Aaron D. Bossler, MD, PhD

Portrait
Director, Molecular Pathology Laboratory
Director, Molecular Genetic Pathology Fellowship
Director, Resident Rotation in Molecular Pathology
Clinical Professor of Pathology

Contact Information

Primary Office: C606 General Hospital
Iowa City, IA 52242
319-384-9566

Education

BA, Biochemistry, Columbia University, New York City, NY
MD, University of Iowa Carver College of Medicine, Iowa City, IA
PhD, Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IA

Resident, Clinical Pathology, University of Iowa Carver College of Medicine, Iowa City, IA
Fellow, Molecular Genetic Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA

Licensure and Certifications

Diplomat in Molecular Genetic Pathology - American Board of Pathology
State of Iowa Medical License - Iowa Board of Medicine
Diplomat in Clinical Pathology - American Board of Pathology

Research Summary

Dr. Bossler's clinical service duties include directing the molecular pathology laboratory, developing and validating new, rapid, and cost effective molecular assays for genetic, neoplastic and infectious disease testing, and interpreting and reporting patient results from clinical molecular testing. His research interest is in understanding the mechanisms and pathways which lead to oncogenesis particularly regarding the association of infection with high risk human papillomavirus (HPV) and the development of squamous cell cancer.

Publications

Guseva, N. V., Jaber, O., Stence, A. A., Sompallae, K., Bashir, A., Sompallae, R., Bossler, A. D., Jensen, C. S. & Ma, D. (2018). Simultaneous detection of single-nucleotide variant, deletion/insertion, and fusion in lung and thyroid carcinoma using cytology specimen and an RNA-based next-generation sequencing assay. Cancer cytopathology. PMID: 29364576.

Wessels, D., Lusche, D. F., Voss, E., Kuhl, S., Buchele, E. C., Klemme, M. R., Russell, K. B., Ambrose, J., Soll, B. A., Bossler, A., Milhem, M., Goldman, C. & Soll, D. R. (2017). Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44. PLOS ONE, 12(3), e0173400. DOI: 10.1371/journal.pone.0173400.

Zakharia, Y., Monga, V., Swami, U., Bossler, A. D., Freesmeier, M., Frees, M., Khan, M., Frydenlund, N., Srikantha, R., Vanneste, M., Henry, M. & Milhem, M. (2017). Targeting epigenetics for treatment of BRAF mutated metastatic melanoma with decitabine in combination with vemurafenib: A phase lb study. Oncotarget, 8(51), 89182-89193. PMID: 29179510.

Sabatini, L. M., Mathews, C., Ptak, D., Doshi, S., Tynan, K., Hegde, M. R., Burke, T. L. & Bossler, A. D. (2016). Genomic Sequencing Procedure Microcosting Analysis and Health Economic Cost-Impact Analysis: A Report of the Association for Molecular Pathology. The Journal of molecular diagnostics : JMD, 18(3), 319-28. PMID: 27080370.

Tilak, A., Sompallae, R., Stence, A., Guseva, N. & Bossler, A. (2016). Development of a targeted panel for acute myeloid leukemia (AML) by using next-generation sequencing (NGS). (Vols. 22). (1 Supplement), pp. 01-01. Clinical Cancer Research. DOI: 10.1158/1557-3265.pmsclingen15-01.

Guseva, N. V., Tanas, M. R., Stence, A. A., Sompallae, R., Schade, J. C., Bossler, A. D., Bellizzi, A. M. & Ma, D. (2016). The NAB2-STAT6 gene fusion in solitary fibrous tumor can be reliably detected by anchored multiplexed PCR for targeted next-generation sequencing. Cancer genetics, 209(7-8), 303-12. PMID: 27292373.

Guseva, N. V., Jaber, O., Tanas, M. R., Stence, A. A., Sompallae, R., Schade, J., Fillman, A. N., Miller, B. J., Bossler, A. D. & Ma, D. (2016). Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novel USP6 fusions and upregulation of USP6 expression in aneurysmal bone cyst. Genes, chromosomes & cancer. PMID: 27910166.

Lekostaj, J., Hornberg, S. M., Milhem, M., Bossler, A. D. & Ma, D. (2015). Multi-plexiform mutation analysis of gastrointestinal stromal tumor and histologic-clinical correlation. Boston MA: US and Canadian Academy of Pathology's 104th Annual Meeting.

Keeney, M., Tilak, A., Sompallae, R., Guseva, N. V. & Bossler, A. D. (2015). Potential for Next Generation Sequencing to identify therapeutic targets in EGFR mutation/ALK rearrangement-negative lung cancer. Boston MA: US and Canadian Academy of Pathology's 104th Annual Meeting.

Clamon, G. H., Bossler, A. D., Abu Hejileh, T. A. & Furqan, F. (2015). Germline mutations predisposing to non-small cell lung cancer: A review. Familial Cancer. PMID: 25813228.

Brownstein, C. A., 81 intervening authors, & Bossler, A. D. (2014). An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biology, 15(3), R53. PMID: 24667040.

Ma, D., Stence, A. A., Bossler, A. D., Hackman, J. R. & Bellizzi, A. M. (2014). Identification of KIT activating mutations in paediatric solitary mastocytoma. Histopathology, 64(2), 218-225. PMID: 24128084.

Dhiman, N., Weinberg, A., Bossler, A. D., Cobb, B., Butcher, A., Luk, K., Canchola, J., Ogden, J. & Renenrt, H. (2014). CMV DNA VL Test: A Comparison between Methods at Low CMV DNA Levels. 30th Annual Meeting of the Pan American Society for Clinical Virology, Daytona, FL.

Gao, L., Stence, A. A., Pruessner, J. A., Zubcic, M. T., Guseva, N. V., Hackman, J. R., Forde, S., Darbro, B. W., Jensen, C. S. & Bossler, A. D. (2014). FGFR3 Mutation in Archival Urinary Tract Cytology Specimens: A Simple Method for Detection with Preservation of Cytomorphology. United States & Canadian Academy of Pathology’s 103nd Annual Meeting, March, 2014, San Diego, CA.

Gao, L., Darbro, B. & Bossler, A. D. (2014). FGFR3 Mutational Analysis in Urinary Tract Cytology Specimens with Abnormal UroVysion. Association for Molecular Pathology, 2014 Annual Meeting, Washington, D.C..

Snow, A. N., Stence, A. A., Bossler, A. D. & Ma, D. (2014). A simple and cost-effective method of DNA extraction from small formalin-fixed paraffin-embedded tissue for molecular oncologic testing. BMC Clin Pathol, 14(30). PMID: 25067909.

Gao, L., Stence, A. A., Ma, D. & Bossler, A. D. (2014). Molecular Characterization of High Grade Urothelial Carcinoma by Next Generation Sequencing. Association for Molecular Pathology, 2014 Annual Meeting, Washington, D.C..

Guseva, N. V., Mathur, G., Sompallae, R., Stence, A. A., Casey, S., Tilak, A., Ma, D., Heusel, J. & Bossler, A. D. (2014). Performance and Validation of Tumor mutation profiling using the Personal Genome Machine. Association for Molecular Pathology, 2014 Annual Meeting, Washington, D.C..

Snow, A., Milhem, M. & Bossler, A. D. (2013). Frequent Loss of PTEN and NM23H1 in Melanomas Harboring a BRAF V600E Mutation-Implications for Targeted Therapy. United States & Canadian Academy of Pathology’s 102nd Annual Meeting, Baltimore, MD.

Snow, A. N., Stence, A. A., Pruessner, J., Forde, S., Edler, S., Bossler, A. D. & Ma, D. (2013). A Simple and Cost-Effective Method of DNA Extraction from Small Formalin-Fixed Paraffin-Embedded Tissue for Molecular Oncology Testing: A Practical Approach. Baltimore, MD: United States & Canadian Academy of Pathology’s 102nd Annual Meeting.

Bossler, A. D., Snow, A. N., Wilson, N., Knutson, T., Button, A. & Milhem, M. M. (2013). BRAF and NRAS Mutations in Nodular and Superficial Spreading Melanoma. Association for Molecular Pathology, 2013 Annual Meeting, Phoenix, AZ. Association for Molecular Pathology, 2013 Annual Meeting, Phoenix, AZ.

Bossler, A. D., Caliendo, A. M. (2012). Molecular Methods in Diagnosis and Monitoring of Infectious Diseases. In Burtis , Ashwood , Bruns (Eds.) Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Fifth Edition. pp. 1309-37. Elsevier, New York.

Gunsolly, C. S., Jordan, J. & Bossler, A. D. (2012). Performance of the cobas® 4800 HPV Test on SurePath Cytology Specimens. Association for Molecular Pathology Annual Meeting, Long Beach, CA.

Marko, D. C., Saffert, R. T., Cunningham, S. A., Hyman, J., Walsh, J., Arbefeville, S., Howard, W., Pruessner, J., Safwat, N., Cockerill, F. R., Bossler, A. D., Patel, R. & Richter, S. S. (2012). Evaluation of the Bruker Biotyper and Vitek MS matrix-assisted laser desorption ionization-time of flight mass spectrometry systems for identification of nonfermenting gram-negative bacilli isolated from cultures from cystic fibrosis patients. Journal of clinical microbiology, 50(6), 2034-9. PMID: 22495566.

Caponetti, G. C., Racila, E., Ma, D., Heusel, J. W. & Bossler, A. D. (2012). Improved Detection of the BRAF c.1799T>A (p.V600E) Mutation in Melanoma with a Single Nucleotide Primer Extension Assay. United States and Canadian Academy of Pathology’s 101st Annual Meeting, Vancouver, Canada.

Savage, J. M., Ma, D., Caponetti, G., Bossler, A. D. & Heusel, J. W. (2012). Microsatellite Instability Discordance in Synchronous Colorectal Adenocarcinoma-Evidence for Parallel Oncogenic Pathways Involving Distinct Molecular Mechanisms. Association for Molecular Pathology Annual Meeting, Long Beach, CA.

Ma, D., Caponetti, G., Hackman, J., Heusel, J. W. & Bossler, A. D. (2012). Evaluation of Multiplex Quantitative Measurement of BCR-ABL1 Using the International Reporting Scale. Association for Molecular Pathology Annual Meeting, Long Beach, CA.

Ma, D., Caponetti, G., Heusel, J. W. & Bossler, A. D. (2012). Identification of c-KIT Activating Mutation in Pediatric Isolated Mastocytoma. Association for Molecular Pathology Annual Meeting, Long Beach, CA.

Marko, D. C., Saffert, R. T., Cunningham, S. A., Hyman, J., Walsh, J., Arbefeville, S., Howard, W., Pruessner, J., Safwat, N., Cockerill, F. R., Bossler, A. D., Patel, R. & Richter, S. (2011). Evaluation of the Bruker Biotyper and Axima@Saramis Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) Systems for the Identification of Non-Fermenting Gram Negative Rods (NFGNR) From Cystic Fibrosis (CF) Patients. American Society of Microbiology Annual Meeting.

Arbefeville, S. S., Bossler, A. D. (2011). Human Papillomavirus Infection and ASC-US Triage. In Shrijver (Eds.) Diagnostic Molecular Pathology in Practice. pp. 269-76. Springer-Verlag, Berlin Heidelberg.

Gunsolly, C., Bossler, A. D. (2011). Cobas®4800 Versus Cervista® HPV Test Performance on SurePath™ Cytology Specimens. 27th International Papillomavirus Conference, Berlin.

Arbefeville, S. S., Bossler, A. D. (2011). Bronchiolitis in an Infant; Infection with Human Metapneumovirus. In Shrijver (Eds.) Diagnostic Molecular Pathology in Practice. pp. 307-14. Springer-Verlag, Berlin Heidelberg.

Bossler, A., Gunsolly, C., Pyne, M. T., Rendo, A., Rachel, J., Mills, R., Miller, M., Sipley, J., Hillyard, D., Jenkins, S., Essmyer, C., Young, S., Lewinski, M. & Rennert, H. (2011). Performance of the COBAS® AmpliPrep/COBAS TaqMan® automated system for hepatitis C virus (HCV) quantification in a multi-center comparison. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 50(2), 100-3. PMID: 21145783.

Bossler, A. D., Arbefeville, S. S., Stence, A. A., Pruessner, J. A. & Heusel, J. W. (2011). Comparison of somatic point mutation detection methods in colorectal carcinoma; addressing the challenges of analytical sensitivity. Association for Molecular Pathology, Annual Meeting, Dallas, TX.

Harris, G. F., Bossler, A. D. (2010). PTPN13 expression correlates with survival in HPV-positive HNSCC. In Otolaryngology-Head and Neck Surgery, Vol 143, No 2S2, August 2010. (Vols. 143). (252), pp. Supp p 70. Otolaryngol Head Neck Surg. DOI: doi: 10.1016/j.otohns.2010.06.093.

Shenoy, A. M., Markowitz, J. A., Bonnemann, C. G., Krishnamoorthy, K., Bossler, A. D. & Tseng, B. S. (2010). Muscle-Eye-Brain disease. Journal of clinical neuromuscular disease, 11(3), 124-6. PMID: 20215985.

Tsumagari, K., Chen, D., Hackman, J. R., Bossler, A. D. & Ehrlich, M. (2010). FSH dystrophy and a subtelomeric 4q haplotype: a new assay and associations with disease. Journal of medical genetics, 47(11), 745-51. PMID: 20710047.

Lace, M. J., Anson, J. R., Klingelhutz, A. J., Harada, H., Taniguchi, T., Bossler, A. D., Haugen, T. H. & Turek, L. P. (2009). Interferon-beta treatment increases human papillomavirus early gene transcription and viral plasmid genome replication by activating interferon regulatory factor (IRF)-1. Carcinogenesis, 30(8), 1336-44. PMID: 19541854.

Lace, M. J., Anson, J. R., Klingelhutz, A. J., Lee, J. H., Bossler, A. D., Haugen, T. H. & Turek, L. P. (2009). Human papillomavirus (HPV) type 18 induces extended growth in primary human cervical, tonsillar, or foreskin keratinocytes more effectively than other high-risk mucosal HPVs. Journal of virology, 83(22), 11784-94. PMID: 19740985.

Hoover, A. C., Strand, G. L., Nowicki, P. N., Anderson, M. E., Vermeer, P. D., Klingelhutz, A. J., Bossler, A. D., Pottala, J. V., Hendriks, W. J. & Lee, J. H. (2009). Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway. Oncogene, 28(45), 3960-70. PMID: 19734941.

Gunsolly, C. S., Jordan, J. & Bossler, A. D. (2009). Performance evaluation of the cobas® 4800 HPV Test on SurePath Cytology Specimens. Association for Molecular Pathology, Annual Meeting, Kissimmee, FL.

Harris, G. F., Strand, G., Gunsolly, C. S., Lee, J. H. & Bossler, A. D. (2009). Pilot study to assess correlation of expression of PTPN13 in HPV-positive HNSCC with patient survival. Otolaryngology Resident Research Day, University of Iowa.

Arbefeville, S. S., Junkins, A. D., Nasr, M. R., Richter, S. S. & Bossler, A. D. (2009). Implementation of 16S rRNA Gene Sequencing for Bacterial Identification in the Clinical Microbiology Laboratory. Department of Pathology Research Day.

Arbefeville, S. S., Junkins, A. D., Nasr, M. R., Richter, S. S. & Bossler, A. D. (2009). Implementation of 16S rRNA Gene Sequencing for Bacterial Identification in the Clinical Microbiology Laboratory. American Society of Microbiology, Annual Meeting, Philadelphia, PA.

Gunsolly, C., Bossler, A. D. (2009). Performance Evaluation of the COBAS® Ampliprep/COBAS® TaqMan® HCV Test. University of Iowa, 2008, Department of Pathology Research Day and Research Week.

Gunsolly, C. S., Jordan, J. & Bossler, A. D. (2009). Performance of the cobas® 4800 HPV Test on SurePath Cytology Specimens. University of Iowa, Department of Pathology Research Day.

Spanos, W. C., Hoover, A., Harris, G. F., Wu, S., Strand, G. L., Anderson, M. E., Klingelhutz, A. J., Hendriks, W., Bossler, A. D. & Lee, J. H. (2008). The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth. Journal of virology, 82(5), 2493-500. PMID: 18160445.

Strand, G., Gunsolly, C., Hoover, A., Anderson, M., Lee, J. & Bossler, A. D. (2008). Role of PTPN13 in HPV related head and neck cancer. University of Iowa, College of Medicine; Research Week.

Spanos, W. C., Geiger, J., Anderson, M. E., Harris, G. F., Bossler, A. D., Smith, R. B., Klingelhutz, A. J. & Lee, J. H. (2008). Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells. Head & neck, 30(2), 139-47. PMID: 17657785.

Nowicki, P., De Geest, K., Goodheart, M., Strand, G., Bossler, A. D. & Lee, J. H. (2008). Protein tyrosine phosphatase (PTPN13) as a novel tumor suppressor in cervical carcinoma. University of Iowa, College of Medicine; Research Week.

Strand, G., Gunsolly, C. S., Hoover, A., Anderson, M. E., Kuragp, Z. B., Klingelhutz, A. J., Lee, j. H. & Bossler, A. D. (2008). Loss of PTPN13 correlates with a subset of HPV positive oropharyngeal cancers. Molecular Biology of DNA Tumor Viruses, Madison, WI.

Strand, G., Gunsolly, C. S., Hoover, A., Anderson, M. E., Kurago, Z. B., Klingelhutz, A. J., Lee, j. H. & Bossler, A. D. (2008). Loss of PTPN13 correlates with a subset of HPV positive oropharyngeal cancers. and University of Iowa, Department of Pathology Research Day.

VanDeerlin, V., Bossler, A. D. (2008). Conventional and Real Time PCR. In , Tubbs , Stoler (Eds.) Foundations in Diagnostic Pathology: Cell and Tissue Based Molecular Diagnostics, First Edition. pp. 33-49. Elsevier, New York .

Hoover, A., Strand, G., Nowicki, P., Anderson, M. E., Klingelhutz, A. J., Bossler, A. D. & Lee, J. H. (2008). An Invasion Mechanism for HPV Related Cancers: HPV 16 E6 Degrades PTPN13 Allowing Enhanced MAP Kinase Signaling. Molecular Biology of DNA Tumor Viruses, Madison, WI.

Bernardino, L. P., Nagy, P. N., Bossler, A. D. & Heusel, J. W. (2008). Simultaneous Detection of FLT3-ITD, FLT3-D835 and NPM1 mutations in AML. Association for Molecular Pathology, Annual Meeting.

Nikiforova, M., Unger, E., Bossler, A. D. & VanDeerlin, V. V. (2008). Update to "Molecular Pathology: Introduction to DNA Technology and Diagnostic Applications". CAP Education by the Experts.

Barker, S. D., McCormick, R., Bedi, j., Bossler, A. D., Schneider, E. & Kalman, L. (2008). New Foci for the Genetic Testing Reference Material (GeT-RM) Program: Molecular Oncology and Infectious Disease. Association for Molecular Pathology Annual Meeting.

Barker, S. D., McCormick, R., Bedi, j., Bossler, A. D., Schneider, E. & Kalman, L. (2008). New Foci for the Genetic Testing Reference Material (GeT-RM) Program: Molecular Oncology and Infectious Disease. University of Iowa, Department of Pathology Research Day.

Gunsolly, C., Bossler, A. D. (2008). Performance Evaluation of the COBAS® Ampliprep/COBAS® TaqMan® HCV Test. Association for Molecular Pathology, Annual Meeting.

Strand, G., Gunsolly, C., Anderson, M., Klingelhutz, A., Lee, J. & Bossler, A. D. (2007). Loss of PTPN13 expression correlates with a subset of HPV positive squamous cell carcinomas of the oropharynx. University of Iowa, Department of Pathology Research Day.

Wang, H. Y., Bossler, A. D., Schaffer, A., Tomczak, E., DiPatri, D., Frank, D. M., Nowell, P. C. & Bagg, A. (2007). A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma. Cancer genetics and cytogenetics, 172(1), 45-53. PMID: 17175379.

Bossler, A. D., Richards, J., George, C., Godmilow, L. & Ganguly, A. (2006). Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype. Human mutation, 27(7), 667-75. PMID: 16752392.

Link, B. K., Ballas, Z. K., Weisdorf, D., Wooldridge, J. E., Bossler, A. D., Shannon, M., Rasmussen, W. L., Krieg, A. M. & Weiner, G. J. (2006). Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma. Journal of immunotherapy, 29(5), 558-68. PMID: 16971811.

Gunsolly, C., Erwin, M., Strand, G., Richter, S. & Bossler, A. D. (2006). Comparison of rRNA gene sequencing with traditional biochemical testing for identification of unusual bacteria. University of Iowa, Department of Pathology Research Day.

Bossler, A. D., Strubinger, J., Gilmar, C. & Van Deerlin, V. (2006). Clinical laboratory testing for viral respiratory pathogens using real-time PCR is sensitive and rapid. Association for Molecular Pathology Annual Meeting.

Nikiforova, M., Unger, E., Bossler, A. D. & VanDeerlin, V. V. (2005). Molecular Pathology: Introduction to DNA Technology and Diagnostic Applications. CAP Education by the Experts.

Bossler, A. D., George, C., Richards, J., Godmilow, L. & Ganguly, A. (2005). Results from a clinical molecular screening program for hereditary hemorrhagic telangiectasia. Association for Molecular Pathology Annual Meeting.

Bossler, A. D., Edler, S. L., Forde, S., Stence, A. A., Cooper, L. C., Murphy, K. M., Kemp, J. D., Kirby, P. & Heusel, J. W. (2004). Comparison of PCR-based methods for detection of chromosome 1p and 19q deletions in oligodendrogliomas. Association for Molecular Pathology, Annual Meeting.

Soares, M. B., Malchenko, M. F., Martin, J., Kucaba, T., Scheetz, T., Brown, B., Smothers, A., Huang, J., Kuo, S., Manzella, L., Koroleva, I., Bossler, A. D., DeYoung, B., Seftor, E., Gitelis, S., Hohl, R., Buckwalter, J. A., Hendrix, M., Casavant, T. & Morcuende, J. A. (2003). Development of a comprehensive non-redundant collection of cDNAs/ESTs from human chondrosarcoma primary tumors and metastatic lung lesions. American Association for Cancer Research, Annual Meeting.

Bossler, A. D., Richter, S. S., Chavez, A. J., Vogelgesang, S. A., Sutton, D. A., Grooters, A. M., Rinaldi, M. G., de Hoog, G. S. & Pfaller, M. A. (2003). Exophiala oligosperma causing olecranon bursitis. Journal of clinical microbiology, 41(10), 4779-82. PMID: 14532219.

Bossler, A. D., Richter, S. S., Chavez, A. J., Sutton, D. A., Grooters, A. M., Rinaldi, M., deHoog, G. S. & Pfaller, M. A. (2002). Melanchlenus oligospermus and Prototheca wickerhamii causing olecranon bursitis. American Society of Microbiology, Annual Meeting. Salt Lake City, UT.

Bossler, A. D., Kellokoski, J., Lace, M. J., Jäkel, K. T., Anson, J. R., Hubert, W., Haugen, T. H., Mitchell, P. J. & Turek, L. P. (2000). Cooperation of activator protein (AP)-2 alpha and transcriptional enhancer factor (TEF)-1 is necessary for the keratinocyte-dependent transcription and the establishment of infection by HPV types 16 and 31. Experimental Biology, F.A.S.E.B Meeting, San Diego, CA.

Bossler, A. D. (2000). Thesis: Keratinocyte-dependent regulation of the human papillomavirus oncogenes.

Bossler, A. D., Kellokoski, J., Lace, M. J., Jäkel, K. T., Anson, J. R., Hubert, W., Haugen, T. H., Mitchell, P. J. & Turek, L. P. (1999). Cooperation of activator protein (AP)-2 alpha and transcriptional enhancer factor (TEF)-1 is necessary for the keratinocyte-dependent transcription and the establishment of infection by HPV types 16 and 31. Imperial Cancer Research Fund DNA Tumour Virus Meeting, Cambridge, UK.

Bossler, A. D., Kellokoski, J., Lace, M. J., Jäkel, K. T., Anson, J. R., Hubert, W., Haugen, T. H., Mitchell, P. J. & Turek, L. P. (1999). Cooperation of activator protein (AP)-2 and transcriptional enhancer factor (TEF)-1 is necessary for the keratinocyte-dependent transcription and the initial DNA replication of HPV types 16 and 31. 17th International Papillomavirus Conference, Charleston, SC.

Bossler, A. D., Kellokoski, J., Lace, M. J., Jäkel, K. T., Anson, J. R., Hubert, W., Haugen, T. H., Mitchell, P. J. & Turek, L. P. (1998). Cooperation of activator protein (AP)-2 alpha and transcriptional enhancer factor (TEF)-1 is necessary for the keratinocyte-dependent transcription of human papillomavirus (HPV)-16. Molecular Biology of Small DNA Tumor Viruses, Madison, WI.

Bossler, A. D., Kellokoski, J., Lace, M. J., Jäkel, K. T., Anson, J. R., Hubert, W., Haugen, T. H., Mitchell, P. J. & Turek, L. P. (1998). Cooperation of activator protein (AP)-2 alpha and transcriptional enhancer factor (TEF)-1 is necessary for the keratinocyte-dependent transcription of human papillomavirus (HPV)-16. The 13th Annual National M.D./Ph.D. Student Conference, Aspen, CO.

Bossler, A. D., Kellokoski, J., Lace, M. J., Jäkel, K. T., Anson, J. R., Hubert, W., Haugen, T. H., Mitchell, P. J. & Turek, L. P. (1997). Cooperation of activator protein (AP)-2 and transcriptional enhancer factor (TEF)-1 is necessary and sufficient for the keratinocyte-dependent activation of a viral cis-element and necessary for E6-E7 promoter activity of HPV-16. 16th International Papillomavirus Conference, Siena, Italy.

Bulinski, J. C., Bossler, A. D. (1994). Purification and characterization of ensconsin, a novel microtubule stabilizing protein. Journal of cell science, 107, 2839-49. PMID: 7876351.