Dao-Fu Dai, MD, PhD

Portrait
Assistant Professor of Pathology

Contact Information

Primary Office: 106C Medical Research Center
25 S. Grand Avenue
Iowa City, IA 52242
319-335-0194

Education

MD, Medicine, Kaohsiung Medical University
MS, Clinical Medicine, National Taiwan University School of Medicine
PhD, Pathology, University of Washington

Fellow, Cardiology, National Taiwan University Hospital
Postdoctoral Fellow, University of Washington Pathology/Genome Science, University of Washington
Fellow, Renal Pathology, University of Washington
Resident, Pathology, AP, University of Washington
Postdoctoral Fellow, Cardiovascular Pathology, University of Washington

Publications

Dai, D. F., Danoviz, M. E., Wiczer, B., Laflamme, M. A. & Tian, R. (2017). Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes. Stem cells international, 2017, 5153625. PMID: 28421116.

Yang, L., Dai, D. F., Yuan, C., Westenbroek, R. E., Yu, H., West, N., de la Iglesia, H. O. & Catterall, W. A. (2016). Loss of ß-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure. Proceedings of the National Academy of Sciences of the United States of America, 113(49), E7976-E7985. PMID: 27864509.

Hartman, M. E., Dai, D. F. & Laflamme, M. A. (2016). Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair. Advanced drug delivery reviews, 96, 3-17. PMID: 25980938.

Basisty, N., Dai, D. F., Gagnidze, A., Gitari, L., Fredrickson, J., Maina, Y., Beyer, R. P., Emond, M. J., Hsieh, E. J., MacCoss, M. J., Martin, G. M. & Rabinovitch, P. S. (2016). Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy. Aging Cell, 15(4), 634-45. PMID: 27061426.

Chiao, Y. A., Lakatta, E., Ungvari, Z., Dai, D. F. & Rabinovitch, P. S. (2015). Cardiovascular Disease and Aging. In F. Sierra (Eds.) Advances in Geroscience. Springer.

Karunadharma, P. P., Basisty, N., Dai, D. F., Chiao, Y. A., Quarles, E. K., Hsieh, E. J., Crispin, D., Bielas, J. H., Ericson, N. G., Beyer, R. P., MacKay, V. L., MacCoss, M. J. & Rabinovitch, P. S. (2015). Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects. Aging cell, 14(4), 547-57. PMID: 25807975.

Karunadharma, P. P., Basisty, N., Chiao, Y. A., Dai, D. F., Drake, R., Levy, N., Koh, W. J., Emond, M. J., Kruse, S., Marcinek, D., Maccoss, M. J. & Rabinovitch, P. S. (2015). Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3582-92. PMID: 25977255.

Dai, D., Chiao, Y., Wessels, R. J., Bodmer, R. & Rabinovitch, P. S. (2015). Cardiac Aging. In Handbook of Biology of Aging. Springer.

Dai, D. F., Sasaki, K., Lin, M. Y., Smith, K. D., Nicosia, R. F., Alpers, C. E. & Najafian, B. (2015). Interstitial eosinophilic aggregates in diabetic nephropathy: allergy or not. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(8), 1370-6. PMID: 25813275.

Quarles, E. K., Dai, D. F., Tocchi, A., Basisty, N., Gitari, L. & Rabinovitch, P. S. (2015). Quality control systems in cardiac aging. Ageing research reviews, 23(Pt A), 101-15. PMID: 25702865.

Dai, D. F., Chiao, Y. A., Marcinek, D. J., Szeto, H. H. & Rabinovitch, P. S. (2014). Mitochondrial oxidative stress in aging and healthspan. Longevity & healthspan, 3, 6. PMID: 24860647.

Dai, D. F., Swanson, P. E., Krieger, E. V., Liou, I. W., Carithers, R. L. & Yeh, M. M. (2014). Congestive hepatic fibrosis score: a novel histologic assessment of clinical severity. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(12), 1552-8. PMID: 24925051.

Dai, D. F., Karunadharma, P. P., Chiao, Y. A., Basisty, N., Crispin, D., Hsieh, E. J., Chen, T., Gu, H., Djukovic, D., Raftery, D., Beyer, R. P., MacCoss, M. J. & Rabinovitch, P. S. (2014). Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart. Aging cell, 13(3), 529-39. PMID: 24612461.

Dai, D. F., Hsieh, E. J., Chen, T., Menendez, L. G., Basisty, N. B., Tsai, L., Beyer, R. P., Crispin, D. A., Shulman, N. J., Szeto, H. H., Tian, R., MacCoss, M. J. & Rabinovitch, P. S. (2013). Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides. Circulation. Heart failure, 6(5), 1067-76. PMID: 23935006.

Frock, R. L., Chen, S. C., Dai, D. F., Frett, E., Lau, C., Brown, C., Pak, D. N., Wang, Y., Muchir, A., Worman, H. J., Santana, L. F., Ladiges, W. C., Rabinovitch, P. S. & Kennedy, B. K. (2012). Cardiomyocyte-specific expression of lamin A improves cardiac function in Lmna-/- mice. PloS one, 7(8), e42918. PMID: 22905185.

Dai, D. F., Chen, T., Johnson, S. C., Szeto, H. & Rabinovitch, P. S. (2012). Cardiac aging: from molecular mechanisms to significance in human health and disease. Antioxidants & redox signaling, 16(12), 1492-526. PMID: 22229339.

Hsieh, E. J., Shulman, N. J., Dai, D. F., Vincow, E. S., Karunadharma, P. P., Pallanck, L., Rabinovitch, P. S. & MacCoss, M. J. (2012). Topograph, a software platform for precursor enrichment corrected global protein turnover measurements. Molecular & cellular proteomics : MCP, 11(11), 1468-74. PMID: 22865922.

Ramos, F. J., Chen, S. C., Garelick, M. G., Dai, D. F., Liao, C. Y., Schreiber, K. H., MacKay, V. L., An, E. H., Strong, R., Ladiges, W. C., Rabinovitch, P. S., Kaeberlein, M. & Kennedy, B. K. (2012). Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Science translational medicine, 4(144), 144ra103. PMID: 22837538.

Dai, D. F., Rabinovitch, P. S. & Ungvari, Z. (2012). Mitochondria and cardiovascular aging. Circulation research, 110(8), 1109-24. PMID: 22499901.

Dai, D. F., Hsieh, E. J., Liu, Y., Chen, T., Beyer, R. P., Chin, M. T., MacCoss, M. J. & Rabinovitch, P. S. (2012). Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress. Cardiovascular research, 93(1), 79-88. PMID: 22012956.

Dai, D. F., Rabinovitch, P. S. & Ungvari, Z. (2012). Mitochondria and cardiovascular aging. Circulation research, 110(8), 1109-24. PMID: 22499901.

Dai, D. F., Johnson, S. C., Villarin, J. J., Chin, M. T., Nieves-Cintrón, M., Chen, T., Marcinek, D. J., Dorn, 2nd, G. W., Kang, Y. J., Prolla, T. A., Santana, L. F. & Rabinovitch, P. S. (2011). Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circulation research, 108(7), 837-46. PMID: 21311045.

Dai, D. F., Rabinovitch, P. (2011). Mitochondrial oxidative stress mediates induction of autophagy and hypertrophy in angiotensin-II treated mouse hearts. Autophagy, 7(8), 917-8. PMID: 21505274.

Dai, D. F., Chen, T., Szeto, H., Nieves-Cintrón, M., Kutyavin, V., Santana, L. F. & Rabinovitch, P. S. (2011). Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy. Journal of the American College of Cardiology, 58(1), 73-82. PMID: 21620606.

Wanagat, J., Dai, D. F. & Rabinovitch, P. (2010). Mitochondrial oxidative stress and mammalian healthspan. Mechanisms of ageing and development, 131(7-8), 527-35. PMID: 20566356.

Dai, D. F., Hwang, J. J., Chen, C. L., Chiang, F. T., Lin, J. L., Hsu, K. L., Tseng, C. D. & Tseng, Y. Z. (2010). Effect of physical activity on the prevalence of metabolic syndrome and left ventricular hypertrophy in apparently healthy adults. Journal of the Formosan Medical Association = Taiwan yi zhi, 109(10), 716-24. PMID: 20970068.

Dai, D. F., Chen, T., Wanagat, J., Laflamme, M., Marcinek, D. J., Emond, M. J., Ngo, C. P., Prolla, T. A. & Rabinovitch, P. S. (2010). Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging cell, 9(4), 536-44. PMID: 20456298.

Adamo, C. M., Dai, D. F., Percival, J. M., Minami, E., Willis, M. S., Patrucco, E., Froehner, S. C. & Beavo, J. A. (2010). Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America, 107(44), 19079-83. PMID: 20956307.

Dai, D., Wessels, R., Bodmer, R. & Rabinovitch, P. (2010). Cardiac Aging. In Comparative Biology of Aging. Springer.

Enns, L. C., Morton, J. F., Treuting, P. R., Emond, M. J., Wolf, N. S., Dai, D. F., McKnight, G. S., Rabinovitch, P. S. & Ladiges, W. C. (2009). Disruption of protein kinase A in mice enhances healthy aging. PloS one, 4(6), e5963. PMID: 19536287.

Dai, D. F., Santana, L. F., Vermulst, M., Tomazela, D. M., Emond, M. J., MacCoss, M. J., Gollahon, K., Martin, G. M., Loeb, L. A., Ladiges, W. C. & Rabinovitch, P. S. (2009). Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation, 119(21), 2789-97. PMID: 19451351.

Dai, D. F., Rabinovitch, P. S. (2009). Cardiac aging in mice and humans: The role of mitochondrial oxidative stress. Trends in cardiovascular medicine, 19(7), 213-20. PMID: 20382344.

Dai, D. F., Thajeb, P., Tu, C. F., Chiang, F. T., Chen, C. H., Yang, R. B. & Chen, J. J. (2008). Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke. Journal of the American College of Cardiology, 51(22), 2173-80. PMID: 18510966.

Dai, D. F., Hwang, J. J., Lin, J. L., Lin, J. W., Hsu, C. N., Lin, C. M., Chiang, F. T., Lai, L. P., Hsu, K. L., Tseng, C. D. & Tseng, Y. Z. (2008). Joint effects of N-terminal pro-B-type-natriuretic peptide and C-reactive protein vs angiographic severity in predicting major adverse cardiovascular events and clinical restenosis after coronary angioplasty in patients with stable coronary artery disease. Circulation journal : official journal of the Japanese Circulation Society, 72(8), 1316-23. PMID: 18654020.

Thajeb, P., Dai, D. F. (2007). Current opinion on the clinical approach to the diagnosis of mitochondrial disorders. Int J Gerontol, 1(1), 22-30.

Thajeb, P., Thajeb, T. & Dai, D. (2007). Cross-cultural studies using a modified mini mental test for healthy subjects and patients with various forms of vascular dementia. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 14(3), 236-41. PMID: 17258132.

Lin, J. W., Dai, D. F., Chou, Y. H., Huang, L. Y. & Hwang, J. J. (2007). Exploring the effects of C-reactive protein (CRP) and interleukin-1 beta single nucleotide polymorphisms on CRP concentration in patients with established coronary artery disease. Classification tree approach. International heart journal, 48(4), 463-75. PMID: 17827818.

Thajeb, P., Thajeb, T. & Dai, D. F. (2007). Clinical analysis of first-ever acute ischemic stroke in the territory of paramedian mesencephalic arteries. Central European Journal of Medicine, 2(1), 37-46.

Thajeb, T., Chen, Y. M., Dai, D. F., Thajeb, D. D. & Thajeb, P. (2007). Botulism: A frequently forgotten old malady, review article. (Vols. 1). (3) International Journal of Gerontology.

Dai, D. F., Lin, J. W., Kao, J. H., Hsu, C. N., Chiang, F. T., Lin, J. L., Chou, Y. H., Hsu, K. L., Tseng, C. D., Tseng, Y. Z. & Hwang, J. J. (2007). The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events. The Journal of clinical endocrinology and metabolism, 92(7), 2532-7. PMID: 17426096.

Dai, D. F., Chiang, F. T., Lin, J. L., Huang, L. Y., Chen, C. L., Chang, C. J., Lai, L. P., Hsu, K. L., Tseng, C. D., Tseng, Y. Z. & Hwang, J. J. (2007). Human C-reactive protein (CRP) gene 1059G>C polymorphism is associated with plasma CRP concentration in patients receiving coronary angiography. Journal of the Formosan Medical Association = Taiwan yi zhi, 106(5), 347-54. PMID: 17561469.

Lin, J. W., Hwang, J. J., Dai, D. F. & Tseng, Y. Z. (2006). Using structural equation model to illustrate the relationship between metabolic risk factors and cardiovascular complications in Taiwan. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 13(4), 633-9. PMID: 16874156.

Thajeb, P., Dai, D., Chiang, M. F. & Shyu, W. C. (2006). Genotype-phenotype correlation of maternally inherited disorders due to mutations in mitochondrial DNA. Taiwanese journal of obstetrics & gynecology, 45(3), 201-7. PMID: 17175464.

Tu, C. F., Su, Y. H., Huang, Y. N., Tsai, M. T., Li, L. T., Chen, Y. L., Cheng, C. J., Dai, D. F. & Yang, R. B. (2006). Localization and characterization of a novel secreted protein SCUBE1 in human platelets. Cardiovascular research, 71(3), 486-95. PMID: 16753137.

Thajeb, P., Thajeb, T. & Dai, D. (2004). Fatal strokes in patients with rhino-orbito-cerebral mucormycosis and associated vasculopathy. Scandinavian journal of infectious diseases, 36(9), 643-8. PMID: 15370650.