Active Grant Awards

Dr. Ashu Mangalam and Dr. Edward Filardo ( Department of Surgery) received a seed grant award from the Center for Biocatalysis and Bioprocessing (CBB) at the University of Iowa. The title of the project is Harnessing Gut Microbiome-mediated Metabolism of the Natural Isoflavone Daidzein to Treat Breast Cancer. The total funding for this award is $35,000 and the project period is August 1, 2018 through July 31, 2019.

Drs. Vladimir Badovinac and Kevin Legge were awarded a Carver Trust Collaborative Pilot Grant from the College of Medicine. The title of the project is Impairment and Recovery of Dendritic Cell Immunity after Sepsis. The total funding for this award is $50,000 and the project period is July 1, 2018 through June 30, 2020.

Dr. Bing-Hua Jiang received R01 grant funding from the National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS). The title of the grant is Chromium in carcinogenesis and angiogenesis. The total direct funding for this award is $1,085,880 and the project period is July 1, 2018 through June 30, 2023.

Drs. Bing-Hua Jiang and Ling-Zhi Liu (Co-PIs) received R01 grant funding from the National Institutes of Health/National Cancer Institute (NIH/NCI). The title of the grant is Mechanism of lung cancer resistance to tyrosine kinase inhibitor and radiation treatments. The total direct funding for this award is $1,977,035 and the project period is July 1, 2018 through June 30, 2023.

Dr. Michael Knudson received contract award funding from Terumo Corporation as part of a multi-institutional study investigating platelet transfusions. The title of the award is Clinical Effectiveness of Conventional Versus Mirasol-treated Apheresis Platelets in Patients with Hypoproliferative Thrombocytopenia (MIPLATE). The total direct funding for this award is $1,100,000 and the project period is December 13, 2017 through December 31, 2020.

Dr. Ling-Zhi Liu received a five-year NIH K02 award from the National Institutes of Health/National Institute of Environmental Health Sciences (NIH/ NIEHS). The title of this project is New Mechanism of Arsenic Carcinogenesis. The total direct costs for this award are $567,190. The entire period for this project is April 1, 2018 through March 31, 2023.

Dr. Ashu Mangalam received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of the grant is Linking diet, gut microbiota and autoimmune disease: Bacteria induced phytoestrogen metabolites impact immune function in Experimental Autoimmune Encephalitis. The total direct funding for this award is $1,000,000 and the project period is February 15, 2018 through January 31, 2023.

Dr. Ashu Mangalam received a Pilot Grant Award from the Environmental Health Sciences Research Center at the University of Iowa. The title of the project is Effect of exposure to the herbicide glyphosate on the host gut microbiome and systemic inflammation in mice. The total funding for this award is $40,000 and the project period is September 1, 2017 to August 31, 2018.

Dr. Chen Zhao received a Pilot Grant Award from the Lymphoma SPORE Developmental Research Program at the University of Iowa and Mayo Clinic. The title of the project is Synergy of NF-κB and Notch signaling in B cell lymphomatous transformation and B cell plasticity. The total funding for this award is $50,000 and the project period is July 1, 2017 to June 30, 2018.

Drs. Kevin Legge and Thomas Waldschmidt received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this grant is Nanovaccine-Mediated Immune Protection Against Influenza Virus. The total direct funding for this award is $2,226,287 and the project period is June 1, 2017 through May 31, 2022.

Dr. Hasem Habelhah received a two-year NIH R21 grant from the National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS). The title of this project is HtrA2-mediated RIP1 Cleavage Regulates Neuronal Inflammation and Death. The total direct costs for this award are $275,000. The entire period for this project is June 1, 2017 through May 31, 2019.

Dr. Nitin Karandikar received Merit Award grant funding from the Department of Veteran Affairs. The title of this project is Immunotherapeutic Regulatory CD8 T cells in Autoimmune Demyelinating Disease. The total direct costs for this award are $650,000. The entire period for this project is July 1, 2017 through June 30, 2021.

Dr. Jian Zhang received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is Regulation of Innate Immune System Sensing of C. Albicans Infections. The total direct costs for this award are $1,395,000. The entire period for this project is April 1, 2016 through March 31, 2021.

Dr. Jian Zhang received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is NEDD4 in T Helper Cell Development and Autoimmunity. The total direct costs for this award are $1,657,000. The entire period for this project is June 20, 2016 through May 31, 2021.

Dr. Jian Zhang received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is Role of Protein Ubiquitination in Sepsis. The total direct costs for this award are $1,125,000. The entire period for this project is June 24, 2016 through May 31, 2021.

Zeb Zacharias, an Immunology Ph.D. student in Dr. Kevin Legge’s laboratory, has been awarded a $2000 Levitt Center Travel Award to present results from his thesis project at the 2017 Annual Meeting of the American Association of Immunologists in Washington D.C. Zeb will present his work focused on regulatory factors that control the magnitude of T cell responses after influenza virus infection.

Dr. Weizhou Zhang received a Oberley Seed Grant Award from the Experimental Therapeutics ET Program within Holden Comprehensive Cancer Center. The title of the project is Targeting mismatch repair in immunotherapy for basal-like breast cancer. The total funding for this award is $20,000 and the project period is April 1, 2017 to March 31, 2018.

Dr. Siegfried “Siggy” Janz, and collaborators Drs. Carol Holman, Xuefang Jing and Ramakrishna “Rama” Sompallae received a Pilot Grant Award from the Holden Comprehensive Cancer Center for studies utilizing the High Throughput Screening Facility. The project will focus on identifying small-compound FOXM1 inhibitors for treatment of myeloma and other FOXM1 driven cancers. The total funding for this award is $10,000 and the project period is March 1, 2017 through February 28, 2018.

Dr. Munir Tanas, and collaborator Dr. Chris Stipp (Biology) received a Pilot Grant Award from the Holden Comprehensive Cancer Center for studies utilizing the High Throughput Screening Facility. The project will focus on identifying small-compound TAZ and YAP inhibitors for treatment of sarcomas and other cancers driven by the Hippo pathway. The total funding for this award is $10,000 and the project period is March 1, 2017 through February 28, 2018.

Dr. Weizhou Zhang and collaborator Dr. Mohammed Milhem (Internal Medicine) received a Pilot Grant Award from the Holden Comprehensive Cancer Center. The title of the project is CD177 defines a new cancer-infiltrating regulatory T cell population. The total funding for this award is $30,000 and the project period is March 1, 2017 through February 28, 2018.

Dr. Weizhou Zhang has been named the recipient of the Kimberly A. Stack Basler Breast Cancer Research Fund. This is a five-year pledge by Philip C. Stack in the amount of $50,000 for Dr. Zhang’s research focused on molecular targets in basal-like breast cancer and the development of novel small molecular inhibitors for therapeutic applications.

Dr. Weizhou Zhang and collaborators Dr. Julia Klesney-Tait (Internal Medicine) Dr. David Meyerholz, Dr. John Harty (Microbiology) and Dr. Alexy Tivanski (Chemistry) received a Team Science Pilot Grant Award from the Institute for Clinical and Translational Science. The title of the project is The role of TREM-1 in lung metastasis. The total funding for this award is $75,000 and the project period is October 1, 2016 through March 31, 2018.

Dr. Bradley Ford and Dr. James McNamara (Internal Medicine) received a Carver Trust Medical Research Initiative Grant. The title of the project is Rapid Antibiotic Resistance Profiling of Uropathogens. The total funding for this award is $30,000 and the project period is February 1, 2017 through March 31, 2019.

Dr. Siegfried “Siggy” Janz, and collaborators Drs. Carol Holman, Xuefang Jing and Ramakrishna “Rama” Sompallae received a Carver Trust Medical Research Initiative Grant. The title of the project is Transgenic Mouse Model of Human KSHV-associated B-lymphocyte Disorders. The total funding for this award is $30,000 and the project period is February 1, 2017 through March 31, 2019.

Dr. Kevin Legge and collaborators Drs. Thomas Waldschmidt and Balaji Narasimhan (Iowa State University) received a Carver Trust Medical Research Initiative Grant. The title of the project is Nanoparticle Vaccination Against Influenza Virus. The total funding for this award is $30,000 and the project period is February 1, 2017 through March 31, 2019.

Dr. Ashutosh Mangalam received a Carver Trust Medical Research Initiative Grant. The title of the project is Deciphering the Mechanism of Obesity Induced Inflammation in Multiple Sclerosis Utilizing Human Leucocyte Antigen (HLA) Class-II Transgenic Mice. The total funding for this award is $30,000 and the project period is February 1, 2017 through March 31, 2019.

Mr. Nick Borcherding received an F30 NRSA Fellowship award from the National Institutes of Health/National Cancer Institute (NIH/NCI). The title of this project is The Role of Paracrine WNT5A/RYK in ErbB2-driven Tumorigenesis. The total funding for this award is $151,513 and the project period is January 1, 2017 through December 31, 2020.

Dr. Siegfried Janz received grant funding from the National Institutes of Health/National Cancer Institute (NIH/NCI). The title of this project is Biological Validation of Candidate Myeloma Driver Genes. The total funding for this award is $1,810,940 and the project period is January 1, 2017 through December 31, 2021.

Dr. Munir Tanas received Merit Award grant funding from the Department of Veteran Affairs. The title of this project is Upstream regulation of TAZ and YAP in sarcomas: towards combinatorial therapy targeting the Hippo Pathway. The total direct costs for this award are $631,572. The entire period for this project is January 1, 2017 through December 31, 2020.

Dr. Siegfried Janz received grant funding from the National Institutes of Health/National Cancer Institute (NIH/NCI). The title of this project is Validation of FOXM1 as a New Therapeutic Target in High-risk Myeloma.The total direct costs for this award are $239,250. The entire period for this project is July 18, 2016 through June 30, 2018.

Dr. Weizhou Zhang received grant funding from the National Institutes of Health/National Cancer Institute (NIH/NCI). The title of this project is CD177 Suppresses Breast-cancer Development by Inhibiting Beta-catenin. The total direct costs for this award are $1,143,750. The entire period for this project is July 1, 2016 through June 30, 2021.

Dr. Fred Dee received grant funding from the Edward J. Stemmler MD Medical Education Research Fund (National Board of Medical Examiners). Dr. Dee is co-principal investigator on the project with Dr. Kristi Ferguson, Director of OCRME. The title of the project is Validation of a Case Diagramming Tool to Assess Higher-Order Thinking Skills. The total direct costs for the grant are $148,000 and the project period is July 2016 through July 2018.

Dr. Nitin Karandikar received grant funding from the National Institute of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is Immune Dysregulation During Multiple Sclerosis Relapse. The total direct costs for this award are $2,401,480. The period for this project is May 19, 2016 through April 30, 2021.

Dr. Kevin Legge received grant funding from the National Institutes of Health/National Institute of Alcohol Abuse and Alcoholism (NIH/NIAAA). The title of this project is Chronic Alcohol Alteration of Influenza-Specific CD8 T Cell Immunity and Protection. This funding total is $397,699 and is for the period of May 5, 2016 and should be complete by April 30, 2018.

Dr. Weizhou Zhang received grant funding from the National Institutes of Health/National Cancer Institute (NIH/NCI). The title of this project is Obesity, Inflammation and Breast Cancer. This funding total is $1,736,951 and is for the period of December 7, 2015 and should be complete by November 30, 2020.

Dr. Steven Moore has a new consulting agreement with Flagship Biosciences, Inc. The agreement total is $7,228. This agreement is for the period of October 20, 2015 through October 20, 2018.

Dr. David Meyerholz has a new research contract negotiated with the Children’s Tumor Foundation for a research project titled The NF1 Porcine Model Collaborative Research Program. The contract total is $931,395. This contract is for the period of October 1, 2015 through October 1, 2018.

Dr. Vladimir Badovinac received grant funding from the National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS). The title of this project is Impairment and Recovery of CD8 T Cell Responses after Sepsis. This funding total is $1,203,872 and is for the period of September 1, 2015 and should be complete by July 31, 2019.

Dr. Hasem Habelhah received grant funding from the US Department of Defense/Congressionally Directed Medical Research Program (DOD/CDMRP). The title of this project is Therapeutic Efficacy of Combined TBK1 and AKT Inhibition in Breast Cancer. This funding total is $531,875 and is for the period of September 1, 2015 and should be complete by August 31, 2018.

Dr. Alexander Boyden, a Postdoctoral Fellow in Dr. Nitin Karandikar’s research lab, was awarded a National Multiple Sclerosis Society Postdoctoral Fellowship.  The title of this project is The role of CD8+ regulatory T cells in modulating B cell function during EAE.  The award total is $161,218 and is for the period of July 1, 2015 and should be complete by June 30, 2018.

Dr. Daniel Diekema has a new research contract negotiated with bioMerieux, Inc. for a research project titled VITEK 2 and VITEK 2 Compact GP18 Antimicrobial Susceptibility Tests. The contract total is $64,000. This contract is for the period of May 1, 2015 through May 11, 2018.

Dr. Ashutosh Mangalam received a notice of grant funding from the National Multiple Sclerosis Society.  The title of this project is Therapeutic potential of combination therapy using Human Gut-derived commensal bacteria and conventional MS drugs.  The amount of this award is $563,264.  The period for this project is April 1, 2015 through March 31, 2018.

Dr. Vladimir Badovinac received a Co-PI grant funding with Dr. John Harty from the Department of Microbiology.  The grant was awarded from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID).  The title of this project is Memory CD8 T cell localization and protection from influenza.   This funding total is $1,900,000 and is for the period of November 1, 2014 and should be complete by October 31, 2019.

Dr. Andrean Simons-Burnett received grant funding from the National Institutes of Health/National Institute of Dental & Craniofacial Research (NIH/NIDCR). The title of this project is Role of inflammation in resistance to EGFR inhibitors in head and neck cancer. This funding total is $1,878,808 and is for the period of July 2, 2014 and should be complete by April 30, 2019.