 Apr 19;3(1):178-184. doi: 10.1089/neur.2021.0051. eCollection 2022.

Limb-Girdle Muscular Dystrophy R9 due to a Novel Complex Insertion/Duplication Variant in FKRP Gene. Willis E, Moore SA, Cox MO, Stefans V, Aravindhan A, Gokden M, Veerapandiyan A. Child Neurol Open. 2022 Apr 28;9:2329048X221097518. doi: 10.1177/2329048X221097518. eCollection 2022 Jan-Dec.

MET exon 14 Skipping Mutations: Essential Considerations for Current Management of Non-Small-Cell Lung Cancer. Davies KD, Ritterhouse LL, Snow AN, Sidiropoulos N. J Mol Diagn. 2022 May 9:S1525-1578(22)00118-0. doi: 10.1016/j.jmoldx.2022.04.005. Online ahead of print.

Week of May 10, 2022
Pharmacological ascorbate improves the response to platinum-based chemotherapy in advanced stage non-small cell lung cancer. Furqan M, Abu-Hejleh T, Stephens LM, Hartwig SM, Mott SL, Pulliam CF, Petronek M, Henrich JB, Fath MA, Houtman JC, Varga SM, Bodeker KL, Bossler AD, Bellizzi AM, Zhang J, Monga V, Mani H, Ivanovic M, Smith BJ, Byrne MM, Zeitler W, Wagner BA, Buettner GR, Cullen JJ, Buatti JM, Spitz DR, Allen BG. Redox Biol. 2022 Apr 20;53:102318. doi: 10.1016/j.redox.2022.102318. Online ahead of print.

Lymphoplasma Exchange Improves Myasthenia Gravis Exacerbations: A Retrospective Study in a Chinese Center. Ouyang S, Yin W, Zeng Q, Li B, Zhang J, Duan W, Li Y, Liang Y, Wang J, Tan H, Yang H. Front Immunol. 2022 Apr 14;13:757841. doi: 10.3389/fimmu.2022.757841. eCollection 2022.

Impact of COVID-19 on the Antifungal Susceptibility Profiles of Isolates Collected in a Global Surveillance Program that Monitors Invasive Fungal Infections. Pfaller MA, Carvalhaes CG, DeVries S, Rhomberg PR, Castanheira M. Med Mycol. 2022 May 2;60(5):myac028. doi: 10.1093/mmy/myac028. Online ahead of print.

Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis. Li Y, Talbot CL, Chandravanshi B, Ksiazek A, Sood A, Chowdhury KH, Maschek JA, Cox J, Babu AKS, Paz HA, Babu PVA, Meyerholz DK, Wankhade UD, Holland W, Shyong Tai E, Summers SA, Chaurasia B. Sci Rep. 2022 May 4;12(1):7273. doi: 10.1038/s41598-022-11219-3.

The frequency and significance of radiographic findings in the staging workup of patients with mycosis fungoides and Sezary syndrome. Eckburg A, Mott S, Dittmer M, Zafar F, Link B, Liu V. Int J Dermatol. 2022 May 4. doi: 10.1111/ijd.16178. Online ahead of print.

TH17 cells promote CNS inflammation by sensing danger signals via Mincle. Zhang Q, Liu W, Wang H, Zhou H, Bulek K, Chen X, Zhang CJ, Zhao J, Zhang R, Liu C, Kang Z, Bermel RA, Dubyak G, Abbott DW, Xiao TS, Nagy LE, Li X. Nat Commun. 2022 May 3;13(1):2406. doi: 10.1038/s41467-022-30174-1.

Clinicopathologic Features of Facial Dermatofibromas, a Cohort Study, and a Systematic Review of Literature. Alsawas M, Dundar B, Prokop L, Murad MH, Swick B. Am J Dermatopathol. 2022 Apr 27. doi: 10.1097/DAD.0000000000002211. Online ahead of print.

Week of May 3, 2022
Dual diagnosis of histiocytoid Sweet syndrome and anti-neutrophil cytoplasmic antibody-associated vasculitis. Jónsdóttir H, Sanders ML, Goettsche L, Honkanen I, Schwartz A, Holanda D, Stone MS, Jabbari A. JAAD Case Rep. 2022 Apr 1;23:117-119. doi: 10.1016/j.jdcr.2022.03.007. eCollection 2022 May.

Staphylococcus aureus detection from CF respiratory samples is improved using alternative media. Zirbes CF, Pitcher NJ, Davis JC, Bartels AR, Krogh JD, Teresi M, Farber T, Milavetz F, Pamatmat AJ, Rozen AL, Reinhardt LD, Boyken L, Singh SB, Twait E, Reeb VC, Ford BA, Fischer AJ. J Cyst Fibros. 2022 Apr 28:S1569-1993(22)00105-9. doi: 10.1016/j.jcf.2022.04.017. Online ahead of print.

Duodenal adenocarcinoma presenting as duodenal cystic dystrophy. Durham K, Zheng X, Bosch DE, Ashat M. Gastrointest Endosc. 2022 Apr 26:S0016-5107(22)00334-0. doi: 10.1016/j.gie.2022.04.021. Online ahead of print.

Multiple sclerosis patients have an altered gut mycobiome and increased fungal to bacterial richness. Yadav M, Ali S, Shrode RL, Shahi SK, Jensen SN, Hoang J, Cassidy S, Olalde H, Guseva N, Paullus M, Cherwin C, Wang K, Cho T, Kamholz J, Mangalam AK. PLoS One. 2022 Apr 26;17(4):e0264556. doi: 10.1371/journal.pone.0264556. eCollection 2022.

Week of April 26, 2022
Establishment of Novel Neuroendocrine Carcinoma Patient-Derived Xenograft Models for Receptor Peptide-Targeted Therapy. Tran CG, Borbon LC, Mudd JL, Abusada E, AghaAmiri S, Ghosh SC, Vargas SH, Li G, Beyer GV, McDonough M, Li R, Chan CHF, Walsh SA, Wadas TJ, O'Dorisio T, O'Dorisio MS, Govindan R, Cliften PF, Azhdarinia A, Bellizzi AM, Fields RC, Howe JR, Ear PH. Cancers (Basel). 2022 Apr 10;14(8):1910. doi: 10.3390/cancers14081910.

Ferret Lung Transplantation Models Differential Lymphoid Aggregate Morphology Between Restrictive and Obstructive Forms of Chronic Lung Allograft Dysfunction. Lynch TJ, Ahlers BA, Swatek AM, Ievlev V, Pai AC, Brooks L, Tang Y, Evans IA, Meyerholz DK, Engelhardt JF, Parekh KR. Transplantation. 2022 Apr 15. doi: 10.1097/TP.0000000000004148. Online ahead of print.

Histologic Features of Dermal Regeneration Template Identified in Mohs Layer Frozen Sections. McGuinness AE, Richey PM, Stone MS, Ferguson NN. Dermatol Surg. 2022 Feb 1;48(2):253-255. doi: 10.1097/DSS.0000000000003322.

Week of April 19, 2022
Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. J Biol Chem. 2022 Apr 13:101938. doi: 10.1016/j.jbc.2022.101938. Online ahead of print.

Publisher Correction: Tcf1 preprograms the mobilization of glycolysis in central memory CD8+ T cells during recall responses. Shan Q, Hu SS, Zhu S, Chen X, Badovinac VP, Peng W, Zang C, Xue HH. Nat Immunol. 2022 Apr 12. doi: 10.1038/s41590-022-01202-5. Online ahead of print.

Week of April 12, 2022
Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment. Borcherding N, Severson KJ, Henderson NT, Dos Santos Ortolan L, Rosenthal AC, Bellizzi AM, Liu V, Link BK, Mangold AR, Jabbari A. Blood Adv. 2022 Apr 7:bloodadvances.2021005991. doi: 10.1182/bloodadvances.2021005991. Online ahead of print.

The evolution of microtubule associated proteins - a reference proteomic perspective. Gottschalk AC, Hefti MM. BMC Genomics. 2022 Apr 6;23(1):266. doi: 10.1186/s12864-022-08502-y.

Commentary on White blood cell transfusions for control of infections in neutropenic patients by Vallejos C. (Transfusion 1975; 15(1):28-33). Strauss RG. Transfusion. 2022 Apr;62(4):731-739. doi: 10.1111/trf.16859.

Antibodies against biotin-labeled red blood cells can shorten posttransfusion survival. Mock DM, Stowell SR, Franco RS, Kyosseva SV, Nalbant D, Schmidt RL, Cress GA, Strauss RG, Cancelas JA, von Goetz M, North AK, Widness JA. Transfusion. 2022 Apr;62(4):770-782. doi: 10.1111/trf.16849. Epub 2022 Mar 11.

Cross-sectional Neuromuscular Phenotyping Study of Patients With Arhinia With SMCHD1 Variants. Mohassel P, Chang N, Inoue K, Delaney A, Hu Y, Donkervoort S, Saade D, Billioux BJ, Meader B, Volochayev R, Konersman CG, Kaindl AM, Cho CH, Russell B, Rodriguez A, Foster KW, Foley AR, Moore SA, Jones PL, Bonnemann CG, Jones T, Shaw ND. Neurology. 2022 Mar 29;98(13):e1384-e1396. doi: 10.1212/WNL.0000000000200032. Epub 2022 Feb 4.

National Kidney Foundation Laboratory Engagement Working Group Recommendations for Implementing the CKD-EPI 2021 Race-Free Equations for Estimated Glomerular Filtration Rate: Practical Guidance for Clinical Laboratories. Miller WG, Kaufman HW, Levey AS, Straseski JA, Wilhelms KW, Yu HE, Klutts JS, Hilborne LH, Horowitz GL, Lieske J, Ennis JL, Bowling JL, Lewis MJ, Montgomery E, Vassalotti JA, Inker LA. Clin Chem. 2022 Mar 31;68(4):511-520. doi: 10.1093/clinchem/hvab278.

Renal Infarction in a Patient Found to Have a Dysproteinemia. Patel J, Holman CJ, Fraer M. Kidney360. 2020 Nov 25;1(11):1332-1333. doi: 10.34067/KID.0003082020. eCollection 2020 Nov 25.

Week of April 4, 2022
Comparison of Interleukin-1 Ligand Expression by Human Papilloma Virus Status in HNSCCs. Khan IN, Gibson-Corley KN, Coppock JD, Simons AL. Head Neck Pathol. 2022 Mar 25. doi: 10.1007/s12105-022-01440-x. Online ahead of print.

Plasma Neurofilament Light and Glial Fibrillary Acidic Protein Levels over 30 days in a Porcine Model of Traumatic Brain Injury. Shin S, Hefti MM, Mazandi VM, Issadore DA, Meaney D, Christman Schneider ALLC, Diaz-Arrastia R, Kilbaugh TJ. J Neurotrauma. 2022 Apr 4. doi: 10.1089/neu.2022.0070. Online ahead of print.

Centrizonal hepatocyte dropout in allograft liver biopsies: a clinicopathological study. Bosch DE, Swanson PE, Yeh MM. Histopathology. 2022 Mar;80(4):708-719. doi: 10.1111/his.14606. Epub 2022 Feb 7.

Week of March 29, 2022
Suspected Fanconi syndrome from cadmium toxicity exacerbated by heavy kratom use. A rare occurrence. Sekar A, Katzman S, O'Donnell M, Velani S, Conway KS. Clin Toxicol (Phila). 2022 Mar 24:1-2. doi: 10.1080/15563650.2022.2046774. Online ahead of print.

Eicosanoid signaling blockade protects middle-aged mice from severe COVID-19. Wong LR, Zheng J, Wilhelmsen K, Li K, Ortiz ME, Schnicker NJ, Thurman A, Pezzulo AA, Szachowicz PJ, Li P, Pan R, Klumpp K, Aswad F, Rebo J, Narumiya S, Murakami M, Zuniga S, Sola I, Enjuanes L, Meyerholz DK, Fortney K, McCray PB Jr, Perlman S. Nature. 2022 Mar 21. doi: 10.1038/s41586-022-04630-3. Online ahead of print.

Week of March 22, 2022
Case Report: Clinical and Pathological Findings of a Recurrent C3 Glomerulopathy With Superimposed Membranoproliferative Glomerulonephritis Pattern and Cryoglobulinemia Associated With COVID-19. Daneshgar N, Liang PI, Michels CJ, Nester CM, Harshman LA, Dai DF. Front Pediatr. 2022 Mar 4;10:827466. doi: 10.3389/fped.2022.827466. eCollection 2022.

Molecular Pathology Education: A Suggested Framework for Primary Care Resident Training in Genomic Medicine: A Report of the Association for Molecular Pathology Training and Education Committee. Arcila ME, Snow AN, Akkari YMN, Chabot-Richards D, Pancholi P, Tafe LJ. J Mol Diagn. 2022 Mar 15:S1525-1578(22)00064-2. doi: 10.1016/j.jmoldx.2021.12.013. Online ahead of print.

Oxidation of ferumoxytol by ionizing radiation releases iron. An electron paramagnetic resonance study. Petronek MS, Spitz DR, Buettner GR, Allen BG. J Radiat Res. 2022 Mar 17:rrac008. doi: 10.1093/jrr/rrac008. Online ahead of print.

Not All Küttner Tumors Are IgG4-Related Disease (IgG4-RD). Marcus KS, Hoffman HT, Rajan Kd A. Head Neck Pathol. 2021 Dec;15(4):1322-1327. doi: 10.1007/s12105-020-01268-3. Epub 2021 Jan 4.

Week of March 15, 2022
Tumor to Tumor Metastasis: A Case Report of Metastatic Angiosarcoma to an Ovarian Brenner Tumor and Review of the Literature. Dundar B, Alrwashdeh A, Dahmoush L. Int J Gynecol Pathol. 2022 Mar 11. doi: 10.1097/PGP.0000000000000854. Online ahead of print.

Clinical Images: Extranodal Natural Killer/T Cell Lymphoma As a Rare Mimicker of Granulomatosis With Polyangiitis. Strouse J, Rajan A, Chang HB, Dimachkie MD, Halbur C, Bettendorf B. Arthritis Rheumatol. 2022 Mar;74(3):474. doi: 10.1002/art.41956. Epub 2022 Jan 12.

Advancing Diagnostic Stewardship for Healthcare-Associated Infections, Antibiotic Resistance, and Sepsis. Curren EJ, Lutgring JD, Kabbani S, Diekema DJ, Gitterman S, Lautenbach E, Morgan DJ, Rock C, Salerno RM, McDonald LC. Clin Infect Dis. 2022 Mar 1;74(4):723-728. doi: 10.1093/cid/ciab672.

Week of March 8, 2022
Potential Role of MANF, an ER Stress Responsive Neurotrophic Factor, in Protecting Against Alcohol Neurotoxicity. Wen W, Li H, Luo J. Mol Neurobiol. 2022 Mar 7. doi: 10.1007/s12035-022-02786-7. Online ahead of print.

Evaluation of Rezafungin Provisional CLSI Clinical Breakpoints and Epidemiological Cutoff Values Tested against a Worldwide Collection of Contemporaneous Invasive Fungal Isolates (2019 to 2020). Carvalhaes CG, Klauer AL, Rhomberg PR, Pfaller MA, Castanheira M. J Clin Microbiol. 2022 Mar 7:e0244921. doi: 10.1128/jcm.02449-21. Online ahead of print.

Hemolytic disease of the fetus and newborn in the sensitizing pregnancy where anti-D was incorrectly identified as RhIG. Walhof ML, Leon J, Greiner AL, Scott JR, Knudson CM. J Clin Lab Anal. 2022 Mar 3:e24323. doi: 10.1002/jcla.24323. Online ahead of print.

Impact of Interfacing Near Point of Care Clinical Chemistry and Hematology Analyzers at Urgent Care Clinics at an Academic Health System. Fleishhacker ZJ, Rastogi P, Davis SR, Aman DR, Morris CS, Dyson RL, Krasowski MD. J Pathol Inform. 2022 Jan 20;13:100006. doi: 10.1016/j.jpi.2022.100006. eCollection 2022.

Extra-articular tophaceous gout of the Achilles tendon mimicking infection. Chen BC, Chen SJT, Duchman KR, Sekar P. BMJ Case Rep. 2022 Mar 2;15(3):e247647. doi: 10.1136/bcr-2021-247647.

A Single-Cell Atlas of Large and Small Airways at Birth in a Porcine Model of Cystic Fibrosis. Thurman AL, Li X, Villacreses R, Yu W, Gong H, Mather SE, Romano-Ibarra GS, Meyerholz DK, Stoltz DA, Welsh MJ, Thornell IM, Zabner J, Pezzulo AA. Am J Respir Cell Mol Biol. 2022 Mar 2. doi: 10.1165/rcmb.2021-0499OC. Online ahead of print.

Deficiency of mesencephalic astrocyte-derived neurotrophic factor affects neurogenesis in mouse brain. Wang Y, Wen W, Li H, Xu H, Xu M, Ma M, Luo J. Brain Res Bull. 2022 Feb 25;183:49-56. doi: 10.1016/j.brainresbull.2022.02.019. Online ahead of print.

Week of March 1, 2022
Genomic Profiling of Metastatic Uveal Melanoma Shows Frequent Coexisting BAP1 or SF3B1 and GNAQ/GNA11 Mutations and Correlation With Prognosis. Isaacson AL, Sompallae RR, Guseva NV, Bellizzi AM, Bossler AD, Ma D. Am J Clin Pathol. 2022 Feb 25:aqac019. doi: 10.1093/ajcp/aqac019. Online ahead of print.

Tcf1 preprograms the mobilization of glycolysis in central memory CD8+ T cells during recall responses. Shan Q, Hu SS, Zhu S, Chen X, Badovinac VP, Peng W, Zang C, Xue HH. Nat Immunol. 2022 Feb 21. doi: 10.1038/s41590-022-01131-3. Online ahead of print.

Coronavirus disease 2019 (COVID-19) research agenda for healthcare epidemiology. Mody L, Akinboyo IC, Babcock HM, Bischoff WE, Cheng VC, Chiotos K, Claeys KC, Coffey KC, Diekema DJ, Donskey CJ, Ellingson KD, Gilmartin HM, Gohil SK, Harris AD, Keller SC, Klein EY, Krein SL, Kwon JH, Lauring AS, Livorsi DJ, Lofgren ET, Merrill K, Milstone AM, Monsees EA, Morgan DJ, Perri LP, Pfeiffer CD, Rock C, Saint S, Sickbert-Bennett E, Skelton F, Suda KJ, Talbot TR, Vaughn VM, Weber DJ, Wiemken TL, Yassin MH, Ziegler MJ, Anderson DJ; SHEA Research Committee. Infect Control Hosp Epidemiol. 2022 Feb;43(2):156-166. doi: 10.1017/ice.2021.25. Epub 2021 Jan 25.

A Dramatic Presentation of Immune-Mediated Necrotizing Myopathy. Diel RJ, Hannah CE, Moore SA, Bettendorf B. J Clin Rheumatol. 2021 Dec 1;27(8S):S817-S818. doi: 10.1097/RHU.0000000000001443.

Week of February 22, 2022
Intron Mutations and Early Transcription Termination in Duchenne and Becker muscular dystrophy. Waldrop MA, Moore SA, Mathews KD, Darbro BW, Medne L, Finkel R, Connolly AM, Crawford TO, Drachman D, Wein N, Habib AA, Krzesniak-Swinarska MA, Zaidman CM, Collins JJ, Jokela M, Udd B, Day JW, Ortiz-Guerrero G, Statland J, Butterfield RJ, Dunn DM, Weiss RB, Flanigan KM. Hum Mutat. 2022 Feb 14. doi: 10.1002/humu.24343. Online ahead of print.

Association of ABO Blood Group, Age, Body Mass Index and Symptomatic COVID-19 Infection with Signal Levels of Antibodies to COVID-19. Maxwell T, Wendt L, Castaneda C, Marsden K, Merrill AE, Swartz SR, Steffen HA, Johnson A, Ten Eyck P, Kenne KA, Rysavy MB, Jackson JB. Gynecol Reprod Health. 2022; 6(1): 1-5.

Week of February 15, 2022
Use of a transnasal flexible laryngoscope tip for laryngeal culturing: A novel in-office technique. Michael A, Vesole AS, Diekema DJ, Stegall H, Hoffman HT. Laryngoscope Investig Otolaryngol. 2021 Dec 7;7(1):197-201. doi: 10.1002/lio2.712. eCollection 2022 Feb.

The inflammatory pathology of dysferlinopathy is distinct from calpainopathy, Becker muscular dystrophy, and inflammatory myopathies. Becker N, Moore SA, Jones KA. Acta Neuropathol Commun. 2022 Feb 8;10(1):17. doi: 10.1186/s40478-022-01320-z.

Posterior Embryotoxon Revisited: An Immunohistologic Study. Alwadani S, Alward WLM, Syed NA, Bouhenni RA, Brownstein S, Edward DP. Ophthalmol Glaucoma. 2022 Feb 4:S2589-4196(22)00018-7. doi: 10.1016/j.ogla.2022.01.003. Online ahead of print.

Perfusion with 10% neutral-buffered formalin is equivalent to 4% paraformaldehyde for histopathology and immunohistochemistry in a mouse model of experimental autoimmune encephalomyelitis. Snyder JM, Radaelli E, Goeken A, Businga T, Boyden AW, Karandikar NJ, Gibson-Corley KN. Vet Pathol. 2022 Feb 7:3009858221075588. doi: 10.1177/03009858221075588. Online ahead of print.

A Curriculum for Genomic Education of Molecular Genetic Pathology Fellows: A Report of the Association for Molecular Pathology Training and Education Committee. Rosenbaum JN, Berry AB, Church AJ, Crooks K, Gagan JR, López-Terrada D, Pfeifer JD, Rennert H, Schrijver I, Snow AN, Wu D, Ewalt MD. J Mol Diagn. 2021 Oct;23(10):1218-1240. doi: 10.1016/j.jmoldx.2021.07.001. Epub 2021 Jul 7.

Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria. Mishra A, Liu S, Promes J, Harata M, Sivitz W, Fink B, Bhardwaj G, O'Neill BT, Kang C, Sah R, Strack S, Stephens S, King T, Jackson L, Greenberg AS, Anokye-Danso F, Ahima RS, Ankrum J, Imai Y. JCI Insight. 2021 May 10;6(9):e144341. doi: 10.1172/jci.insight.144341.

Week of February 8, 2022
Cross-sectional, Neuromuscular Phenotyping Study of Arhinia Patients With SMCHD1 Variants. Mohassel P, Chang N, Inoue K, Delaney A, Hu Y, Donkervoort S, Saade D, Billioux BJ, Meader B, Volochayev R, Konersman CG, Kaindl AM, Cho CH, Russell B, Rodriguez A, Foster KW, Foley AR, Moore SA, Jones PL, Bonnemann CG, Jones T, Shaw ND. Neurology. 2022 Feb 4:10.1212/WNL.0000000000200032. doi: 10.1212/WNL.0000000000200032. Online ahead of print.

Attenuation of actinic prurigo eruptions with Polypodium leucotomos supplementation. Stump M, Dhinsa H, Powers J, Stone M. Pediatr Dermatol. 2022 Jan;39(1):145-146. doi: 10.1111/pde.14876. Epub 2021 Dec 9.

WDR26 and MTF2 are therapeutic targets in multiple myeloma. Sun F, Cheng Y, Riordan JD, Dupuy A, Dubois W, Pisano M, Dong J, Mock B, Zhan F, Hari P, Janz S. J Hematol Oncol. 2021 Dec 7;14(1):203. doi: 10.1186/s13045-021-01217-9.

Prevalence of Running as Aerobic Exercise among Students in a College of Medicine. Kallner K, Wendt L, Spring J, Jackson JB. J Medic Educ Training 2021; 5:069.

Week of February 1, 2022
Limited Variation between SARS-CoV-2-Infected Individuals in Domain Specificity and Relative Potency of the Antibody Response against the Spike Glycoprotein. Van Ert HA, Bohan DW, Rogers K, Fili M, Rojas Chávez RA, Qing E, Han C, Dempewolf S, Hu G, Schwery N, Sevcik K, Ruggio N, Boyt D, Pentella MA, Gallagher T, Jackson JB, Merrill AE, Knudson CM, Brown GD, Maury W, Haim H. Microbiol Spectr. 2022 Jan 26:e0267621. doi: 10.1128/spectrum.02676-21. Online ahead of print.

Quantum chemical insight into the effects of the local electron environment on T2*-based MRI. Petronek MS, St-Aubin JJ, Lee CY, Spitz DR, Gillan EG, Allen BG, Magnotta VA. Sci Rep. 2021 Oct 21;11(1):20817. doi: 10.1038/s41598-021-00305-7.

Ectopic Tcf1 expression instills a stem-like program in exhausted CD8+ T cells to enhance viral and tumor immunity. Shan Q, Hu S, Chen X, Danahy DB, Badovinac VP, Zang C, Xue HH. Cell Mol Immunol. 2021 May;18(5):1262-1277. doi: 10.1038/s41423-020-0436-5. Epub 2020 Apr 27

Week of January 25, 2022
Role of microbiome and metabolome in the pathobiology of MS. Mangalam AK, Giri S. Clin Immunol. 2022 Jan 20:108934. doi: 10.1016/j.clim.2022.108934. Online ahead of print.

Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis. Li H, Wen W, Luo J. Biomedicines. 2022 Jan 5;10(1):108. doi: 10.3390/biomedicines10010108.

Elderly versus nonelderly patients with invasive fungal infections: species distribution and antifungal resistance, SENTRY antifungal surveillance program 2017-2019. Pfaller MA, Carvalhaes CG, DeVries S, Huband MD, Castanheira M. Diagn Microbiol Infect Dis. 2021 Dec 24;102(4):115627. doi: 10.1016/j.diagmicrobio.2021.115627. Online ahead of print.

Implementation and assessment of an effective, novel, student-centered, remotely accessible, dermatology education program: A prospective cohort study. Poggemiller AM, Kreiter C, Naridze R, Melrose E, Fenton P, Wanat KA, Liu V. J Am Acad Dermatol. 2021 Dec;85(6):1645-1647. doi: 10.1016/j.jaad.2021.01.011. Epub 2021 Jan 8.

Induction and maintenance of remission with mycophenolate mofetil in ANCA-associated vasculitis: A systematic review and meta-analysis. Berti A, Alsawas M, Jawaid T, Prokop LJ, Lee JM, Jeong GH, Quintana LF, Moiseev S, Vaglio A, Tesar V, Geetha D, Shin JI, Kronbichler A. Nephrol Dial Transplant. 2021 Dec 15:gfab357. doi: 10.1093/ndt/gfab357. Epub ahead of print. 

Week of January 18, 2022
Data on the frequency and causes of icteric interference in clinical chemistry laboratory tests. Merrill AE, Mainali S, Krasowski MD. Data Brief. 2021 Dec 30;40:107771. doi: 10.1016/j.dib.2021.107771. eCollection 2022 Feb.

Novel Mouse Model of Murine Cytomegalovirus-Induced Adaptive NK Cells. Jensen IJ, Martin MD, Tripathy SK, Badovinac VP. Immunohorizons. 2022 Jan 14;6(1):8-15. doi: 10.4049/immunohorizons.2100113.

Respiratory Syncytial Virus Provides Protection against a Subsequent Influenza A Virus Infection. Hartwig SM, Miller AM, Varga SM. J Immunol. 2022 Jan 12:ji2000751. doi: 10.4049/jimmunol.2000751. Online ahead of print.

Oral estrogen leads to falsely low concentrations of estradiol in a common immunoassay. Cirrincione LR, Crews BO, Dickerson JA, Krasowski MD, Rongitsch J, Imborek KL, Goldstein Z, Greene DN. Endocr Connect. 2022 Jan 1:EC-21-0550.R1. doi: 10.1530/EC-21-0550. Online ahead of print.

Skeletal Muscle Regeneration: A Potential Histologic Pitfall for the Mohs Surgeon. Richey PM, Patrick AP, Swick BL, Van Beek MJ. Dermatol Surg. 2022 Jan 5. doi: 10.1097/DSS.0000000000003372. Online ahead of print.

Week of January 11, 2022
Implementation of large-scale laboratory-based detection of COVID-19 in the Veterans Health Administration, March 2020 - February 2021. Sharma A, Oda G, Icardi M, Mole L, Holodniy M. Diagn Microbiol Infect Dis. 2021 Dec 11;102(3):115617. doi: 10.1016/j.diagmicrobio.2021.115617. Online ahead of print.

Impact of COVID-19 on an infection prevention and control program, Iowa 2020-2021. Alsuhaibani M, Kobayashi T, McPherson C, Holley S, Marra AR, Trannel A, Dains A, Abosi OJ, Jenn KE, Meacham H, Sheeler L, Etienne W, Kukla ME, Wellington M, Edmond MB, Diekema DJ, Salinas JL. Am J Infect Control. 2021 Dec 23:S0196-6553(21)00763-X. doi: 10.1016/j.ajic.2021.11.015. Online ahead of print.

Medullary Serotonergic Binding Deficits and Hippocampal Abnormalities in Sudden Infant Death Syndrome: One or Two Entities? Haynes RL, Kinney HC, Haas EA, Duncan JR, Riehs M, Trachtenberg F, Armstrong DD, Alexandrescu S, Cryan JB, Hefti MM, Krous HF, Goldstein RD, Sleeper LA. Front Pediatr. 2021 Dec 21;9:762017. doi: 10.3389/fped.2021.762017. eCollection 2021.

Administration of Human Derived Upper gut Commensal Prevotella histicola delays the onset of type 1 diabetes in NOD mice. Marietta E, Horwath I, Meyer S, Khaleghi-Rostamkolaei S, Norman E, Luckey D, Balakrishnan B, Mangalam A, Choung RS, Taneja V, Murray JA. BMC Microbiol. 2022 Jan 4;22(1):8. doi: 10.1186/s12866-021-02406-9.

Antifungal drugs work together to treat germs causing fungal infections. Pfaller MA, Messer SA, Deshpande LM, Rhomberg PR, Utt EA, Castanheira M. Future Microbiol. 2021 Jul;16:765-768. doi: 10.2217/fmb-2021-0086. Epub 2021 Jun 29.

Week of January 4, 2022
Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits. Cooper TK, Meyerholz DK, Beck AP, Delaney MA, Piersigilli A, Southard TL, Brayton CF. ILAR J. 2022 Jan 4:ilab022. doi: 10.1093/ilar/ilab022. Online ahead of print.

COVID-19-associated necrotizing encephalopathy presenting without active respiratory symptoms: a case report with histopathology. Rettenmaier LA, Abdel-Wahed L, Abdelmotilib H, Conway KS, Narayanan N, Groth CL. J Neurovirol. 2021 Dec 30:1-5. doi: 10.1007/s13365-021-01042-3. Online ahead of print.

Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease. Aggarwal N, Deerhake ME, DiPalma D, Shahi SK, Gaggioli MR, Mangalam AK, Shinohara ML. Cell Rep. 2021 Dec 28;37(13):110170. doi: 10.1016/j.celrep.2021.110170.

Identification of HnRNPC as a novel Tau exon 10 splicing factor using RNA antisense purification mass spectrometry. Xing S, Wang J, Wu R, Hefti MM, Crary JF, Lu Y. RNA Biol. 2021 Dec 29:1-13. doi: 10.1080/15476286.2021.2015175. Online ahead of print.

The Neuropathology of 1p36 Deletion Syndrome: An Autopsy Case Series. Conway KS, Ghafoor F, Gottschalk AC, Laakman J, Eigsti RL, Nashelsky M, Blau J, Hefti MM. J Neuropathol Exp Neurol. 2021 Sep 27;80(9):856-860. doi: 10.1093/jnen/nlab072.

Genomic Analysis of Vascular Invasion in HCC Reveals Molecular Drivers and Predictive Biomarkers. Krishnan MS, Rajan Kd A, Park J, Arjunan V, Garcia Marques FJ, Bermudez A, Girvan OA, Hoang NS, Yin J, Nguyen MH, Kothary N, Pitteri S, Felsher DW, Dhanasekaran R. Hepatology. 2021 Jun;73(6):2342-2360. doi: 10.1002/hep.31614. Epub 2021 May 8.

Week of December 28, 2021
Elamipretide treatment during pregnancy ameliorates the progression of polycystic kidney disease in maternal and neonatal mice with PKD1 mutations. Daneshgar N, Liang PI, Lan RS, Horstmann M, Pack L, Bhardwaj G, Penniman CM, O'Neill BT, Dai DF. Kidney Int. 2021 Dec 22:S0085-2538(21)01164-9. doi: 10.1016/j.kint.2021.12.006. Online ahead of print.

Catalase Overexpression Drives an Aggressive Phenotype in Glioblastoma. Flor S, Oliva CR, Ali MY, Coleman KL, Greenlee JD, Jones KA, Monga V, Griguer CE. Antioxidants (Basel). 2021 Dec 14;10(12):1988. doi: 10.3390/antiox10121988.

A Recursive Partitioning Analysis Demonstrating Risk Subsets for 8-Year Biochemical Relapse After Margin-Positive Radical Prostatectomy Without Adjuvant Hormone or Radiation Therapy. Seyedin SN, Watkins JM, Mayo Z, Snow AN, Laszewski M, Russo JK, Mott SL, Tracy CR, Smith MC, Buatti JM, Caster JM. Adv Radiat Oncol. 2021 Aug 14;6(6):100778. doi: 10.1016/j.adro.2021.100778. eCollection 2021 Nov-Dec.

Metallothionein immunohistochemistry has high sensitivity and specificity for detection of Wilson disease. Rowan DJ, Mangalaparthi KK, Singh S, Moreira RK, Mounajjed T, Lamps L, Westerhoff M, Cheng J, Bellizzi AM, Allende DS, Pandey A, Graham RP. Mod Pathol. 2021 Dec 21. doi: 10.1038/s41379-021-01001-7. Online ahead of print.

Week of December 21, 2021
In vitro activity of a novel aminomethylcycline antibacterial (KBP-7072), a third-generation tetracycline, against clinical isolates with molecularly characterized tetracycline resistance mechanisms. Pfaller MA, Li L, Liu Q, Zhang J, Huband MD, Lindley JM, Mendes RE. JAC Antimicrob Resist. 2021 Dec 14;3(4):dlab177. doi: 10.1093/jacamr/dlab177. eCollection 2021 Dec.

Days of Antibiotic Spectrum Coverage (DASC): A Novel Metric for Inpatient Antibiotic Consumption. Kakiuchi S, Livorsi DJ, Perencevich EN, Diekema DJ, Ince D, Prasidthrathsint K, Kinn P, Percival K, Heintz BH, Goto M. Clin Infect Dis. 2021 Dec 15:ciab1034. doi: 10.1093/cid/ciab1034. Online ahead of print.

Ceftolozane-tazobactam activity against clinical isolates of Pseudomonas aeruginosa from ICU patients with pneumonia: United States, 2015-2018. Pfaller MA, Shortridge D, Harris KA, Garrison MW, DeRyke CA, DePestel DD, Moise PA, Sader HS. Int J Infect Dis. 2021 Nov;112:321-326. doi: 10.1016/j.ijid.2021.09.064. Epub 2021 Sep 29.

Week of December 14, 2021
Analysis of entire hepatitis B virus genomes reveals reversion of mutations to wild type in natural infection, a 15 year follow-up study. Chen QY, Jia HH, Wang XY, Shi YL, Zhang LJ, Hu LP, Wang C, He X, Harrison TJ, Jackson JB, Wu L, Fang ZL.Infect Genet Evol. 2021 Dec 10:105184. doi: 10.1016/j.meegid.2021.105184. Online ahead of print.

Paraneoplastic erythema annulare centrifugum associated with mycosis fungoides. Thompson HJ, King BJ, Link B, Liu V. JAAD Case Rep. 2021 Oct 5;17:65-68. doi: 10.1016/j.jdcr.2021.09.027. eCollection 2021 Nov.

DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium. Yamanashi T, Nagao T, Wahba NE, Marra PS, Crutchley KJ, Meyer AA, Andreasen AJ, Hellman MM, Jellison SS, Hughes CG, Pandharipande PP, Howard Iii MA, Kawasaki H, Iwata M, Hefti MM, Shinozaki G.Transl Psychiatry. 2021 Dec 9;11(1):627. doi: 10.1038/s41398-021-01752-6.

Data on the utilization of paraneoplastic syndrome autoantibody testing at an academic medical center. Krasowski MD, Dolezal A, Steussy BW, Gailey MP, Darbro BW.Data Brief. 2021 Nov 18;39:107578. doi: 10.1016/j.dib.2021.107578. eCollection 2021 Dec.

Week of December 7, 2021
Using nasal povidone-iodine to prevent bloodstream infections and transmission of Staphylococcus aureus among haemodialysis patients: a stepped-wedge cluster randomised control trial protocol. Racila AM, O'Shea AMJ, Nair R, Dukes K, Herwaldt LA, Boyken L, Diekema D, Ward MA, Cobb J, Jacob J, Pegues D, Bleasdale S, Vijayan A, Mutneja A, Fraer M, O'Connell-Moore D, Tolomeo P, Mendez M, Jaworski E, Schweizer ML. BMJ Open. 2021 Dec 3;11(12):e048830. doi: 10.1136/bmjopen-2021-048830.

SARS-CoV-2 antibody changes in patients receiving COVID-19 convalescent plasma from normal and vaccinated donors. Leon J, Merrill AE, Rogers K, Kurt J, Dempewolf S, Ehlers A, Jackson JB, Knudson CM. Transfus Apher Sci. 2021 Nov 23:103326. doi: 10.1016/j.transci.2021.103326. Online ahead of print.

The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice. Simonsen D, Cady N, Zhang C, Shrode RL, McCormick ML, Spitz DR, Chimenti MS, Wang K, Mangalam A, Lehmler HJ. Toxicol Sci. 2021 Nov 29:kfab142. doi: 10.1093/toxsci/kfab142. Online ahead of print.

Optimal Urine Culture Diagnostic Stewardship Practice- Results from an Expert Modified-Delphi Procedure. Claeys KC, Trautner BW, Leekha S, Coffey KC, Crnich CJ, Diekema D, Fakih MG, Goetz MB, Gupta K, Jones MM, Leykum L, Liang SY, Pineles L, Pleiss A, Spivak ES, Suda KJ, Taylor J, Rhee C, Morgan DJ. Clin Infect Dis. 2021 Nov 29:ciab987. doi: 10.1093/cid/ciab987. Online ahead of print.

Week of November 30, 2021
Centrizonal hepatocyte dropout in allograft liver biopsies: A clinicopathologic study. Bosch DE, Swanson PE, Yeh MM. Histopathology. 2021 Nov 29. doi: 10.1111/his.14606. Online ahead of print.

Molecular Pathology Education: An AMP Webinar Series on Emerging and Evolving Biomarkers Structured for Specific Audiences. Barker LP, Ritterhouse LL, Snow AN, Davies KD. J Mol Diagn. 2021 Nov 24:S1525-1578(21)00389-5. doi: 10.1016/j.jmoldx.2021.11.003. Online ahead of print.

Meningitis Caused by the Live Varicella Vaccine Virus: Metagenomic Next Generation Sequencing, Immunology Exome Sequencing and Cytokine Multiplex Profiling. Ramachandran PS, Wilson MR, Catho G, Blanchard-Rohner G, Schiess N, Cohrs RJ, Boutolleau D, Burrel S, Yoshikawa T, Wapniarski A, Heusel EH, Carpenter JE, Jackson W, Ford BA, Grose C. Viruses. 2021 Nov 16;13(11):2286. doi: 10.3390/v13112286.

Data on the relationship between lamotrigine and levetiracetam serum/plasma levels and toxicity: Experience at an academic medical center. Wood KE, Palmer KL, Krasowski MD. Data Brief. 2021 Nov 8;39:107555. doi: 10.1016/j.dib.2021.107555. eCollection 2021 Dec.

Data on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center. Chopra S, Krasowski MD. Data Brief. 2021 Nov 6;39:107549. doi: 10.1016/j.dib.2021.107549. eCollection 2021 Dec.

Week of November 23, 2021
Influence of SARS-CoV-2 on airway mucus production: A review and proposed model. Meyerholz DK, Reznikov LR. Vet Pathol. 2021 Nov 18:3009858211058837. doi: 10.1177/03009858211058837. Online ahead of print.

An elderly man with bilateral cavitary lesions in the globus pallidus. Halvorson TS, Stauffer SL, Jones KA. Brain Pathol. 2021 Nov 16:e13025. doi: 10.1111/bpa.13025. Online ahead of print.

Week of November 16, 2021
Surveillance of omadacycline activity tested against clinical isolates from the United States: Report from the SENTRY Antimicrobial Surveillance Program, 2019: Omadacycline 2019 Surveillance - USA. Pfaller MA, Huband MD, Shortridge D, Flamm RK. J Glob Antimicrob Resist. 2021 Nov 11:S2213-7165(21)00235-6. doi: 10.1016/j.jgar.2021.09.011. Online ahead of print.

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Sugiura A, Andrejeva G, Voss K, Heintzman DR, Xu X, Madden MZ, Ye X, Beier KL, Chowdhury NU, Wolf MM, Young AC, Greenwood DL, Sewell AE, Shahi SK, Freedman SN, Cameron AM, Foerch P, Bourne T, Garcia-Canaveras JC, Karijolich J, Newcomb DC, Mangalam AK, Rabinowitz JD, Rathmell JC. Immunity. 2021 Nov 3:S1074-7613(21)00448-9. doi: 10.1016/j.immuni.2021.10.011. Online ahead of print.

Neutrophilic inflammation in gallbladder carcinoma correlates with patient survival: A case-control study. Bosch DE, Salipante SJ, Schmidt RA, Swanson PE, Bryan A, SenGupta DJ, Truong CD, Yeh MM. Ann Diagn Pathol. 2021 Oct 30;56:151845. doi: 10.1016/j.anndiagpath.2021.151845. Online ahead of print.

Frequency of icteric interference in clinical chemistry laboratory tests and causes of severe icterus. Mainali S, Merrill AE, Krasowski MD. Pract Lab Med. 2021 Oct 23;27:e00259. doi: 10.1016/j.plabm.2021.e00259. eCollection 2021 Nov.

Week of November 9, 2021
Ultrasound and Sialogram Correlates to Parotid Immunoglobulin G4-Related Disease. Moore AE, Marcus KS, Rajan Kd A, Maley JE, Hoffman HT. Ear Nose Throat J. 2021 Nov 3:1455613211051651. doi: 10.1177/01455613211051651. Online ahead of print.

Mice with diverse microbial exposure histories as a model for preclinical vaccine testing. Fiege JK, Block KE, Pierson MJ, Nanda H, Shepherd FK, Mickelson CK, Stolley JM, Matchett WE, Wijeyesinghe S, Meyerholz DK, Vezys V, Shen SS, Hamilton SE, Masopust D, Langlois RA. Cell Host Microbe. 2021 Oct 27:S1931-3128(21)00463-7. doi: 10.1016/j.chom.2021.10.001. Online ahead of print.

Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Lefebvre MN, Surette FA, Anthony SM, Vijay R, Jensen IJ, Pewe LL, Hancox LS, Van Braeckel-Budimir N, van de Wall S, Urban SL, Mix MR, Kurup SP, Badovinac VP, Butler NS, Harty JT. Cell Rep. 2021 Nov 2;37(5):109956. doi: 10.1016/j.celrep.2021.109956.

Week of November 2, 2021
Genome-wide association study and functional validation implicates JADE1 in tauopathy. Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF. Acta Neuropathol. 2021 Nov 1. doi: 10.1007/s00401-021-02379-z. Online ahead of print.

Cutting Edge: Subunit Booster Vaccination Confers Sterilizing Immunity against Liver-Stage Malaria in Mice Initially Primed with a Weight-Normalized Dose of Radiation-Attenuated Sporozoites. Lefebvre MN, Drewry LL, Pewe LL, Hancox LS, Reyes-Sandoval A, Harty JT. J Immunol. 2021 Oct 29:ji2100818. doi: 10.4049/jimmunol.2100818. Online ahead of print.

Autoimmunity Increases Susceptibility to and Mortality from Sepsis. Jensen IJ, Jensen SN, McGonagill PW, Griffith TS, Mangalam AK, Badovinac VP. Immunohorizons. 2021 Oct 26;5(10):844-854. doi: 10.4049/immunohorizons.2100070.

Pharmacologic Ascorbate Enhances the Therapeutic Index of ATM-Inhibitor Based Chemoradiation for Colorectal Cancer. Callaghan CM, Abukhiran I, VanRheeden R, Ali MY, Petronek MS, Mapuskar KA, Seyedin SN, Kalen AL, Rodman S, Cullen JJ, Coleman M, Goswami P, Buatti J, Spitz DR Jr, Allen BG, Caster JM. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):S56. doi: 10.1016/j.ijrobp.2021.07.144.

Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome. Tang J, Xiao Y, Lin G, Guo H, Deng HX, Tu S, Langdon WY, Yang H, Tao L, Li Y, Pope RM, Gupta N, Zhang J. Sci Signal. 2021 Oct 26;14(706):eabe3410. doi: 10.1126/scisignal.abe3410. Epub 2021 Oct 26.

Week of October 26, 2021
Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets. Maharjan CK, Ear PH, Tran CG, Howe JR, Chandrasekharan C, Quelle DE. Cancers (Basel). 2021 Oct 12;13(20):5117. doi: 10.3390/cancers13205117.

ASO Visual Abstract: Management of Duodenal Neuroendocrine Tumors-Surgical Versus Endoscopic Mucosal Resection. Tran CG, Sherman SK, Suraju MO, Nayyar A, Gerke H, El Abiad RG, Chandrasekharan C, Ear PH, O'Dorisio TM, Dillon JS, Bellizzi AM, Howe JR. Ann Surg Oncol. 2021 Oct 20. doi: 10.1245/s10434-021-10852-y. Online ahead of print.

Recent Advances of WEE1 Inhibitors and Statins in Cancers With p53 Mutations. Meng X, Gao JZ, Gomendoza SMT, Li JW, Yang S. Front Med (Lausanne). 2021 Oct 4;8:737951. doi: 10.3389/fmed.2021.737951. eCollection 2021.

Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants. Daneshgar N, Baguley AW, Liang PI, Wu F, Chu Y, Kinter MT, Benavides GA, Johnson MS, Darley-Usmar V, Zhang J, Chan KS, Dai DF. Commun Biol. 2021 Oct 20;4(1):1200. doi: 10.1038/s42003-021-02730-w.

Antimicrobial activity of manogepix, a first-in-class antifungal, and comparator agents tested against contemporary invasive fungal isolates from an international surveillance programme (2018-2019). Pfaller MA, Huband MD, Flamm RK, Bien PA, Castanheira M. J Glob Antimicrob Resist. 2021 Sep;26:117-127. doi: 10.1016/j.jgar.2021.04.012. Epub 2021 May 26.

Week of October 19, 2021
Evolving Frontline Immunochemotherapy for Mantle Cell Lymphoma and the Impact on Survival Outcomes. Castellino A, Wang Y, Larson MC, Maurer MJ, Link BK, Farooq U, Feldman A, Syrbu SI, Habermann TM, Paludo J, Inwards DJ, Witzig TE, Ansell SM, Allmer C, Slager SL, Cohen JB, Martin P, Cerhan JR, Nowakowski GS. Blood Adv. 2021 Oct 18:bloodadvances.2021005715. doi: 10.1182/bloodadvances.2021005715. Online ahead of print.

Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells. Jensen IJ, Li X, McGonagill PW, Shan Q, Fosdick MG, Tremblay MM, Houtman JC, Xue HH, Griffith TS, Peng W, Badovinac VP. Elife. 2021 Oct 15;10:e70989. doi: 10.7554/eLife.70989. Online ahead of print.

Prevalence of maternal obesity at delivery and association with maternal and neonatal outcomes. Castaneda C, Marsden K, Maxwell T, Ten Eyck P, Kuwaye D, Kenne KA, Merryman AS, Steffen HA, Swartz SR, Merrill AE, Krasowski MD, Jackson JB, Rysavy MB. J Matern Fetal Neonatal Med. 2021 Oct 12:1-8. doi: 10.1080/14767058.2021.1988563. Online ahead of print.

Week of October 12, 2021
Fungal microbiome and multiple sclerosis: The not-so-new kid on the block. Mangalam AK. EBioMedicine. 2021 Oct 5;72:103621. doi: 10.1016/j.ebiom.2021.103621. Online ahead of print.

Week of October 5, 2021
Hypoglycemia secondary to insulinoma masking the onset of type 1 diabetes in an adolescent. Subramani S, Bellizzi AM, Borcherding N, Kao SC, Dillon J, Howe J, Norris AW, Tansey MJ, Pinnaro CT. Clin Case Rep. 2021 Sep 24;9(9):e04868. doi: 10.1002/ccr3.4868. eCollection 2021 Sep.

Single Center Experience with Isolated Spinal Cord Neurosarcoidosis. Park BJ, Ray E, Bathla G, Bruch LA, Streit JA, Cho TA, Hitchon PW. World Neurosurg. 2021 Sep 25:S1878-8750(21)01432-7. doi: 10.1016/j.wneu.2021.09.089. Online ahead of print.

Monocytes Exposed to Immune Complexes Reduce pDC Type 1 Interferon Response to Vidutolimod. Sabree SA, Lemke-Miltner CD, Blackwell SE, Yin C, Bossler A, Ebeid K, Salem AK, Weiner GJ. Vaccines (Basel). 2021 Sep 2;9(9):982. doi: 10.3390/vaccines9090982.

Week of September 28, 2021
Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy. Smith SJ, Fabian L, Sheikh A, Noche R, Cui X, Moore SA, Dowling JJ. Hum Mol Genet. 2021 Sep 25:ddab278. doi: 10.1093/hmg/ddab278. Online ahead of print.

Asymptomatic Pre-Operative COVID-19 Screening for Essential and Elective Surgeries: Early Results of Universal Screening at a Midwestern Academic Medical Center. Hendrickson NR, Kesler K, DeMik DE, Glass NA, Watson MK, Ford BA, Salinas JL, Pugely AJ. Iowa Orthop J. 2021;41(1):33-38.

PTCH1-GLI1 Fusion-Positive Ovarian Tumor: Report of a Unique Case With Response to Tyrosine Kinase Inhibitor Pazopanib. Alwaqfi RR, Samuelson MI, Guseva NN, Ouyang M, Bossler AD, Ma D. J Natl Compr Canc Netw. 2021 Sep 20;19(9):998-1004. doi: 10.6004/jnccn.2021.7058.

Week of September 21, 2021
Interpreting SARS-CoV-2 Test Results. Coffey KC, Diekema DJ, Morgan DJ. JAMA. 2021 Sep 17. doi: 10.1001/jama.2021.16146. Online ahead of print.

The Emerging World of Microbiome in Autoimmune Disorders: Opportunities and Challenges. Mangalam AK, Yadav M, Yadav R. Indian J Rheumatol. 2021 Mar;16(1):57-72. doi: 10.4103/injr.injr_210_20. Epub 2021 Mar 23.

Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center. Wood KE, Palmer KL, Krasowski MD. Toxicol Rep. 2021 Aug 30;8:1592-1598. doi: 10.1016/j.toxrep.2021.08.005. eCollection 2021.

Cellular Fibroma of Tendon Sheath With Novel TNC-USP6 Gene Fusion Clinically Mimicking Arthritis in a 7-Year-Old Boy. Eisenberg JM, Buckwalter V JA, Snow AN, Davick J. Pediatr Dev Pathol. 2021 Sep 14:10935266211043869. doi: 10.1177/10935266211043869. Online ahead of print.

Week of September 14, 2021
Management of Duodenal Neuroendocrine Tumors: Surgical versus Endoscopic Mucosal Resection. Tran CG, Sherman SK, Suraju MO, Nayyar A, Gerke H, Abiad RGE, Chandrasekharan C, Ear PH, O'Dorisio TM, Dillon JS, Bellizzi AM, Howe JR. Ann Surg Oncol. 2021 Sep 13. doi: 10.1245/s10434-021-10774-9. Online ahead of print.

Oncogenic Activity of Solute Carrier Family 45 Member 2 and Alpha-Methylacyl-Coenzyme A Racemase Gene Fusion Is Mediated by Mitogen-Activated Protein Kinase. Zuo ZH, Yu YP, Ren BG, Liu S, Nelson J, Wang Z, Tao J, Pradhan-Sundd T, Bhargava R, Michalopoulos G, Chen Q, Zhang J, Ma D, Pennathur A, Luketich J, Satdarshan Monga P, Nalesnik M, Luo JH. Hepatol Commun. 2021 Sep 10. doi: 10.1002/hep4.1724. Online ahead of print.

Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer. Schachter NF, Adams JR, Skowron P, Kozma KJ, Lee CA, Raghuram N, Yang J, Loch AJ, Wang W, Kucharczuk A, Wright KL, Quintana RM, An Y, Dotzko D, Gorman JL, Wojtal D, Shah JS, Leon-Gomez P, Pellecchia G, Dupuy AJ, Perou CM, Ben-Porath I, Karni R, Zacksenhaus E, Woodgett JR, Done SJ, Garzia L, Sorana Morrissy A, Reimand J, Taylor MD, Egan SE. Nat Commun. 2021 Sep 2;12(1):5238. doi: 10.1038/s41467-021-25467-w.

V-Type ATPase Mediates Airway Surface Liquid Acidification in Pig Small Airway Epithelial Cells. Li X, Villacreses R, Thornell IM, Noriega J, Mather S, Brommel CM, Lu L, Zabner A, Ehler A, Meyerholz DK, Stoltz DA, Zabner J. Am J Respir Cell Mol Biol. 2021 Aug;65(2):146-156. doi: 10.1165/rcmb.2020-0349OC.

TIMAP Upregulation Correlates Negatively with Survival in HER2- Negative Subtypes of Breast Cancer. Obeidat M, Bodoor K, Alqudah M, Masaadeh A, Barukba M, Almomani R. Asian Pacific journal of cancer prevention: APJCP. 06/01/2021; 22 (6): 1899-1905.

Association of Body Mass Index with Hypertension in Patients with Healthy Weight. J. Brooks Jackson, Linder Wendt, Patrick Ten Eyck. Clin Rev Cases. 2021; 3(2): 1-3.

Association of Body Mass Index with Chronic Conditions and Procedures in General Medicine Clinics at an Academic Health Center. Jackson JB, Wendt L, Ten Eyck P. J Med - Clin Res & Rev. 2021; 5(8): 1-6.

Week of September 7, 2021

Severity of Sepsis Determines the Degree of Impairment Observed in Circulatory and Tissue-Resident Memory CD8 T Cell Populations. Moioffer SJ, Danahy DB, van de Wall S, Jensen IJ, Sjaastad FV, Anthony SM, Harty JT, Griffith TS, Badovinac VP. J Immunol. 2021 Sep 3:ji2001142. doi: 10.4049/jimmunol.2001142. Online ahead of print.

Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer. Schachter NF, Adams JR, Skowron P, Kozma KJ, Lee CA, Raghuram N, Yang J, Loch AJ, Wang W, Kucharczuk A, Wright KL, Quintana RM, An Y, Dotzko D, Gorman JL, Wojtal D, Shah JS, Leon-Gomez P, Pellecchia G, Dupuy AJ, Perou CM, Ben-Porath I, Karni R, Zacksenhaus E, Woodgett JR, Done SJ, Garzia L, Sorana Morrissy A, Reimand J, Taylor MD, Egan SE. Nat Commun. 2021 Sep 2;12(1):5238. doi: 10.1038/s41467-021-25467-w.

Multimodality imaging in a case of multiple pulmonary hyalinizing granulomas - A decade follow-up. Soni N, Ora M, Gupta S, Maheshwarappa RP, Priya S, Graham MM. Lung India. 2021 Sep-Oct;38(5):477-480. doi: 10.4103/lungindia.lungindia_1004_20.

Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects. Abu El-Haija M, Ye Y, Chu Y, Herz H, Linden B, Shahi SK, Zarei K, Mangalam AK, Mcelroy SJ, Mokadem M. Surg Obes Relat Dis. 2021 Aug 2:S1550-7289(21)00372-5. doi: 10.1016/j.soard.2021.07.019. Online ahead of print.

Week of August 31, 2021
Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity. Pack AD, Schwartzhoff PV, Zacharias ZR, Fernandez-Ruiz D, Heath WR, Gurung P, Legge KL, Janse CJ, Butler NS. Cell Rep. 2021 Aug 24;36(8):109586. doi: 10.1016/j.celrep.2021.109586.

Extranodal NK/T-cell lymphoma as a rare mimicker of GPA. Strouse J, Chang HB, Dimachkie MD, Halbur C, Rajan Kd A, Bettendorf B. Arthritis Rheumatol. 2021 Aug 24. doi: 10.1002/art.41956. Online ahead of print.

Week of August 24, 2021
Hepatocellular carcinoma in primary sclerosing cholangitis and primary biliary cholangitis: a clinical and pathological study in an uncommon but emerging setting. Bosch DE, Zen Y, Boukhar SA, Liu Y, Cheng L, Yeh MM. Virchows Arch. 2021 Aug 20. doi: 10.1007/s00428-021-03183-6. Online ahead of print.

Correction: Antifungal susceptibilities of opportunistic filamentous fungal pathogens from the Asia and Western Pacific Region: data from the SENTRY Antifungal Surveillance Program (2011-2019). Pfaller MA, Carvalhaes CG, Rhomberg P, Messer SA, Castanheira M. J Antibiot (Tokyo). 2021 Aug 18. doi: 10.1038/s41429-021-00460-z. Online ahead of print.

Stable Clostridioides difficile Infection Rates After the Discontinuation of Ultraviolet Light for Terminal Disinfection at a Tertiary Care Center, Iowa 2019-2020. Abosi OJ, Kobayashi T, Holley S, Kukla ME, Dains A, Alsuhaibani M, Marra AR, Jenn KE, Meacham H, Sheeler LL, Etienne W, Trannel A, Garringer J, Millard W, Diekema DJ, Edmond MB, Wellington M, Salinas JL. Am J Infect Control. 2021 Aug 13:S0196-6553(21)00521-6. doi: 10.1016/j.ajic.2021.08.005. Online ahead of print.

Week of August 17, 2021
American Association of Immunologists Recommendations for an Undergraduate Course in Immunology. Porter E, Amiel E, Bose N, Bottaro A, Carr WH, Swanson-Mungerson M, Varga SM, Jameson JM. Immunohorizons. 2021 Jun 16;5(6):448-465. doi: 10.4049/immunohorizons.2100030.

Bat intrusions at a tertiary care center in Iowa, 2018-2020. Alsuhaibani MA, Dains A, Kobayashi T, Sheeler LL, Trannel A, Holley S, Marra AR, Abosi OJ, Jenn KE, Meacham H, Etienne W, Kukla ME, Millard B, Wellington M, Diekema DJ, Salinas JL. Infect Control Hosp Epidemiol. 2021 Aug 16:1-3. doi: 10.1017/ice.2021.355. Online ahead of print.

Case Report: Severe COVID-19 in a Kidney Transplant Recipient Without Humoral Response to SARS-CoV-2 mRNA Vaccine Series. Yamada M, Matsumoto E, Thomas CP, Carlson JR, Klutts JS, Kumar B, Streit JA, Swee ML. Transplant Direct. 2021 Aug 6;7(9):e743. doi:0.1097/TXD.0000000000001193. eCollection 2021 Sep.

Validation of Optical Genome Mapping for the Molecular Diagnosis of Facioscapulohumeral Muscular Dystrophy (FSHD). Stence AA, Thomason JG, Pruessner JA, Sompallae RR, Snow AN, Ma D, Moore SA, Bossler AD. J Mol Diagn. 2021 Aug 9:S1525-1578(21)00246-4. doi: 10.1016/j.jmoldx.2021.07.021. Online ahead of print.

HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype. Shahi SK, Ali S, Jaime CM, Guseva NV, Mangalam AK. Immunohorizons. 2021 Aug 11;5(8):627-646. doi: 10.4049/immunohorizons.2100024.

Nationwide practices in the use of central venous catheters for therapeutic plasma exchange in the inpatient setting. Chopra S, Garg A, Schlueter AJ, Blau JL. J Clin Apher. 2021 Aug 11. doi: 10.1002/jca.21929. Online ahead of print. 34379813

Week of August 10, 2021

The Neuropathology of 1p36 Deletion Syndrome: An Autopsy Case Series. Conway KS, Ghafoor F, Gottschalk AC, Laakman J, Eigsti RL, Nashelsky M, Blau J, Hefti MM. J Neuropathol Exp Neurol. 2021 Aug 7:nlab072. doi: 10.1093/jnen/nlab072. Online ahead of print.

Utilization of anti-factor Xa levels to guide reversal of oral factor Xa inhibitors in the emergency department. Zepeski AE, Faine BA, Merrill AE, Sutamtewagul G, Bhagavathi S. Am J Health Syst Pharm. 2021 Aug 7:zxab326. doi: 10.1093/ajhp/zxab326. Online ahead of print.

Expression of cancer stem cell markers in tall cell variant papillary thyroid cancer identifies a molecular profile predictive of recurrence in classic papillary thyroid cancer. Beck AC, Rajan A, Landers S, Kelley S, Bellizzi AM, Lal G, Sugg SL, Howe JR, Chan CH, Weigel RJ. Surgery. 2021 Aug 3:S0039-6060(21)00653-X. doi: 10.1016/j.surg.2021.03.076. Online ahead of print.

In vitro activity of posaconazole and comparators versus opportunistic filamentous fungal pathogens globally collected during 8 years. Pfaller MA, Carvalhaes CG, Messer SA, Rhomberg PR, Castanheira M. Diagn Microbiol Infect Dis. 2021 Jul 1;101(3):115473. doi: 10.1016/j.diagmicrobio.2021.115473. Online ahead of print.

Vascular Involvement in Neurosarcoidosis: Early Experiences From Intracranial Vessel Wall Imaging. Bathla G, Abdel-Wahed L, Agarwal A, Cho TA, Gupta S, Jones KA, Priya S, Soni N, Wasserman BA. Neurol Neuroimmunol Neuroinflamm. 2021 Aug 4;8(6):e1063. doi: 10.1212/NXI.0000000000001063. Print 2021 Nov.

Advancing Diagnostic Stewardship for Healthcare Associated Infections, Antibiotic Resistance, and Sepsis. Curren EJ, Lutgring JD, Kabbani S, Diekema DJ, Gitterman S, Lautenbach E, Morgan DJ, Rock C, Salerno RM, McDonald LC. Clin Infect Dis. 2021 Aug 4:ciab672. doi: 10.1093/cid/ciab672. Online ahead of print.

The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19. Li K, Meyerholz DK, Bartlett JA, McCray PB Jr. mBio. 2021 Aug 3:e0097021. doi: 10.1128/mBio.00970-21. Online ahead of print.

Week of August 3, 2021
Directed movement toward, translocation along, penetration into and exit from vascular networks by breast cancer cells in 3D. Wessels DJ, Pujol C, Pradhan N, Lusche DF, Gonzalez L, Kelly SE, Martin EM, Voss ER, Park YN, Dailey M, Sugg SL, Phadke S, Bashir A, Soll DR. Cell Adh Migr. 2021 Dec;15(1):224-248. doi: 10.1080/19336918.2021.1957527.

Real-World Clinical Performance Evaluation of a Fourth-Generation HIV Antigen/Antibody Differentiation Test. Krasowski MD, Wier D, Smith S, Riedel A, Lauseker-Hao Y, Kelner M, Wang S. J Appl Lab Med. 2021 Aug 1:jfab069. doi: 10.1093/jalm/jfab069. Online ahead of print.

Intratumoral talimogene laherparepvec injection with concurrent preoperative radiation in patients with locally advanced soft-tissue sarcoma of the trunk and extremities: phase IB/II trial. Monga V, Miller BJ, Tanas M, Boukhar S, Allen B, Anderson C, Stephens L, Hartwig S, Varga S, Houtman J, Wang L, Zhang W, Jaber O, Thomason J, Kuehn D, Rajput M, Metz C, Zamba KD, Mott S, Abanonu C, Bhatia S, Milhem M. J Immunother Cancer. 2021 Jul;9(7):e003119. doi: 10.1136/jitc-2021-003119.

Identification of COVID-19 Virus in Human Intraocular Tissues. Syed NA, Grose C. JAMA Ophthalmol. 2021 Jul 29. doi: 10.1001/jamaophthalmol.2021.2806. Online ahead of print.

Suspected COVID-19 Reinfections at a Tertiary Care Center, Iowa, 2020. Kobayashi T, Ortiz ME, Imborek KL, Alsuhaibani M, Holley SA, Trannel A, Marra AR, Etienne W, Jenn KE, Abosi OJ, Meacham H, Sheeler LL, Dains A, Kukla ME, McCray PB Jr, Perlman S, Ford B, Diekema DJ, Wellington M, Salinas JL, Pezzulo AA. Open Forum Infect Dis. 2021 Apr 14;8(7):ofab188. doi: 10.1093/ofid/ofab188. eCollection 2021 Jul.

Sepsis and multiple sclerosis: causative links and outcomes. Miljković Đ, Stanisavljević S, Jensen IJ, Griffith TS, Badovinac VP. Immunol Lett. 2021 Jul 25:S0165-2478(21)00117-6. doi: 10.1016/j.imlet.2021.07.008. Online ahead of print.

An Unusual Presentation of CLN3-Associated Batten Disease With Classic Histopathologic and Ultrastructural Findings. Evans LP, Gibson-Corley KN, Mullins RF, Tucker BA, Trent A, Stone EM, Jones KA. J Neuropathol Exp Neurol. 2021 Jul 27:nlab064. doi: 10.1093/jnen/nlab064. Online ahead of print.

Week of July 27, 2021
Early intrahepatic duct defects in a cystic fibrosis porcine model. Zarei K, Meyerholz DK, Stoltz DA. Physiol Rep. 2021 Jul;9(14):e14978. doi: 10.14814/phy2.14978.

HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity. Nuro-Gyina PK, Tang N, Guo H, Yan C, Zeng Q, Waldschmidt TJ, Zhang J. J Immunol. 2021 Jul 19:ji2100083. doi: 10.4049/jimmunol.2100083. Online ahead of print.

Week of July 20, 2021
Deep Neural Network Analysis of Pathology Images With Integrated Molecular Data for Enhanced Glioma Classification and Grading. Pei L, Jones KA, Shboul ZA, Chen JY, Iftekharuddin KM. Front Oncol. 2021 Jul 1;11:668694. doi: 10.3389/fonc.2021.668694. eCollection 2021.

Lack of intrafollicular memory CD4 + T cells is predictive of early clinical failure in newly diagnosed follicular lymphoma. Mondello P, Fama A, Larson MC, Feldman AL, Villasboas JC, Yang ZZ, Galkin I, Svelolkin V, Postovalova E, Bagaev A, Ovcharov P, Varlamova A, Huet S, Tesson B, McGrath KR, Slager S, Link BK, Syrbu S, Novak AJ, Habermann TM, Witzig TE, Nowakowski GS, Salles G, Cerhan JR, Ansell SM. Blood Cancer J. 2021 Jul 15;11(7):130. doi: 10.1038/s41408-021-00521-4.

Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer. Chau J, Yadav M, Liu B, Furqan M, Dai Q, Shahi S, Gupta A, Mercer KN, Eastman E, Hejleh TA, Chan C, Weiner GJ, Cherwin C, Lee STM, Zhong C, Mangalam A, Zhang J. BMC Cancer. 2021 Jul 13;21(1):808. doi: 10.1186/s12885-021-08530-z.

Side-Effects of COVID-19 on Patient Care: An INR Story. Pearson LN, Johnson SA, Greene DN, Chambliss AB, Farnsworth CW, French D, Herman DS, Kavsak PA, Merrill AE, Lo SM, Lyon ME, SoRelle JA, Schmidt RL. J Appl Lab Med. 2021 Jul 7;6(4):953-961. doi: 10.1093/jalm/jfab025.

 Week of July 13, 2021

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles. Hasibuzzaman MM, Ross KA, Salem AK, Narasimhan B, Simons AL. J Vis Exp. 2021 Jun 28;(172). doi: 10.3791/62683.

COVID-19 Incidence After Exposures in Shared Patient Rooms, Tertiary Care Center, Iowa, July 2020-May 2021. Trannel A, Kobayashi T, Dains A, Abosi OJ, Jenn KE, Meacham H, Sheeler LL, Etienne W, Kukla ME, Alsuhaibani M, Holley S, Strandberg K, Marra AR, Kritzman J, Ford B, Wellington M, Diekema DJ, Salinas JL. Infect Control Hosp Epidemiol. 2021 Jul 12:1-13. doi: 10.1017/ice.2021.313. Online ahead of print.

A Curriculum for Genomic Education of Molecular Genetic Pathology Fellows:A Report of the Association for Molecular Pathology Training and Education Committee. Rosenbaum JN, Berry AB, Church AJ, Crooks K, Gagan JR, López-Terrada D, Pfeifer JD, Rennert H, Schrijver I, Snow AN, Wu D, Ewalt MD. J Mol Diagn. 2021 Jul 7:S1525-1578(21)00201-4. doi: 10.1016/j.jmoldx.2021.07.001. Online ahead of print.

Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis. Jensen SN, Cady NM, Shahi SK, Peterson SR, Gupta A, Gibson-Corley KN, Mangalam AK. Sci Adv. 2021 Jul 9;7(28):eabd4595. doi: 10.1126/sciadv.abd4595. Print 2021 Jul.

Molecular epidemiology of large coronavirus disease 2019 (COVID-19) clusters before and after the implementation of routine serial testing at an academic medical center in Iowa, 2020. Ortiz ME, Kobayashi T, Imborek K, Alsuhaibani M, Holley S, Trannel A, Marra AR, Etienne W, Jenn KE, Abosi OJ, Meacham H, Sheeler L, Dains A, Kukla ME, McCray PB, Perlman S, Ford B, Diekema DJ, Wellington M, Pezzulo AA, Salinas JL. Infect Control Hosp Epidemiol. 2021 Jun 24:1-3. doi: 10.1017/ice.2021.301. Online ahead of print.

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection. Dampalla CS, Zheng J, Perera KD, Wong LR, Meyerholz DK, Nguyen HN, Kashipathy MM, Battaile KP, Lovell S, Kim Y, Perlman S, Groutas WC, Chang KO. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2101555118. doi: 10.1073/pnas.2101555118.

Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma. Oishi N, Hundal T, Phillips JL, Dasari S, Hu G, Viswanatha DS, He R, Mai M, Jacobs HK, Ahmed NH, Syrbu SI, Salama Y, Chapman JR, Vega F, Sidhu J, Bennani NN, Epstein AL, Medeiros JL, Clemens MW, Miranda RN, Feldman AL. Haematologica. 2021 Jun 1;106(6):1714-1724. doi: 10.3324/haematol.2019.245860.

Week of July 6, 2021
Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model. Senthil K, Morgan RW, Hefti MM, Karlsson M, Lautz AJ, Mavroudis CD, Ko T, Nadkarni VM, Ehinger J, Berg RA, Sutton RM, McGowan FX, Kilbaugh TJ. Resusc Plus. 2021 Apr 29;6:100124. doi: 10.1016/j.resplu.2021.100124. eCollection 2021 Jun.

Use of Middleware Data to Dissect and Optimize Hematology Autoverification. Starks RD, Merrill AE, Davis SR, Voss DR, Goldsmith PJ, Brown BS, Kulhavy J, Krasowski MD. J Pathol Inform. 2021 Apr 7;12:19. doi: 10.4103/jpi.jpi_89_20. eCollection 2021.

MRSA Strains with Distinct Accessory Genes Predominate at Different Ages in Cystic Fibrosis. Porterfield HS, Maakestad LJ, LaMarche MM, Thurman AL, Kienenberger ZE, Pitcher NJ, Hansen AR, Zirbes CF, Boyken L, Muyskens BL, Pezzulo AA, Singh SB, Twait E, Ford B, Diekema DJ, Reeb V, Fischer AJ. Pediatr Pulmonol. 2021 Jul 5. doi: 10.1002/ppul.25559. Online ahead of print.

Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5-based COVID-19 vaccine. An D, Li K, Rowe DK, Diaz MCH, Griffin EF, Beavis AC, Johnson SK, Padykula I, Jones CA, Briggs K, Li G, Lin Y, Huang J, Mousa J, Brindley M, Sakamoto K, Meyerholz DK, McCray PB Jr, Tompkins SM, He B. Sci Adv. 2021 Jul 2;7(27):eabi5246. doi: 10.1126/sciadv.abi5246. Print 2021 Jul.

Iron-Refractory Iron Deficiency Anemia in an 11-year-old Girl. Swaminathan N, Lieberman SM, Bhagavathi S, Sharathkumar A. Pediatr Rev. 2021 Jul;42(7):393-398. doi: 10.1542/pir.2020-0081.

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection. Dampalla CS, Zheng J, Perera KD, Wong LR, Meyerholz DK, Nguyen HN, Kashipathy MM, Battaile KP, Lovell S, Kim Y, Perlman S, Groutas WC, Chang KO. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2101555118. doi: 10.1073/pnas.2101555118.

Considerations for a Respiratory Syncytial Virus Vaccine Targeting an Elderly Population. Stephens LM, Varga SM. Vaccines (Basel). 2021 Jun 9;9(6):624. doi: 10.3390/vaccines9060624.

Successful Patient-Derived Organoid Culture of Gynecologic Cancers for Disease Modeling and Drug Sensitivity Testing. Bi J, Newtson AM, Zhang Y, Devor EJ, Samuelson MI, Thiel KW, Leslie KK. Cancers (Basel). 2021 Jun 10;13(12):2901. doi: 10.3390/cancers13122901.

RABL6A Promotes Pancreatic Neuroendocrine Tumor Angiogenesis and Progression In Vivo. Maharjan CK, Umesalma S, Kaemmer CA, Muniz VP, Bauchle C, Mott SL, Zamba KD, Breheny P, Leidinger MR, Darbro BW, Stephens SB, Meyerholz DK, Quelle DE. Biomedicines. 2021 Jun 2;9(6):633. doi: 10.3390/biomedicines9060633.

A plain language summary of the EXPLORER-HCM study: mavacamten for obstructive hypertrophic cardiomyopathy. Pfaller MA, Messer SA, Deshpande LM, Rhomberg PR, Utt EA, Castanheira M. Future Microbiol. 2021 Jun 29. doi: 10.2217/fmb-2021-0086.

Sepsis, Cytokine Storms, and Immunopathology: The Divide between Neonates and Adults. Greenfield KG, Badovinac VP, Griffith TS, Knoop KA. Immunohorizons. 2021 Jun 28;5(6):512-522. doi: 10.4049/immunohorizons.2000104.

Week of June 29, 2021
Early Lung Disease Exhibits Bacterial-Dependent and -Independent Abnormalities in Cystic Fibrosis Pigs. Bouzek DC, Abou Alaiwa MH, Adam RJ, Pezzulo AA, Reznikov LR, Cook DP, Aguilar Pescozo MI, Ten Eyck P, Wu C, Gross TJ, Hornick DB, Hoffman EA, Meyerholz DK, Stoltz DA. Am J Respir Crit Care Med. 2021 Jun 25. doi: 10.1164/rccm.202102-0451OC. Online ahead of print.

COVID-19 Admission Screening, and Assessment of Infectiousness at an Academic Medical Center, Iowa 2020. Alsuhaibani M, Kobayashi T, Trannel A, Holley S, Abosi OJ, Jenn KE, Meacham H, Sheeler L, Etienne W, Dains A, Kukla ME, Ward E, Ford B, Edmond MB, Wellington M, Diekema DJ, Salinas JL. Infect Control Hosp Epidemiol. 2021 Jun 24:1-19. doi: 10.1017/ice.2021.294. Online ahead of print.

Umbilical Cord Drug Screening in Multiple Births: Experience from a Reference Laboratory and Academic Medical Center. Nelson HA, Wood KE, McMillin GA, Krasowski MD. J Anal Toxicol. 2021 Jun 24:bkab077. doi: 10.1093/jat/bkab077. Online ahead of print.

Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle. Moose DL, Williams-Perez S, Cafun R, Krog BL, Henry MD. J Vis Exp. 2021 Apr 27;(170). doi: 10.3791/62478.

Aberrant redox biology and epigenetic reprogramming: Co-conspirators across multiple human diseases. Domann FE, Hitchler MJ. Free Radic Biol Med. 2021 Jul;170:2-5. doi: 10.1016/j.freeradbiomed.2021.04.020. Epub 2021 Apr 29.

Introduction to the special issue on 'epigenetics and redox signaling'. Domann FE, Hitchler MJ. Free Radic Biol Med. 2021 Jul;170:1. doi: 10.1016/j.freeradbiomed.2021.04.015. Epub 2021 Apr 13.

The epigenetic and morphogenetic effects of molecular oxygen and its derived reactive species in development. Hitchler MJ, Domann FE. Free Radic Biol Med. 2021 Jul;170:70-84. doi: 10.1016/j.freeradbiomed.2021.01.008. Epub 2021 Jan 12.

Political party preference of freshmen university students and its association with student lifestyle characteristics and the influence of 1 year public university. Pohl D, Choi A, Marcus K, Ten Eyck P, Jackson JB. J Child and Adolescent Health 2021:5-1-12.

Week of June 22, 2021
Prolonged Reactive Oxygen Species Production following Septic Insult. Jensen IJ, McGonagill PW, Berton RR, Wagner BA, Silva EE, Buettner GR, Griffith TS, Badovinac VP. Immunohorizons. 2021 Jun 18;5(6):477-488. doi: 10.4049/immunohorizons.2100027.

Protective function and durability of mouse lymph node-resident memory CD8+ T cells. Anthony SM, Van Braeckel-Budimir N, Moioffer SJ, van de Wall S, Shan Q, Vijay R, Sompallae R, Hartwig SM, Jensen IJ, Varga SM, Butler NS, Xue HH, Badovinac VP, Harty JT.Elife. 2021 Jun 18;10:e68662. doi: 10.7554/eLife.68662.

Week of June 8, 2021
SETDB1 in cancer: overexpression and its therapeutic implications. Lazaro-Camp VJ, Salari K, Meng X, Yang S. Am J Cancer Res. 2021 May 15;11(5):1803-1827. eCollection 2021.

Successful autologous peripheral blood stem cell collection using large volume leukapheresis in patients with very low or undetectable peripheral blood CD34+ progenitor cells. Destrampe E, Schlueter AJ. Transfus Apher Sci. 2021 May 21:103170. doi: 10.1016/j.transci.2021.103170. Online ahead of print.

Ketogenic Diet with Concurrent Chemoradiation in Head and Neck Squamous Cell Carcinoma: Preclinical and Phase 1 Trial Results. Ma DC, Anderson CM, Rodman SN, Buranasudja V, McCormick ML, Davis A, Loth E, Bodeker KL, Ahmann L, Parkhurst JR, Sun W, Follmer KR, Simons AL, Buatt JM, Spitz DR, Fath MA, Allen BG. Radiat Res. 2021 Jun 4. doi: 10.1667/RADE-20-00150.1. Online ahead of print.

Skeletal Muscle Regeneration in Post-Myofascial Flap Reconstruction Specimens Mimicking Sarcoma: A Potential Diagnostic Pitfall. Patrick AP, Swick BL. J Cutan Pathol. 2021 Jun 4. doi: 10.1111/cup.14074. Online ahead of print.

ANCA GLOMERULONEPHRITIS POST MODERNA COVID-19 VACCINATION. Sekar A, Campbell R, Tabbara J, Rastogi P. Kidney Int. 2021 May 31:S0085-2538(21)00555-X. doi: 10.1016/j.kint.2021.05.017. Online ahead of print.

Diagnostic Challenges of Focal Nodular Hyperplasia: Interobserver Variability, Accuracy, and the Utility of Glutamine Synthetase Immunohistochemistry. Rowan DJ, Allende DS, Bellizzi AM, Gill RM, Liu X, McKenzie CA, Moreira RK, Mounajjed T, Said S, Westerhoff M, Jenkins SM, Batts KP, Burgart LJ, Lamps LW, Graham RP. Histopathology. 2021 Jun 3. doi: 10.1111/his.14424. Online ahead of print.

Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors. Bindra S, McGill MA, Triplett MK, Tyagi A, Thaker PH, Dahmoush L, Goodheart MJ, Ogden RT, Owusu-Ansah E, R Karan K, Cole S, Sood AK, Lutgendorf SK, Picard M. Sci Rep. 2021 Jun 2;11(1):11595. doi: 10.1038/s41598-021-89934-6.

RABL6A Regulates Schwann Cell Senescence in an RB1-Dependent Manner. Kohlmeyer JL, Kaemmer CA, Umesalma S, Gourronc FA, Klingelhutz AJ, Quelle DE. Int J Mol Sci. 2021 May 20;22(10):5367. doi: 10.3390/ijms22105367.

Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D. Zheng J, Meyerholz D, Wong LR, Gelb M, Murakami M, Perlman S. J Clin Invest. 2021 Jun 1;131(11):147201. doi: 10.1172/JCI147201.

A Hot Flash about Menopause Hormone Therapy. Johnson A, Graf E, Jackson JB. Clin Rev Cases. 2021; 3(1):1-4.

COVID-19 Infection and Disease Severity not associated with Increased Parity among Pregnant Women. Marsden KA, Ten Eyck PP, Maxwell TN, Castaneda CN, Kenne KA, Swartz SR, Steffen HA, Jackson JB, Rysavy MB. J Med - Clin Res & Rev. 2021; 5(6): 1-4.

Middle East respiratory syndrome coronavirus Spike protein variants exhibit geographic differences in virulence. Wong LR, Zheng J, Sariol A, Lowery S, Meyerholz DK, Gallagher T, Perlman S. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2102983118. doi: 10.1073/pnas.2102983118.

Week of June 1, 2021
Antimicrobial Activity of First-in-Class Antifungal, Manogepix, and Comparator Agents Testing against Contemporary Invasive Fungal Isolates from an International Surveillance Program (2018-2019): In Vitro Activity of Manogepix against Fungal Isolates. Pfaller MA, Huband MD, Flamm RK, Bien PA, Castanheira M. J Glob Antimicrob Resist. 2021 May 26:S2213-7165(21)00111-9. doi: 10.1016/j.jgar.2021.04.012. Online ahead of print.

Teaching Pathology in an Integrated Preclinical Medical School Curriculum and Adaptations to COVID-19 Restrictions. Krasowski MD, Blau JL, Chen SJ, Jones KA, Schmidt TJ, Bruch LA. Acad Pathol. 2021 May 19;8:23742895211015337. doi: 10.1177/23742895211015337. eCollection 2021 Jan-Dec.

Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection. Kirk SG, Murphy PR, Wang X, Cash CJ, Barley TJ, Bowman BA, Batty AJ, Ackerman WE 4th, Zhang J, Nelin LD, Hafner M, Liu Y. J Immunol. 2021 May 26:ji2001468. doi: 10.4049/jimmunol.2001468. Online ahead of print.

Week of May 25, 2021
Chronic alcohol exposure promotes HCC stemness and metastasis through β-catenin/miR-22-3p/TET2 axis. Chen D, Yan Y, Wang X, Li S, Liu Y, Yu D, He Y, Deng R, Liu Y, Xu M, Luo J, Gao H, Wang S. Aging (Albany NY). 2021 May 21;13. doi: 10.18632/aging.203059. Online ahead of print.

A Review of Clinical and Imaging Findings in Tumefactive Demyelination. Nakayama M, Naganawa S, Ouyang M, Jones KA, Kim J, Capizzano AA, Moritani T. AJR Am J Roentgenol. 2021 May 19:1-12. doi: 10.2214/AJR.20.23226. Online ahead of print.

Patient Portal Activation and Use in Hospitalized Children at an Academic Medical Center. Wood KE, Greene HR, Krasowski MD. Hosp Pediatr. 2021 May 18:hpeds.2020-003707. doi: 10.1542/hpeds.2020-003707. Online ahead of print.

Palliative care consultation in patients with Staphylococcus aureus bacteremia. Kobayashi T, Salinas JL, Ten Eyck P, Chen B, Ando T, Inagaki K, Alsuhaibani M, Auwaerter PG, Molano I, Diekema DJ. Palliat Med. 2021 Apr;35(4):785-792. doi: 10.1177/0269216321999574. Epub 2021 Mar 24.

Up-front Treatment With Romiplostim in Children With Acquired Bone Marrow Failure: A Single Institutional Pediatric Case Series. Al-Huniti A, Rathi N, Modi A, Bhagavathi S, Mitten R, Sharathkumar AA. J Pediatr Hematol Oncol. 2021 Apr 1;43(3):e431-e435. doi: 10.1097/MPH.0000000000001810.