April 23, 2018

Alex Boyden is a Postdoctoral Research Fellow in Nitin Karandikar's laboratory.  Alex submitted a poster entitled "Neuroantigen-specific CD8 T cells inhibit ongoing demyelinating disease by autoregulating CD4 T cell responses using temporally distinct IFNγ- and perforin-dependent mechanisms" which was selected as a most outstanding entry for the Carver College of Medicine Health Sciences Research Week poster competition. The research described shows that CD8 T cells recognizing myelin antigens use an ordered effector program over a number of days in vivo to suppress neuroantigen-specific CD4 T cell-driven inflammation and can effectively treat ongoing demyelinating disease in mice. This research was funded by grant awards from the NIH, National MS Society, and US Department of Veterans Affairs.